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标准化螨变应原特异性免疫治疗维持期换瓶不减量方案在儿童气道过敏性疾病人群中的疗效和安全性研究

中华预防医学杂志 2024年第6期58卷 768-777页

作者：梁英钟奕李云艳祝铃萍杨丽芬欧淑娴陈壮桂张萍萍中山大学附属第三医院儿科广州510630

目的探讨儿童气道过敏性疾病标准化螨变应原免疫治疗的优化方案,观察其临床疗效、安全性和依从性。方法采用回顾性真实世界研究,选取2019年6月至2020年9月在中山大学附属第三医院儿科接受双螨变应原制剂皮下免疫治疗(Subcutaneous immun... 详细信息

目的探讨儿童气道过敏性疾病标准化螨变应原免疫治疗的优化方案,观察其临床疗效、安全性和依从性。方法采用回顾性真实世界研究,选取2019年6月至2020年9月在中山大学附属第三医院儿科接受双螨变应原制剂皮下免疫治疗(Subcutaneous immunotherapy,SCIT)的变应性鼻炎(allergic rhinitis,AR)和(或)过敏性哮喘(支气管哮喘,bronchial asthma,BA)的5~16岁共156例患儿的临床资料,包括性别、年龄、不同时间节点(治疗前,启动脱敏治疗后4~6个月、1年、2年时)总VAS(视觉模拟量表)评分和CSMS(综合症状和用药评分)评分、外周血中嗜酸性粒细胞计数(EOS)、血清总IgE(tIgE)、特异性IgE(sIgE)、tIgG4、局部及全身不良反应发生率。所有患者在初始治疗阶段(剂量递增阶段)的方案一致,均按说明书进行。其中,81例(观察组)在剂量维持阶段持续继续每4~6周皮下注射1次,每次注射3号瓶1 ml;75例(对照组)维持阶段按照旧的传统方案进行(即换新瓶减半量3号瓶0.5 ml,1~2周后0.75 ml,再间隔1~2周1 ml)。比较两组患者治疗的临床疗效、安全性及依从性。结果156例患儿中观察组共纳入81例,其中AR患儿有58例,BA患儿15例,AR合并BA患儿有8例;常规对照组共纳入75例,AR患儿有52例,BA患儿16例,AR合并BA患儿有7例。在安全性方面,两组患者的局部和全身不良反应发生率差异均无统计学意义(局部不良反应对照组χ^(2)=1.541,观察组χ^(2)=0.718;全身不良反应对照组χ^(2)=0.483,观察组χ^(2)=0.179,P值均>0.05),且均无Ⅱ级以上全身不良反应发生。对照组随访2年脱漏15例,脱落率20.0%;观察组随访2年脱漏7例,脱落率8.6%,两组患者脱落率差异有统计学意义(χ^(2)=4.147,P<0.05)。血清学指标及疗效对比(在治疗后3个不同的时间节点即治疗4~6个月、1年及2年时与基线进行比较),观察组和常规对照组治疗4~6个月、1年及2年时CSMS评分较基线状态明显下降(常规组t值分别为13.783,20.086,20.384,P值均<0.001;观察组t值分别为15.480,27.087,28.938,P值均<0.001);两组患者治疗4~6个月、1年及2年时VAS评分也均较基线状态明显下降(常规组t值分别为14.008,17.963,27.512,P值均<0.001;观察组t值分别为9.436,13.184,22.377,P值均<0.001);组间比较结果显示,基线状态、4~6个月、1年及2年时CSMS差异无统计学意义(t值分别为0.621,0.473,1.825,0.342;P值分别为0.536,0.637,0.070,0.733),VAS在不同时间点的组间比较差异也无统计学意义(t值分别为1.663,0.095,0.305,0.951;P值分别为0.099,0.925,0.761,0.343);提示观察组和常规对照组的治疗方案均临床显效,且两种方案疗效相当。观察组和常规对照组治疗4~6个月、1年及2年时外周血嗜酸性粒细胞计数均较基线状态明显下降(常规组t值分别为3.453,5.469,6.273,P值均<0.05;观察组t值分别为2.900,4.575,5.988,P值均<0.05),两组患者在治疗4~6个月、1年及2年时较基线状态tIgE呈现先升高后降低的趋势(常规组t值分别为-5.328,-4.254,-0.690,P值分别为0.000,0.000,0.492;观察组t值分别为-6.087,-5.087,-0.324,P值分别为0.000,0.000,0.745)。但组间比较结果显示血清学指标及疗效在基线状态、4~6个月、1年及2年时外周血嗜酸性粒细胞计数在两组之间无明显统计学差异(t值分别为0.723,1.553,0.766,0.234;P值分别为0.471,0.122,0.445,0.815),tIgE(t值分别为0.170,-0.166,-0.449,0.839;P值分别为0.865,0.868,0.654,0.403),tIgG4(t值分别为1.507,1.467,-0.337,0.804;P值分别为0.134,0.145,0.737,0.422)。结论针对气道过敏性疾病双螨变应原皮下免疫治疗的两种免疫治疗方案均有显著的临床疗效,不良反应发生率低,观察组较对照组患者依从性更好。

