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Combination of p-Coumaric acid and lactoferrin ameliorates cognitive deficits through suppressing C/EBPβ/AEP pathway and modulating intestinal flora in APP/PS1 mice

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Food Science and Human Wellness 2024年

作者： Yan Zhou Yi-Tian Sun Hui Guo Yan-zi Liang Si-Yuan Zhu Yu Sha Zhong-Xiao Wan Jia-Ying xu Jian-Rong Jiang Li-Qiang Qin Yun-Hong Li Department of Nutrition and Food Hygiene， School of Public Health， Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases， MOE Key Laboratory of Geriatric Diseases and Immunology， Suzhou Medical college of Soochow University Department of Medical Technology， Suzhou Vocational Health College State Key Laboratory of Radiation Medicine and Protection， School of Radiation Medicine and Protection， Suzhou Medical college of Soochow University Suzhou Municipal Center for Disease Control and Prevention

Alzheimer's disease （AD） has become an important public health issue worldwide. P-Coumaric acid （CA） and lactoferrin （Lf） possessed antioxidant， anti-inflammatory， and anti-AD activities. Herein， we hypothesized that a combination treatment of CA and Lf would synergistically improve AD symptoms and studied its mechanisms. Twelve-week-old APP/PS1 mice were treated with CA， Lf， or both CA and Lf for 8 weeks. Results showed that individual and combined treatments could ameliorate cognitive deficits to varying degrees， with stronger effects for combined intervention than for CA or Lf alone. Specifically， combined treatment was most effective in improving nesting ability and reducing Aβ1-42deposition in mice. Moreover， combined treatment was more effective in suppressing APP， BACE1， and inflammation; it inhibited the CCAAT-enhancer-binding protein （C/EBPβ）/asparagine endopeptidase （AEP） signaling pathway in the hippocampus and colon and upregulated the expression of tight junction protein ZO-1 in the colon; it also decreased the F/B ratio at the phylum level and increased the relative abundance of Prevotellaceae， Lachnospira， and Eubacterium at the genus level. Overall， the combination of CA and Lf may ameliorate cognitive deficits in APP/PS1 mice by improving inflammation and inhibiting the C/EBPβ/AEP signaling pathway via modulating gut microbiome.

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关于国密算法SM2的模乘优化方法

密码学报（中英文） 2024年第3期11卷 649-661页

作者：于子钦许光午山东大学密码技术与信息安全教育部重点实验室青岛266237 山东大学网络空间安全学院青岛266237 山东区块链研究院济南250101 泉城实验室济南250103

为了提高运算效率,密码学中一些标准的椭圆曲线所在的基域特征常为广义Mersenne素数,如NIST曲线P-256和国密SM2.在基本算术运算中,这样特殊的素数使得影响最大的模乘运算变得非常高效.对于P-256,Brown等利用Solinas方法设计的快速模约... 详细信息

为了提高运算效率,密码学中一些标准的椭圆曲线所在的基域特征常为广义Mersenne素数,如NIST曲线P-256和国密SM2.在基本算术运算中,这样特殊的素数使得影响最大的模乘运算变得非常高效.对于P-256,Brown等利用Solinas方法设计的快速模约减算法可以归结成计算9个由字的向量组成的中间变量的代数和.对于SM2也有一些相关研究,但情况似乎没有那么简单.目前这方面最好的结果需要14个(字的向量组成的)中间变量.本文的目的是推进SM2素域上的快速模乘运算,以期得到接近NIST P-256的模约减算法.具体地,本文提出了两个优化方法.在第一个结果中,就SM2素数的情形加细了Solinas和Brown等人的处理方法,所需的(字的向量的)中间变量个数降低到13.在第二个结果中,采用一种新的处理技巧,通过对运算公式进行适当变换来消去变量以进一步优化,得到的方法只需11个(字的向量的)中间变量.

关键词： SM2椭圆曲线快速模乘广义Mersenne素数

Revealing interaction of pyridinic N in N-doped carbon with Sn sites for improved CO2 reduction

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Rare Metals 2024年第11期 6096-6104页

作者： Hui-Juan Yang xu-Hong Yan Cheng Yan zi-Qin Min Lei Chai Chun-Ran Wang Li-Na Chen Wei Xiao Tao Wang Chong Xie Da-Wei Pang Xi-Fei Li School of Key Laboratory of Advanced Batteries Materials for Electrie Vehicles of China Petroleum and Chemical Industry Federation Institute of Advanced Electrochemical Energy and School of Materials Science and EngineeringXi'an University of Technology Department of Chemistry University of Oxford Tan Kah Kee Innovation Laboratory College of Chemistry and Chemical EngineeringXiamen University Beijing Key Laboratory of Microstructure and Property of Advanced Materials Faculty of Materials and Manufacturing Beijing University of Technology

N-doped carbon （NC） materials have emerged as attractive supports for metal-based catalysts,enhancing their catalytic performance through the metal-support ***,gaining fundamental insights into the metalsupport interaction between NC support and Sn metal sites for improving the electrocatalytic CO2reduction reaction（CO2RR） performance remains challenging.

