检索结果-南通市图书馆

Liver injury changes the biological characters of serum small extracellular vesicles and reprograms hepatic macrophages in mice

引用

World Journal of Gastroenterology 2021年第43期27卷 7509-7529页

作者： xiu-fang lv An-Qi Zhang Wei-Qi Liu Min Zhao Jing Li Li He Li Cheng Yu-Feng Sun Gang Qin Peng Lu Yu-Hua Ji Ju-Ling Ji Department of Pathology Medical School of Nantong UniversityNantong 226001Jiangsu ProvinceChina Key Laboratory of Microenvironment and Translational Cancer Research Science and Technology Bureau of Nantong CityNantong 226001Jiangsu ProvinceChina Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pathology Nanjing Jinling HospitalNanjing University School of MedicineNanjing 210093Jiangsu ProvinceChina Department of Pathology Affiliated Jiangyin Hospital of Southeast University Medical CollegeJiangyin 214400Jiangsu ProvinceChina Nantong Institute of Liver Diseases Nantong Third People’s HospitalNantong UniversityNantong 226006Jiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Nantong UniversityNantong 226001Jiangsu ProvinceChina Institute of Immunology College of Life Science and TechnologyJinan UniversityGuangzhou 510632Guangdong ProvinceChina

BACKGROUND Serum small extracellular vesicles(sEVs)and their small RNA(sRNA)cargoes could be promising biomarkers for the diagnosis of liver ***,the dynamic changes in serum sEVs and their sRNA components during liver injury have not been well *** that hepatic macrophages can quickly clear intravenously injected sEVs,the effect of liver injury-related serum sEVs on hepatic macrophages deserves to be *** To identify the characteristics of serum sEVs and the sRNAs during liver injury and explore their effects on hepatic *** To identify serum sEV biomarkers for liver injury,we established a CCL4-induced mouse liver injury model in C57BL/6 mice to simulate acute liver injury(ALI),chronic liver injury(CLI)and *** sEVs were obtained and characterized by transmission electron microscopy and nanoparticle tracking *** sEV sRNAs were profiled by sRNA *** expressed microRNAs(miRNAs)were compared to mouse liver-enriched miRNAs and previously reported circulating miRNAs related to human liver *** biological significance was evaluated by Ingenuity Pathway Analysis of altered sEV miRNAs and conditioned cultures of ALI serum sEVs with primary hepatic *** We found that both ALI and CLI changed the concentration and morphology of serum *** proportion of serum sEV miRNAs increased upon liver injury,with the liver as the primary *** altered serum sEV miRNAs based on mouse studies were consistent with human liver disease-related circulating *** established serum sEV miRNA signatures for ALI and CLI and a panel of miRNAs(miR-122-5p,miR-192-5p,and miR-22-3p)as a common marker for liver *** differential serum sEV miRNAs in ALI contributed mainly to liver steatosis and inflammation,while those in CLI contributed primarily to hepatocellular carcinoma and *** serum sEVs decreased both CD86 and CD206 expression in monocyte-derived ma

关键词： MicroRNA Small RNA sequencing Biomarker Monocyte-derived macrophage Resident macrophage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Essential role of protein kinase C in morphine-induced rewarding memory

Essential role of protein kinase C in morphine-induced rewar...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xing-Jie PING~#,Yao-Ying MA~#,Yi-Jing LI,Chong QI,Xiao-Wei SUN,xiu-fang lv,Cai-Lian CUI~* Neuroscience Research Institute,Department of Neurobiology,School of Basic Medical Sciences,Key Laboratory of Neuroscience,The Ministry of Education and the Ministry of Public Health,Peking University,Beijing 100191,China

＜正＞Objective Protein kinase C（PKC） is involved in intra-cellular signal transduction in various physiological and pathological processes including substance *** the present study,the role of PKC in morphine-induced rewarding memory was investigated using the conditioned place preference（CPP） *** CPP was induced by different doses of morphine（0-10 mg/kg,i.p.）.To observe the effect of PKC on the development of CPP （induced by 3 mg/kg morphine,i.p.）,microinjection cannulas were bilaterally implanted in NAc shell and PKC translocation inhibitor yV5-3 was infused before the conditioning of morphine-induced ***（1） We found a significant translocation of PKCs from cytosol to membrane component in nucleus accumbens（NAc） of morphine-conditioned rats in a dose-dependent *** translocation was reduced gradually with the maintenance of morphine-induced ***,the protein level of PKCy in membrane of the NAc was increased in morphine CPP rats,and decreased during the attenuation of morphine-induced CPP,while the protein level of PKCy in cytosol of the NAc showed an opposite change.（2） The PKC translocation inhibitor yV5-3 impaired the morphine-induced CPP when microinjected into the *** These findings indicated that PKC,especially the y isoform,is essential for the acquisition and maintenance of morphine associated reward memory.

