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Anti-osteosarcoma trimodal synergistic therapy using NiFe-LDH and MXene nanocomposite for enhanced biocompatibility and efficacy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1329-1344页

作者： yani xu Lan Yang Min Li Haozhou Shu Na Jia Yunzhen Gao Rongying Shi Xiaojia Yang Zhirong Zhang Ling Zhang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Osteosarcoma is usually resistant to immunotherapy and,thus primarily relies on surgical resection and high-dosage ***,less invasive or toxic therapies such as photothermal therapy(PTT)and chemodynamic therapy(CDT)generally failed to show satisfactory *** multimodal therapies with proper safety profiles may provide better solutions for ***,a simple nanocomposite that synergistically combines CDT,PTT,and chemotherapy for osteosarcoma treatment was *** this composite,small 2D Ni Fe-LDH flakes were processed into 3D hollow nanospheres via template methods to encapsulate 5-Fluorouracil(5-FU)with high loading *** nanospheres were then adsorbed onto larger 2D Ti3C2MXene monolayers and finally shielded by bovine serum albumin(BSA)to form 5-FU@Ni Fe-LDH/Ti3C2/BSA nanoplatforms(5NiTiB).Both in vitro and in vivo data demonstrated that the 5-FU induced chemotherapy,Ni Fe-LDH driven chemodynamic effects,and MXene-based photothermal killing collectively exhibited a synergistic“all-in-one”anti-tumor effect.5NiTiB improved tumor suppression rate from<5%by 5-FU alone to~80.1%.This nanotherapeutic platform achieved higher therapeutic efficacy with a lower agent dose,thereby minimizing side ***,the composite is simple to produce,enabling the fine-tuning of dosages to suit different ***,the platform is versatile and efficient,with potential for further development.

关键词： Osteosarcoma NiFe-LDH MXene Chemodynamic therapy Photothermal therapy Chemotherapy 5-Fluorouracil Nanocomposite

Efficiency and safety of acupuncture for women with premature ovarian insufficiency:study protocol for a randomized controlled trial

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Journal of Traditional Chinese Medicine 2023年第6期43卷 1268-1274页

作者： xu yani ZHANG Yutong HE Weile DAI Linglin TANG Ding WANG Jialing ZHANG xufen CHEN Qin CHEN Lifang WANG Zhanglian ZHAN Mingjie the Third School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Acupuncture the Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310005China

Acupuncture has been widely used as an alternative and complementary therapy for premature ovarian insufficiency(POI)in ***,research to date has not shown that acupuncture is effective for POI compared with hormone replacement therapy(HRT).We will conduct a randomized,controlled,and outcome assessor-blind trial to evaluate the efficacy and safety of acupuncture on ***-six patients with POI will be randomly assigned to two *** treatment group will receive twenty-eight one-hour sessions of acupuncture treatments,and the control group will receive 12-week *** whole study will consist of a 12-week treatment plan and a 12-week follow-up *** primary outcome is measured by changes in serum anti-Müllerian hormone and follicle-stimulating hormone(FSH)levels at weeks 12 and *** outcome measures include estradiol,luteinizing hormone(LH),LH/FSH ratio,Kupperman index,and menstrual *** trial is expected to clarify whether or not acupuncture is effective and safe for POI compared with HRT.

关键词： acupuncture primary ovarian insufficiency hormone replacement therapy randomized controlled trial study protocols

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Research on Control System of Quadrotor based on ADRC

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Research on Control System of Quadrotor based on ADRC

Bridge Crack Image Segmentation Based on Improved Watershed Algorithm

第30届中国控制与决策会议

作者： yani xu Wenguang Luo Liang Zhang School of Electrical & Information Engineering Guangxi University of Science & Technology

In this paper, the hardware and software systems for quadrotors are discussed. Because quadrotors are susceptible to outside interference, the auto-disturbance rejection controller(ADRC) is proposed to control quadrotor. The control effect of ADRC is compared with that of cascade PID controller. Experimental results show that ADRC can realize the attitude control of quadrotor with stronger robustness.

关键词： Quadrotor ADRC Interference and Robustness

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Bridge Crack Image Segmentation Based on Improved Watershed ...

第30届中国控制与决策会议

作者： Liang Zhang Wenguang Luo yani xu School of Electrical and Information Engineering Guangxi University of Science and Technology

In order to solve the problem of over-segmentation of bridge fractures by the watershed algorithm, an improved watershed segmentation algorithm based on threshold marker is proposed. Firstly, the original gradient image is obtained from the gray image by using morphological operation, and the second-order Butterworth low-pass filtering is performed on the original gradient image to obtain the low-frequency component of the gradient image. And then apply the best threshold for the use of Otsu method to be applied to the morphological extended minimum transform technique, and the technique is used to extract the local minimum value which is highly correlated with the bridge crack feature information from the low frequency components of the gradient image;Finally, the original gradient image is used to compose the minimum gradient of the original gradient image to obtain the modified gradient image, and watershed segmentation is performed on these gradient images. The experimental results show that the crack image of the bridge is accurate and clear, and the over-segmentation phenomenon is effectively reduced.

