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Effects of hormone replacement therapy on mood and sleep quality in menopausal women

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World Journal of Psychiatry 2024年第7期14卷 1087-1094页

作者： Qing Liu Zhen Huang ping xu Department of Gynecology Ganzhou Women’s and Children’s HospitalGanzhou 341000Jiangxi ProvinceChina

BACKGROUND Hormone replacement therapy is an effective treatment strategy for the management of symptoms in naturally menopausal ***,some patients report experiencing adverse *** To analyze the effects of hormone replacement therapy in menopausal female *** A total of 152 menopausal female patients admitted to the Gynecology Department of the Ganzhou Maternal and Child Health Hospital between January 2021 and December 2023 were divided into the observation group(n=76,conventional treatment+hormone replacement therapy)and the control group(n=76,conventional treatment only)via random *** improvement observed in the following items were compared between the groups:Kupperman menopausal index(KMI),emotional state[The Positive and Negative Affect Scale(PANAS)],sleep quality[Self-Rating Scale of Sleep(SRSS)],treatment effectiveness,and treatment *** The modified KMI and SRSS scores of the observation group were lower than those of the control group after three rounds of *** improvement in the PANAS score observed in the observation group was greater than that observed in the control group(P<0.05).The total treatment effectivity rate in the observation group was higher than that in the control group(86.84%vs 96.05%,χ2=4.121,P=0.042).The incidence rate of adverse reactions in the two groups was comparable(6.58%vs 9.21%,χ2=0.361,P=0.547).CONCLUSION Hormone replacement therapy effectively improved the clinical symptoms,actively channeled negative emotions,and improved the quality of sleep in menopausal patients,indicating its effectiveness and safety.

关键词： Hormone replacement therapy Menopause Women Mood states Sleep quality Sex hormones

A case of solitary choroidal tuberculoma with highly positive tuberculin skin test and negative interferon gamma release assays

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 969-972页

作者： Lin Zhou Bin Hu Zhu-ping xu Department of Ophthalmology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina Department of Ophthalmology Chengdu Tianfu New District People’s HospitalChengdu 641400Sichuan ProvinceChina Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Dear Editor,Tuberculosis(TB)is an infectious disease which has been considered as a global public health emergency problem during the past *** World Health Organization has estimated that approximately one-third of the world’s population are infected by ***,only 10%of patients with TB is *** can affect multiple organs throughout the *** percent of those infected are pulmonary *** TB can occur with or without lung or other systemic *** is a rare extrapulmonary form of the disease and occupied about 3.5%–5%of all of the *** should not be disregarded as its potential influence on vision *** intraocular and/or extraocular structures could be impacted by ocular TB[1].Uvea was the most common affected structure[2].

关键词： organs ocular infected

The innovative safe herbicide dienediamine saves paraquat

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Molecular Plant 2024年第1期17卷 11-12页

作者： Jin-Qiu Xia ping xu Cheng-Bin Xiang Division of Life Sciences and Medicine Division of Molecular&Cell BiophysicsHefei National Science Center for Physical Sciences at the MicroscaleMOE Key Laboratory for Membraneless Organelles and Cellular DynamicsUniversity of Science and Technology of ChinaThe Innovation Academy of Seed DesignChinese Academy of SciencesHefeiAnhui Province 230027China Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterCAS Center for Excellence in Molecular Plant SciencesShanghai 201602China

Throughout the history of agriculture,the challenge of weed management has endured,necessitating significant investments to facilitate ideal crop growth and maximize *** for weed control mainly involve manual and chem... 详细信息

关键词： approach. manual chemical

Mechanical Property and Microstructure of Cement Mortar with Carbonated Recycled Powder

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 689-697页

作者：丁亚红张美香 YANG Xiaolin xu ping SUN Bo GUO Shuqi Department of Civil Engineering Henan Polytechnic UniversityJiaozuo 454150China College of Architectural Engineering Xinyu UniversityXinyu 336500China

Carbonated recycled powder as cementitious auxiliary material can reduce carbon emissions and realize high-quality recycling of recycled *** this paper,microscopic property of recycled powder with three carbonation methods was tested through XRD and SEM,the mechanical property and microstructure of recycled powder mortar with three replacement rates were studied by ISO method and SEM,and the strengthening mechanism was *** results showed that the mechanical property of recycled powder mortar decreased with the increasing of replacement *** is suggested that the replacement rate of recycled powder should not exceed 20%.The strength index and activity index of carbonated recycled powder mortar were improved,in which the flexural strength was increased by 27.85%and compressive strength was increased by 20%at the *** powder can be quickly and completely carbonated,and the improvement effect of CH pre-soaking carbonation was the *** activity index of carbonated recycled powder can meet the requirements of Grade II technical standard for recycled *** results revealed the activation mechanism of carbonated recycled powder such as surplus calcium source effect,alkaline polycondensation effect and carbonation enhancement effect.

