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Moxibustion regulates inflammatory mediators and colonic mucosal barrier in ulcerative colitis rats

World Journal of Gastroenterology 2016年第8期22卷 2566-2575页

作者： Tie-Ming Ma na xu Xian-De Ma Zeng-Hua Bai Xing Tao Hong-Chi Yan Liaoning University of Traditional Chinese Medicine Shenyang 110847 Liaoning Province China

AIM: To observe the efficacy and mechanism of grain-sized moxibustion at different acupoints in a rat model of ulcerative colitis (UC). METHODS: Sprague-Dawley rats were randomly divided into control, UC model, grain-sized moxibustion at a single acupoint (CV 12), grain-sized moxibustion at two acupoints (CV 12 and CV 4), grain-sized moxibustion at three acupoints (CV 12, CV 4, and ST 36), and medication groups (n = 8/group). The UC model was established by enema of trinitrobenzene sulfonic acid. Direct moxibustion was used once a day for 7 d. Disease activity index (DAI) was evaluated before and after the treatment. Morphologic changes of intestinal tissue were observed under an optical microscope. The expression of tumor necrosis factor (TNF)-alpha and p38 mitogen-activated protein kinase (p38MAPK) in colonic tissue was detected using Western blot, and the levels of occludin and zonula occludens-1 (ZO-1) mRnas were detected using reverse transcription PCR. RESULTS: Compared with the control group, the intestinal mucosae were incomplete in the model group, glandular structures were irregular, and submucosae were edematous, hyperemic, and infiltrated with inflammatory cells. The DAI scores and expression of TNF-alpha and p38MAPK were increased significantly in the model group compared to controls (Ps na levels of occludin and ZO-1 were reduced significantly (Ps na levels of occludin and ZO-1 were increased significantly (Ps < 0.01). The improvements in the above indices in the three acupoints group and the medication group were superior to those in the single and two acupoints groups (all P < 0.05). CONCLUSION: Reduction of TNF-alpha and p38MAPK and increased expre

关键词： Different acupoints Grain-sized moxibustion Inflammatory factors Intestinal mucosal barrier Ulcerative colitis

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Doxorubicin-loaded PLGA Microparticles with Internal Pores for Longacting Release in Pulmonary Tumor Inhalation Treatment

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Chinese Journal of Polymer Science 2015年第7期33卷 947-954页

作者： Tian-shi Feng 田华雨 Cai-na xu Lin Lin Michael Hon-Wah Lam Hao-jun Liang xue-si Chen CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences Department of Biology and Chemistry City University of Hong Kong Advanced Laboratory of Environmental Research and Technology(ALERT) Joint Advanced Research Center

Doxorubicin（DOX） loaded poly（lactic-co-glycolic acid）（PLGA） microparticles with internal pores（MP-D） were developed for long-acting release in pulmonary inhalation treatment. The PLGA microparticles exhibited favorable aerodynamic properties for pulmonary delivery. In vitro drug release profile suggested that MP-D have the advantage of long-term maintenance of drug concentrations. MTT assay demonstrated the in vitro anti-tumor efficiency of the DOX loaded PLGA microparticles. Furthermore, melanoma lung metastasis model was established to determine the in vivo antitumor efficiency. The mice treated with MP-D showed significantly fewer lesions than the untreated ones. The survival analysis indicated that MP-D prolonged the survival time of tumor-bearing mice. These results suggested that DOX loaded PLGA microparticles with internal pores have the potential to be used as long-acting release carriers in clinical lung cancer treatment.

关键词： Doxorubicin Poly(lactic-co-glycolic acid) Internal pores Long-acting release Pulmonary inhalation

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I_κB kinase-beta inhibitor attenuates hepatic fibrosis in mice

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World Journal of Gastroenterology 2011年第47期17卷 5203-5213页

作者： Jue Wei Min Shi Wei-Qi Wu Hui xu Ting Wang na Wang Jia-Li Ma Yu-Gang Wang Department of Gastro-enterology Shanghai Changning Central Hospital Shanghai200336 China

