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Experimental Observing Damage Evolution in Cement Pastes Exposed to External Sulfate Attack by in situ X-ray Computed Tomography

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 164-170页

作者： WU min CAO Kailei XIAO Weirong YU Zetai CAO Jierong ding Qingjun LI Jinhui China Railway Construction Corporation Harbour and Channel Engineering Bureau Group Co. LTDZhuhai 519000China Con-struction Headquarters of Zhoushan Liuheng Bridge Phase II Project Zhoushan 316000China China Railway Construction Bridge En-gineering Bureau Group Co. LTDTianjin 300000China State Key Laboratory of Silicate Material for Architecture(Wuhan University of Technology) Wuhan 430070China College of Materials Science and Engineering Wuhan Textile UniversityWuhan 430200China

The paper presents experimental investigation results of crack pattern change in cement pastes caused by external sulfate attack(ESA).To visualize the formation and development of cracks in cement pastes under ESA,an X-ray computed tomography(X-ray CT)was used,i e,the tomography system of Zeiss Xradia 510 *** results indicate that X-CT can monitor the development process and distribution characteristics of the internal cracks of cement pastes under ESA with attack *** addition,the C3A content in the cement significantly affects the damage mode of cement paste specimens during sulfate *** damage of ordinary Portland cement(OPC)pastes subjected to sulfate attack with high C3A content are severe,while the damage of sulfate resistant Portland cement(SRPC)pastes is much smaller than that of OPC ***,a quadratic function describes the correlation between the crack volume fraction and development depth for two cement pastes immermed in sulfate solution.

关键词： concrete external sulfate attack damage evolution situ X-ray computed tomography

中心体α、γ-微管蛋白在乳腺癌前病变及乳腺癌中的表达及其意义初探

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中华医学杂志 2006年第1期86卷 56-60页

作者：牛昀王颖于泳丁秀敏吕淑华肖绪祺天津医科大学附属肿瘤医院国家教育部乳腺癌防治重点实验室 300060 天津南开大学医学院

目的探讨中心体α-微管蛋白和γ-微管蛋白在人乳腺癌前病变和乳腺癌中的表达及其在乳腺癌发生发展过程中的作用。方法采用免疫组织化学S-P法检测乳腺导管上皮不典型增生、乳腺导管内癌和浸润性导管癌各40例中中心体α-微管蛋白和γ-微... 详细信息

目的探讨中心体α-微管蛋白和γ-微管蛋白在人乳腺癌前病变和乳腺癌中的表达及其在乳腺癌发生发展过程中的作用。方法采用免疫组织化学S-P法检测乳腺导管上皮不典型增生、乳腺导管内癌和浸润性导管癌各40例中中心体α-微管蛋白和γ-微管蛋白表达水平,30例正常乳腺组织作为对照组,并用W estern印迹进行验证。所得数据经统计学分析并结合随访情况进行评价。结果不同样本组α-微管蛋白、γ-微管蛋白表达水平不同(P=0.000),随正常上皮组织到出现不典型增生至进展为原位癌和浸润性癌的发展变化,α-微管蛋白、γ-微管蛋白表达量呈增高趋势,以浸润性癌为最高(40例中分别有14例、11例表达为+++),各组间差异均有统计学意义(P=0.001)。比较同例和同组α、γ-微管蛋白的表达程度差异无统计学意义(P>0.05)。癌前病变、导管内癌、浸润性导管癌组α、γ-微管蛋白的表达水平与预后具有相关性。结论中心体异常为乳腺癌细胞恶性表型的明显特征之一,并可能为乳腺癌形成过程中的早期事件。α、γ-微管蛋白的表达情况可为乳腺癌发生机制探讨、高危病例筛选及估测预后提供一种新的途径。

关键词：乳腺肿瘤微管蛋白中心体乳腺癌前病变

Engineering high-performance chemiluminescent probes via enzymatic pocket targeting: high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma

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Science China Chemistry 2025年

作者： Shuai Huang Shuaige Bai Ting Luo Bin Feng min Liu Fan Zheng Shuang Huang Yanpeng Fang Dan ding Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

Hepatocellular carcinoma （HCC） is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of HCC can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of HCC. However, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. Here, we have constructed a series of chemiluminescent probes for carboxylesterase detection based on the strategy of enzymatic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. Here, CE-2 has been successfully used for high-throughput screening of rapid carboxylesterase inhibitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully used for image-guided surgery of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study may promote advances in the rapid detection and screening of inhibitory drugs for CE and the field of surgical navigation in HCC.

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Physarum polycephalum-inspired adaptive optimization design of artificial microtubular networks

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Science China Chemistry 2025年

作者： Si-min Zeng Di-Wei Zheng Ting Pan Xing-Lan ding Yun Zhang Chi-Hui Yang Si-Xue Cheng Xian-Zheng Zhang Key Laboratory of Biomedical Polymers of ministry of Education&Department of Chemistry Wuhan University

Natural biological microtubular networks have undergone adaptive evolutionary selection and may offer viable solutions to design challenges in artificial microtubular networks. The plasmodium of the slime mold Physarum polycephalum(P. polycephalum) extends continuously to form a protoplasmic microtubular network structure, directly connecting food *** simulations revealed that the formation of this adaptive P. polycephalum microtubular network could be captured by a mathematical algorithm. Inspired by the P. polycephalum microtubular networks, we propose an adaptive optimization design method for artificial microtubular networks. Specifically, we utilized hydrogels with biodegradable and tissue-adhesive properties to replicate the P. polycephalum microtubular networks via photomask. In Rhodamine B diffusion and glucosecatalyzed reaction experiments, we found that the P. polycephalum microtubular networks exhibited significantly enhanced efficiency compared to vascular and artificial networks. Furthermore, we demonstrated the potential for uric acid(UA) degradation of the hydrogels with a real P. polycephalum microtubular network loaded with urate oxidase(UOx) in a rodent model of hyperuricemia. And this network achieved more than double the effect of the artificial network. This underscores the potential of natural microtubular networks to replace artificial microtubular networks.