关键词：变应性鼻炎过敏性哮喘免疫治疗依从性

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Influence of Ca treatment on particle-microstructure relationship in heat-affected zone of shipbuilding steel with Zr-Ti deoxidation after high-heat-input welding

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Journal of Iron and Steel Research International 2022年第8期29卷 1291-1298页

作者： Hong-bo Liu Ju Kang xiu-juan Zhao Cai-dong zhang zhang-guo Lin Hong-yong Yao Zhi-qiang Tian Zhan-li Liu Jie Li Chao Li Technology Research Institute HBIS GroupShijiazhuang 050023HebeiChina Beijing Key Laboratory of Pipeline Critical Technology and Equipment for Deepwater Oil and Gas Development Beijing Institute of Petrochemical TechnologyBeijing 102617China Department of Material Engineering Hebei Vocational University of Industry and TechnologyShijiazhuang 050091HebeiChina HBIS Company Limited Shijiazhuang 050023HebeiChina School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China HBIS Group Shisteel Company Shijiazhuang 050031HebeiChina

The effects of Ca treatment on the particle, microstructure, and toughness of heat-affected zone (HAZ) of shipbuilding steel with Zr-Ti deoxidation after high-heat-input welding were investigated. The simulated welding at a high-heat-input welding of 200 kJ/cm was carried out using Gleeble-3800 welding simulation. Then, particle characteristics were characterized using an Aztec-Feature automatic particle analysis system. Additionally, an in-situ observation experiment was performed to study the relationships between particle and microstructure by high-temperature confocal laser scanning microscopy (HT-CLSM). The results indicated that the average HAZ toughness at -40 ℃ was increased from 183 to 290 J by adding 0.0026 wt.% Ca. Meanwhile, the formation of acicular ferrite ratio was increased from 49.34% to 60.28% due to the addition of Ca. The scanning electron microscopy results clearly showed that CaO-Al_(2)O_(3)-TiOx-ZrO_(2)-MnS particles could act as effective nucleation sites for the formation of acicular ferrite, which has been verified by the observation of the particle-microstructure relationship under HT-CLSM. Furthermore, particle characterization results show that the cumulative frequency of particles with the size of 1-3 lm was 33.2% in HAZ of Zr-Ti shipbuilding steel but 66.2% in HAZ of Zr-Ti-Ca shipbuilding steel.

关键词： Shipbuilding steel Heat-affected zone Impact toughness Microstructure Particle characterization

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Functional characterization of an orexin neuropeptide in amphioxus reveals an ancient origin of orexin/orexin receptor system in chordate

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Science China(Life Sciences) 2019年第12期62卷 1655-1669页

作者： Peng Wang Meng Wang Liping zhang Shenjie zhong Wanyue Jiang Ziyue Wang Chen Sun Shicui zhang Zhenhui Liu Institute of Evolution & Marine Biodiversity College of Marine Life Science Ocean University of China

Amphioxus belongs to the subphylum cephalochordata, an extant representative of the most basal chordates, whose regulation of endocrine system remains ambiguous. Here we clearly demonstrated the existence of a functional orexin neuropeptide in amphioxus, which is able to interact with orexin receptor, activate both PKC and PKA pathways, decrease leptin expression, and stimulate lipogenesis. We also showed the transcription level of amphioxus orexin was affected by fasting or temperature,indicating a role of this gene in the regulation of energy balance. In addition, the expression of the amphioxus orexin was detected at cerebral vesicle, which has been proposed to be a homolog of the vertebrate brain. These data collectively suggest that a functional orexin neuropeptide has already emerged in amphioxus, which provide insights into the evolutionary origin of orexin in chordate and the functional homology between the cerebral vesicle and vertebrate brain.