AIM: To investigate the anti-fibrosis effect of IκB kinase-beta inhibitor (IKK2 inhibitor IMD0354) in liver fibrosis. METHODS: Twenty male C57BL6 mice were divided into four groups. Five high-fat fed mice were injected with lipopolysaccharide (LPS, 10 mg/kg) intraperitoneally and five high-fat fed mice were without LPS injection to build models of liver injury, and the intervention group (five mice) was injected intraperitoneally with IKK2 inhibitor (IMD 30 mg/kg for 14 d), while the remaining five mice received a normal diet as controls. Hepatic function, pathological evaluation and liver interleukin-6 (IL-6) expression were examined. Western blotting and real-time polymerase chain reaction were used to detect the expressions of nuclear factor-κB (NF-κB), alpha-smooth muscle actin (α-SMA), tumor growth factor-beta1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), typeⅠand type Ⅲ collagen proteins and mRna. RESULTS: A mouse model of liver injury was successfully established, and IMD decreased nuclear transloca-tion of NF-κB p65 in liver cells. In the IMD-treated group, the levels of alanine aminotransferase (103 ± 9.77 μ/L vs 62.4 ± 7.90 μ/L, P na were downregulated in the IMD group compared to the fibrosis control groups (P < 0.05). CONCLUSION: IKK2 inhibitor IMD markedly improved non-alcoholic fatty liver disease in mice by lowering NF-κB activation, which could be

关键词： Liver fibrosis IKK2 inhibitor Nuclear factor-kappa B Tumor growth factor-beta1 Interleukin-6 Alpha-smooth muscle actin C57BL mouse

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Inheritance of Several Plant Type Characters in Truss Tomato

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Agricultural Sciences in China 2008年第5期7卷 535-541页

作者： FENG Hui WANG Wu-hong xu na LU Bo ZHANG Ting CHEN Hong-bo College of Horticulture Shenyang Agricultural University Shenyang 110161 P.R.China College of Life Science Liaoning Normal University Dalian 116021 RR.China

Plant type characters of truss tomato were studied for exploring the inheritance of leaf angle, and providing a theoretical basis for breeding truss tomato cultivars in compact plant type. Participant truss tomato inbred lines were involved in the cross and backcross for multi-generations, and the mixed major genes plus polygene inheritance model was employed to analyze the inheritance model of leaf angle, plant width, and leaf drooping value. The inheritance of leaf angle and plant width was controlled by one pair of additive major genes plus additive-dominant polygene （D-2）. The additive effect of the major genes controlling leaf angle was 6.51, the additive effect of the polygene was 15.01, the potential ratio was 0.914, and the dominant degree was 0; the heritability of the major genes was 45.61% in B1 generation, 37.29% in B2 generation, and 47.71% in F2 generation. The additive effect of the major genes controlling plant width was 3.08, while the additive effect and dominant effect of the polygene were 3.58 and -1.59, respectively, with the potential ratio of -0.44 and 0 dominant degree; the heritability of the major genes was 23.30% in B1 generation, 20.73% in B2 generation, and 36.11% in F2 generation; leaf-drooping-value trait was controlled by one pair of negative complete dominant major genes plus additive-dominant polygene （D-4）. The additive effect of the major genes was 8.18, the dominant effect was -8.18, the additive effect in the polygene was 3.12, the dominant effect was 19.07, the potential ratio was 6.09, and the dominant degree was -1; the heritability of the polygene was 69.15% in B1 generation, 68.5% in B2 generation, and 49.57% in F2 generation. The improvement on leaf angle and plant width of 173×101 should be focused on the major genes and the selection should be made in early generations, while the improvement on leaf-drooping-value of 173×01 should be made in late generations.

关键词： tomato plant type inheritance

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Ferromagnetic interactions in EO-azido-bridged binuclear transition metal(Ⅱ) systems: Syntheses, crystal structures and magnetostructural correlations

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中国科学:化学 2012年第6期42卷 895-896页

