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Pd/C-catalyzed selective reduction of aromatic azides with Hantzsch 1,4-dihydropyridine

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Chinese Chemical Letters 2008年第8期19卷 885-888页

作者： Zhen Gang Liu xiu Qin Niu wei yu Li Yang Zhong Li Liu State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 China

The reagent combination of Hantzsch 1,4-dihydropyridine and Pd/C was found to be an efficient reducing system for the selective reduction of aromatic azides.

关键词： Reduction Hantzsch 1,4-dihydropyridine Pd/C Aromatic azides

Dmrt1 regulates the immune response by repressing the TLR4 signaling pathway in goat male germline stem cells

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Zoological Research 2021年第1期42卷 14-27页

作者： yu-Dong wei Xiao-Min Du Dong-Hui Yang Fang-Lin Ma xiu-wei yu Meng-Fei Zhang Na Li Sha Peng Ming-Zhi Liao Guang-Peng Li Chun-Ling Bai wei-Shuai Liu Jin-Lian Hua College of Veterinary Medicine Northwest A&F UniversityShaanxi Centre of Stem Cells Engineering&TechnologyYanglingShaanxi 712100China College of Life Sciences Northwest A&F UniversityYanglingShaanxi 712100China State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock School of Life SciencesInner Mongolia UniversityHohhotInner Mongolia 010021China Department of Pathology Yangling Demonstration Zone HospitalYangling Shaanxi 712100China

Double sex and mab-3-related transcription factor 1(Dmrt1),which is expressed in goat male germline stem cells(mGSCs)and Sertoli cells,is one of the most conserved transcription factors involved in sex *** this study,we highlighted the role of Dmrt1 in balancing the innate immune response in goat ***1 recruited promyelocytic leukemia zinc finger(Plzf),also known as zinc finger and BTB domain-containing protein 16(Zbtb16),to repress the Toll-like receptor 4(TLR4)-dependent inflammatory signaling pathway and nuclear factor(NF)-κ*** of Dmrt1 in seminiferous tubules resulted in widespread degeneration of germ and somatic cells,while the expression of proinflammatory factors were significantly *** also demonstrated that Dmrt1 stimulated proliferation of mGSCs,but repressed apoptosis caused by the immune ***,Dmrt1 is sufficient to reduce inflammation in the testes,thereby establishing the stability of spermatogenesis and the testicular microenvironment.

关键词： Male germline stem cells(mGSCs) Goat Dmrt1 Plzf Immune response

HLA-G expression in the peripheral blood of live kidney transplant recipients

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Chinese Medical Journal 2013年第14期126卷 2652-2655页

作者： XIAO Li ZHOU Wen-qiang SHI Bing-yi FENG Kai HE xiu-yun wei yu-xiang GAO yu MENG Xiao-yun XIAO wei Beijing Key Laboratory of Immunology Regulatory and Organ Transplantation Basic Research Lab of Organ Transplant Institue 309th Hospital of the People's Liberation Army Beijing 100091 China

Background The human leukocyte antigen-G （HLA-G） has been considered to be an important tolerogeneic molecule playing an essential role in maternal-fetal tolerance, upregulated in the context of transplantation, malignancy, and inflammation, and has been correlated with various clinical outcomes. The aim of this study was to investigate the clinical relevance of the expression of membrane HLA-G （mHLA-G）, intracellular HLA-G （iHLA-G）, and soluble HLA-G （sHLA-G） in the peripheral blood of live kidney transplant recipients. Methods We compared the expression of the three HLA-G isoforms in three groups, healthy donors （n=20）, recipients with acute rejection （n=19）, and functioning transplants （n=30）. Flow cytometry was used to detect the expression of mHLA-G and iHLA-G in the T lymphocytes of peripheral blood from subjects in the three groups. Enzyme-linked immunosorbent assays were used to detect sHLA-G in the plasma from the three groups. Results There were no significant differences in mHLA-G and intracellular HLA-G among the three groups, but the sHLA-G plasma level was higher in the functioning group than in the acute rejection or healthy group. We found a subset of CD4＊HLA-G~ and CD8~HLA-G＋T lymphocytes with low rates of mHLA-G expression in the peripheral blood of kidney transplantation recipients. Intracellular expression of HLA-G was detected in T lymphocytes. However, there was no correlation between acute rejection and the mHLA-G or intracellular HLA-G expression. Conclusion sHLA-G was the major isoform in the peripheral blood of live kidney transplant recipients and high sHLA-G levels were associated with allograft acceptance.

关键词： HLA-G kidney transplantation

时效析出对2E12铝合金疲劳断裂行为的影响

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中国有色金属学报 2008年第4期18卷 589-594页

作者：李海郑子樵魏修宇王芝秀江苏工业学院材料科学与工程学院常州213164 中南大学材料科学与工程学院长沙410083

测试等屈服强度条件下190℃,1 h欠时效和190℃,46 h过时效状态Al-Cu-Mg系2E12铝合金的疲劳寿命,并分别采用扫描电镜和透射电镜观察了疲劳断口形貌及时效析出特征,并在此基础上解释时效析出对2E12铝合金疲劳断裂行为的影响。结果表明:疲... 详细信息

测试等屈服强度条件下190℃,1 h欠时效和190℃,46 h过时效状态Al-Cu-Mg系2E12铝合金的疲劳寿命,并分别采用扫描电镜和透射电镜观察了疲劳断口形貌及时效析出特征,并在此基础上解释时效析出对2E12铝合金疲劳断裂行为的影响。结果表明:疲劳裂纹主要萌生于试样表面的粗大残留相位置;由于过时效试样晶内析出大量的S平衡相降低疲劳变形时的位错滑移可逆性,加剧晶界处位错塞积程度;同时晶界上较宽的无析出带和沿晶界析出的粗大针状S相进一步促进晶界集中变形和开裂,从而降低过时效试样的疲劳寿命。