关键词： amphioxus orexin neuropeptide evolution

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散结透脓方外敷联合消肿清热解毒汤内服治疗泛发性肛周脓肿术后的效果及对创面愈合时间、肛门功能的影响

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河北中医 2024年第5期46卷 740-744页

作者：李洪剑修洁谭思思张洪也龙包亮重庆市合川区人民医院中医肛肠科重庆401520

目的观察散结透脓方外敷联合消肿清热解毒汤内服在泛发性肛周脓肿术后的应用效果及对创面愈合时间、肛门功能的影响。方法将102例热毒炽盛型泛发性肛周脓肿术后患者按照随机数字表法分为2组,对照组51例术后予以抗感染及对症支持等治疗方... 详细信息

目的观察散结透脓方外敷联合消肿清热解毒汤内服在泛发性肛周脓肿术后的应用效果及对创面愈合时间、肛门功能的影响。方法将102例热毒炽盛型泛发性肛周脓肿术后患者按照随机数字表法分为2组,对照组51例术后予以抗感染及对症支持等治疗方法,治疗组51例在对照组基础上予以散结透脓方外敷联合消肿清热解毒汤内服治疗,2组均治疗4周。比较2组治疗后创面愈合情况(创面腐肉脱落时间、创面愈合时间、治疗2周创面回缩率)、治疗前后中医证候评分、治疗前和治疗2周疼痛视觉模拟评分(VAS)、治疗前和术后2个月肛门失禁Wexner评分量表评分、治疗前和治疗2周炎症相关指标[白细胞计数(WBC)、C反应蛋白(CRP)、白细胞介素6(IL-6)],并统计2组临床疗效,记录治疗期间不良反应发生情况。结果治疗组总有效率90.20%(46/51),对照组总有效率74.51%(38/51),治疗组临床疗效优于对照组(P<0.05)。2组治疗后中医证候各项评分均较本组治疗前降低(P<0.05),且治疗组治疗后均低于对照组(P<0.05)。治疗组创面腐肉脱落时间、愈合时间均低于对照组(P<0.05),治疗2周时创面回缩率高于对照组(P<0.05)。2组治疗2周时疼痛VAS均较本组治疗前降低(P<0.05),且治疗组治疗2周时疼痛VAS低于对照组同期(P<0.05)。2组术后2个月Wexner评分均较本组治疗前降低(P<0.05),且治疗组术后2个月Wexner评分低于对照组同期(P<0.05)。2组治疗2周后外周血WBC、CRP、IL-6水平均较本组治疗前降低(P<0.05),且治疗组治疗2周后均低于对照组同期(P<0.05)。结论散结透脓方外敷联合消肿清热解毒汤内服可提高泛发性肛周脓肿术后疗效,缩短愈合时间,减轻术后疼痛,缓解炎症反应,有利于改善患者肛门功能。

关键词：肛周脓肿中药疗法中药外敷

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Research on constraints of internal controls in Chinese enterprises

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Journal of Modern Accounting and Auditing 2010年第11期6卷 59-63页

作者： zhong Wei TANG Hai-xiu Research Institute for Fiscal Science Ministry of Finance Beijing 100142 China

From the practice of Chinese enterprises, the paper discusses three constraint conditions of China＇s internal controls including the system environmental constraint, cost constraint and organization constraint, and a... 详细信息

关键词： internal controls system environment cost constraint organization constraint

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Highly efficient conversion of mouse fibroblasts into functional hepatic cells under chemical induction

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Journal of Molecular Cell Biology 2023年第11期15卷 43-57页