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Optical facet coatings for high-performance LWIR quantum cascade lasers atλ∼8.5μm

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红外与毫米波学报 2024年第4期43卷 497-502页

作者： MA Yuan LIN Yu-Zhe WAN Chen-Yang WANG zi-Xian ZHOU xu-Yan ZHANG Jin-Chuan LIU Feng-Qi ZHENG Wan-Hua Laboratory of Solid-State Optoelectronics Information Technology Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Weifang Academy of Advanced Opto-Electronic Circuits Weifang 261021China

We report on the performance improvement of long-wave infrared quantum cascade lasers(LWIR QCLs)by studying and optimizing the anti-reflection(AR)optical facet *** to the Al2O3 AR coat⁃ing,the Y_(2)O_(3)AR coating exhibits higher catastrophic optical mirror damage(COMD)level,and the optical facet coatings of both material systems have no beam steering effect.A 3-mm-long,9.5-μm-wide buried-heterostruc⁃ture(BH)LWIR QCL ofλ~8.5μm with Y_(2)O_(3)metallic high-reflection(HR)and AR of~0.2%reflectivity coating demonstrates a maximum pulsed peak power of 2.19 W at 298 K,which is 149%higher than that of the uncoated *** continuous-wave(CW)operation,by optimizing the reflectivity of the Y_(2)O_(3)AR coating,the maximum output power reaches 0.73 W,which is 91%higher than that of the uncoated device.

关键词： quantum cascade lasers long-wave infrared optical facet coatings catastrophic optical mirror damage

OsNLP3 enhances grain weight and reduces grain chalkiness in rice

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Plant Communications 2024年第10期5卷 82-99页

作者： Liang-Qi Sun Yu Bai Jie Wu Shi-Jun Fan Si-Yan Chen Zheng-Yi Zhang Jin-Qiu Xia Shi-Mei Wang Yu-Ping Wang Peng Qin Shi-Gui Li Ping xu Zhong Zhao ChengBin Xiang zi-Sheng Zhang Division of Life Sciences and Medicine Division of Molecular&Cell BiophysicsHefei National Science Center for Interdisciplinary Sciences at the MicroscaleUniversity of Science and Technology of ChinaThe Innovation Academy of Seed DesignChinese Academy of SciencesHefeiAnhui Province 230027China Experimental Center of Engineering and Materials Science University of Science and Technology of ChinaHefei 230027China Rice Research Institute Anhui Academy of Agricultural ScienceHefeiChina State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Rice Research InstituteSichuan Agricultural UniversityChengduSichuanChina Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterChinese Academy of SciencesShanghaiChina

Grain weight,a key determinant of yield in rice(Oryza sativa L.),is governed primarily by genetic factors,whereas grain chalkiness,a detriment to grain quality,is intertwined with environmental factors such as mineral ***(N)is recognized for its effect on grain chalkiness,but the underlying molecular mechanisms remain to be *** study revealed the pivotal role of rice NODULE INCEPTION-LIKE PROTEIN 3(OsNLP3)in simultaneously regulating grain weight and grain *** investigation showed that loss of OsNLP3 leads to a reduction in both grain weight and dimension,in contrast to the enhancement observed with OsNLP3 ***3 directly suppresses the expression of OsCEP6.1 and OsNF-YA8,which were identified as negative regulators associated with grain ***,two novel regulatory modules,OsNLP3-OsCEP6.1 and OsNLP3-OsNF-YA8,were identified as key players in grain weight ***,the OsNLP3-OsNF-YA8 module not only increases grain weight but also mitigates grain chalkiness in response to *** research clarifies the molecular mechanisms that orchestrate grain weight through the OsNLP3-OsCEP6.1 and OsNLP3-OsNF-YA8 modules,highlighting the pivotal role of the OsNLP3-OsNF-YA8 module in alleviating grain *** findings reveal potential targets for simultaneous enhancement of rice yield and quality.

关键词： OsNLP3 OsCEP6.1 OsNF-YA8 grain weight grain chalkiness rice Oryza sativa L.