关键词：铝合金疲劳断裂行为时效析出

南岭走廊古村落的信仰空间与文化记忆——以黄姚街为例

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广西民族大学学报（哲学社会科学版） 2016年第6期38卷 37-42页

作者：韦秀玉广西艺术学院美术学院

通过田野调查与文献阅读相结合,重点考察南岭走廊古村落昭平县黄姚街空间营建的理论及元素。古代先民根据地理环境营造文化景观,营建精神信仰空间,以达到空间的和谐均衡,形成神人合一、天人合一之境。南岭走廊古村落是中国古代先民精神... 详细信息

通过田野调查与文献阅读相结合,重点考察南岭走廊古村落昭平县黄姚街空间营建的理论及元素。古代先民根据地理环境营造文化景观,营建精神信仰空间,以达到空间的和谐均衡,形成神人合一、天人合一之境。南岭走廊古村落是中国古代先民精神家园建构的优秀遗存,是探寻文化记忆、留住乡愁的绝佳处所,记载着南北之间、民间社会与帝国之间的文化互动,凝聚着中华民族精神信仰与生态伦理的智慧。

关键词：南岭走廊古村落黄姚街信仰空间

Single-cell RNA sequencing reveals atlas of dairy goat testis cells

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Zoological Research 2021年第4期42卷 401-405页

作者： xiu-wei yu Tong-Tong Li Xiao-Min Du Qiao-Yan Shen Meng-Fei Zhang yu-Dong wei Dong-Hui Yang Wen-Jing Xu Wen-Bo Chen Chun-Ling Bai Xue-Ling Li Guang-Peng Li Na Li Sha Peng Ming-Zhi Liao Jin-Lian Hua College of Veterinary Medicine Northwest A&F UniversityShaanxi Centre of Stem Cells Engineering&TechnologyYanglingShaanxi 712100China College of Life Science Northwest A&F UniversityYanglingShaanxi 712100China Key Laboratory for Mammalian Reproductive Biology and Biotechnology Ministry of EducationInner Mongolia UniversityHohhotInner Mongolia 010021China

Single-cell RNA sequencing(scRNA-seq)is useful for exploring cell *** large animals,however,little is known regarding spermatogonial stem cell(SSC)selfrenewal regulation,especially in dairy *** this study,we described a high-resolution scRNA-seq atlas derived from a dairy *** identified six somatic cell and five spermatogenic cell *** spermatogenesis,genes with significantly changed expression were mainly enriched in the Notch,TGF-β,and Hippo signaling pathways as well as the signaling pathway involved in the regulation of stem cell *** detected and screened specific candidate marker genes(TKTL1 and AES)for *** study provides new insights into goat spermatogenesis and the development of testicular somatic cells.

关键词： Notch insight atlas

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping yu Emily Choi Michael QJiang Ling wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

Resistance of Cement-based Grouting Materials with Nano- SiO_(2) Emulsion to Chloride Ion Penetration

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 114-119页

作者： LI Shuiping CHENG Jian wei Chao yuAN Bin yu Chengxiao College of Architectural Science and Engineering Yangzhou UniversityYangzhou 225127China

The chloride penetration resistance of cement-based grout materials was improved by nano-silica *** of mixtures containing different nano-silica particles or emulsions were exposed in sodium chloride solutions of specific concentrations with different test *** properties of the mixes were assessed in terms of weight loss and compressive strength.X-ray diffraction(XRD)and scanning electron microscopy(SEM)of mixes were performed to analysis the phase evolution and *** results demonstrated that the introduction of nano-SiO_(2) emulsion significantly decreased the compressive strength loss and calcium hydroxide(CH)crystal content of hydration production,and then enhanced the resistance of cement-based grouting materials to chloride ion *** improvement derives from the filling and pozzolanic effects of nano-SiO_(2) particles,which were incorporated via an emulsion and attributed to a well dispersion in grouting matrix.

关键词： grouting materials nano-SiO_(2)emulsion chloride ion penetration,weight loss strength loss

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ML377铝锂合金热稳定性研究

材料热处理学报 2008年第1期29卷 71-74页

作者：魏修宇郑子樵陈小珍李世晨中南大学材料科学与工程学院湖南长沙410083

研究了ML377铝锂合金高温拉伸性能以及长时间热暴露后的室温力学性能,同时对合金热暴露前后的显微组织进行了透射电镜观察。实验结果表明:ML377合金高温拉伸强度随拉伸温度的升高而逐渐降低,在200℃下的高温瞬时拉伸性能优于传统高温用... 详细信息

研究了ML377铝锂合金高温拉伸性能以及长时间热暴露后的室温力学性能,同时对合金热暴露前后的显微组织进行了透射电镜观察。实验结果表明:ML377合金高温拉伸强度随拉伸温度的升高而逐渐降低,在200℃下的高温瞬时拉伸性能优于传统高温用铝合金。在107℃、150℃热暴露条件下,ML377合金的强度没有明显下降,这是因为合金中T1相在此温度下具有较强的抗粗化能力;但200℃热暴露条件下,T1相显著粗化,部分T1相溶解向平衡相转化,导致合金力学性能明显下降。

关键词： ML377铝锂合金热暴露耐热性能 T1相