关键词： nucleus accumbens morphine conditioned place preference protein kinase C protein kinase Cγ γV5-3

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

浮游藻类物候遥感监测研究进展

引用

湖泊科学 2025年第1期37卷 1-13页

作者：严照江房冲宋开山王翔宇吕云峰中国科学院东北地理与农业生态研究所长春130102 长春师范大学地理科学学院长春130032

浮游藻类广泛分布于海洋和内陆水体生态系统中,其生长和发育过程具有明显的时空异质性,对气候变化的响应也极为复杂。藻类物候描述了其在长期适应气候、水质和人类干预等因素下的周期性变化,从而形成一种与环境条件相适应的生长发育节... 详细信息

浮游藻类广泛分布于海洋和内陆水体生态系统中,其生长和发育过程具有明显的时空异质性,对气候变化的响应也极为复杂。藻类物候描述了其在长期适应气候、水质和人类干预等因素下的周期性变化,从而形成一种与环境条件相适应的生长发育节律。它主要包括藻类的出现时间、增长高峰以及减少或消亡的时间等特征。遥感技术通过高时空分辨率持续获取叶绿素a浓度数据(浮游藻类生物量的表征参数),实现对藻类物候的长期监测。本文详细地回顾了近年来遥感藻类物候监测和提取方法的进展,指出目前存在的问题与不足,并对未来的发展趋势进行展望。首先,回顾了现有卫星遥感提供大范围时空连续的藻类生长信息。其次,总结了浮游藻类物候阶段的监测,以及估计藻类特定物候阶段的方法。同时,介绍了用于遥感时间序列估算藻类物候的常用数据处理方法,探讨了浮游藻类物候特性的变化趋势。最后,探索了可能影响藻类物候变化的因素和驱动机制。基于以上分析,本文指出未来藻类物候遥感的研究应重点关注:(1)开发并验证适用于不同水域环境的通用算法,结合机器学习等智能算法改进物候模型,提高物候监测精度和算法的业务化应用水平;(2)结合数值模型和生态系统动态模型,深入研究浮游藻类物候背后的驱动机制。

关键词：藻类物候叶绿素a 海洋和内陆水体

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cone-beam computed tomography noise reduction method based on U-Net with convolutional block attention module in proton therapy

引用

Nuclear Science and Techniques 2024年第7期35卷 89-100页

作者： Xing-Yue Ruan xiu-fang Li Meng-Ya Guo Mei Chen Ming lv Rui Li Zhi-Ling Chen Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai201800China University of Chinese Academy of Sciences Beijing100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China Department of Radiation Oncology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai Key Laboratory of Proton therapy Shanghai201801China

Cone-beam computed tomography(CBCT) is mostly used for position verification during the treatment process. However,severe image artifacts in CBCT hinder its direct use in dose calculation and adaptive radiation therapy re-planning for proton therapy. In this study, an improved U-Net neural network named CBAM-U-Net was proposed for CBCT noise reduction in proton therapy, which is a CBCT denoised U-Net network with convolutional block attention modules. The datasets contained 20 groups of head and neck images. The CT images were registered to CBCT images as ground truth. The original CBCT denoised U-Net network, sCTU-Net, was trained for model performance comparison. The synthetic CT(SCT) images generated by CBAM-U-Net and the original sCTU-Net are called CBAM-SCT and U-Net-SCT images, respectively. The HU accuracies of the CT, CBCT, and SCT images were compared using four metrics: mean absolute error(MAE), root mean square error(RMSE), peak signal-to-noise ratio(PSNR), and structure similarity index measure(SSIM). The mean values of the MAE, RMSE, PSNR, and SSIM of CBAM-SCT images were 23.80 HU, 64.63 HU, 52.27 dB, and 0.9919, respectively,which were superior to those of the U-Net-SCT images. To evaluate dosimetric accuracy, the range accuracy was compared for a single-energy proton beam. The γ-index pass rates of a 4 cm × 4 cm scanned field and simple plan were calculated to compare the effects of the noise reduction capabilities of the original U-Net and CBAM-U-Net on the dose calculation results. CBAM-U-Net reduced noise more effectively than sCTU-Net, particularly in high-density tissues. We proposed a CBAM-U-Net model for CBCT noise reduction in proton therapy. Owing to the excellent noise reduction capabilities of CBAM-U-Net, the proposed model provided relatively explicit information regarding patient tissues. Moreover, it maybe be used in dose calculation and adaptive treatment planning in the future.

