检索结果-南通市图书馆

BIOTRANSFORMATION　OF　2α，5α，10β，14β－TETRA－ACETOXY－4（20），11－TAXADIENE　BY　THE　FUNGIJS　CUNNINGHAMELLA　ECHINULATA

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1996年第6期7卷 543-544页

作者： Shang Hut HU xu fang tian Wei Hua ZHU and Qi Cheng fang(Institute of Materia Medica, Chinese Academy or Medical Sciencesand Peking Union Medical College, Beijing 1000050) Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050

?5α,10β,14β-Tetra-acctoxy-4(20).11-taxadicne (1) could be regioselectively transfonnedinto 6α 10β-dihydroxy-2α,5α,14β-triacetoxy-4(20). 11- taxadiene (2) by Cunninghamella echinnlata infair yield. 6βM.10β-Dihydroxy-2α,5α,14β-triacet 11-taxadienc (3). 10β-hydroxy-2α,5α,14β-triacetoxy-4(20).11-taxadiene (4), 10 β-hyboxy-4β,20-epoxy -2α,5α,14β-triacetoxy- tax - 11- ene (5)asminor prpducts were also isolated

关键词： TETRA OF FUNGIJS THE CUNNINGHAMELLA ECHINULATA BY ACETOXY BIOTRANSFORMATION

Microbial Transformation of Taxoids and Synthesis of Taxoids with an Oxetane Ring

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1998年第1期9卷 39-43页

作者： Shang Hut HU xu fang tian Wen Yi HE Man KONG Di An SUN Qi Cheng fang(Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050) Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China Peking Union Med Coll Beijing 100050 Peoples R China

Microbial trdrisformation of taxoids was inveStigared: taxoid 2 was transformed into 1β and 14β hydroxylated derivahves 3 and 4, unnatural taxoid 6 was transformed into 1β-hydroxy derivative 7 and 11(15-1) abeotaxa... 详细信息

关键词： Taxoid abeotaxane oxetane ring chemoenzymatic method

Advances in the Development of Gradient Scaffolds Made of Nano-Micromaterials for Musculoskeletal Tissue Regeneration

在线全文

学校读者我要写书评

暂无评论

NANO-MICRO LETTERS 2025年第1期17卷 1-46页

作者： fang, Lei Lin, Xiaoqi xu, Ruian Liu, Lu Zhang, Yu tian, Feng Li, Jiao Jiao xue, Jiajia Beijing Univ Chem Technol Beijing Lab Biomed Mat Beijing 100029 Peoples R China Beijing Univ Chem Technol State Key Lab Organ Inorgan Composites Beijing 100029 Peoples R China Univ Technol Sydney Fac Engn & IT Sch Biomed Engn Sydney NSW 2007 Australia

This review highlights the gradient variations in the structural composition of musculoskeletal tissues and comprehensively examines recent progress in the fabrication and application of biomimetic gradient scaffolds for musculoskeletal *** challenges and prospects of gradient scaffolds for clinical application are discussed. The intricate hierarchical structure of musculoskeletal tissues, including bone and interface tissues, necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered substitutes. This has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic outcomes. Building on the anatomical characteristics of bone and interfacial tissues, this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues, specifically focusing on methods used to construct compositional and structural gradients within the scaffolds. The latest applications of gradient scaffolds for the regeneration of bone, osteochondral, and tendon-to-bone interfaces are presented. Furthermore, the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed, as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

淫羊藿苷促进间充质干细胞成骨分化:为治疗骨缺损提供一个良好的方向

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国组织工程研究 2016年第50期20卷 7594-7600页

作者：陈震东高辉徐房添赣南医学院江西省赣州市341000 赣南医学院第一临床医学院江西省赣州市341000

背景:近年来研究表明,淫羊藿苷能够促进间充质干细胞成骨分化,是一种良好的骨性诱导因子,给骨缺损的治疗提供了新的希望。目的:综述近年来淫羊藿苷对骨组织代谢的药理作用及对间充质干细胞成骨分化影响的研究成果。方法:由第一作者用中... 详细信息

背景:近年来研究表明,淫羊藿苷能够促进间充质干细胞成骨分化,是一种良好的骨性诱导因子,给骨缺损的治疗提供了新的希望。目的:综述近年来淫羊藿苷对骨组织代谢的药理作用及对间充质干细胞成骨分化影响的研究成果。方法:由第一作者用中国知网数据库和PubMed数据库,检索词分别为"淫羊藿苷;干细胞;成骨"和"icariin,stem cell,osteogenesis",语言分别设定为中文和英文。纳入与"淫羊藿苷、干细胞、成骨"相关的研究。共检索到754篇文章,按纳入和排除标准文献进行筛选,共纳入41篇文章进行综述分析。结果与结论:淫羊藿苷是中国传统中药淫羊藿的主要成分,能够促进骨髓间充质干细胞成骨分化,是一种良好的骨性营养因子。近年来研究表明,淫羊藿苷亦可促进脂肪、脐带以及牙周膜等组织来源的间充质干细胞成骨分化,但是这类研究尚少。目前各间充质干细胞成骨实验效果欠佳,良好的骨性营养因子促进间充质干细胞体内成骨是一种较好的解决方法。因此,淫羊藿苷促进间充质干细胞成骨将可能为治疗骨缺损提供一个良好的方向。