基于敏感度分析的单自由度Stephenson机构多目标轨迹综合方法

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机械工程学报 2024年第5期60卷 59-69页

作者：赵萍张涯婷程悦徐宏伟訾斌合肥工业大学机械工程学院合肥230009

单自由度机构控制简单、稳定性强,但只能实现一个特定的运动形式。因此提出多模式单自由度六杆Stephenson机构设计方法,使其在保留单自由度机构优点的同时,能够通过选定的可调参数来实现多个目标轨迹。对单自由度Stephenson机构进行了... 详细信息

单自由度机构控制简单、稳定性强,但只能实现一个特定的运动形式。因此提出多模式单自由度六杆Stephenson机构设计方法,使其在保留单自由度机构优点的同时,能够通过选定的可调参数来实现多个目标轨迹。对单自由度Stephenson机构进行了运动分析,并结合其运动学方程,对九个杆长设计参数实施了敏感度分析,明确不同设计参数的变化趋势对末端生成轨迹的影响。依据轨迹变化趋势的差异化程度设计评价函数,构建不同可调参数的分析与对比方法,并以来自不同人群的多条下肢步态轨迹综合为例,通过敏感度分析及评价函数值对比,确定l_(6)为最优的可调设计参数,进行多模式Stephenson六杆机构的多目标轨迹综合和参数设计。结果表明,通过调节l_(6)杆长参数,三条目标轨迹均可在该单自由度机构上得到较好实现。对该多模式单自由度Stephenson机构进一步分析表明,其运动学性能良好,以此机构为执行器设计下肢步态康复装置,不仅结构简单、控制方便,还能对不同的目标人群都具有较好的适应性。

关键词：单自由度机构敏感度分析轨迹综合康复机构设计

基于香气与滋味物质特征分析不同干燥方式美味牛肝菌的风味差异

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食品科学 2024年第11期45卷 163-174页

作者：李为兰杨豪资璐熙徐柠檬郭磊西南林业大学生物与食品工程学院云南昆明650224

为了解不同干燥方式美味牛肝菌干制品的风味与滋味特征,探究不同干制方法之间的风味差异,对热风干燥、真空冷冻干燥及真空干燥美味牛肝菌的挥发性风味物质与非挥发性滋味物质进行测定分析。气相色谱-离子迁移谱(gas chromatography-ion ... 详细信息

为了解不同干燥方式美味牛肝菌干制品的风味与滋味特征,探究不同干制方法之间的风味差异,对热风干燥、真空冷冻干燥及真空干燥美味牛肝菌的挥发性风味物质与非挥发性滋味物质进行测定分析。气相色谱-离子迁移谱(gas chromatography-ion mobility spectrometry,GC-IMS)和气相色谱-质谱(gas chromatography-mass spectrometry,GC-MS)分别定性64、85种挥发性有机物;指纹图谱分析结果表明,不同干制方法处理组间存在较大差异,真空干燥组的差异特征最为显著;正交偏最小二乘判别分析从GC-IMS结果中筛选出17个差异特征标记物,GC-MS中筛选出22个,结合相对气味活度值进一步分析可知,1-辛烯-3-醇为关键挥发性有机物。非挥发性滋味物质分析结果表明,游离氨基酸与5’-核苷酸在热风干燥组中含量最大,分别为234.57 mg/g和27.870 mg/g;16种游离氨基酸中谷氨酸是呈鲜味的主要成分。综上,热风干燥更有利于美味牛肝菌中滋味物质的积累,真空干燥更利于风味物质的产生和积累。本研究表征3种干制方法的风味特征,可为新鲜美味牛肝菌采后干制加工工艺的选择提供参考。

关键词：美味牛肝菌干燥方式挥发性有机物指纹图谱滋味物质

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2024年

作者： Shuai Liu Wen-Qiang xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo zi-Fei xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase SpeF and P450 monooxygenase SpeG, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, SpeF/SpeG metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-mA with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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基于“脾-内质网相关”学说探讨巨噬细胞焦亡与动脉粥样硬化相关性

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中国中药杂志 2024年第16期49卷 4532-4536页

作者：谭咪刘悦徐宁阳韩晓萌赵誉刘粽蔡媛媛李子威徐子鉴辽宁中医药大学辽宁沈阳110847

动脉粥样硬化(AS)的中医发病关键在于脾虚所致痰瘀互结,现代医学认为细胞焦亡可导致动脉粥样硬化,而内质网应激已被研究证明促进细胞焦亡的发生。基于“脾-内质网相关”学说,以脾主运化及内质网健运蛋白功能为导向,认为脾虚所致痰瘀互... 详细信息

动脉粥样硬化(AS)的中医发病关键在于脾虚所致痰瘀互结,现代医学认为细胞焦亡可导致动脉粥样硬化,而内质网应激已被研究证明促进细胞焦亡的发生。基于“脾-内质网相关”学说,以脾主运化及内质网健运蛋白功能为导向,认为脾虚所致痰瘀互结与内质网应激导致巨噬细胞焦亡促进炎症反应加速AS进展有共通之处。因此,该文深入探究脾虚所致痰瘀互结与内质网应激介导细胞焦亡的关联,从现代医学角度探讨中医脾虚痰瘀互结影响AS的分子机制,有助于丰富“脾-内质网相关”学说,为中医以健脾祛痰化瘀法防治AS提供科研思路,为临床应用健脾中药治疗AS提供丰富的理论基础。

关键词：脾-内质网相关细胞焦亡动脉粥样硬化