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Gut microbiome and serum metabolome analyses identify Bacteroides fragilis as regulators of serotonin content and PRL secretion in broody geese

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Journal of Integrative Agriculture 2024年第6期23卷 2033-2051页

作者： Yu Zhang Ning Zhou Jia Wu Lina Song Qiang Bao Kaiqi weng Yang Zhang Wanwipa Vongsangnak Guohong Chen Qi Xu College of Animal Science and Technology Yangzhou UniversityYangzhou 225009China Joint International Research Laboratory of Agriculture&Agri-Product Safety of Ministry of Education Yangzhou UniversityYangzhou 225009China Department of Zoology Faculty of ScienceKasetsart UniversityBangkok 10900Thailand

Broody behavior is regulated by hypothalamic prolactin secretion,which seriously affects egg production in poulty *** studies have provided evidence that animal behavior is governed by dynamic bidirectional communication between specific gut bacteria and their host via the brain-gut-microbiome ***,little research focused on how the gut microbiota influence broody behavior in *** this study,Zhedong white geese in laying and brooding phases were *** differentially abundant bacteria in cecum were detected between brooding and laying geese through metagenomic analyses and 16S rRNA sequencing(P<0.05),and Bacteroides fragilis was specifically identified as a key driver species in the brooding ***,the serum metabolites were quantified,and the 313 differentially abundant metabolites were found between the two groups of different physiological *** were primarily enriched in the tryptophan metabolism *** correlation analyses revealed there was a significant positive correlation between *** abundance and the context of 11 tryptophan metabolism-related metabolites(such as serotonin,etc.)in broody geese,which hinted that those tryptophan metabolites might be produced or driven by ***,the serum hormone levels were also *** found there was a positive correlation between *** abundance and content of ***,prolactin secreted by the pituitary gland was greater in brooding geese than that in laying geese,which was also highly correlated with *** *** result implied that *** could promote the secretion of prolactin by the pituitary ***,the current study findings provided the information on gut microbiota influencing broody behavior,*** produced or driven more serum serotonin,and stimulated the pituitary gland to secret more prolactin,which potentially offered a new enlightenment for the intervention of broody behavior in pou

关键词： geese broody behavior gut microbiota serotonin prolactin

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Myokines:metabolic regulation in obesity and type 2 diabetes

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Life Metabolism 2024年第3期3卷 21-45页

作者： Zhi-Tian Chen Zhi-Xuan weng Jiandie D.Lin Zhuo-Xian Meng Department of Pathology and Pathophysiology and Department of Cardiology of the Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhouZhejiang 310058China Key Laboratory of Disease Proteomics of Zhejiang Province School of MedicineZhejiang UniversityHangzhouZhejiang 310058China Zhejiang University-University of Edinburgh Institute(ZJE) School of MedicineZhejiang UniversityHainingZhejiang 314400China Life Sciences Institute and Department of Cell and Developmental Biology University of MichiganAnn ArborMI 48109United States Department of Geriatrics Affiliated Hangzhou First People’s HospitalHangzhouZhejiang 310006China

Skeletal muscle plays a vital role in the regulation of systemic metabolism,partly through its secretion of endocrine factors which are collectively known as *** myokine levels are associated with metabolic diseases,such as type 2 diabetes(T2D).The significance of interorgan crosstalk,particularly through myokines,has emerged as a fundamental aspect of nutrient and energy ***,a comprehensive understanding of myokine biology in the setting of obesity and T2D remains a major chal*** this review,we discuss the regulation and biological functions of key myokines that have been extensively studied during the past two decades,namely interleukin 6(IL-6),irisin,myostatin(MSTN),growth differentiation factor 11(GDF11),fibroblast growth factor 21(FGF21),apelin,brain-derived neurotrophic factor(BDNF),meteorin-like(Metrnl),secreted protein acidic and rich in cysteine(SPARC),β-aminoisobutyric acid(BAIBA),Musclin,and Dickkopf 3(Dkk3).Related to these,we detail the role of exercise in myokine expression and secretion together with their contributions to metabolic physiology and *** significant advancements in myokine research,many myokines remain challenging to measure accurately and investigate ***,new research techniques and detection methods should be developed and rigorously ***,developing a comprehensive perspective on myokine biology is crucial,as this will likely offer new insights into the pathophysiological mechanisms underlying obesity and T2D and may reveal novel targets for therapeutic interventions.

