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Calculation Models of Interlamellar Spacing of Pearlite in High-Speed 82B Rod

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Journal of Iron and Steel Research International 2008年第4期15卷 57-60页

作者： xu jin-qiao liu ya-zheng zhou shu-mei School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

With the investigated subject of 82B rod, the interlamellar spacings of pearlite at different isothermal transformation temperatures and different cooling rates during continuous cooling transformation were measured, and the effect of the isothermal transformation temperature and cooling rate on the interlamellar spacing was analyzed quantitatively. Moreover, the relationship models between undercooling and interlamellar spacing were presented by data regression. The experimental results show that the relationship between undercooling and reciprocal interlamellar spacing remains linear when the undercooling is not very large, or else, the interlamellar spacing tends to be constant and the relationship will deviate from linearity.

关键词： interlamellar spacing calculation model high-speed rod 82B

Epidemiological Survey of Hemoglobinopathies Based on Next-Generation Sequencing Platform in Hunan Province,China

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Biomedical and Environmental Sciences 2023年第2期36卷 127-134页

作者： XI Hui liu Qin XIE Dong Hua zhou xu TANG Wang Lan TANG De Guo ZENG Chun yan WANG Qiong NIE Xing Hui PENG jin Ping GAO Xiao ya WU Hong Liang ZHANG Hao Qing QIU Li FENG Zong Hui WANG shu Yuan zhou shu Xiang HE Jun zhou Shi Hao zhou Fa Qun zheng Jun Qing WANG shun yao CHEN Shi Ping zheng Zhi Fen MA Xiao Yuan FANG Jun Qun LIANG Chang Biao WANG Hua NHC Key Laboratory of Birth Defect for Research and Prevention Hunan Provincial Maternal and Child Health Care HospitalChangsha 410028HunanChina Yongzhou Hospital for Maternal and Child Health Care Yongzhou 425000HunanChina Changde Hospital for Maternal and Child Health Care Changde 415099HunanChina Hengyang Hospital for Maternal and Child Health Care Hengyang 421009HunanChina Shaoyang Hospital for Maternal and Child Health Care Shaoyang 422001HunanChina Yiyang Hospital for Maternal and Child Health Care Yiyang 413099HunanChina Yueyang Hospital for Maternal and Child Health Care Yueyang 414021HunanChina Center of Prenatal Diagnosis Chenzhou No.1 People’s HospitalChenzhou 423099HunanChina Loudi Hospital for Maternal and Child Health Care Loudi 417599HunanChina Huaihua Hospital for Maternal and Child Health Care Huaihua 418099HunanChina Xiangtan Hospital for Maternal and Child Health Care Xiangtan 411104HunanChina Zhuzhou Hospital for Maternal and Child Health Care Zhuzhou 412008HunanChina Changsha Hospital for Maternal and Child Health Care Changsha 410007HunanChina Xiangxi Tujia and Miao Autonomous Prefecture Hospital for Maternal and Child Health Care Jishou 416000HunanChina Zhang Jiajie Centre for maternal and child health family planning services Zhangjiajie 427299HunanChina BGI Genomics BGI-ShenzhenShenzhen 518083GuangdongChina Clinical Laboratory of BGI Health BGI-ShenzhenShenzhen 518083GuangdongChina BGI-Wuhan Clinical Laboratories BGI-ShenzhenWuhan 430074HubeiChina SEBIA Representative Office Shanghai 200001China

Objective This study was aimed at investigating the carrier rate of,and molecular variation in,α-andβ-globin gene mutations in Hunan *** We recruited 25,946 individuals attending premarital screening from 42 districts and counties in all 14 cities of Hunan *** screening was performed,and molecular parameters were *** The overall carrier rate of thalassemia was 7.1%,including 4.83%forα-thalassemia,2.15%forβ-thalassemia,and 0.12%for bothα-andβ-*** highest carrier rate of thalassemia was in Yongzhou(14.57%).The most abundant genotype ofα-thalassemia andβ-thalassemia was-α^(3.7)/αα(50.23%)andβ^(IVS-Ⅱ-654)/β^(N)(28.23%),***α-globin mutations[CD108(ACC>AAC),CAP+29(G>C),Hb Agrinio and Hb Cervantes]and sixβ-globin mutations[CAP+8(C>T),IVS-Ⅱ-848(C>T),-56(G>C),beta nt-77(G>C),codon 20/21(-TGGA)and Hb Knossos]had not previously been identified in ***,this study provides the first report of the carrier rates of abnormal hemoglobin variants andα-globin triplication in Hunan Province,which were 0.49%and 1.99%,*** Our study demonstrates the high complexity and diversity of thalassemia gene mutations in the Hunan *** results should facilitate genetic counselling and the prevention of severe thalassemia in this region.