作者： Zhi zhong Jiangchuan Du Xiangjie Zhu Lingting Guan Yanyu Hu Peilin zhang Hongyang Wang Fudan University Shanghai Cancer Center Department of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China National Center for Liver Cancer Naval Medical UniversityShanghai 201805China Institute of Metabolism and Integrative Biology Fudan UniversityShanghai 200438China

Previous studies have shown that hepatocyte-like cells can be generated from fibroblasts using either lineage-specific transcription factors or chemical induction ***,these methods have their own deficiencies that restrict the therapeutic applications of such induced *** this study,we present a transgene-free,highly efficient chemical-induced direct reprogramming approach to generate hepatocyte-like cells from mouse embryonic fibroblasts(MEFs).Using a small molecule cocktail(SMC)as an inducer,MEFs can be directly reprogrammed into hepatocyte-like cells,bypassing the intermediate stages of pluripotent and immature *** chemical-induced hepatocyte-like cells(ciHeps)closely resemble mature primary hepatocytes in terms of morphology,biological behavior,gene expression patterns,marker expression levels,and hepatic ***,transplanted ciHeps can integrate into the liver,promote liver regeneration,and improve survival rates in mice with acute liver *** can also ameliorate liver fibrosis caused by chronic injuries and enhance liver ***,ciHeps exhibit no tumorigenic potential either in vitro or in ***,SMC-induced mesenchymal-to-epithelial transition and suppression of SNAI1 contribute to the fate conversion of fibroblasts into *** results indicate that this transgene-free,chemical-induced direct reprogramming technique has the potential to serve as a valuable means of producing alternative hepatocytes for both research and therapeutic ***,this method also sheds light on the direct reprogramming of other cell types under chemical induction.

关键词： direct cell reprogramming chemicals fibroblasts hepatocyte-like cells high efficiency regenerative medicine

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Met-Controlled Allosteric Module of Neural Generation as A New Therapeutic Target in Rodent Brain Ischemia

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Chinese Journal of Integrative Medicine 2021年第12期27卷 896-904页

作者： LI Kang-ning zhang Ying-ying YU Ya-nan WU Hong-li WANG zhong Department of Traditional Chinese Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijing(100070)China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing(100700)China

Objective To investigate a Met-controlled allosteric module(AM)of neural generation as a potential therapeutic target for brain *** We selected Markov clustering algorithm(MCL)to mine functional modules in the related target *** to the topological similarity,one functional module was predicted in the modules of baicalin(BA),jasminoidin(JA),cholic acid(CA),compared with I/R model *** functional module included three genes:Inppl1,Met and Dapk3(IMD).By gene ontology enrichment analysis,biological process related to this functional module was *** functional module participated in generation of *** blotting was applied to present the compound-dependent regulation of ***-immunoprecipitation was used to reveal the relationship among the three *** used IF to determine the number of newborn neurons between compound treatment group and ischemia/reperfusion *** expressions of vascular endothelial growth factor(VEGF)and matrix metalloproteinase 9(MMP-9)were supposed to show the changing circumstances for neural generation under cerebral *** Significant reduction in infarction volume and pathological changes were shown in the compound treatment groups compared with the I/R model group(P<0.05).Three nodes in one novel module of IMD were found to exert diverse compound-dependent ischemic-specific excitatory regulatory *** anti-ischemic excitatory allosteric module(AME)of generation of neurons(AME-GN)was validated successfully in *** neurons increased in BJC treatment group(P<0.05).The expression of VEGF and MMP-9 decreased in the compound treatment groups compared with the I/R model group(P<0.05).Conclusions AME demonstrates effectiveness of our pioneering approach to the discovery of therapeutic *** novel approach for AM discovery in an effort to identify therapeutic targets holds the promise of accelerating elucidation of underlying pharmacological mechanisms in cere

关键词： allosteric module InppM-Met-Dapk3 generation of neurons brain ischemia

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A modified simplified coherent potential approximation model of band gap energy of III-V ternary alloys

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Science China(Physics,Mechanics & Astronomy) 2012年第3期55卷 400-403页

