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用于多标记学习的阈值确定算法

计算机工程 2010年第21期36卷 214-216页

作者：秦锋黄俊程泽凯安徽工业大学计算机学院安徽马鞍山243032

提出一种多标记学习阈值确定算法(DTML),为每个类别标记确定一个阈值。当分类器将一个测试示例预测为某个类别标记的分值大于该类别标记的阈值时,则将该类别标记添加到该测试示例的最终分类结果中。该算法采用编程实现,并将其应用于PT5... 详细信息

提出一种多标记学习阈值确定算法(DTML),为每个类别标记确定一个阈值。当分类器将一个测试示例预测为某个类别标记的分值大于该类别标记的阈值时,则将该类别标记添加到该测试示例的最终分类结果中。该算法采用编程实现,并将其应用于PT5方法和TML算法。实验结果表明,利用DTML算法为多标记学习算法确定阈值,能够得到较好的分类效果。

关键词：数据挖掘多标记学习阈值确定

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改进的各向异性扩散方程的超声图像滤波方法

光学精密工程 2017年第6期25卷 1662-1668页

作者：许贤泽赵文成徐逢秋刘盼盼武汉大学电子信息学院湖北武汉430072

针对传统各项异性扩散模型容易产生板块分区,模糊图像细节等问题,提出一种改进的各项异性滤波算法。该方法引用双曲正切函数构造扩散模型的扩散系数,避免了传统各项异性扩散模型在均匀区域产生的板块分区问题;并通过使用衰减因子提高在... 详细信息

针对传统各项异性扩散模型容易产生板块分区,模糊图像细节等问题,提出一种改进的各项异性滤波算法。该方法引用双曲正切函数构造扩散模型的扩散系数,避免了传统各项异性扩散模型在均匀区域产生的板块分区问题;并通过使用衰减因子提高在非均匀区域的扩散敏感性,能够更好地保留图像的边缘细节信息;同时引入相对平滑增量,自适应监控图像的滤波程度,并自动终止迭代过程。仿真实验表明,提出的滤波方法能够有效滤除超声图像斑点噪声,并消除传统各项异性扩散模型产生的板块分区问题,提高了对图像细节信息的保留能力,并增强了与原图像的结构相似度,是一种有效的斑点噪声降噪方法。

关键词：超声图像斑点噪声各项异性扩散图像滤波

An efficient route to prepare suspended monolayer for feasible optical and electronic characterizations of two-dimensional materials

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InfoMat 2022年第2期4卷 126-138页

作者： Yuan Huang Yun-Kun Wang Xin-Yu Huang Guan-Hua Zhang xu Han Yang Yang Yunan Gao Lei Meng Yushu Wang Guang-Zhou Geng Li-Wei Liu Lin Zhao Zhi-Hai cheng Xin-feng Liu ze-feng Ren Hui-Xia Yang Yufeng Hao Hong-Jun Gao Xing-Jiang Zhou Wei Ji Ye-Liang Wang Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijingChina Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijingChina Songshan Lake Materials Laboratory DongguanChina State Key Laboratory for Artificial Microstructure and Mesoscopic Physics School of PhysicsPeking UniversityBeijingChina Frontiers Science Center for Nanooptoelectronics&Collaborative Innovation Center of Quantum Matter BeijingChina State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianChina Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuanChina Minzu University of China BeijingChina National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional MaterialsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjingChina School of Information and Electronics MIIT Key Laboratory for Low-Dimensional Quantum Structure and DevicesBeijing Institute of TechnologyBeijingChina Department of Physics and Beijing Key Laboratory of Optoelectronic Functional Materials&Micro-Nano Devices Renmin University of ChinaBeijingChina National Center for Nanoscience and Technology(NCNST)of China BeijingChina Haian Institute of New Technology Nanjing UniversityHaianChina University of Chinese Academy of Sciences BeijingChina

Two-dimensional(2D)materials are highly sensitive to substrates,interfaces,and the surrounding *** 2D materials are free from substrate-induced effects,thus an ideal approach to study their intrinsic ***,it is very challenging to prepare large-area suspended 2D materials with high *** we report a universal method,based on pretreatments of densely patterned hole array substrates with either oxygenplasma or gold film deposition,to prepare large-area suspended mono-and few-layer 2D *** structural,optical,and electrical characterization tools were used to fully evaluate the improved performance of various suspended 2D *** of these observations reported in this study are:(1)Observation of a new Raman low frequency mode for the suspended MoS_(2);(2)Significantly stronger photoluminescence(PL)and second harmonic generation(SHG)signals of suspended WSe_(2),which enables the study of new optical transition processes;(3)The low energy electron diffraction pattern on suspended MoS_(2) also exhibits much sharper spots than that on the supported area;and(4)The mobility of suspended graphene device approaches 300000 cm^(2) V^(-1) s^(-1),which is desirable to explore the intrinsic properties of *** work provides an innovative and efficient route for fabricating suspended 2D materials,and we expect that it can be broadly used for studying intrinsic properties of 2D materials and in applications of hybrid active nanophotonic and electronic devices.