关键词： Proton therapy Cone-beam CT CBAM-U-Net γ-index

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phyllosphere microbiota:Community dynamics and its interaction with plant hosts

引用

Journal of Integrative Plant Biology 2021年第2期63卷 297-304页

作者： Tianyu Gong xiu-fang Xin National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China University of the Chinese Academy of Sciences Beijing 100049China The Chinese Academy of Sciences(CAS)and CAS John Innes Centre of Excellence for Plant and Microbial Sciences Shanghai 200032China

Plants are colonized by various microorganisms in natural *** many studies have demonstrated key roles of the rhizosphere microbiota in regulating biological processes such as nutrient acquisition and resistance against abiotic and biotic challenges,less is known about the role of the phyllosphere microbiota and how it is established and *** review provides an update on current understanding of phyllosphere community assembly and the mechanisms by which plants and microbes establish the phyllosphere microbiota for plant health.

关键词： community assembly dysbiosis phyllosphere microbiota plant immunity plant–microbe interaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bio-inspired micro/nanostructures for flexible and stretchable electronics

引用

Nano Research 2020年第5期13卷 1244-1252页

作者： Hongbian Li Suye lv Ying fang CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China CAS Center for Excellence in Brain Science and Intelligence Technology Institute of NeuroscienceChinese Academy of SciencesShanghai 200031China

The remarkable ability of biological systems to sense and adapt to complex environmental conditions has inspired the design of next-generation electronics with advanced *** review focuses on emerging bio-inspired strategies for the development of flexible and stretchable electronics that can accommodate mechanical deformations and integrate seamlessly with biological *** will provide an overview of the practical considerations in the materials and structure designs of flexible and stretchable *** progress in bio-inspired pressure/strain sensors,stretchable electrodes,mesh electronics,and flexible energy devices are then discussed,with an emphasis on their unconventional micro/nanostructure designs and advanced ***,current challenges and future perspectives are identified and discussed.

关键词： bio-inspired structures mechanical sensors stretchable electrodes mesh electronics flexible energy devices

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regulation and integration of plant jasmonate signaling:a comparative view of monocot and dicot

引用

Journal of Genetics and Genomics 2022年第8期49卷 704-714页

作者： Shiwei Wan xiu-fang Xin National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China University of Chinese Academy of Sciences Beijing 100049China CAS-JIC Center of Excellence for Plant and Microbial Sciences(CEPAMS) Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China

The phytohormone jasmonate plays a pivotal role in various aspects of plant life,including developmental programs and defense against pests and pathogens.A large body of knowledge on jasmonate biosynthesis,signal transduction as well as its functions in diverse plant processes has been gained in the past two *** addition,there exists extensive crosstalk between jasmonate pathway and other phytohormone pathways,such as salicylic acid(SA)and gibberellin(GA),in co-regulation of plant immune status,fine-tuning the balance of plant growth and defense,and so on,which were mostly learned from studies in the dicotyledonous model plants Arabidopsis thaliana and tomato but much less in ***,existing evidence suggests both conservation and functional divergence in terms of core components of jasmonate pathway,its biological functions and signal integration with other phytohormones,between monocot and *** this review,we summarize the current understanding on JA signal initiation,perception and regulation,and highlight the distinctive characteristics in different lineages of plants.