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Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

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Journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul Navik Eryu Wang Xiao ding Huang Yunyi Yiyu Liu Jia Li Guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (Guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO 2 capture Climate change Plasma treatment Graphene aerogel

Modular assembly of complex C-alkyl glycoside enabled via cooperative NHC and photoredox catalysis

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Science China Chemistry 2025年

作者： Rui-Qiang Jiao ming Li Xi Chen Mei-Ze Xu Tian ding Xiao-Ping Gong Zhuo-Mei Li Xue-Yuan Liu Yong-min Liang State Key Laboratory of Applied Organic Chemistry Lanzhou University College of Chemistry and Chemical Engineering Northwest Normal University

C-Alkyl glycosides are found in natural products and are indispensable in drug development programs,owing to their diverse range of medicinal ***-component reactions involving glycosyl radical addition are well documented and proved efficient for the C-alkyl glycosides ***,multicomponent reactions for the rapid and controllable construction of structurally diversified C-alkyl glycosides in a single step remains a significant challenge due to the issues associated with balancing reactivity,compatibility,and ***,we report an NHC and photoredox co-catalyzed three-component method to access complex and valuable C-alkyl *** protocol exhibits broad substrate scope and excellent chemoand ***,nine types of sugars are compatible with this *** addition,the generality of this catalytic strategy was further highlighted by the potential for scalable production,the feasibility of further modifications of the products and its successful application in the late-stage functionalization of pharmaceutical skeletons.

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关于链格孢的毒性及其产毒条件的研究

真菌学报 1988年第4期 245-251页

作者：甄应中韩绍印王秀林徐岷丁兰萍河南医科大学食管癌研究室河南医科大学食管癌研究室郑州

本文报告了从食管癌高发区林县分离的具有强烈毒性和致突变性的链格孢（Alternariaalternata）“D10-A2”菌株粗提物半数致死量的测定,结果为71.25g 培养物/kg 体重;7个菌株粗提物的程序外 DNA 合成（UDS）试验,6个菌株粗提物的 DNA 合... 详细信息

本文报告了从食管癌高发区林县分离的具有强烈毒性和致突变性的链格孢（Alternariaalternata）“D10-A2”菌株粗提物半数致死量的测定,结果为71.25g 培养物/kg 体重;7个菌株粗提物的程序外 DNA 合成（UDS）试验,6个菌株粗提物的 DNA 合成抑制（DSI）试验。结果 UDS 试验6个菌株为阳性,DSI 试验5个菌株为阳性。说明互隔交链孢提取物可致人体细胞 DNA 的损伤。本文还报道了链格孢适宜的产毒条件。链格孢在一般粮食上均能生长繁殖产毒,适温为25℃,适宜的湿度根据粮食品种不同而为33—50％含水量。在北方侵染的主要粮食为小麦,当麦粒灌浆成熟期遇到较长时间的阴雨天气,或在收割脱粒时遇到连阴雨,麦粒被雨水浸泡。污染非发生于贮存期。

关键词：链格孢半数致死量致突变性程序外 DNA 合成 DNA 合成抑制

Global Stability of Multi-wave Configurations for the Compressible Non-isentropic Euler System

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Chinese Annals of Mathematics,Series B 2021年第6期42卷 921-952页

作者： min ding Department of Mathematics School of ScienceWuhan University of TechnologyWuhan 430070China

This paper is contributed to the structural stability of multi-wave configurations to Cauchy problem for the compressible non-isentropic Euler system with adiabatic exponentγ∈(1,3].Given some small BV perturbations of the initial state,the author employs a modified wave front tracking method,constructs a new Glimm functional,and proves its monotone decreasing based on the possible local wave interaction estimates,then establishes the global stability of the multi-wave configurations,consisting of a strong 1-shock wave,a strong 2-contact discontinuity,and a strong 3-shock wave,without restrictions on their strengths.

关键词： Structural stability Multi-wave configuration Shock Contact discontinuity Compressible non-isentropic Euler system Wave front tracking method

Stability of Rarefaction Wave to the 1-D Piston Problem for the Pressure-Gradient Equations

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Chinese Annals of Mathematics,Series B 2019年第2期40卷 161-186页

作者： min ding Department of Mathematics School of Science Wuhan University of Technology

The 1-D piston problem for the pressure gradient equations arising from the flux-splitting of the compressible Euler equations is considered. When the total variations of the initial data and the velocity of the piston are both sufficiently small, the author establishes the global existence of entropy solutions including a strong rarefaction wave without restriction on the strength by employing a modified wave front tracking method.

关键词： Piston problem Pressure gradient equations Rarefaction wave Wave front tracking method Interaction of waves