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Influence of immunosuppressive drugs on natural killer cells in therapeutic drug exposure in liver transplantation

Hepatobiliary Surgery and Nutrition 2023年第6期12卷 835-853,I0002-I0005页

作者： Rongrong Qin Jiwei Qin xuefeng Li zhijun xu Peiqi He Xiaodong Yuan Cheng Sun Björn Nashan Department of Organ Transplantation The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Organ Transplantation&Immunology Laboratory Division of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiChina

Background:Natural killer(NK)cells are enriched in the liver and are the main regulators in liver transplantation regarding rejection or tolerance,viral infection,or tumor *** consists of a triple drug standard regimen comprising tacrolimus(TAC)and corticosteroids(CS)with either mycophenolate mofetil(MMF)or sirolimus(SIR)/everolimus(EVE).The aim of this study was to evaluate the impact of trough levels of these regimens under clinical conditions and exposure on human NK-cell activity and function in order to better understand the antiviral and anti-tumor effects of mammalian target of rapamycin inhibitor(mTORI).Methods:Peripheral blood mononuclear cells(PBMCs)were collected from liver transplant recipients and healthy *** and phenotypes of NK cells in vivo were analyzed by flow *** this study we simulated the immunosuppressive microenvironment in *** were cultured at the clinically effective plasma concentration of drugs for 3 d to detect the effect of immunosuppressants on NK *** type and concentration:single drug[EVE,5 ng/mL;SIR,5 ng/mL;TAC,5 ng/mL;cyclosporine A(CSA),125 ng/mL;MMF,15μg/mL;CS,0.5μg/mL]and combined immunosuppressants(Group 1:TAC,5 ng/mL+MMF,15μg/mL+CS,0.5μg/mL;Group 2:TAC,5 ng/mL+SIR,5 ng/mL+CS,0.5μg/mL;Group 3:TAC,5 ng/mL+EVE,5 ng/mL+CS,0.5μg/mL).In addition,NK cells were sorted from PBMCs and treated under the above conditions to detect NK cell killing function and RNA transcription ***:CS significantly impaired the cytolytic activity of NK cells,followed by MMF and SIR/*** and TAC/CSA significantly decreased the secretion of IFN-γand *** cell function in liver transplant recipients was most pronouncedly inhibited by a triple immunosuppressive regimen,with CS playing the most prominent role compared with the other *** MMF-containing regimen demonstrated a significant increase in the expression of suppressive genes,especially of the Siglec7/9 ***

关键词： Liver transplantation NK cells immunosuppressants calcineurin inhibitor(CNI) everolimus

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Performance enhancement of perovskite solar cells:surface is the key

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Science China Materials 2024年第1期67卷 375-376页

作者： Wenzhuo Li zhijun Ning School of Physical Science and Technology Shanghaitech UniversityShanghai 201210China

Metal halide perovskite solar cells(PSCs)stand out as one of the most promising contenders among photovoltaic technologies for the *** the past decade,PSCs with high power conversion efficiency(PCE)predominantly adopted the normal(ni-p)device ***,a common p-type organic small molecule,Spiro-OMe TAD,which is widely employed at the top layer of n-i-p devices[1],faces issues such as susceptibility to water absorption and poor thermal stability.

关键词： structure stability perovskite

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INVARIANTS-PRESERVING DU FORT-FRANKEL SCHEMES AND THEIR ANALYSES FOR NONLINEAR SCHRÖDINGER EQUATIONS WITH WAVE OPERATOR

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Journal of Computational Mathematics 2024年第3期42卷 814-850页

作者： Dingwen Deng zhijun Li College of Mathematics and Information Science Nanchang Hangkong UniversityNanchang 330063China