关键词： myokines skeletal muscle obesity type 2 diabetes metabolism

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Two-phase flow thermo-hydro-mechanical modeling for a water flooding field case

Rock Mechanics Bulletin

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Rock Mechanics Bulletin 2024年第3期3卷 81-90页

作者： Yuhao Liu fengshou Zhang Dingwei weng Hongbo Liang Chunming He Keita Yoshioka Key Laboratory of Geotechnical&Underground Engineering of Ministry of Education Tongji UniversityShanghai200092China Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai200092China PetroChina Research Institute of Petroleum Exploration&Development Beijing100083China CNPC Key Laboratory of Oil&Gas Reservoir Stimulation Langfang065007China Department of Petroleum Engineering Montanuniversitat LeobenLeobenLeoben8700Austria

Simulation of subsurface energy system involves multi-physical processes such as thermal,hydraulical,and mechanical(THM)processes,and requires a so-called THM coupled modeling *** coupled modeling is commonly performed in geothermal energy ***,for hydrocarbon extraction,we need to consider multiphase flow *** this paper,we describe a three-dimensional numerical model of non-isothermal two-phase flow in the deformable porous medium by integrating governing equations of two-phase mixture in the porous media flow in the *** account for inter-woven impacts in subsurface condi-tions,we introduced a temperature-dependent fluid viscosity and a fluid density along with a strain-dependent reservoir ***,we performed numerical experiments of a ten-year water flooding pro-cess employing the open-source parallelized code,*** considered different well patterns with colder water injection in realistic *** results demonstrate that our model can simulate complex interactions of temperature,pore pressure,subsurface stress and water saturation simultaneously to evaluate the recovery *** temperature can promote fluid flow while cold water injection under non-isothermal conditions causes the normal stress reduction by significant thermal *** different well patterns the displacement efficiency will be changed by the relative location between injection and production *** finding has provided the important reference for fluid flow and induced stress evolution during hydrocarbon exploitation under the environment of large reservoir depth and high temperature.

关键词： THM coupling Two phase flow OpenGeoSys Water flooding Field-scale model

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Optimizing Spatial Crowdsourcing:A Quality-Aware Task Assignment Approach for Mobile Communication

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Journal of Electronic Research and Application 2024年第3期8卷 104-111页

作者： Jiali weng Xike Xie University of Science and Technology of China Hefei 230026Anhui ProvinceChina

The widespread use of advanced electronic devices has led to the emergence of spatial crowdsourcing,a method that taps into collective efforts to perform real-world tasks like environmental monitoring and traffic *** research focuses on a specific type of spatial crowdsourcing that involves ongoing,collaborative efforts for continuous spatial data ***,due to limited budgets and workforce availability,the collected data often lacks completeness,posing a data deficiency *** address this,we propose a reciprocal framework to optimize task assignments by leveraging the mutual benefits of spatiotemporal subtask *** introduce an entropy-based quality metric to capture the combined effects of incomplete data acquisition and interpolation *** on this,we explore a quality-aware task assignment method,corresponding to spatiotemporal assignment *** the assignment problem is NP-hard,we develop a polynomial-time algorithm with the guaranteed approximation *** indexing and pruning techniques are proposed to further enhance *** experiments conducted on datasets validate the effectiveness of our methods.

关键词： Spatiotemporal crowdsourcing Mobile communication Task quality

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Genetic mechanism of body size variation in groupers:Insights from phylotranscriptomics

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Zoological Research 2024年第2期45卷 314-328页

作者： Wei-Wei Zhang Zhuo-Ying weng Xi Wang Yang Yang Duo Li Le Wang Xiao-Chun Liu Zi-Ning Meng State Key Laboratory of Biocontrol Institute of Aquatic Economic Animals and Guangdong Province Key Laboratory of Aquatic Economic AnimalsSchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Southern Laboratory of Ocean Science and Engineering(Zhuhai) ZhuhaiGuangdong 519000China Area of Ecology and Biodiversity School of Biological SciencesUniversity of Hong KongHong Kong SAR 999077China Molecular Population Genetics Group Temasek Life Sciences LaboratorySingapore City 117604Singapore