关键词： mechanical exfoliation photoluminescence Raman spectrum suspended 2D materials

Adult sacrococcygeal teratoma: a retrospective study over eight years at a single institution

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第8期20卷 670-678页

作者： Xiang-Ming xu feng Zhao Xiao-Fei cheng Wei-Xiang Zhong Jing-Peng Liu Wei-qin Jiang Xiao-Kai Yu Jian-Jiang Lin Department of Colorectal Surgery the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Department of Radiation Oncology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Department of Pathology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Department of Radiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Cancer Biotherapy Center the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective: To determine the clinical, imaging, and histological features, and surgical resection modalities and outcomes of adult sacrococcygeal teratoma (SCT). Methods: Adult patients with histopathologically diagnosed SCT were enrol ed in our hospital between August 2010 and August 2018. Each patient's characteristics and clinical information were reviewed. Results: There were 8 patients in the study (2 males, 6 females) with a median age of 34 years (range, 18-67 years). The time to clinical symptoms was 14 d to 35 years, with a median time of 4 years. Six patients presented with symptoms of sacrococcygeal pain, and four with signs of sacrococcygeal mass and ulceration in the sacrococcygeal region. Six patients were evaluated using a combination of computed tomography (CT) and magnetic resonance imaging (MRI). Al patients showed a presacral tumor with heterogeneous intensity on CT images. Al patients underwent surgical treatment, including 6 parasacral, 1 transabdominal, and 1 combined anterior-posterior surgery cases. Seven patients were histopathological y diagnosed with benign mature SCT, and have shown no recurrence. One patient had malignant SCT, with recurrence at 84 months after surgery. After a second surgery, the patient had no recurrence within 6 months fol ow-up after re-resection. Conclusions: Our retrospective study demon-strated: (1) adult SCT is difficult to diagnose because of a lack of typical clinical symptoms and signs;(2) a combination of CT and MRI examination is beneficial for preoperative diagnosis;(3) the choice of surgical approach and surgical resection modality depends on the size, location, and components of the tumor, which can be defined from preoper-ative CT and MRI evaluation;(4) most adult SCTs are benign;the surgical outcome for the malignant SCT patient was good after complete resection. Even for the patient with recurrent malignant SCT, the surgical outcome was good after re-resection.

关键词： Sacrococcygeal teratoma (SCT) Clinical features Computed tomography (CT) Magnetic resonance imaging (MRI) Surgical resection modality

禁止投资产业政策:基于《市场准入负面清单》与《产业结构调整指导目录》的比较

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税务与经济 2021年第3期 73-79页

作者：徐炎泽尹成凤山西大学政治与公共管理学院山西太原030006 太原市粮食技工学校山西太原030031

与西方发达国家和其他新兴经济体不同,中国独立的产业政策和投资政策是社会主义市场经济的一个重要特征。我国产业政策的代表是国家发展和改革委员会根据国务院《促进产业结构调整暂行规定》制定出台的《产业结构调整指导目录》和根据... 详细信息

与西方发达国家和其他新兴经济体不同,中国独立的产业政策和投资政策是社会主义市场经济的一个重要特征。我国产业政策的代表是国家发展和改革委员会根据国务院《促进产业结构调整暂行规定》制定出台的《产业结构调整指导目录》和根据《优化营商环境条例》制定出台的《市场准入负面清单》。改革开放以来,我国产业政策的发展经历了前目录阶段、目录阶段、清单阶段三个时期,未来将实现由《目录》到《清单》的演进。《目录》与《清单》在功能定位、内涵外延、作用领域等方面存在诸多不同,特别是禁止投资产业政策在设立和效力、与环境保护政策的竞合等方面存在亟待解决的问题。因此,我国应进一步制定社会投资法,明确由法律设定禁止投资产业政策;修订目录,仅保留鼓励类产业政策,并授权各省选择适用;理顺环境保护政策与宏观调控产业政策的关系,将环境准入清单纳入统一的负面清单。