Du Fort-Frankel finite difference method(FDM)was firstly proposed for linear diffusion equations with periodic boundary conditions by Du Fort and Frankel in *** is an explicit and unconditionally von Neumann stable ***,there has been no research work on numerical solutions of nonlinear Schrödinger equations with wave operator by using Du Fort-Frankel-type finite difference methods(FDMs).In this study,a class of invariants-preserving Du Fort-Frankel-type FDMs are firstly proposed for one-dimensional(1D)and two-dimensional(2D)nonlinear Schrödinger equations with wave *** using the discrete energy method,it is shown that their solutions possess the discrete energy and mass conservative laws,and conditionally converge to exact solutions with an order of for ofο(T^(2)+h_(x)^(2)+(T/h_(x))^(2))1D problem and an order ofο(T^(2)+h_(x)^(2)+h_(Y)^(2)+(T/h_(X))^(2)+(T/h_(y))^(2))for 2D problem in ***,τdenotes time-step size,while,hx and hy represent spatial meshsizes in x-and y-directions,***,by introducing a stabilized term,a type of stabilized invariants-preserving Du Fort-Frankel-type FDMs are *** not only preserve the discrete energies and masses,but also own much better stability than original ***,numerical results demonstrate the theoretical analyses.

关键词： Nonlinear Schrodinger equations with wave operator Du Fort-Frankel finite difference methods Discrete energy and mass conservative laws Numerical convergence

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高温蒸汽凝结法相对湿度测量

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国外电子测量技术 2024年第7期43卷 140-147页

作者：高琳锋徐志军梁俊钦张彩良皇甫永春陈建利中国辐射防护研究院太原030006 福建宁德核电有限公司宁德355000 中广核惠州核电有限公司惠州516003

为实现露点温度100℃以上高温压力蒸汽相对湿度的精确测量,设计了以凝结称重装置、不凝气体含湿量测量装置、数据处理系统为核心部件的凝结法相对湿度测量系统。测量系统依据蒸汽相对湿度与含湿量对应关系,采用蒸汽快速凝结,实时监测冷... 详细信息

为实现露点温度100℃以上高温压力蒸汽相对湿度的精确测量,设计了以凝结称重装置、不凝气体含湿量测量装置、数据处理系统为核心部件的凝结法相对湿度测量系统。测量系统依据蒸汽相对湿度与含湿量对应关系,采用蒸汽快速凝结,实时监测冷凝液质量与不凝气流含湿量的方式实现了目标蒸汽所处温度、压力条件下相对湿度的在线测量。凝结法测量工艺能实现露点温度-40℃~130℃条件下气体相对湿度0.15%~100%范围内的有效测量。在露点温度128℃、相对湿度95%条件下,测量不确定度0.59%,测量偏差小于0.4%,具有测量精度高、测量速率快的特点。该系统能开展瞬态条件下蒸汽相对湿度测量,湿度测量值能溯源到国际单位制基本单位。

关键词：蒸汽凝结湿度测量瞬态条件计量溯源

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DIELECTRIC AND FERROELECTRIC PROPERTIES OF(Li,Ce)-DOPED Sr_(2)Bi_(4)Ti_(5)O_(18)LEAD-FREE CERAMICS

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Journal of Advanced Dielectrics 2011年第4期1卷 439-445页

作者： QIAN CHEN zhijun xu RUIQING CHU YONG LIU College of Materials Science and Engineering Liaocheng University Liaocheng 252059P.R.China

The infuence of(Li,Ce)doping on the electrical properties of bismuth layer Sr_(2)Bi_(4)Ti_(5)O_(18)[abbreviated to SBTi-(Li,Ce)_(x/2)]ceramics was investigated.X-ray difraction analy sisshowed that all the ceramic samples were'single-phase ***(Li,Ce)modification *** decreased the dielectric loss of Sr,Bi,Ti,O 1s ceramics and greatly improved the piezo-electric *** x/2=0.0125,the SBTi-(Li,Ce)_(x/2)ceramics exhibited the excellent propertieswith high remnant polarization(Pr=9.3μc/cm^(2))and high Curie temperat ure(T_(c)=299°C).Meanwhijle,the SBTi-(Li,Ce)_(0.0125)ceramics had the largest piezoelectric constant(d_(33)=26 pC/N).Theresultsshowed that the SBTi-(Li,Ce)_(x/2)ceramic was a promisinglead-free piezoelectric mat erial.

