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Amniotic membrane covering promotes healing of cornea epithelium and improves visual acuity after debridement for fungal keratitis

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 785-789页

作者： Bo Zeng Ping Wang Ling-juan xu Xin-Yu Li Hong Zhang Gui-Gang Li Department of Ophthalmology Wuhan General Hospital of Guangzhou Military Department of Ophthalmology Renhe Hospital of China Three Gorges University Department of Ophthalmology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

AIM:To investigate the effect of amniotic membrane covering(AMC) on the healing of cornea epithelium and visual acuity for fungal keratitis after ***:Twenty fungal keratitis patients were divided into two groups randomly, the AMC group and the control group, ten patients each group. Both debridement of the infected cornea tissue and standard anti-fungus drugs treatments were given to every patients, monolayer amniotic membrane were sutured to the surface of the entire cornea and bulbar conjunctiva with 10-0 nylon suture for patients in the AMC *** diameter of the ulcer was determined with slit lamp microscope and the depth of the infiltration was determined with anterior segment optical coherence tomography. Uncorrected visual acuity(UCVA) was tested before surgery and three month after healing of the epithelial layer. The healing time of the cornea epithelium, visual acuity(VA) was compared between the two groups using t- ***:There was no statistical difference of the diameter of the ulcer, depth of the infiltration, height of the hypopyon and VA between the two groups beforesurgery(P >0.05). The average healing time of the AMC group was 6.89 ±2.98 d, which was statistically shorter than that of the control group(10.23±2.78d)(P <0.05).The average UCVA of the AMC group was 0.138 ±0.083,which was statistically better than that of the control group(0.053±0.068)(P <0.05).CONCLUSION:AMC surgery could promote healing of cornea epithelium after debridement for fungal keratitis and lead to better VA outcome.

关键词： amniotic membrane fungal keratitis cornea epithelium visual acuity

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Researches on chemically modified electrode *** reduction of oxygen on iron porphyrin modified electrode

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Chinese Journal of Chemistry 1984年第2期2卷 95-104页

作者： DONG Shao-Jun xu Li-juan MA Yue Changchun Institute of Applied Chemistry,Academia Sinica Changchun Institute of Applied Chemistry Academia Sinica

By surface organic synthesis a Fe(Ⅲ)tetra-o-aminophenyl porphyrin modified electrodewas successfully prepared on glassy carbon electrode surface through *** preparativeconditions were investigated in *** cyclic voltammetry and semidifferential neo-polarogra-phy in an acidic aqueous solution the behavior of the catalytic reduction ofoxygen on iron porphyriamodified electrode was *** on experimental results it was shown that the irreversibleprocess of 2-electron-reduction to hydrogen peroxide belongs to EC parallel catalytic process.

关键词： TAPP Researches on chemically modified electrode V.Catalytic reduction of oxygen on iron porphyrin modified electrode

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An Overview Study of Performance Evaluation of Intellectual Property Administrative and Judicial Protection in China

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International Journal of Technology Management 2015年第8期 146-150页

作者： xu Xingxiang Luo juan Southwest Jiaotong University Chengdu611756 China

Whether IP Administrative and judicial Protection in China is good or bad depends on the evaluation of protection effects of administrative and judicial organs. In China the evaluation system of IP protection performance consists of evaluation principles, evaluation elements and evaluation methods, evaluation principles includes the principle of designing two sets of indicators, the principle of closely linking with China＇ s national intellectual property strategy, the principle of openness and flexibility of performance evaluation indicators,the principle of standardability of the determination of performance evaluation indicators; evaluation elements consist of evaluator, evaluation tools and objects evaluated; evaluation methods here refers to the Delphi method and the method of network questionary survey.

关键词： Performance Evaluation Evaluation Principle Evaluation Element Evaluation Method

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A procedural study of building up a performance evaluation indicator system of intellectual property protection

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International Journal of Technology Management 2015年第10期 113-116页

作者： Luo juan xu Xingxiang Southwest Jiaotong University Chengdu611756 China

The intellectual property protection, whether judicial or administrative, is evaluated through a performance evaluation indicator system. To building up such a system, we must follow certain working procedures which usually consist of four steps： to determine the performance objectives, to design the structure of indicator system, to specify the indicators and to set up the weight of indicators. Each step plays a different role in performance evaluation indicator system and has its own impact on the realization of performance evaluation objectives respectively. So the scientifically building up a performance evaluation indicator system is the key to determine whether the intellectual property is protected well or not.

关键词： lntellectual property protection performance evaluation indicator system performance objective evaluating indicators weights of indicators

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Characterization of an IncX3 type plasmid harboring Escherichia coli ST410 clinical strain isolated from a urinary tract infection

Characterization of an IncX3 type plasmid harboring Escheric...

