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Injectable melatonin-loaded carboxymethyl chitosan(CMCS)-based hydrogel accelerates wound healing by reducing inflammation and promoting angiogenesis and collagen deposition

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Journal of Materials Science & Technology 2021年第4期63卷 236-245页

作者： Kai Chen Changci Tong Jinge Yang Peifang Cong Ying liu Xiuyun Shi xu liu Jun Zhang Rufei Zou Keshen Xiao Yuyang Ni Lei xu Mingxiao Hou Hongxu Jin Yunen liu Shangrao Normal University the Innovation Institute of Agricultural TechnologyCollege of Life ScienceShangrao 334001China Department of Emergency Medicine the General Hospital of Northern Theater CommandLaboratory of Rescue Center of Severe Trauma PLAShenyang l10016China Jiangxi Medical College Shangrao 334001China College of Physical Education Yanshan UniversityQinhuangdao 066004China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

Carboxymethyl chitosan(CMCS)-based hydrogels have antibacterial activity,and have shown the abilities of preventing wound infection,promoting cell proliferation,accelerating collagen deposition,and stimulating hyaluronic acid formation during wound *** a hormone produced by the pineal gland in humans and animals,melatonin promotes skin wound healing by regulating the release of inflammatory mediators and accelerating the proliferation and migration of cells,angiogenesis,and collagen ***,the combined effects of CMCS and melatonin on wound healing remain *** CMCS-based hydrogels containing melatonin were prepared,and their healing effects were evaluated using a full-thickness cutaneous wound model in *** with the control and the hydrogel with no melatonin groups,the melatonin-loaded hydrogel significantly increased the percentage of wound closure,promoted the proliferation of granulation tissue and re-epithelialization,and accelerated collagen ***,the melatonin-loaded hydrogel promoted angiogenesis and vascular endothelial growth factor receptor protein expression and increased the expression of cyclooxygenase-2 and inducible nitric oxide *** melatonin-loaded hydrogel also markedly increased the expression of collagen III,α-smooth muscle actin,and transforming growth factor-β1 proteins and reduced collagen I *** results suggest that the melatonin-loaded hydrogel promoted granulation tissue formation and accelerated wound healing by reducing inflammation and promoting angiogenesis and collagen deposition.

关键词： healing wound inflammation

Fabrication and Optical Property of Cu_7S_4 Hollow Nanoparticles Formed Through Kirkendall Effect

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Chemical Research in Chinese Universities 2008年第2期24卷 249-250页

作者： WANG Chen-guang xu Zhu-de liu Run Physical Chemistry Research Institute Department of Chemistry Zhejiang University Hangzhou 310027 P. R. China

1 Introduction In recent years, there has been increasing interest in the controlled synthesis of hollow nanoparticles because of their widespread potential applications. The hollow nanoparticles can be used as catalysts, adsorbents, drug-delivery carriers, chemical reactors, and so on^[1-6]. Some nano and micro spheres are em- ployed as hard or soft templates to produce hollow structures＆[7-10].

关键词： Kirkendall effect Hollow Nanoparticle Morphology

Synthesis and Properties of Biodegradable Copolymers of 9-Phenyl-2, 4, 8, 10-tetraoxaspiro-[5, 5]undcane-3-one and Ethylene Ethyl Phosphate

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Chinese Chemical Letters 2006年第10期17卷 1365-1368页

作者： Jian xu Zhi Lan liu Ren Xi ZHUO Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University Wuhan 430072

Novel biodegradable copolymer poly（CC-co-EEP） was synthesized by ring-opening copolymerization of cyclic carbonate 9-phenyl-2, 4, 8, 10-tetraoxaspiro-[5, 5]undcane-3-one （CC） and ethylene ethyl phosphate （EEP）. The obtained poly （CC-co-EEP）s were characterized by FTIR, ^1H NMR, ^13C NMR and gel permeation chromatography （GPC）. In vitro hydrolytic degradation of the copolymers were investigated in phosphate buffer solution （pH=7.4）. Hydrophilic phosphate units apparently improved the degradability of poly（carbonate-phosphate）.

关键词： Poly(carbonate-phosphate) ring-opening copolymerization biodegradable polymers.

