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RANKL-RANK signaling regulates osteoblast differentiation and bone formation

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Bone Research 2018年第4期6卷 426-427页

作者： xu cao Department of Orthopedic Surgery Johns Hopkins University School of Medicine

In the recent two decades, it has been well elucidated that receptor activator of nuclear factor-κB ligand （RANKL; also known as TNFSF11） binding to its receptor RANK （also known as TNFRSF11A） drives osteoclast d... 详细信息

关键词： RANKL-RANK signaling regulates osteoblast differentiation and bone formation BMSCs

The structural characteristics of dietary fibers from Tremella fuciformis and their hypolipidemic effects in mice

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Food Science and Human Wellness 2023年第2期12卷 503-511页

作者： Shanshan Zhang Xinle xu xu cao Tingting Liu School of Food Science and Engineering Jilin Agricultural UniversityChangchun 130118China Scientific Research Base of Edible Mushroom Processing Technology Integration Ministry of Agriculture and Rural AffairsChangchun 130118China Engineering Research Center of Grain Deep-processing and High-effeciency Utilization of Jilin Province Changchun 130118China Key Laboratory of Technological Innovations for Grain Deep-processing and High-effeciency Utilization of By-products of Jilin Province Changchun 130118China

In this study,Tremella fuciformis residues as raw material,dietary fibers from tremella were prepared by multiple *** structure of dietary fibers from tremella was studied by Fourier transform infrared(FTIR),X-ray diffraction analysis(XRD)and scanning electron microscopy(SEM).We analyzed their lipidlowering properties in vitro(water holding,oil holding swelling cholesterol and sodium cholate binding capacitises)and the hypolipidemic effects in *** results showed that tremella dietary fibers presented the infrared absorption spectrum characteristics of polysaccharides and the characteristic diffraction peaks of cellulose type *** results indicated that the surface of insoluble dietary fiber(IDF)was porous,while the soluble dietary fiber(SDF)was relatively compact and *** exhibited significantly higher water holding,oil holding,and swelling binding capacities than the corresponding ***,SDF exhibited significantly higher viscosity than *** results showed tremella dietary fibers were significant in swelling,water holding and oil holding,cholesterol and bile *** vivo experiment results in mice indicated that SDF has the best effect on hyperlipidemia mice than IDF and total dietary fiber(TDF).SDF showed that the total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)contents dropped by 28.33%,18.65%,and 48.97%,respectively,while high density lipoprotein cholesterol(HDL-C)content increased by 43.80%.Compared with the high-fat control(HCM)group,the arteriosclerosis index(AI)and liver index(LI)of the SDF group mice showed significant differences,indicating that SDF has a good auxiliary effect of lowering blood *** administration of tremella fibers improved the lipid metabolism disorderly situation of hyperlipidemia *** results provide a reference for further research and rational development of ***.

关键词： Tremella fuciformis Dietary fiber Structural characterization Hypolipidemic effects

3D-QSAR Studies on the Imidazopyrimidine Derivatives

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Chinese Journal of Structural Chemistry 2020年第11期39卷 1985-1989页

作者： TONG Jian-Bo cao xu Shaanxi Key Laboratory of Chemical Additives for Industry Shaanxi University of Science and TechnologyXi'an 710021China

Comparative molecular field analysis(CoMFA) and comparative molecular similarity indices analysis(CoMSIA) for imidazopyrimidine derivatives were performed to get the molecular active conformation selection, molecular alignment, as well as the establishment of corresponding 3 D-QSAR model. The model established by this method has good ability to predict such compounds. For CoMFA model, the cross-validated q2 and non-cross-validated r2 values are 0.665 and 0.872, respectively. The best q2 value for CoMSIA model is 0.632 and r2 value is 0.923. Using this information and the three-dimensional equipotential map for molecular design can theoretically obtain some new antibacterial drugs with higher activity. There are two newly designed molecules with activity values of 7.921 and 7.872, which are higher than that of the template molecule No. 12 with an activity value of 7.850, and the QSAR research results can provide a theoretical reference for the synthesis of new drugs.

关键词： 3D-QSAR comparative molecular force field analysis molecular design

A method of autonomous orbit determination for satellite using star sensor

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Science China(Physics,Mechanics & Astronomy) 2005年第3期48卷 268-281页

作者： MA Jianbo xu Jin cao Zhibin Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China

In this paper a method of autonomous orbit determination using star sensor is studied. By building relatively consummate dynamical models which simulate attitude motion of satellite and observation from satellite to background stars, the simulant computation of this method is executed, and it is shown that the method of autonomous orbit determination is feasible. Academic and calculation analyses have been done for the relation between the direction of star sensor with respect to satellite-body coordinate system and the accuracy of autonomous orbit determination.

关键词： autonomous orbit determination of satellite, star sensor, attitude of satellite.

Quantitative Analysis of Frosting Characteristics on the Drip Tray of A Cryogenic Valve for LNG Ships

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China Ocean Engineering 2024年第4期38卷 572-585页

作者： BAI xu CHEN Guan-yu DU Yue xu cao CHEN Jia-jing School of Naval Architecture&Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Cryogenic valves play a crucial role in the production and transportation of liquefied natural gas(LNG),and are primarily responsible for efficiently controlling the inflow and outflow of LNG and regulating ***,due to their operation in low-temperature and high-humidity environments,crucial components such as drip trays are susceptible to frosting,which may lead to LNG leakage,thereby causing severe safety *** this study,the user-defined function(UDF)is employed to redevelop Fluent,which integrates the frost growth model with the Eulerian multiphase flow model,to conduct a quantitative analysis of frosting on drip trays of cryogenic *** effects of environmental parameters,such as wind speed,ambient temperature,air humidity,and cold surface temperature on the growth of the frost layer were *** study reveals a limiting wind speed between 1 m/s and 2 m/*** reaching this limit speed,the growth of the frost layer reaches its maximum,and further increases in the wind speed have no significant effect on the growth of the frost ***,the influence of the change in the flow field on droplet impingement and freezing during the growth of the frost layer is considered through the coupling method of the kinematic characteristics of water droplets and the collection coefficient of water *** study identifies the influence of different parameters on the droplet impact efficiency,leading to the modification of the frost layer on the drip tray.