作者： ZHANG ShiYuan WANG BingWu xu na SHI Wei GAO Song CHENG Peng Key Laboratory of Advanced Energy Materials Chemistry(MOE) Department of ChemistryNankai UniversityTianjin 300071China Beijing national Laboratory for Molecular Sciences Beijing 100190China State Key Lab of Rare Earth Materials Chemistry and Applications College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Three new isostructural binuclear transition metal complexes with azido ion and 1,2-bis(3-(pyridin-2-yl)-1H-pyrazol-1-yl)ethane (bppe), formulated as [M2(N3)2(bppe)2](ClO4)2 (M = Co, 1; Ni, 2; Cu, 3), were successfully synthesized. They were structurally and magnetically characterized. In 1-3, the double azido ions link two adjacent octahedral metal centers together in the end-to-on mode (EO), with the M-NEO-M angles of 99.41°, 100.24° and 99.80°, respectively. The co-ligand bppe acts as terminal ligand to saturate the remaining coordination sites. The magnetic properties of 1-3 have been investigated in the temperature range of 2-300 K. Fitting of the magnetic susceptibility data revealed the occurrence of the strong ferromagnetic interactions [J = 26.32 cm-1 (1), J = 38.23 cm-1 (2) and J = 139.83 cm-1 (3)]. Density functional theory calculations have been performed on 1-3 to provide a magneto-structural correlation of the ferromagnetic behavior.

关键词：过渡金属配合物铁磁相互作用晶体结构相互作用系统双核合成桥联叠氮

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Polylysine-modified Polyethylenimines as siRna Carriers for Effective Tumor Treatment

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Chinese Journal of Polymer Science 2015年第6期33卷 830-837页

作者： Jie Chen Zi-xue Jiao Lin Lin Zhao-pei Guo Cai-na xu Yan-hui Li 田华雨 xue-si Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Science School of Materials Science and Technology Changchun University of Science and Technology

Polyethylenimine-poly（L-lysine）（PEI-PLL） copolymer was synthesized via ring-opening polymerization of L-lysine N-carboxyanhydride （Lys（Z）-NCA） initiated by PEI. The complexation of PEI-PLL with siRna was studied by particle size and zeta potential measurements. The flow cytometric analysis and confocal imaging showed its excellent intracellular trafficking ability. PEI-PLL displayed higher gene silencing efficiency and lower cytotoxicity than commercial PEI-25k in vitro. In the antitumor study, PEI-PLL was further combined with siVEGF and showed obviously tumor inhibition effect for the treatment of CT26 tumor model. Therefore, PEI-PLL is a promising siRna carrier candidate for further antitumor treatment in vivo.

关键词： Gene carrier Gene silencing Polylysine Tumor treatment VEGF siRna.

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Iatrogenic pneumopericardium after therapeutic pericardiocentesis for pericardial effusion: a case report

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Journal of Geriatric Cardiology 2023年第6期20卷 479-482页

作者： Yang-Yang ZHU Ting-Ting WANG Xiao-na xu Jing-Yue xu Hua-Ying FU Guang-Ping LI Tong LIU Chang-Le LIU Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of CardiologySecond Hospital of Tianjin Medical UniversityTianjinChina

Pneumopericardium refers to the presence of air inside the pericardial cavity,which is a rare entity that has been reported ***,et al.[1]classified the causes of pneumopericardium into four categories:iatrogenic,peric... 详细信息

关键词： organs pericardial

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A cloud optical and microphysical property product for the advanced geosynchronous radiation imager onboard China's Fengyun-4 satellites: The first version

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Atmospheric and Oceanic Science Letters 2023年第3期16卷 52-57页

作者： Chao Liu Yuxing Song Ganning Zhou Shiwen Teng Bo Li na xu Feng Lu Peng Zhang Collaborative Innovation Center on Forecast and Evaluationof Meteorological Disasters/China Meteorological Administration Aerosol-Cloud-Precipitation Key Laboratory School of Atmospheric PhysicsNanjing University of Information Science&TechnologyNanjingChina Innovation Center for FengYun Meteorological Satellite(FYSIC) National Satellite Meteorological Center(National Center for Space Weather)BejingChina Jiangsu Yangzhou Meteorological Bureau YangzhouChina College of Oceanic and Atmospheric Sciences Ocean University of ChinaQingdaoChina

风云四号作为中国新一代静止气象卫星,提供了高时空分辨率的监测产品。本文介绍风云四号搭载的先进地球同步轨道辐射成像仪AGRI的云光学和微物理特性产品.该产品包含了基于双光谱通道反演的云光学厚度和云粒子有效半径产品,以及基于机... 详细信息