Animal body size variation is of particular interest in evolutionary biology,but the genetic basis remains largely *** studies have shown the presence of two parallel evolutionary genetic clusters within the fish genus Epinephelus with evident divergence in body size,providing an excellent opportunity to investigate the genetic basis of body size variation in ***,we performed phylotranscriptomic analysis and reconstructed the phylogeny of 13 epinephelids originating from the South China *** genetic clades with an estimated divergence time of approximately 15.4 million years ago were correlated with large and small body size,respectively.A total of 180 rapidly evolving genes and two positively selected genes were identified between the two *** enrichment analyses of these candidate genes revealed distinct enrichment categories between the two *** pathways and genes may play important roles in body size variation in groupers through complex regulatory *** on our results,we speculate that the ancestors of the two divergent groups of groupers may have adapted to different environments through habitat selection,leading to genetic variations in metabolic patterns,organ development,and lifespan,resulting in body size divergence between the two locally adapted *** findings provide important insights into the genetic mechanisms underlying body size variation in groupers and species differentiation.

关键词： Phylotranscriptomics Grouper Body size Rapidly evolving genes(REGs) Positively selected genes(PSGs)

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Privacy Enhanced Mobile User Authentication Method Using Motion Sensors

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 3013-3032页

作者： Chunlin Xiong Zhengqiu weng Jia Liu Liang Gu Fayez Alqahtani Amr Gafar Pradip Kumar Sharma Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen518052China Sangfor Technologies Inc. Shenzhen518055China School of Data Science and Artificial Intelligence Wenzhou University of TechnologyWenzhou325035China College of Computer Science&Technology Zhejiang University of TechnologyHangzhou310023China Software Engineering Department College of Computer and Information SciencesKing Saud UniversityRiyadh12372Saudi Arabia Math&Computer Science Department Faculty of ScienceMenofia UniversityShebin El-KomEgypt Computing Science Department University of AberdeenAberdeenUK

With the development of hardware devices and the upgrading of smartphones,a large number of users save privacy-related information in mobile devices,mainly smartphones,which puts forward higher demands on the protection of mobile users’privacy *** present,mobile user authenticationmethods based on humancomputer interaction have been extensively studied due to their advantages of high precision and non-perception,but there are still shortcomings such as low data collection efficiency,untrustworthy participating nodes,and lack of *** this end,this paper proposes a privacy-enhanced mobile user authentication method with motion sensors,which mainly includes:(1)Construct a smart contract-based private chain and federated learning to improve the data collection efficiency of mobile user authentication,reduce the probability of the model being bypassed by attackers,and reduce the overhead of data centralized processing and the risk of privacy leakage;(2)Use certificateless encryption to realize the authentication of the device to ensure the credibility of the client nodes participating in the calculation;(3)Combine Variational Mode Decomposition(VMD)and Long Short-TermMemory(LSTM)to analyze and model the motion sensor data of mobile devices to improve the accuracy of model *** experimental results on the real environment dataset of 1513 people show that themethod proposed in this paper can effectively resist poisoning attacks while ensuring the accuracy and efficiency of mobile user authentication.

关键词： Mobile authentication blockchain federated learning smart contract certificateless encryption VMD LSTM

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How Does E-Commerce Policy Affect Consumption Disparities of Rural Households?-Evidence from China

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China Economist 2024年第4期19卷 107-128页

作者： Zhang Cheng weng Xiyan School of Business Shantou UniversityShantouChina Institute for Economic and Social Research Jinan UniversityGuangzhouChina

In the context of China’s ongoing efforts to promote countryside revitalization and facilitate domestic economic circulation,it is of great significance to reduce the consumption disparity among rural households and unleash the consumption potential in the *** on data from China Family Panel Studies,this paper adopts a staggered difference-in-differences method to assess the impact of the e-commerce to enter rural areas on the consumption disparity among rural ***:the comprehensive demonstration work of promoting e-commerce to enter rural areas has reduced the consumption disparity among rural households through the following ***,this policy initiative has mitigated the consumption-inhibiting effect on rural household consumption due to the local market size and external market accessibility by promoting the distribution of consumer goods to ***,this policy initiative has also increased the agricultural income of rural households and reduced their consumption disparity by distributing farm produce to cities and enhancing the agricultural income of rural ***,the work is characterized by inclusive growth and is not susceptible to the“elite capture”phenomenon.