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2019年浙江省医学会医学微生物与免疫学分会学术大会

作者： juan xu Fang He Institute of Hygiene Zhejiang Academy of Medical Sciences Department of Clinical Laboratory Zhejiang Provincial People's HospitalPeople's Hospital of Hangzhou Medical College

Objectives:The emergence of New Delhi metallo-beta-lactamase (NDM) carbapenemase-producing Escherichia coli leaves few therapeutic *** due to NDM-7 carbapenemase-producing *** are *** this study,we report the whole genome sequence of an NDM-7 carbapenemase-producing *** belonging to sequence type (ST) 410 isolated from a patient with urinary tract infection in China.

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Genomic analysis of two strains co-isolated from a urinary tract infection:NDM-1 producing Enterobacter cloacae accompanied with ESBL producing Escherichia coli

Genomic analysis of two strains co-isolated from a urinary t...

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2019年浙江省医学会医学微生物与免疫学分会学术大会

Objectives:Escherichia coli and Enterobacter cloacae are two major pathogens of urinary tract *** we characterized the genome of a NDM-1 producing *** strain and an ESBL-producing *** strain that were co-isolated from a urinary tract ***:The genomes of the *** strain EC32 and the *** strain EC33 were sequenced using the Illumina HiSeqTM *** whole genome sequences were assembled using CLC Genomics Workbench and annotated by the NCBI Prokaryotic Genome Annotation Pipeline(PGAP) *** characterization analysis was further ***:The draft genome sequences of *** EC32(sequence type ST66) and *** EC33(sequence type ST1139) consisted of 89 contigs comprising 5,178,393 bp and 62 contigs comprising 5,057,666 bp *** the presence of the blaNDM-1 gene,in total thirteen resistance genes were identified in *** EC32 conferring resistance to beta-lactam,rifampicin,phenicol,fosfomycin,macrolide,quinolone,sulphonamide and *** resistance genes were identified in *** EC33 including the ESBL coding gene ***:To our knowledge,this is the first report of genomic characterization of NDM-1 producing *** and ESBL producing *** that were co-isolated from a urinary tract infection in *** two strains inhabiting in the same environment may give them the chance for horizontal transfer of blaNDM-1 and blaCTX-M-27 which makes clinical treatment even *** report also shed light on a geographically distinct Enterobacteriaceae strains from China enabling a comparative analysis of NDM-1 or ESBL producing strains.

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Sporophytic control of tapetal development and pollen fertility by a mitogen-activated protein kinase cascade in rice

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Journal of Integrative Plant Biology 2024年第7期66卷 1500-1516页

作者： Jianguo Zeng Manman Duan Yiqing Wang Guangtao Li Yujing You Jie Shi Changhao Liu Jinyang Zhang juan xu Shuqun Zhang Jing Zhao Department of Plant Pathology Nanjing Agricultural UniversityNanjing 210095China State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310058China Division of Biochemistry University of MissouriColumbia65211MOUSA

Tapetum,the innermost layer of the anther wall,provides essential nutrients and materials for pollen *** degradation of anther tapetal cells is a prerequisite for normal pollen development in flowering *** cells facilitate male gametogenesis by providing cellular contents after highly coordinated programmed cell death(PCD).Tapetal development is regulated by a transcriptional ***,the signaling pathway(s)involved in this process are poorly *** this study,we report that a mitogen-activated protein kinase(MAPK)cascade composed of OsYDA1/OsYDA2-OsMKK4-OsMPK6 plays an important role in tapetal development and male gametophyte *** of function of this MAPK cascade leads to anther indehiscence,enlarged tapetum,and aborted pollen *** cells in osmkk4 and osmpk6 mutants exhibit an increased presence of lipid body-like structures within the cytoplasm,which is accompanied by a delayed occurrence of *** of a constitutively active version of OsMPK6(CA-OsMPK6)can rescue the pollen defects in osmkk4 mutants,confirming that OsMPK6 functions downstream of OsMKK4 in this *** crosses also demonstrated that the MAPK cascade sporophyticly regulates pollen *** study reveals a novel function of rice MAPK cascade in plant male reproductive biology.

关键词： degradation MAPK cascade pollen fertility rice tapetum

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KDM6B epigenetically regulates odontogenic differentiation of dental mesenchymal stem cells

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International Journal of Oral Science 2013年第4期5卷 200-205页

作者： juan xu Bo Yu Christine Hong Cun-Yu Wang Department of Stomatology Chinese People's Liberation Army General Hospital Division of Oral Biology and Medicine School of DentistryUniversity of California Section of Orthodontics School of DentistryUniversity of California Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California