关键词： Thalassemia Carrier rate Molecular spectrum Abnormal hemoglobin variants α-globin triplication

奥氏体-铁素体区循环形变对X60管线钢力学性能的影响

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热加工工艺 2006年第8期35卷 44-47页

作者：周淑梅刘雅政徐进桥北京科技大学材料科学与工程学院北京100083

通过调整奥氏体-铁素体区循环形变参数,研究了铁素体区变形温度、奥氏体区变形温度、变形速率、冷却速度对X60管线钢力学性能的影响规律。实验结果表明:采用该循环变形工艺所得到的X60管线钢的铁素体晶粒大小为3.7μm,抗拉强度为639MPa... 详细信息

通过调整奥氏体-铁素体区循环形变参数,研究了铁素体区变形温度、奥氏体区变形温度、变形速率、冷却速度对X60管线钢力学性能的影响规律。实验结果表明:采用该循环变形工艺所得到的X60管线钢的铁素体晶粒大小为3.7μm,抗拉强度为639MPa,断面收缩率为79%,与CSP工艺下的组织相比,更加均匀细化,抗拉强度提高了16%。

关键词： X60管线钢奥氏体-铁素体区循环形变力学性能晶粒细化

A detector setup for the measurement of angular distribution of heavy-ion elastic scattering with low energy on RIBLL

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Nuclear Science and Techniques 2017年第7期28卷 85-89页

作者： Gao-Long Zhang Yong-jin yao Guang-Xin Zhang Zhen-Wei Jiao Cheng-Jian Lin ya-zhou Niu Wei-Wei Qu Lei yang Nan-Rou Ma Lei zheng Hui-Ming Jia Li-Jie Sun Xing-Xing liu Xiao-Tong Chu Jie-Cheng yang Jian-Song Wang Shi-Wei xu Peng Ma Jun-Bing Ma Shi-Lun jin Zhen Bai mei-Rong Huang Hong-Liang Zang Biao yang yang liu School of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China China Institute of Atomic Energy Beijing 102413 China School of Radiation Medicine and Protection Medical College of Soochow University Soochow 215123 China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 China School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 China

A detector setup for the measurement of angular distribution of heavy-ion elastic scattering at energies around Coulomb barrier on the radioactive ion beam line in Lanzhou at the heavy-ion research facility in Lanzhou is *** beam profile and the scattering angles on the target are deduced by two parallel plate avalanche counters,and four sets of detector telescopes(including doublesided silicon strip detectors) are placed systematically with the beam line,incorporating with Monte Carlo *** data of ^(16)O on ^(89)Y target were analyzed to compare with the simulation *** is found that the simulated distribution is agreeable with the experimental *** assuming the pure Rutherford scattering at small scattering angles,the angular distribution of elastic scattering of^(16)O+^(89)Y at low energies can be reasonably *** indicates that this set of detector setup can be used for the measurement of angular distributions of heavy-ion elastic scattering at energies around Coulomb barrier.