关键词： LNG carrier drip tray frost effective impact coefficient

SYNTHESIS OF CROSS-CONJUGATED(p-PHENYLENE)S-POLY(p-PHENYLENEVINYLENE)S HYBRIDS WITH LOW CONTENT OF STRUCTURAL DEFECTS

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Chinese Journal of Polymer Science 2007年第2期25卷 171-179页

作者： Shi-jun Zheng Qun xu Shao-kui cao College of the Material Science and Engineertng Zhengzhou University Zhengzhou 450052 China

The novel shish-kebab-type liquid crystalline cross-conjugated （p-phenylene）s-poly（p-phenylenevinylene）s hybrid was synthesized through Gilch polymerization. Their structures and properties were characterized by NMR, GPC, DSC, X-ray diffraction and polarizing optical microscope （POM）. ^1H-NMR investigation of the polymers indicates that the shish-kebab-structure has a strong ability to suppress the structural defects in the polymers. The polymers are enantiotropic liquid crystals. The melting point （Tm） of the polymers decreases when the length of the alkoxy tails of the mesogenic units increases. The mesophase was identified by X-ray diffraction method. They showed not only a smectic LC phase, but also a strong green fluorescence in chloroform. The maximum absorption band of the ＂kebabs＂ of the two, 5-bis（4＇- alkoxyphenyl）benzene at 280 nm did not appear in absorption spectra of the polymers. The same phenomena were also observed in the fluorescence spectra. These results imply that the polymers have formed a cross-conjugated uniform structure and achieved an extended n-conjugation polymer.

关键词： Gilch polymerization Conjugated polymer Liquid crystal Shish-kebab Fluorescence.

Multi-omics-driven development of alternative crops for natural rubber production

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Journal of Integrative Agriculture 2023年第4期22卷 959-971页

作者： YANG Ning YANG Dan-dan YU xu-chen xu cao State Key Laboratory of Plant Genomics National Center for Plant Gene Research(Beijing)Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101P.R.China CAS-JIC Centre of Excellence for Plant and Microbial Science(CEPAMS) Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China

Natural rubber(NR)is an irreplaceable biopolymer of economic and strategic importance owing to its unique physical and chemical *** Parárubber tree(Hevea brasiliensis(*** ***.)Mü***.)is currently the exclusive commercial source of NR,and it is primarily grown in plantations restricted to the tropical and subtropical areas of Southeast ***,current Parárubber production barely meets the sharply increasing global industrial demand for ***-based synthetic rubber(SR)has been used to supplement the shortage of NR but its industrial performance is not comparable to that of ***,there is an urgent need to develop new productive rubber crops with broader environmental *** review summarizes the current research progress on alternative rubberproducing plants,including horticultural plants(Taraxacum kok-saghyz Rodin and Lactuca ***),woody plants(Parthenium argentatum *** and Eucommia ulmoides Oliv.),and other plant species with potential for NR *** an emphasis on the molecular basis of NR biosynthesis revealed by a multi-omics approach,we highlight new integrative strategies and biotechnologies for exploring the mechanism of NR biosynthesis with a broader scope,which may accelerate the breeding and improvement of new rubber crops.

关键词： natural rubber multi-omics genomics transcriptomics proteomics new crops

CONDITION MONITOR OF DEEP-HOLE DRILLING BASED ON MULTI-SENSOR INFORMATION FUSION

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Chinese Journal of Mechanical Engineering 2006年第1期19卷 140-142页

作者： xu xusong cao Yanlong YANG Jiangxin Institute of Contemporary Manufacturing Engineering Zhejiang University Hangzhou 310027 China

A condition monitoring method of deep-hole drilling based on multi-sensor information fusion is discussed. The signal of vibration and cutting force are collected when the condition of deep-hole drilling on stainless steel 0Cr17Ni4Cu4Nb is normal or abnormal. Four eigenvectors are extracted on time-domain and frequency-domain analysis of the signals. Then the four eigenvectors are combined and sent to neural networks to dispose. The fusion results indicate that multi-sensor information fusion is superior to single-sensor information, and that cutting force signal can reflect the condition of cutting tool better than vibration signal.

关键词： Information fusion Neural networks Condition monitoring Fault diagnosis

Experimental research on charging characteristics of a solar photovoltaic system by the pressure-control method

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第6期12卷 470-474页

作者： Hua ZHU Zhang-lu xu Zi-juan cao Institute of Thermal Science and Power Systems Zhejiang University Hangzhou 310027 China

The charging characteristics of the valve-regulated lead acid(VRLA) battery driven by solar energy were experimentally studied through the pressure-control method in this *** aims of the research were to increase charging efficiency to make the most of solar energy and to improve charging quality to prolong life of *** charging process of a 12 V 12 A·h VRLA battery has been tested under the mode of a stand-alone photovoltaic(PV) *** show that the pressure-control method can effectively control PV charging of the VRLA battery and make the best of PV cells through the maximum power point tracking(MPPT).The damage of VRLA battery by excess oxygen accumulation can be avoided through the inner pressure control of VRLA *** such as solar radiation intensity,charging power,inner pressure of the battery,and charging current and voltage during the charging process were measured and analyzed.

关键词： Solar photovoltaic(PV) system Charging characteristics Pressure-control method