Construction of a sustainable 3-hydroxybutyrate-producing probiotic Escherichia coli for treatment of colitis

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Cellular & Molecular Immunology 2021年第10期18卷 2344-2357页

作者： xu Yan Xin-Yi liu Dian Zhang Yu-Dian Zhang Zi-Hua Li xu liu Fuqing Wu Guo-Qiang Chen Center for Synthetic and Systems Biology Tsinghua UniversityBeijingChina School of Life Sciences Tsinghua UniversityBeijingChina MOE Key Lab for Industrial Biocatalysis Dept.Chemical EngineeringTsinghua UniversityBeijingChina

Colitis is a common disease of the colon that is very difficult to *** bacteria could be an effective *** probiotic Escherichia coli Nissle 1917(EcN)was engineered to synthesize the ketone body(R)-3-hydroxybutyrate(3HB)for sustainable production in the gut lumen of mice suffering from *** of heterologous 3HB synthesis routes were constructed,expressed,optimized,and inserted into the EcN genome,combined with deletions in competitive branch *** genome-engineered EcN produced the highest 3HB level of 0.6 g/L under microaerobic *** live therapeutic was found to colonize the mouse gastrointestinal tract over 14 days,elevating gut 3HB and short-chain-length fatty acid(SCFA)levels 8.7-and 3.1-fold compared to those of wild-type EcN,*** sustainable presence of 3HB in mouse guts promoted the growth of probiotic bacteria,especially Akkermansia spp.,to over 31%from the initial 2%of all the *** a result,the engineered EcN termed EcNL4 ameliorated colitis induced via dextran sulfate sodium(DSS)in *** to wild-type EcN or oral administration of 3HB,oral EcNL4 uptake demonstrated better effects on mouse weights,colon lengths,occult blood levels,gut tissue myeloperoxidase activity and proinflammatory cytokine ***,a promising live bacterium was developed to improve colonic microenvironments and further treat *** proof-of-concept design can be employed to treat other diseases of the colon.

关键词： Escherichia coli Nissle 1917 Colitis β-hydroxybutyrate 3HB Synthetic biology Metabolic engineering Microbiomes Probiotics Colonic microenvironment

Atomization Inhalation of Terbutaline and Budesonide Efficiently Improved Immunity and Lung Function of AECOPD Patients

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Cellular & Molecular Immunology 2008年第4期5卷 287-291页

作者： Guilan Xiong Lijun xu liu Wei Xiaodan Li Department of Respiratory Medicine The First Hospital of Jilin UniversityChangchun 130021 China

Chronic obstructive pulmonary disease （COPD） is a syndrome of chronic progressive airflow limitation as a result of chronic inflammation of the airways and lung parenchyma. COPD patients always have airway hyperreactivity （AHR）, so how to reduce AHR becomes the key purpose of clinical treatment. It is hypothesized that combined inhalation of corticosteroids and β2-agonists can reduce the AHR in COPD. In this study, atomization inhalation of budesonide and terbutaline plus conventional therapies was applied to treat AECOPD （acute exacerbation of chronic obstructive pulmonary disease） patients for two weeks. The results showed that additional inhalation of budesonide and terbutaline could upregulate serum IL-2 levels, the percentages of CD3^＋ T and CD4^＋ T cells, and CD4/CD8 ratio, and decrease eosinophils and serum CRP level more efficiently than conventional treatment in patients with AECOPD. And the lung function of the atomization inhalation group was improved more obviously after the treatment compared with the conventional treatment group. Thus, atomization inhalation of terbutaline and budesonide can control AECOPD effectively, and has wide clinical perspective in controlling and preventing the exacerbation of COPD. Cellular ＆ Molecular Immunology. 2008;5（4）：287-291.