关键词：兰州放射性束流线重离子研究装置探测器望远镜角分布测量弹性散射低能量设置平行板雪崩计数器

GCH1 variants contribute to the risk and earlier age-at-onset of Parkinson's disease:a two-cohort case-control study

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Translational Neurodegeneration 2020年第3期9卷 409-420页

作者： Hong-xu Pan Yu-wen Zhao Jun-pu mei zheng-huan Fang Yige Wang xun zhou yang-jie zhou Rui Zhang Kai-lin Zhang Li Jiang Qian Zeng yan He zheng Wang Zhen-hua liu Qian xu Qi-ying Sun yang yang ya-cen Hu ya-se Chen Juan Du Li-fang Lei Hai-nan Zhang Chun-yu Wang Xin-xiang yan Lu Shen Hong Jiang Jie-qiong Tan jin-chen Li Bei-sha Tang Ji-feng Guo Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Centre for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangsha 410008China Department of Geriatrics Xiangya HospitalCentral South UniversityChangsha 410008China Department of Neurology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Neurology The Second Xiangya HospitalCentral South UniversityChangsha 410011China Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangsha 410008China

Background:Common and rare variants of guanosine triphosphate cyclohydrolase 1(GCH1)gene may play important roles in Parkinson's disease(PD).However,there is a lack of comprehensive analysis of GCH1 genotypes,especially in non-coding *** aim of this study was to explore the genetic characteristics of GCH1,including rare and common variants in coding and non-coding regions,in a large population of PD patients in Chinese mainland,as well as the phenotypic characteristics of GCH1 variant ***:In the first cohort of this case-control study,we performed whole-exome sequencing in 1555 patients with early-onset or familial PD and 2234 healthy controls;then in the second cohort,whole-genome sequencing was performed in sporadic late-onset PD samples(1962 patients),as well as 1279 *** at target GCH1 regions were extracted,and then genetic and detailed phenotypic data were analyzed using regression models and the sequence kernel association *** also performed a meta-analysis to correlate deleterious GCH1 variants with age at onset(AAO)in PD ***:For coding variants,we identified a significant burden of GCH1 deleterious variants in early-onset or familial PD cases compared to controls(1.2%VS 0.1%,P<0.0001).In the analysis of possible regulatory variants in GCH1 non-coding regions,rs12323905(P=0.001,odds ratio=1.19,95%CI 1.07-1.32)was significantly associated with PD,and variant sets in untranslated regions and intron regions,GCH1 brain-specific expression quantitative trait loci,and two possible promoter/enhancer(GH14J054857 and GH14J054880)were suggestively associated with *** phenotype correlation analysis revealed that the carriers of GCH1 deleterious variants manifested younger AAO(P<0.0001),and had milder motor symptoms,milder fatigue symptoms and more autonomic nervous ***-analysis of six studies demonstrated 6.4-year earlier onset in GCH1 deleterious variant carriers(P=0.0009).Conclusions:The results

关键词： Parkinson's disease Age at onset GCH1 Deleterious variants Non-coding variants

非调质N80石油套管轧制工艺优化的实验研究

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钢铁 2006年第7期41卷 41-44,53页

作者：刘雅政刘照徐进桥张玉胜乔爱云北京科技大学材料科学与工程学院北京100083 包头钢铁集团公司无缝钢管厂内蒙古包头014040

针对用34Mn2VN钢生产非调质N80级石油套管冲击韧性偏低的问题，在动态相变规律研究的基础上进行了不同轧制工艺参数的热模拟实验，分析了工艺参数对34Mn2VN钢组织演变规律及冲击韧性的影响。通过优化工艺参数，将终轧温度控制为850℃，... 详细信息

针对用34Mn2VN钢生产非调质N80级石油套管冲击韧性偏低的问题，在动态相变规律研究的基础上进行了不同轧制工艺参数的热模拟实验，分析了工艺参数对34Mn2VN钢组织演变规律及冲击韧性的影响。通过优化工艺参数，将终轧温度控制为850℃，轧后冷速为0．8～1．5℃／s，在包钢≠180机组上稳定生产出高质量的非调质N80级石油套管。结果表明，不经在线正火，能稳定生产符合APISPEC5CT第七版标准的非调质N80级石油套管，显著提高产品的冲击韧性，并实现节能降耗。

关键词：非调质钢工艺参数优化冲击韧性石油套管

Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer:final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1310-1317页