Mesenchymal stem cells （MSCs） have been identified and isolated from dental tissues, including stem cells from apical papilla, which demonstrated the ability to differentiate into dentin-forming odontoblasts. The histone demethylase KDM6B （also known as JMJD3） was shown to play a key role in promoting osteogenic commitment by removing epigenetic marks H3K27me3 from the promoters of osteogenic genes. Whether KDM6B is involved in odontogenic differentiation of dental MSCs, however, is not known. Here, we explored the role of KDM6B in dental MSC fate determination into the odontogenic lineage. Using shRNA-expressing lentivirus, we performed KDM6B knockdown in dental MSCs and observed that KDM6B depletion leads to a significant reduction in alkaline phosphate （ALP） activity and in formation of mineralized nodules assessed by Alizarin Red staining. Additionally, mRNA expression of odontogenic marker gene SP7 （osterix, OSX）, as well as extracellular matrix genes BGLAP （osteoclacin, OCN） and SPP1 （osteopontin, OPN）, was suppressed by KDM6B depletion. When KDM6B was overexpressed in KDM6B-knockdown MSCs, odontogenic differentiation was restored, further confirming the facilitating role of KDM6B in odontogenic commitment. Mechanistically, KDM6B was recruited to bone morphogenic protein 2 （BMP2） promoters and the subsequent removal of silencing H3K27me3 marks led to the activation of this odontogenic master transcription gene. Taken together, our results demonstrated the critical role of a histone demethylase in the epigenetic regulation of odontogenic differentiation of dental MSCs. KDM6B may present as a potential therapeutic target in the regeneration of tooth structures and the repair of craniofacial defects.

关键词： bone morphogenic protein dental mesenchymal stem cell epigenetics KDM6B odontogenic differentiation

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Prediction of Meteorological Drought in the Lower Nu River by Statistical Model

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American Journal of Climate Change 2020年第2期9卷 87-99页

作者： Wenhua Chen juan xu Shuangcheng Li School of Resources and Environment Baoshan University Baoshan China College of Urban and Environmental Sciences Peking University Beijing China

Global climate change, temperature rise and some kinds of extreme meteorological disaster, such as the drought, threaten the development of the natural ecosystem and human society. Forecasting in drought is an important step toward developing a disaster mitigation system. In this study, we utilized the statistical, autoregressive integrated moving average (ARIMA) model to predict drought conditions based on the standardized precipitation index (SPI) and standardized precipitation evapotranspiration index (SPEI) in a major tributary in the lower reaches of Nu River. We employed data from 2001 to 2010 to fit the model and data from 2011 to 2013 for model validation. The results showed that the coefficients of determination (R2) was over 0.85 in each index series, and the root-mean-square error and mean absolute error were low, implying that the ARIMA model is effective and adequate for this region.

关键词： Meteorological Drought Climate Change Lower Nu River Statistical Model

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Differentiation of expression profi les of two calcineurin subunit genes in chicken skeletal muscles during early postnatal growth depending on anatomical location of muscles and breed

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Journal of Integrative Agriculture 2016年第5期15卷 1085-1094页

作者： SHAN Yan-ju xu Wen-juan SHU Jing-ting ZHANG Ming SONG Wei-tao TAO Zhi-yun ZHU Chun-hong LI Hui-fang Key Laboratory for Poultry Genetics and Breeding of Jiangsu Province Institute of Poultry Science Chinese Academy of Agricultural Science

Calcineurin（Cn or CaN） is implicated in the control of skeletal muscle fiber phenotype and hypertrophy. However, little information is available concerning the expression of Cn in chickens. In the present study, the expression of two Cn subunit genes（Cn Aα and Cn B1） was quantified by q PCR in the lateral gastrocnemius（LG, mainly composing of red fast-twitch myofibers）, the soleus（mainly composing of red slow-twitch myofibers） and the extensor digitorum longus（EDL, mainly composing of white fast-twitch myofibers） from Qingyuan partridge chickens（QY, slow-growing chicken breed） and Recessive White chickens（RW, fast-growing chicken breed） on different days（1, 8, 22, 36, 50 and 64 days post-hatching）. Although Cn Aα and Cn B1 gene expressions were variable with different trends in different skeletal muscles in the two chicken breeds during postnatal growth, it is highly muscle phenotype and breed specific. In general, the levels of Cn Aα and Cn B1 gene expressions of the soleus were lower than those of EDL and LG in both chicken breeds at the same stages. Compared between the two chicken breeds, the levels of Cn Aα gene expression of the three skeletal muscles in QY chickens were higher than those in RW chickens on days 1 and 22. However, on day 64, the levels of both Cn Aα and Cn B1 gene expressions of the three skeletal muscles were lower in QY chickens than those in RW chickens. Correlation analysis of the levels of Cn Aα and Cn B1 gene expressions of the same skeletal muscle showed that there were positive correlations for all three skeletal muscle tissues in two chicken breeds. These results provide some valuable clues to understand the role of Cn in the development of chicken skeletal muscles, with a function that may be related to meat quality.

关键词： calcineurin chicken skeletal muscle expression

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