关键词： AECOPD T lymphocyte subset IL-2 eosinophil C-reactive protein

Optimized design of LED freeform lens for uniform circular illumination

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第12期13卷 929-936页

作者： Peng liu Reng-mao WU Zhen-rong ZHENG Hai-feng LI xu liu State Key Laboratory of Modern Optical Instrumentation Zhejiang University Hangzhou 310027 China

An optimization method is proposed for designing an LED freeform lens which produces a uniform circular pattern with high energy *** method is composed of three main aspects:design of the initial guess,parameterization of the freeform surface,and construction of the merit *** initial guess is created by solving an ordinary differential equation *** approach of selecting optimization points is introduced for parameterization of the freeform *** merit function is constructed by use of the irradiance uniformity and the efficiency of the *** examples are given,and the results show that the irradiance distribution is well controlled with a maximum uniformity(the relative standard deviation of irradiance,RSD) of 0.0122 and a maximum efficiency of 93.88%.This optimization method can be generalized to design freeform lenses with different lighting patterns or without rotational symmetry.

关键词： Illumination design Lenses Light emitting diode(LED) Non-imaging optics

One Step Preparation of Highly Dispersed TiO2 Nanoparticles

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Chemical Research in Chinese Universities 2015年第5期31卷 688-692页

作者： liu xu CHEN Yan JIAO Shihui PANG Guangsheng State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China

A facile approach was developed to prepare highly dispersed TiO2 nanoparticles with selected phase. The crystallization phase of the nanoparticles can be easily tuned from anatase to rutile by the dosage of hydrochloric acid in the reaction system. The crystallite size of the as-prepared anatase TiO2 nanoparticles was ca. 3.2 nm with high dispersion. A transparent TiO2 colloid was obtained by dispersing the as-prepared anatase TiO2 nanoparticles in deionized water without any organic additives added. The concentration of TiO2-H2O colloid can be as high as 1600 g/L. The optical transmittance of TiO2-H2O colloid with a low concentration was nearly 100% in the visible region. Furthermore, anatase TiO2 nanoparticles（TiO2-NPs） showed superior photocatalytic performance compared to rutile TiO2-NPs.

关键词： TiO2 nanoparticle Water-dispersible Colloid

Tailoring the photophysical and photovoltaic properties of boron-difluorodipyrromethene dimers

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Chinese Chemical Letters 2017年第4期28卷 875-880页

作者： Wen-xu liu Jian-Nian Yao Chuan-Lang Zhan Beijing National Laboratory of Molecular Science CAS Key Laboratory of PhotochemistryInstitute of ChemistryChinese Academy of SdencesBeijing 100190China

Five boron-difluorodipyrromethene（BODIPY） dimers have been designed and synthesized successfully via acid-catalysed condensation and Pd-catalysed cross-coupling *** structural modification,including verifying the structures of the π-bridges,altering the positions the bridges link（meso-or β-positions）,and regulating the molecular planarity,can modulate the photophysical properties and the aggregation behaviors of the five dimers ***-processed organic solar cells were fabricated to evaluate the photovoltaic properties of these molecules further either as acceptors or *** using as nonfullerene acceptor and blended with the polymer donor of PTB7,an opencircuit voltaic（V_（oc）） of 1.12 and 1.08 V was achieved from the thiophene and benzodithiophene bridged BODIPY dimers,*** V_（oc） is among the top values achieved from the non-fullerene organic solar cells so far.

关键词： BODIPY Nonfullerene acceptor Small molecule donor Photovoltaic cell Solution-processed

Lead Determination on MWNT/Nafion Composite Modified Glassy Carbon Electrodes

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Chinese Journal of Chemistry 2005年第11期23卷 1510-1514页

作者： xu, Qin liu, Ni-Na ZHU, Jun-Jie Key Labororatory of Analytical Chemistry for Life Science Department of Chemistry Nanjing University Nanjing Jiangsu 210093 China

A composite material of nitric acid oxidized multiwalled carbon nanotube （MWNT） and Nation was prepared. Such composite was modified on a glassy carbon electrode to determine trace of lead by differential pulsed voltammetry. In pH=6.47 NaNO3 solution, Pb^2＋ ions were accumulated on the modified electrode at -0.4 V. Compared with a bare and a Nation film coated electrode, the composite coated GC electrode can reduce the accumulating potential and eliminate the toxic character of mercury. The calibration plots were linear at low concentration of 5.0× 10^-9-2.0× 10^-8 mol/L and high concentration of 2.5× 10^-8-5.0× 10^-6 mol/L. The performances characteristics indicate that the electrode can be used to determine trace Pb^2＋ ions.

关键词： composite lead electrochemistry differential pulsed voltammetry