作者： Wen-Zhao Zhong Hong-Hong yan Ke-Neng Chen Chun Chen Chun-Dong Gu Jun Wang xue-Ning yang Wei-Min Mao Qun Wang Gui-Bin qiao Ying Cheng Lin xu Chang-Li Wang Ming-Wei Chen Xiao-zheng Kang Wan-Pu yan Ri-Qiang Liao jin-Ji yang xu-Chao Zhang Si-yang liu Qing zhou Yi-Long Wu Guangdong Provincial People’s Hospital Guangdong Academy of Medical Sciences510080 GuangzhouChina Peking University Cancer Hospital and Institute 100142 BeijingChina Fujian Medical University Union Hospital 350001 FuzhouChina First Affiliated Hospital of Dalian Medical University 116011 DalianChina Peking University People’s Hospital 100044 BeijingChina Zhejiang Cancer Hospital 310022 HangzhouChina Zhongshan Hospital 200032 ShanghaiChina Guangzhou liuhuaqiao Hospital 510000 GuangzhouChina Jilin Provincial Tumor Hospital 130012 ChangchunChina Jiangsu Cancer Institute and Hospital 210009 NanjingChina Tianjin Medical University Cancer Institute and Hospital 300060 TianjinChina First Affiliated Hospital of Xi’an Jiaotong University 710061 Xi’anChina

EMERGING-CTONG 1103 showed improved progression-free survival(PFS)with neoadjuvant erlotinib *** for patients harbouring EGFR sensibility mutations and R0 resected stage IIIA-N2 non-small cell lung cancer(NSCLC)(NCT01407822).Herein,we report the final *** patients were randomly allocated 1:1 to the erlotinib group(150 mg/day orally;neoadjuvant phase for 42 days and adjuvant phase to 12 months)or to the GC group(gemcitabine 1250 mg/m2 plus cisplatin 75 mg/m2 intravenously;2 cycles in neoadjuvant phase and 2 cycles in adjuvant phase).Objective response rate(ORR),complete pathologic response(pCR),PFS,and overall survival(OS)were assessed along with *** hoc analysis was performed for subsequent treatments after disease *** investigated 72 patients(erlotinib,n=37;GC,n=35),the median follow-up was 62.5 *** median OS was 42.2 months(erlotinib)and 36.9 months(GC)(hazard ratio[HR],0.83;95%confidence interval[CI],0.47-1.47;p=0.513).The 3-and_(5-y)ear OS rates were 58.6%and 40.8%with erlotinib and 55.9%and 27.6%with GC(p_(3-y)=0.819,p_(5-y)=0.252).Subsequent treatment was administered in 71.9%and 81.8%of patients receiving erlotinib and GC,respectively;targeted therapy contributed mostly to OS(HR,0.35;95%CI,0.18-0.70).After disease progression,the ORR was 53.3%,and the median PFS was 10.9 months during the EGFR-TKI *** postoperative therapy,grade 3 or 4 adverse events(AEs)were 13.5%in the erlotinib group and 29.4%in the GC *** serious adverse events were *** exhibited clinical feasibility for resectable IIIA-N2 NSCLC over chemotherapy in the neoadjuvant setting.

关键词： neoadjuvant cisplatin chemotherapy

Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng Zhao Dong Li Shao-Lin Xiong yan-Qiu Zhang yang Su Wei Chen Yi Zhao Xiao-Bo Li Jia-Cong liu Wen-Xi Peng Rui qiao Xin-qiao Li Xiang-yang Wen Li-Ming Song Shi-Jie zheng Xin-Ying Song Xiao-Yun Zhao Yue Huang shuang-Nan Zhang shuo Xiao Ce Cai zheng-Hua An Can Chen Gang Chen Wei Chen yan-Qi Du Min Gao Ke Gong Dong-ya Guo Zhi-Wei Guo Jian-Jian He Bin Li Chao Li Chao-yang Li Gang Li Jian-Hui Li Lu Li Qing-Xin Li yan-Guo Li jing Liang Xiao-Hua Liang jin-Yuan Liao Xiao-jing liu ya-Qing liu Qi Luo Xiang Ma Bin Meng Ge Ou Dong-Li Shi jing-yan Shi Gong-Xing Sun Xi-Lei Sun You-Li Tuo Chen-Wei Wang Hui Wang jin Wang jin-zhou Wang Ping Wang Wen-shuai Wang Hong Wu Sheng-Lun Xie yan-Bing xu Yu-Peng xu Wang-Chen xue Sheng yang Min yao Jian-Ying Ye Qi-Bin Yi Chao-Yue Zhang Da-Li Zhang Fan Zhang Fei Zhang Hong-mei Zhang Kai Zhang Peng Zhang Xiao-Lu Zhang Zhen Zhang Guo-Ying Zhao Shi-Yi Zhao Chao zheng Xing zhou Yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