关键词： recycled powder carbonation activation compound carbonation activity index mechanical property microstructure

Isocyanide-Based One-Pot Cascade Synthesis of 3-Acyl Isoindolinones

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Chinese Journal of Chemistry 2024年第3期42卷 259-263页

作者： Jia Liu Yi-Ming Zhu Xiao-ping xu Shun-Jun Ji Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhouJiangsu215123 China Suzhou Baolidi Functional Materials Research Institute SuzhouJiangsu215144 China

A series of 3-acyl-substituted isoindolinone derivatives were synthesized in a one-pot manner via the reaction of o-bromobenzaldehydes,isocyanides,and carboxylic acids in the presence of palladium catalyst and base. The reaction employing easily available starting materials features simple operation and high efficiency. The mechanistic study showed that the reaction might undergo 1) Pd-catalyzed [3+2] cyclization of o-bromobenzaldehyde with isocyanide and the re-insertion of another molecule of isocyanide,2) addition of carboxylic acid to in situ formed ketenimine followed by a rearrangement relay to give 3,3-diacyl-substituted isoindolinone derivative. Further transformations of the obtained products through decarbonylation could also be realized.

关键词： One-pot reaction Isocyanide Pd catalysis Rearrangement reaction Isoindolinone

Long Non-coding RNA PCED1B Antisense RNA 1 Promotes Cell Proliferation and Invasion in Hepatocellular Carcinoma by Regulating the MicroRNA-34a/CD44 Axis

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Current Medical Science 2024年第3期44卷 503-511页

作者： Jian-gang BI Qi LI Yu-sheng GUO Li-ping LIU Shi-yun BAO ping xu Department of Hepatobiliary and Pancreatic Surgery Shenzhen People's HospitalThe Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Endocrinology Shenzhen People's HospitalThe Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China

Objective This study aimed to examine the role of long non-coding RNA PCED1B antisense RNA 1(PCED1B-AS1)in the development of hepatocellular carcinoma(HCC).Methods A total of 62 pairs of HCC tissues and adjacent non-tumor tissues were obtained from 62 HCC *** interactions of PCED1B-AS1 and microRNA-34a(miR-34a)were detected by dual luciferase activity assay and RNA pull-down *** RNA expression levels of PCED1B-AS1,miR-34a and CD44 were detected by RT-qPCR,and the protein expression level of CD44 was determined by Western *** cell proliferation was detected by cell proliferation assay,and the cell invasion and migration by transwell invasion *** HCC tumor growth after PCED1B-AS1 was downregulated was determined by in vivo animal *** PCED1B-AS1 was highly expressed in HCC tissues,which was associated with poor survival of HCC ***,PCED1B-AS1 interacted with miR-34a in HCC cells,but they did not regulate the expression of each ***,PCED1B-AS1 increased the expression level of CD44,which was targeted by *** cell proliferation and invasion assay revealed that miR-34a inhibited the proliferation and invasion of HCC in vitro,while CD44 exhibited the opposite ***,PCED1B-AS1 suppressed the role of ***,the knockdown of PCED1B-AS1 repressed the HCC tumor growth in nude mice in *** PCED1B-AS1 may play an oncogenic role by regulating the miR-34a/CD44 axis in HCC.

关键词： long non-coding RNA PCED1B antisense RNA 1(PCED1B-AS1) hepatocellular carcinoma microRNA-34a(miR-34a) CD44 proliferation invasion

Solving the subset sum problem by the quantum Ising model with variational quantum optimization based on conditional values at risk

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 43-55页

作者： Qilin Zheng Miaomiao Yu pingyu Zhu Yan Wang Weihong Luo ping xu Institute for Quantum Information and State Key Laboratory of High Performance Computing College of Computer Science and TechnologyNational University of Defense TechnologyChangsha 410073China Hefei National Laboratory Hefei 230088China