作者： Zhao ChuanZhen zhang Rong Liu Bin Fu DeYi Li Ming xiu XiangQian Xie ZiLi Zheng YouDou Nanjing Univ Sch Elect Sci & Engn Jiangsu Prov Key Lab Adv Photon & Elect Mat Nanjing 210093 Jiangsu Peoples R China Tianjin Polytech Univ Sch Elect & Informat Engn Tianjin 300160 Peoples R China

Based on the modification of the simplified coherent potential approximation （SCPA）, a model is developed to calculate the composition dependence of the band gap energy of Ⅲ-V ternary alloys with the same anion. The derived equation is used to fit the experimental band gap energy of InxAl1-xN, InxGa1-xN and A1xGal xN with x from 0 to 1. It is found that the fitting results are better than those done by using SCPA. The fitting results are also better than those obtained by using the formula with a small bowing coefficient, especially for InxAl1-xN. In addition, our model can also be used to describe the composition de- pendence of band gap energy of other Ⅲ-V ternary alloys.

关键词： band gap energy coherent potential approximation ternary alloys

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近净成形快堆支承环用316H不锈钢锻件的晶粒度与力学性能

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材料热处理学报 2024年第4期45卷 122-129页

作者：任利国傅万堂张皓周岩温瑞洁赵德利王宝忠亚稳材料制备技术与科学国家重点实验室燕山大学材料科学与工程学院河北秦皇岛066004 天津重型装备工程研究有限公司天津300457 中国第一重型机械股份公司黑龙江齐齐哈尔161042

采用电渣重熔钢锭,经开坯锻造后,通过热挤压制备高品质坯料,随后在专用模具内进行胎模锻造成形,研制出国内首支外径15.5米、重量15吨的快堆支撑环1/6弧段316H不锈钢锻件,突破了超大规格快堆支撑环锻件制造技术瓶颈。结果表明:锻件各部... 详细信息

采用电渣重熔钢锭,经开坯锻造后,通过热挤压制备高品质坯料,随后在专用模具内进行胎模锻造成形,研制出国内首支外径15.5米、重量15吨的快堆支撑环1/6弧段316H不锈钢锻件,突破了超大规格快堆支撑环锻件制造技术瓶颈。结果表明:锻件各部位晶粒度、拉伸性能均匀一致且无各向异性,疲劳性能完全满足ASME设计曲线标准要求。所采用的近净成形制造工艺大大缩短了产品制造周期,提高了经济效益,实现了同类产品的国产化制造。

关键词： 316H不锈钢锻件晶粒度拉伸性能疲劳性能

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Fe_(2)O_(3)-MWNTs Composite with Reinforced Concrete Structure as High-performance Anode Material for Lithium-ion Batteries

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Chemical Research in Chinese Universities 2023年第2期39卷 240-245页

作者： WANG Suhang ZUO Jinxin LI Yongliang zhong Yiming REN Xiangzhong zhang Peixin SUN Lingna College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen518060P.R.China Babel International College PerthWA6100Australia

A Fe_(2)O_(3)-MWNTs(multi-walled carbon nanotubes)composite with a reinforced concrete structure was fabricated employing a two-step method which involves a sol-gel process followed by high-temperature in situ *** Fe_(2)O_(3)-MWNTs composite,intended to be used as an anode material for lithium-ion batteries,maintained a reversible capacity as high as 896.3 mA·h/g after 100 cycles at a current density of 100 mA/g and the initial coulombic efficiency reached 75.5%.The rate capabilities of the Fe_(2)O_(3)-MWNTs composite,evaluated using the ratios of capacity at 100,200,500,1000,2000 and 100 mA/g after every 10 cycles,were determined to be 904.7,852.1,759.0,653.8,566.8 and 866.3 mA·h/g,*** a superior electrochemical performance of the Fe_(2)O_(3)-MWNTs composite is mainly attributed to the reinforced concrete construction,in which the MWNTs function as the skeleton and conductive *** a structure contributes to shortening the transport pathways for both Li+and electrons,enhancing conductivity and accommodating volume expansion during prolonged *** Fe_(2)O_(3)-MWNTs composite with the designed structure is a promising anode material for high-performance lithium-ion batteries.

关键词： Lithium-ion battery Anode material Fe_(2)O_(3)-multi-walled carbon nanotubes(MWNTs)composite Sol-gel Reinforced concrete structure

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