风云四号作为中国新一代静止气象卫星,提供了高时空分辨率的监测产品。本文介绍风云四号搭载的先进地球同步轨道辐射成像仪AGRI的云光学和微物理特性产品.该产品包含了基于双光谱通道反演的云光学厚度和云粒子有效半径产品,以及基于机器学习的云识别和云相态产品。与时空匹配的主动卫星观测结果对比显示,该产品的云识别和云相态的准确率分别在95%和85%;该产品提供的云光学厚度和云有效粒径与经典的MODIS产品的相关系数达到0.76和0.63.团队将持续优化和更新该云光学和微物理特性定量产品,服务风云四号卫星定量应用。

关键词：风云四号先进地球同步轨道辐射成像仪云相态云光学厚度云有效粒子半径

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Optimized Electronic Modification of S-Doped CuO Induced by Oxidative Reconstruction for Coupling Glycerol Electrooxidation with Hydrogen Evolution

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nano-Micro Letters 2023年第10期15卷 622-637页

作者： Ruo‑Yao Fan xue‑Jun Zhai Wei‑Zhen Qiao Yu‑Sheng Zhang Ning Yu na xu Qian‑Xi Lv Yong‑Ming Chai Bin Dong China State Key Laboratory of Heavy Oil Processing College of Chemistry and Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580People’s Republic of China

Glycerol(electrochemical) oxidation reaction(GOR) producing organic small molecule acid and coupling with hydrogen evolution reaction is a critical aspect of ensuring balanced glycerol capacity and promoting hydrogen generation on a large scale. However, the development of highly efficient and selective non-noble metal-based GOR electrocatalysts is still a key problem. Here, an S-doped CuO nanorod array catalyst(S-CuO/CF) constructed by sulfur leaching and oxidative remodeling is used to drive GOR at low potentials: It requires potentials of only 1.23 and 1.33 V versus RHE to provide currents of 100 and 500 mA cm^(-2), respectively. Moreover, it shows satisfactory comprehensive performance(at 100 mA cm^(-2), V_(cell) = 1.37 V) when assembled as the anode in asymmetric coupled electrolytic cell. Furthermore, we propose a detailed cycle reaction pathway(in alkaline environment) of S-doped CuO surface promoting GOR to produce formic acid and glycolic acid. Among them, the C–C bond breaking and lattice oxygen deintercalation steps frequently involved in the reaction pathway are the key factors to determine the catalytic performance and product selectivity. This research provides valuable guidance for the development of transition metal-based electrocatalysts for GOR and valuable insights into the glycerol oxidation cycle reaction pathway.

关键词： Glycerol oxidation reaction(GOR) Hydrogen evolution reaction(HER) CuO Oxidative reconstruction Electronic modification

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Therapeutic difference between orbital decompression and glucocorticoids administration as the first-line treatment for dysthyroid optic neuropathy:a systematic review

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International Journal of Ophthalmology(English edition) 2021年第7期14卷 1107-1113页

作者： Ming-na xu Zhao-Qi Pan Yun-Hai Tu He-Qing Tao Ke-Si Shi Wen-Can Wu The Eye Hospital of Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina Peking University Third Hospital Beijing 100000China The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou 310000Zhejiang ProvinceChina

To assess all available data to compare the efficacy of glucocorticoids treatment and orbital decompression for dysthyroid optic neuropathy(DON).PubMed,EMBASE,the Cochrane Library databases as well as other sources were searched by two independent reviewers followed by extensive hand-searching for the identification of relevant *** primary outcomes were the improvement in visual acuity and responder *** outcomes were the proptosis reduction,change in diplopia,and clinical activity score(CAS).One randomized controlled trial,three retrospective case series and one prospective case series met the inclusion *** were divided into intravenous high-dose glucocorticoids(ivGC)group and orbital decompression(OD)*** groups demonstrated improvement in visual *** addition,the proportion of patients with improved vision in OD group was higher than that in ivGC group(P<0.001).Post-treatment proptosis reduction was also reported in both ***,weighted mean in proptosis reduction estimated at 1.64 and 5.45 mm in patients treated with ivGC and OD *** study also presented results regarding pre-existing and new-onset *** from diplopia,a wide variety of minor and major complications were noted in 5 included *** most common complication in ivGC group and OD group was Cushing's syndrome and epistaxis *** present systematic review shows that both glucocorticoids treatment and OD are effective in treating DON and OD may work better in improving visual acuity and reducing ***,high-quality,large-sample,controlled studies need to be performed in the future.

关键词： dysthyroid optic neuropathy glucocorticoid orbital decompression

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