关键词：产业政策产业结构调整指导目录市场准入—负面清单法律效力

Long-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates

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Signal Transduction and Targeted Therapy 2022年第1期7卷 322-330页

作者： Hui Zhao Tie-cheng Wang Xiao-feng Li Na-Na Zhang Liang Li Chao Zhou Yong-Qiang Deng Tian-Shu Cao Guan Yang Rui-Ting Li\Yi-Jiao Huang Yuan-Guo Li Yi-Ming Zhang Fang-xu Li Yu-Ren Zhou Yu-Hang Jiang Xi-Shan Lu Shi-Hui Sun Meng-Li cheng Kai-Ping Gu Mei Zhang qing-qing Ma Xiao Yang Bo Ying Yu-Wei Gao cheng-feng qin State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAcademy of Military Medical Sciences100071 BeijingChina Key Laboratory of Jilin Province for Zoonosis Prevention and Control Changchun 130122China School of Medicine Tsinghua University100084 BeijingChina State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of Lifeomics102206 BeijingChina Shandong Normal University Jinan 250014China Suzhou Abogen Biosciences Suzhou 215123China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical Sciences100071 BeijingChina

Messenger RNA(mRNA)vaccine technology has shown its power in preventing the ongoing COVID-19 *** mRNA vaccines targeting the full-length S protein of SARS-CoV-2 have been authorized for emergency ***,we have developed a lipid nanoparticle-encapsulated mRNA(mRNA-LNP)encoding the receptor-binding domain(RBD)of SARS-CoV-2(termed ARCoV),which confers complete protection in mouse ***,we further characterized the protection efficacy of ARCoV in nonhuman primates and the Iong-term stability under normal refrigerator *** immunization of two doses of ARCoV elicited robust neutralizing antibodies as well as cellular response against SARS-CoV-2 in cynomolgus *** importantly,ARCoV vaccination in macaques significantly protected animals from acute lung lesions caused by SARS-CoV-2,and viral replication in lungs and secretion in nasal swabs were completely cleared in all animals immunized with low or high doses of *** evidenee of antibody-dependent enhancement of infection was observed throughout the ***,extensive stability assays showed that ARCoV can be stored at 2-8℃ for at least 6 months without decrease of *** these promising results strongly support the ongoing clinical trial.

关键词： doses stability protected

Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure

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Science China(Life Sciences) 2024年第2期67卷 360-378页

作者： Hongxia Ruan xuejuan Li Lina Zhou Zihan Zheng Rulin Hua xu Wang Yuan Wang Yujie Fan Shuwen Guo Lihua Wang Shafiq ur Rahman Ziwei Wang Yuyuan Wei Shuangyan Yu Rongzhi Zhang Qian cheng Jie Sheng xue Li Xiaoyan Liu Ruqiang Yuan Xiaoyan Zhang Lihong Chen Guowang xu Youfei Guan Jing Nie Hongqiang qin feng Zheng Advanced Institute for Medical Sciences Dalian Medical UniversityDalian 116044China Department of Nephrology Second HospitalDalian Medical UniversityDalian 116023China CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Chongqing International Institute for Immunology Chongqing 401320China Department of Nephrology Shenzhen HospitalSouthern Medical UniversityShenzhen 518101China Wuhu Hospital and Health Science Center East China Normal UniversityShanghai 200241China Peking University First Hospital Peking UniversityBeijing 100034China

Peritoneal fibrosis together with increased capillaries is the primary cause of peritoneal dialysis *** cell loss is an initiating event for peritoneal *** find that the elevated glucose concentrations in peritoneal dialysate drive mesothelial cell pyroptosis in a manner dependent on caspase-3 and Gasdermin E,driving downstream inflammatory responses,including the activation of ***,pyroptosis is associated with elevated vascular endothelial growth factor A and C,two key factors in vascular angiogenesis and lymphatic vessel *** deficiency mice are protected from high glucose induced peritoneal fibrosis and ultrafiltration *** of melatonin abrogates mesothelial cell pyroptosis through a MT1R-mediated action,and successfully reduces peritoneal fibrosis and angiogenesis in an animal model while preserving dialysis ***,melatonin treatment maintains mitochondrial integrity in mesothelial cells,meanwhile activating m TOR signaling through an increase in the glycolysis product dihydroxyacetone *** effects together with quenching free radicals by melatonin help mesothelial cells maintain a relatively stable internal environment in the face of high-glucose ***,Melatonin treatment holds some promise in preserving mesothelium integrity and in decreasing angiogenesis to protect peritoneum function in patients undergoing peritoneal dialysis.