关键词： E-commerce to enter rural areas consumption disparity among rural household market accessibility market size income of rural households

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Unleashing the Power of Bio-based Thermotropic Liquid Crystal Modifiers:Toughening and Reinforcing Petroleum-based Epoxy Resin without Compromising Other Properties

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Chinese Journal of Polymer Science 2024年第8期42卷 1093-1102页

作者： Qing-Yun Lu Hong-Wei Gu Jia-Hui Li Qian-Qian Fan Bei-Tao Liu Yan Kou Xi-Gao Jian Zhi-Huan weng State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart MaterialsLiaoning Technology Innovation Center of High Performance Resin MaterialsDepartment of Polymer Science&EngineeringDalian University of TechnologyDalian 116024China Thermochemistry Laboratory Liaoning Province Key Laboratory of Thermochemistry for Energy and MaterialsDalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Toughening the petroleum-based epoxy resin blends with bio-based modifiers without compromising their modulus,mechanical strength,and other properties is still a big challenge in view of the *** this study,a bio-based liquid crystal epoxy resin(THMT-E P)with an s-triazine ring structure was utilized to modify a petroleum-based bisphenol A epoxy resin(E51)with 4,4'-diaminodiphenylsulfone(DDS)as a curing agent,and the blended systems were evaluated for their thermal stability,mechanical properties,and flame *** results showed that the impact strength of the blended system initially increased and then decreased with the increase in THMT-EP content,and it reached the a maximum value of 26.5 kJ/m^(2)when the THMT-EP content was 5%,which was 31.2%higher than that of E51/***,the flexural strength,modulus,and glass transition tem perature of the blended system were all simultaneously improved with the addition of *** the same time,the addition of THMT-EP enhanced the flame retardancy of the system by increasing the char yield at 700℃and decreasing the peak heat release rate and total heat release *** work paves the way for a more sustainable improvement in the comprehensive performance of epoxy resin.

关键词： Epoxy resin Toughening Bio-based Thermotropic liquid crystal

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Discovery of scheelite in the Zaozigou gold deposit of West Qinling Orogen,Northwest China and its implications for ore genesis

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China Geology 2024年第3期7卷 586-588页

作者： Meng-xu Guo Jia-jun Liu De-gao Zhai Guo-ming weng Rui Zhu State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences and ResourcesChina University of Geosciences(Beijing)Beijing 100083China Zaozigou Gold Mine Zhaojin Mining Industry Co.Ltd.Hezuo 747000China

*** The West Qinling Orogen extends east-west over 1500 km and is endowed with dozens of large-super large scale gold *** Zaozigou gold deposit has a proven reserve of 134 t with an average grade of 3.08 g/t thus is one of the largest deposits in the West Qinling ***,whether the fluid type is metamorphic or magmatichydrothermal and ore-formation processes of the Zaozigou gold deposit are *** is a ubiquitous accessory mineral in geologically diverse ore-deposit types and attested to be a strong indicator of ore-forming conditions and oredeposit genesis.

关键词： deposit gold Qinling

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Zircon U-Pb ages in the Nuratau ophiolitic mélange in the southern Tianshan,Uzbekistan:Implication for the closure of Paleo-Asian Ocean

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China Geology 2024年第2期7卷 365-368,I0004-I0007页

作者： Kai weng Ji-fei Cao Divayev-Farid Karibovich Jahongir-Jurabekovich Movlanov Bo Chen Zhong-ping Ma Xi’an Center of Geological Survey China Geological SurveyXi’an 710119China The Center for Geoinnovation Technologies Doctor of Sciences in Geology and Mineralogy University of Geological ScienceTashkent 100060Uzbekistan

*** The Central Asian Orogenic Belt(CAOB),which is located between the European craton,Siberian craton,and Tarim-North China craton(Fig.1a),is the largest phanerozoic accretionary orogen in the *** resulted from the longterm subduction and accretion of the Paleo-Asian Ocean(PAO).The PAO has been in existence since at least the late Mesoproterozoic(about 1020 Ma).However,there has been debate about the closing time of the PAO.

关键词： Asian Paleo Tianshan

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