The subset sum problem is a combinatorial optimization problem,and its complexity belongs to the nondeterministic polynomial time complete(NP-Complete)*** problem is widely used in encryption,planning or scheduling,and integer *** accurate search algorithm with polynomial time complexity has not been found,which makes it challenging to be solved on classical *** effectively solve this problem,we translate it into the quantum Ising model and solve it with a variational quantum optimization method based on conditional values at *** proposed model needs only n qubits to encode 2ndimensional search space,which can effectively save the encoding quantum *** model inherits the advantages of variational quantum algorithms and can obtain good performance at shallow circuit depths while being robust to noise,and it is convenient to be deployed in the Noisy Intermediate Scale Quantum *** investigate the effects of the scalability,the variational ansatz type,the variational depth,and noise on the ***,we also discuss the performance of the model under different conditional values at *** computer simulation,the scale can reach more than nine *** selecting the noise type,we construct simulators with different QVs and study the performance of the model with *** addition,we deploy the model on a superconducting quantum computer of the Origin Quantum Technology Company and successfully solve the subset sum *** model provides a new perspective for solving the subset sum problem.

关键词： subset sum problem quantum Ising model conditional values at risk variational quantum optimization

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Compositional and Hollow Engineering of Silicon Carbide/Carbon Microspheres as High-Performance Microwave Absorbing Materials with Good Environmental Tolerance

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Nano-Micro Letters 2024年第9期16卷 128-146页

作者： Lixue Gai Yahui Wang Pan Wan Shuping Yu Yongzheng Chen Xijiang Han ping xu Yunchen Du MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China Anhui Provincial Laboratory of Advanced Laser Technology College of Electronic EngineeringNational University of Defense TechnologyHefei 230037People’s Republic of China

Microwave absorbing materials(MAMs)characterized by high absorption efficiency and good environmental tolerance are highly desirable in practical *** silicon carbide and carbon are considered as stable MAMs under some rigorous conditions,while their composites still fail to produce satisfactory microwave absorption performance regardless of the improvements as compared with the ***,we have successfully implemented compositional and structural engineering to fabricate hollow Si C/C microspheres with controllable *** simultaneous modulation on dielectric properties and impedance matching can be easily achieved as the change in the composition of these *** formation of hollow structure not only favors lightweight feature,but also generates considerable contribution to microwave attenuation *** the synergistic effect of composition and structure,the optimized SiC/C composite exhibits excellent performance,whose the strongest reflection loss intensity and broadest effective absorption reach-60.8 dB and 5.1 GHz,respectively,and its microwave absorption properties are actually superior to those of most SiC/C composites in previous *** addition,the stability tests of microwave absorption capacity after exposure to harsh conditions and Radar Cross Section simulation data demonstrate that hollow SiC/C microspheres from compositional and structural optimization have a bright prospect in practical applications.

关键词： SiC/C composites Compositional engineering Hollow engineering Microwave absorption Environmental tolerance

Catalytic asymmetric dearomative azo-Diels–Alder reaction of 2-vinlyindoles

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Chinese Chemical Letters 2024年第4期35卷 357-362页

作者： Yu-Hang Miao Zheng-xu Zhang xu-Yi Huang Yuan-Zhao Hua Shi-Kun Jia Xiao Xiao Min-Can Wang Li-ping xu Guang-Jian Mei Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhou 450052China School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255000China Institute of Pharmaceutical Science and Technology Zhejiang University of TechnologyHangzhou 310014China

Due to the high electrophilic nature of azo-dienophiles, azo-Diels–Alder proceeds rapidly even without the need of a catalyst and is therefore regarded as the “click reaction”. This spontaneity causes strong background reaction and poses a daunting challenge to chemists for developing the catalytic asymmetric version. Reported herein is the first catalytic asymmetric dearomative azo-Diels–Alder reaction between2-vinylindoles and triazoledione. This protocol makes use of the high energy barrier of dearomatization to avert the strong background reaction of azo-Diels–Alder reaction, allowing the implementation of the projected reaction at ambient temperature. Density functional theory calculations have been performed to gain insights into the reaction mechanism and the origins of the enantioselectivity. By using this method,a variety of tetracyclic indole derivatives have been readily prepared in good to excellent yields and with excellent diastereo-and enantio–selectivities(33 examples, up to 97% yield and >99% ee, >20:1 dr).

关键词： Catalytic asymmetric dearomatization Azo-Diels–Alder reaction 2-Vinylindoles Chiral phosphoric acid Tetracyclic indole derivatives