关键词： Ceramics Curie temperat ure piezoelectricity

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A CELL-CENTERED GODUNOV METHOD BASED ON STAGGERED DATA DISTRIBUTION,PART Ⅰ:ONE-DIMENSIONAL CASE

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Journal of Computational Mathematics 2024年第4期42卷 1172-1196页

作者： Jiayin Zhai Xiao Li zhijun Shen Institute of Applied Physics and Computational Mathematics LCPP.O.Box 8009-26Beijing 100088China College of Big Data and Internet Shenzhen Technology UniversityShenzhen 518118China Center for Applied Physics and Technology HEDPSPeking UniversityChina

This paper presents a cell-centered Godunov method based on staggered data distribu-tion in Eulerian *** motivation is to reduce the intrinsic entropy dissipation of classical Godunov methods in the calculation of an isentropic or rarefaction *** the same time,the property of accurate shock capturing is also *** analyzing the factors that cause nonphysical entropy in the conventional Godunov methods,we introduce two velocities rather than a single velocity in a cell to reduce kinetic energy dissipation.A series of redistribution strategies are adopted to update subcell quantities in order to improve *** examples validate that the present method can dramatically reduce nonphysical entropy *** subject classification:35Q35,76N15,76M12.

关键词： Godunov method Riemann solver Rarefaction wave Nonphysical entropy increase.

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深基坑边坡喷锚支护技术

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石油工程建设 1995年第4期21卷 11-17页

作者：徐至钧中外合资北京恒富房地产开发有限公司北京市丰台区100071

近两年，国内在高层建筑深基坑开挖的围护结构中，开始采用喷锚支护技术。该技术具有施工周期短，设备简单，工程造价低，边坡受力条件改善，加固效果显著等优点。本文概述了喷锚支护理论，并结合工程实践介绍喷锚支护设计和施工的若干... 详细信息

近两年，国内在高层建筑深基坑开挖的围护结构中，开始采用喷锚支护技术。该技术具有施工周期短，设备简单，工程造价低，边坡受力条件改善，加固效果显著等优点。本文概述了喷锚支护理论，并结合工程实践介绍喷锚支护设计和施工的若干问题，其中深基坑多层锚杆支护结构内力计算表具有合理、实用、简便的特点，易于设计人员接受。

关键词：基础结构设计深基础边坡喷锚支护

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Stability mechanism and control of the pumpable supports in longwall recovery room

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International Journal of Mining Science and Technology 2024年第7期34卷 957-974页

作者： Dong Zhang Jianbiao Bai zhijun Tian Zizheng Zhang Yonghong Guo Rui Wang Ying xu Hao Fu Shuai Yan Min Deng Shuaigang Liu State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China Key Laboratory of Xinjiang Coal Resources Green Mining Xinjiang Key Laboratory of Coal-bearing Resources Exploration and ExploitationXinjiang Engineering Research Center of Green Intelligent Coal MiningXinjiang Institute of EngineeringUrumqi 830023China Work Safety Key Laboratory on Prevention and Control of Gas and Roof Disasters for Southern Goal Mines Hunan Provincial Key Laboratory of Safe Mining Techniques of Coal MinesHunan University of Science and TechnologyXiangtan 411201China School of Mines China University of Mining and TechnologyXuzhou 221116China