关键词： melatonin mitochondria pyroptosis GSDME peritoneal fibrosis mTOR

Co-infection of HIV and parasites in China: Results from an epidemiological survey in rural areas of Fuyang city, Anhui province, China

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Frontiers of Medicine 2010年第2期4卷 192-198页

作者： Li-Guang TIAN Tian-Ping WANG Jia-xu CHEN Yu-Chun CAI Xiao-Mei YIN Guo-Jin cheng Wei-Duo WU Peter STEINMANN Jian GUO Xiao-Mei TONG Lan-Hua LI qin LIU Li ZHOU feng-feng WANG Zhen-Li WANG Xiao-Nong ZHOU National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionWHO Collaborating Center for MalariaSchistosomiasis and FilariasisShanghai 200025China Anhui Institute of Parasitic Disease Control Wuhu 241000China Fuyang Center for Disease Control and Prevention Fuyang 236000China Department of Epidemiology and Public Health Swiss Tropical and Public Health InstituteBasel CH-4000Switzerland University of Basel Basel CH-4000Switzerland Weifang Medical University Weifang 261000China

The aim of this study was to investigate epidemiological characteristics of co-infection of HIV and intestinal parasites in a HIV/AIDS highly endemic area in China.A cross-sectional survey was carried out in two villages where HIV/AIDS prevalence in residents was over 1%.Stool samples of all residents in the two targeted villages were examined for the presence of intestinal *** examination was performed for the HIV infection detection and anemia test.A questionnaire survey was carried out in all residents participating in the study.A total of 769 individuals were enrolled in the investigation,720 of whom were involved in stool examination of intestinal *** infection rates of parasites in the residents of the targeted villages were as follows:0.56%for Ascaris lumbricoides,4.03%for Hookworm,0.28%for Trichuris trichiura,0.42%for Clonorchis sinensis,21.39%for Blastocystis hominis,3.89%for Giardia lamblia,1.67%for Entamoeba spp.,4.44%for Cryptosporidium spp.,and no infection for Strongyloides *** overall infection rate of intestinal worms was 4.72%,intestinal parasite infection rate was 24.31%,the anemia prevalence rate was 34.68%,the co-infection rate of HIV and intestinal helminthes 2.17%,the co-infection rate of HIV and intestinal protozoa 28.26%,of which the co-infection rates of HIV and Blastocystis hominis,and HIV and Cryptosporidium *** 19.57%and 13.04%,respectively.A signiﬁcant difference of Cryptosporidium *** rate was found between HIV-positive group(13.04%)and HIV-negative group(4.70%)(P50%)and women(>39%).It was concluded that the infection rate of intestinal protozoa in the residents was higher than that of intestinal helminthes in the local setting,and a same pattern appeared in the co-infection rate of HIV and *** interestingﬁnding is that the infection rate of Cryptosporidium *** the HIV-positiv

关键词： human immunodeﬁciency virus(HIV) acquired immunodeﬁciency syndrome(AIDS) co-infec-tion intestinal parasites helminthes protozoa China

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凝胶注模法制备吸声多孔陶瓷及其性能研究

人工晶体学报 2014年第10期43卷 2567-2572页

作者：杨晨税安泽覃东许林峰朱雯莉张勇林吴诚华南理工大学材料科学与工程学院广州510641

以普通建筑陶瓷坯料为原料、天然植物胶为凝胶剂,通过凝胶注模工艺研制了吸声多孔陶瓷。研究了多孔陶瓷的显微结构以及多孔陶瓷的显气孔率、孔径和厚度对吸声性能的影响。结果表明:延长浆料搅拌时间可提高试样的显气孔率,而较大的显气... 详细信息

以普通建筑陶瓷坯料为原料、天然植物胶为凝胶剂,通过凝胶注模工艺研制了吸声多孔陶瓷。研究了多孔陶瓷的显微结构以及多孔陶瓷的显气孔率、孔径和厚度对吸声性能的影响。结果表明:延长浆料搅拌时间可提高试样的显气孔率,而较大的显气孔率使吸声曲线的吸声峰向高频方向偏移,吸声峰值呈现先增加后降低的趋势;适当增加浆料固含量可减小孔径,孔径变小导致试样吸声峰向低频方向缓慢偏移,吸声峰值提高;增加厚度有利于试样吸声峰向低频方向偏移,而不同频率范围内吸声系数变化趋势不同。

关键词：多孔陶瓷凝胶注模吸声系数