关键词： Bridge Crack Watershed Algorithm Butterworth Low-pass Filter Over-segmentation Local Minimum

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重点区域入侵安防设备系统可靠性建模方法

北京航空航天大学学报 2017年第7期43卷 1403-1409页

作者：查国清徐亚妮康锐北京航空航天大学可靠性与系统工程学院北京100083 北京航空航天大学航空科学与工程学院北京100083

为了评估重点区域入侵安防系统设备可靠度,首先给出了重点区域安防系统可靠度的定义,以收集到的安防设备故障信息为基础,对这些数据进行指数分布检验与估计,得出安防设备的故障分布。然后对重点区域中各子区域以及安防系统中各类设备的... 详细信息

为了评估重点区域入侵安防系统设备可靠度,首先给出了重点区域安防系统可靠度的定义,以收集到的安防设备故障信息为基础,对这些数据进行指数分布检验与估计,得出安防设备的故障分布。然后对重点区域中各子区域以及安防系统中各类设备的具体功能进行分析,描述了区域及设备功能间的备份关系以及区域间、区域与设备间的可靠性关系,建立重点区域安防系统、子区域与设备的可靠性框图模型,运用混联可靠性框图计算方法得出重点区域安防系统可靠度。最后进行了实例验证,表明该模型可方便计算重点区域入侵安防系统的可靠度,验证了模型的有效性。

关键词：安防系统入侵报警可靠性分析可靠性框图串并混联

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泉州线上供应链金融发展探究

重庆交通大学学报（社会科学版） 2020年第5期20卷 50-55页

作者：许雅妮黎明职业大学福建泉州362000

线上供应链金融成为当前疫情下助力中小企业融资的重要方式。泉州线上供应链金融发展较快,总结概括泉州的三种供应链金融模式为银行自建平台型供应链金融模式、产业集群供应链平台+金融模式和接入国家级供应链金融平台模式;分析线上供... 详细信息

线上供应链金融成为当前疫情下助力中小企业融资的重要方式。泉州线上供应链金融发展较快,总结概括泉州的三种供应链金融模式为银行自建平台型供应链金融模式、产业集群供应链平台+金融模式和接入国家级供应链金融平台模式;分析线上供应链金融发展中存在供应链金融模式单一、融资平台和产品较少、风控能力较弱等主要问题;分别从平台建设、激发供应链金融主体活力及完善风控体系等方面提出对策。

关键词：线上供应链金融融资模式融资平台

一种用于射频识别阅读器的双频宽带圆极化天线

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电子与信息学报 2024年第3期46卷 960-966页

作者：王丽黎高智勇杜忠红徐亚妮西安理工大学自动化与信息工程学院西安710048 西安市无线光通信与网络研究重点实验室西安710048

该文设计了一种紧凑的用作射频识别(RFID)阅读器的双频宽带圆极化天线。天线由弯折处理的矩形贴片、L形贴片和三角形地板构成,通过微带线进行馈电。两个辐射贴片分别独立控制高低两个频段,其轴比带宽也可独立调整,三角形地板可以使横向... 详细信息

该文设计了一种紧凑的用作射频识别(RFID)阅读器的双频宽带圆极化天线。天线由弯折处理的矩形贴片、L形贴片和三角形地板构成,通过微带线进行馈电。两个辐射贴片分别独立控制高低两个频段,其轴比带宽也可独立调整,三角形地板可以使横向电流和纵向电流发生变化,从而改变横向电流和纵向电流的比值大小,实现圆极化性能。天线尺寸为0.92λ_(0)×0.92λ_(0)×0.0064λ_(0)(λ_(0)为2.40 GHz时的自由空间波长)。测试结果表明在超高频(UHF)频段该天线实现了49%(0.77~1.27 GHz)的阻抗带宽和46%(0.84~1.34 GHz)的轴比带宽,在无线局域网(WLAN)频段实现了47.5%(1.54~2.50 GHz)的阻抗带宽和24.2%(1.96~2.50 GHz)的轴比带宽,可以完整覆盖UHF和WLAN两个频段,具有良好的辐射特性。与其他双频圆极化天线相比,该天线整体结构紧凑、设计简单、避免了使用复杂的馈电网络,且具有较宽的3 dB轴比带宽。

关键词：双频段宽带射频识别阅读器天线圆极化天线

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儒家思想与马克思主义的理论特质及结合路径

安徽冶金科技职业学院学报 2024年第3期34卷 84-85,88页

作者：徐娅妮许蓉南京师范大学江苏南京210023

儒家思想在中国思想文化领域长期占据主导地位,是中华文明的重要组成部分。挖掘儒家思想的合理成分,促进其与马克思主义基本原理相结合,是实现“第二个结合”的内在要求。在实践中,要正确处理二者契合性和异质性的关系,在比较二者理论... 详细信息

儒家思想在中国思想文化领域长期占据主导地位,是中华文明的重要组成部分。挖掘儒家思想的合理成分,促进其与马克思主义基本原理相结合,是实现“第二个结合”的内在要求。在实践中,要正确处理二者契合性和异质性的关系,在比较二者理论特质差异的基础上探究结合路径,在积极的理论对话中深入推进儒家思想现代化和马克思主义中国化。

关键词：儒家思想马克思主义理论特质 “第二个结合”

习近平新时代实践观的主要内容、理论特征与当代启示

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萍乡学院学报 2024年第2期41卷 20-24页

作者：徐娅妮许蓉南京师范大学马克思主义学院江苏南京210023

中国特色社会主义进入新时代以来,习近平总书记着眼新的社会实践,创新发展了马克思主义实践观,对新时代中国特色社会主义伟大实践的实践主体、实践理论指导、实践过程、实践评价标准等作了原创性阐发。其实践观体现出宏大的历史性、鲜... 详细信息

中国特色社会主义进入新时代以来,习近平总书记着眼新的社会实践,创新发展了马克思主义实践观,对新时代中国特色社会主义伟大实践的实践主体、实践理论指导、实践过程、实践评价标准等作了原创性阐发。其实践观体现出宏大的历史性、鲜明的时代性和突出的辩证性等理论特征。在新的历史起点上全面建设社会主义现代化国家、全面推进中华民族伟大复兴,需要进一步坚持和运用习近平新时代实践观,广泛动员各方面力量,不断推动理论创新,制定符合发展阶段的方针政策以及坚持正确的实践价值取向。

关键词：习近平新时代实践观启示

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