Genome assembly of autotetraploid Actinidia arguta highlights adaptive evolution and enables dissection of important economic traits

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Plant Communications 2024年第6期5卷 173-192页

作者： xue-mei Lu Xiao-Fen Yu Guo-Qiang Li Ming-Hao Qu Huan Wang Chuang liu Yu-Ping Man Xiao-Han Jiang Mu-Zi Li Jian Wang Qi-Qi Chen Rui Lei Cheng-Cheng Zhao Yun-Qiu zhou zheng-Wang Jiang Zuo-zhou Li Shang zheng Chang Dong Bai-Lin Wang yan-Xiang Sun Hui-Qin Zhang Jie-Wei Li Quan-Hui Mo Ying Zhang Xin Lou Hai-xu Peng ya-Ting Yi He-Xin Wang Xiu-Jun Zhang Yi-Bo Wang Dan Wang Li Li Qiong Zhang Wen-Xia Wang Yongbo liu Lei Gao jin-Hu Wu yan-Chang Wang CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhanHubeiChina Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhouGansuChina College of Life Sciences University of Chinese Academy of SciencesBeijingChina Wuhan Frasergen Bioinformatics Co. LtdWuhanHubeiChina Institute of Soil and Fertilizer Anhui Academy of Agricultural SciencesHefeiChina College of Agricultural Sciences Xichang UniversityXichangSichuanChina Department of Horticulture Heilongjiang Academy of Agricultural SciencesHarbinHeilongjiangChina College of Life Sciences Langfang Normal UniversityLangfangHebeiChina Institute of Horticulture Zhejiang Academy of Agricultural SciencesHangzhouZhejiangChina Guangxi Institute of Botany Chinese Academy of SciencesGuilinGuangxiChina Xi’an Botanical Garden of Shaanxi Province Institute of Botany of Shaanxi ProvinceXi’anShaanxiChina Institute of Modern Agricultural Research Dalian UniversityDalianLiaoningChina Bioinformatics Center College of Plant Science and TechnologyBeijing University of AgricultureBeijingChina College of Agriculture Eastern Liaoning UniversityDandongLiaoningChina Dalian Institute of Chemical Physics Chinese Academy of SciencesDalianLiaoningChina State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment Chinese Research Academy of Environmental SciencesBeijingChina Hubei Hongshan Laboratory WuhanHubeiChina The New Zealand Institute for Plant and Food Research Limited AucklandNew Zealand

Actinidia arguta,the most widely distributed Actinidia species and the second cultivated species in the genus,can be distinguished from the currently cultivated Actinidia chinensis on the basis of its small and smooth fruit,rapid softening,and excellent cold *** evolution of tetraploid Actinidia species and the genetic basis of their important agronomic traits are still ***,we generated a chromosome-scale genome assembly of an autotetraploid male *** *** genome assembly was 2.77 Gb in length with a contig N50 of 9.97 Mb and was anchored onto 116 *** and clustering of 101 geographically representative accessions showed that they could be divided into two geographic groups,Southern and Northern,which first diverged 12.9 million years *** underwent two prominent expansions and one demographic bottleneck from the midPleistocene climate transition to the late *** genomics studies using paleoclimate data enabled us to discern the evolution of the species’adaptation to different historical *** genes(AaCEL1,AaPME1,and AaDOF1)related to flesh softening were identified by multi-omics analysis,and their ability to accelerate flesh softening was verified through transient expression assays.A set of genes that characteristically regulate sexual dimorphism located on the sex chromosome(Chr3)or autosomal chromosomes showed biased expression during stamen or carpel *** chromosome-level assembly of the autotetraploid *** genome and the genes related to important agronomic traits will facilitate future functional genomics research and improvement of ***.

关键词： kiwiberry dioecism adaptive evolution paleoclimate GEA rapid softening