关键词：干细胞分化淫羊藿苷药理作用骨缺损骨髓间充质干细胞脂肪间充质干细胞脐带间充质干细胞牙周膜干细胞成骨分化分子机制国家自然科学基金

骨组织工程中的间质干细胞:成骨活性、免疫特性、促血管化及成骨效应

在线全文

学校读者我要写书评

暂无评论

中国组织工程研究 2016年第46期20卷 6956-6962页

作者：陈震东徐房添高辉赣南医学院江西省赣州市341000 赣南医学院第一临床医学院江西省赣州市341000

背景:临床治疗由创伤、感染、肿瘤以及先天性疾病导致的骨缺损仍然是一个挑战。骨组织工程的研究,为骨缺损的治疗提供了一种新的解决办法,对治疗骨缺损具有重要的指导意义。目的:回顾近年来间质干细胞在骨组织工程中的增殖和成骨活性、... 详细信息

背景:临床治疗由创伤、感染、肿瘤以及先天性疾病导致的骨缺损仍然是一个挑战。骨组织工程的研究,为骨缺损的治疗提供了一种新的解决办法,对治疗骨缺损具有重要的指导意义。目的:回顾近年来间质干细胞在骨组织工程中的增殖和成骨活性、免疫特性、促血管化以及在体实验的成骨效果的研究进展。方法:检索万方数据库和PubM ed数据库2008年至2016年文献,检索词分别为"间质干细胞、组织工程、成骨、免疫、血管化"和"mesencgymal stem cell,tissueengineering,osteogenesis,immuneproperty,angiogenesis"。纳入与间质干细胞、组织工程、成骨、免疫及血管化相关的研究,排除重复及陈旧文献。共检索到1 772篇文章,按纳入和排除标准文献进行筛选,共纳入41篇文章进行综述分析。结果与结论:在骨组织工程中,骨髓间质干细胞与脂肪间质干细胞应用较为广泛。研究认为骨髓间质干细胞成骨活性高于脂肪间质干细胞。间质干细胞具有明显的免疫调节和组织修复能力,可减少损伤部位炎症反应,加快组织修复。间质干细胞免疫调节作用不只有免疫抑制作用,也有免疫促进作用,脂肪间质干细胞比骨髓间质干细胞具有较强的免疫调节性。低氧培养下的脂肪间质干细胞能够分泌更高的促血管生成因子,生成更多的血管结构。实验研究证实聚乳酸多孔纳米材料结合纳米碳生物材料可以明显促进骨髓间质干细胞的增殖和成骨。由于间质干细胞具有生物向性,可能成瘤分化,故间质干细胞的临床应用一直持谨慎态度。

关键词：间质干细胞骨和骨组织免疫组织工程组织构建骨组织工程增殖成骨血管化国家自然科学基金

价格折扣/运输折扣的库存—运输联合优化模型

在线全文

学校读者我要写书评

暂无评论

大连海事大学学报 2005年第3期31卷 41-44页

作者：张茹秀徐天芳大连海事大学交通工程与物流学院辽宁大连116026

针对一个供应商、多个销售商组成的两级供应链系统,在需求随机、订货提前期随机的情况下,建立含有运输/价格折扣的库存—运输联合优化模型,以计算整合策略中最佳订货点r和订货量Q,使供应链整体盈利最大.算例表明,采取运输/价格折扣可以... 详细信息

针对一个供应商、多个销售商组成的两级供应链系统,在需求随机、订货提前期随机的情况下,建立含有运输/价格折扣的库存—运输联合优化模型,以计算整合策略中最佳订货点r和订货量Q,使供应链整体盈利最大.算例表明,采取运输/价格折扣可以使供应商和销售商的平均利润均有提高.

关键词：物流物流价格/运输折扣联合优化数学模型

Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu fangxia xu Chengcheng Zhou Kaimei Lu Bin fang Lijuan Wang Lina Huang Zifeng xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

无氧阈强度运动治疗对心脏X综合征患者的疗效研究

在线全文

学校读者我要写书评

暂无评论

中国全科医学 2017年第9期20卷 1067-1070,1075页

作者：陈芳徐予田甜张新雨王忠民朱中玉河南中医药大学基础医学院河南省郑州市450000 河南省人民医院心内科河南省郑州市450007

目的观察无氧阈强度运动治疗对心脏X综合征(CSX)患者的临床疗效。方法选取2013年7月—2014年4月在河南省人民医院就诊且符合纳入标准的患者21例。患者在规范药物治疗的基础上进行心肺功能运动负荷试验(CPET),并根据无氧阈值(AT)制定个... 详细信息

目的观察无氧阈强度运动治疗对心脏X综合征(CSX)患者的临床疗效。方法选取2013年7月—2014年4月在河南省人民医院就诊且符合纳入标准的患者21例。患者在规范药物治疗的基础上进行心肺功能运动负荷试验(CPET),并根据无氧阈值(AT)制定个体化有氧运动处方进行干预。3个月后复查CPET,比较干预前后心肺参数〔包括无氧阈值氧耗量(VO_(2AT))、峰值氧耗量(VO_(2峰值))、有氧运动负荷(LAT)、峰值运动负荷(L_(峰值))〕、心绞痛发作频率、舌下含服短效硝酸酯类药物次数、心绞痛持续时间、心绞痛控制情况(采用西雅图心绞痛问卷评价)、生活质量〔采用中文版36条目简明健康调查量表(SF-36)评价〕。结果 20例患者完成最终的运动干预。患者干预后VO_(2AT)、VO_(2峰值)、LAT高于干预前(P0.05)。患者干预后心绞痛发作频率、舌下含服短效硝酸酯类药物次数少于干预前,心绞痛持续时间短于干预前(P0.05)。结论无氧阈强度运动治疗可明显改善CSX患者的心绞痛症状及生活质量,提升运动负荷能力。

关键词： X综合征,心脏无氧阈运动疗法

Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao Zhou Xiongbin Luo Hang Li Shan Guo Zhuang Tong Xiaotao Zhou xu Li Zhaohui Hou Shuquan Liang Guozhao fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Aqueous zinc-ion batteries Interfacial reaction Asymptotic nucleation model Reversible and stable Zn anode