The load-bearing performance(LBP)of pumpable supports(PPS)is crucial for the stability of longwall pre-driven recovery room(PRR)surrounding ***,the unbalanced bearing coefficient(UBC)of the PPS(undertaking unequal load along the mining direction)has not been investigated.A mechanical model of the PRR was established,considering the main roof cantilever beam structure,to derive an assessment formula for the load,the failure criteria,and the UBC of the ***,the generation mechanisms,and influencing factors of the UBC were *** sensitivity analysis shows that the main roof hanging length(l_(2))and the spacing between the PPS(r)significantly impact the UBC.A novel design of the PPS and the coupling control technology were proposed and applied to reduce the UBC of the PPS in the adjacent longwall *** results showed no failure of the PPS at the test site,with the UBC(ζ)reduced to 1.1 consistent with the design value(1.15)basically,fully utilizing the collaborative LBP of the ***,the maximum roof-to-floor convergence of the PRR was 234 mm,effectively controlling the stability of the surrounding rock of the PRR and ensuring the mining equipment recovery.

关键词： Pre-driven recovery room Pumpable supports Unbalanced bearing coefficient Hydraulic fracture Stability analysis Surrounding rock control

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Attitude Estimation of the Multi-rotor UAV Based on Simplified Adaptive Kalman Filter Algorithm

Attitude Estimation of the Multi-rotor UAV Based on Simplifi...

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2015年中国智能自动化学术会议

作者： Xin Zhang Yue Bai zhijun xu Rijun Wang Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences University of Chinese Academy of Sciences School of Electrical and Information Technology Changchun Institute of Technology

A simplified and improved attitude estimation algorithm is put forward,for the problems from the multi-rotor UAV in noise statistical characteristics unknown and time-varying, vibration as the main disturbance source, and highfrequent dynamic changes of the attitude angles. A simplified adaptive Kalman filter algorithm is designed for multi-sensor information fusion. With the attitude angle variance of the real-time dynamic calculation by the gyro and the accelerometer, the system noise variance and the measurement noise variance are estimated, so as to solve the unknown about the noise statistical characteristics, and to prevent the filter divergence. The flight experiment shows that the algorithm can guarantee the accuracy and the stability of the attitude angle estimation. The rootmean-square errors of the pitch and roll angles which are estimated by the simplified algorithm are 2.922° and 1.713°. The accuracy of the algorithm can meet the demands for the autonomous flight of the multi-rotor UAV.

关键词： Multi-rotor UAV Attitude estimation Adaptive Kalman filter Quaternion method

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Effects of cement-enhanced soil on the ultimate lateral resistance of composite pile in clayey soil

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 183-191页

作者： zhijun Yang Kexin Chen xudong Fu Zhiyan Zou School of Civil Engineering Wuhan UniversityWuhan430000China Changjiang Design Group Co. Ltd.Wuhan430000China Institute of Geotechnical Engineering College of Civil Engineering and ArchitectureMOE Key Laboratory of Soft Soils and Geoenvironmental EngineeringZhejiang UniversityHangzhou310000China

The composite pile consisting of core-pile and surrounding cement-enhanced soil is a promising pile foundation in recent ***,how and to what extent the cement-enhanced soil influences the ultimate lateral resistance has not been fully *** this paper,the ultimate lateral resistance of the composite pile was studied by finite element limit analysis(FELA)and theoretical upper-bound *** results of FELA and theoretical analysis revealed three failure modes of laterally loaded composite *** effects of the enhanced soil thickness,strength,and pile-enhanced soil interface characteristics on the ultimate lateral resistance were *** results show that increasing the enhanced soil thickness leads to a significant improvement on ultimate lateral resistance factor(N P),and there is a critical thickness beyond which the thickness no longer affects the N *** the enhanced soil strength induced 6.2%-232.6%increase of N ***,no noticeable impact was detected when the enhanced soil strength was eight times higher than that of the natural *** maximum increment of N P is only 30.5%caused by the increase of interface adhesion factor(a).An empirical model was developed to calculate the N P of the composite pile,and the results show excellent agreement with the analytical results.

关键词： Composite pile Ultimate soil resistance Finite element limit analysis(FELA) Plasticity theory Failure mode

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