关键词： Jasmonate Phytohormone Signaling Crosstalk Plant defense Development Stress response

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Determination of the neutron skin thickness from interaction cross section and charge-changing cross section for B,C,N,O,F isotopes

引用

Nuclear Science and Techniques 2016年第3期27卷 153-158页

作者： xiu-fang Li De-Qing fang Yu-Gang Ma Shanghai Institute of Applied Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

The effective neutron and proton root-meansquare radius of stable and unstable nuclei(^(12-15,17)B,^(12-20)C,^(14-21)N,^(16-24)O and ^(18-21,23-26)F) were deduced from the charge-changing cross section,σ_(cc),and the interaction cross sections,σ_I,by using a statistical abrasion-ablation model *** extracted proton radii are in good agreement with the data from the Atomic Data and Nuclear Data Tables within the ***,we can observe that the neutron skin thickness increases monotonously with the increasing neutron number in these isotopes,which is consistent with the systematical trend of theoretical calculations.

关键词：中子皮厚度作用截面同位素变化截面电荷均方根半径测定不稳定核

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of element substitutions on poisoning behavior of ZrV_(2)alloy:theoretical and experimental investigations

引用

Nuclear Science and Techniques 2023年第7期34卷 253-266页

作者： Shuang Yang Run-Jie fang Guo Yang Li-Jun lv Xing-Bo Han Wei Liu xiu-Jie He Peng-Fei Zhu School of Mathematics Physics and StatisticsShanghai University of Engineering ScienceShanghai 201620China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China China Nuclear Power Technology Research Institute Co.Ltd Shenzhen 518000China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China

A ZrV_(2)alloy is typically susceptible to poisoning by impurity gases,which causes a considerable reduction in the hydrogen storage properties of the *** this study,the adsorption characteristics of oxygen on ZrV_(2)surfaces doped with Hf,Ti,and Pd are investigated,and the effect of oxygen on the hydrogen storage performance of the alloy was ***,the adsorption energy,bond-length change,density of states,and differential charge density of the alloy before and after doping are analyzed using the first-principles *** theoretical results show that Ti doping has a limited effect on the adsorption of oxygen atoms on the ZrV_(2)surface,whereas Hf doping decreases the adsorption energy of oxygen on the ZrV_(2)*** atoms are more difficult to adsorb at most adsorption sites on Pd-substituting surfaces,which indicates that Pd has the best anti-poisoning properties,followed by *** analysis of the differential charge density and partial density of states show that the electron interaction between the oxygen atom and surface atom of the alloys is weakened,and the total energy is reduced after Hf and Pd *** on theoretical calculations,the hydrogen absorption kinetics of ZrV_(2),Zr_(0.9)Hf_(0.1)V_(2),and Zr(V_(0.9)Pd_(0.1))_(2) alloys are studied in a hydrogen-oxygen mixture of 0.5 vol%O_(2) at 25℃.The experimental results show that the hydrogen storage capacities of ZrV_(2),Zr_(0.9)Hf_(0.1)V_(2),and Zr(V_(0.9)Pd_(0.1))_(2) decrease to 19%,69%,and 80%of their original values,*** order of alloy resistance to 0.5 vol%O_(2) poisoning is Zr(V_(0.9)Pd_(0.1))_(2)>Zr_(0.9)Hf_(0.1)V_(2)>ZrV_(2).Pd retains its original hydrogen absorption performance to a greater extent than undoped surfaces,and it has the strongest resistance to poisoning,which is consistent with previous theoretical calculations.

关键词： Hydrogen storage ZrV_(2) First-principles Poisoning effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mechanism of adding rhenium to improve hot corrosion resistance of nickel-based single-crystal superalloys

引用

Rare Metals 2021年第8期40卷 2076-2082页

作者： fang-Min Yang Li-Xian Lian Ying Liu xiu-fang Gong School of Materials Science and Engineering Sichuan UniversityChengdu610065China Dongfang Electric Corporation Dongfang Turbine Co. LTDDeyang618000China State Key Laboratory of Long-Life High Temperature Materials Deyang618000China

Hot corrosion behavior in sulfate salt at 950℃ of Rene N5 single-crystal superalloys with 3 wt%rhenium(NSR)was investigated compared with that of nickel-based single-crystal superalloys without rhenium(NS).After 30-h corrosion,the surface of the NS superalloy is seriously *** holes and exfoliation appear on the *** NSR superalloys exhibit better hot corrosion resistance than the NS *** 30-h corrosion,a continuous and compact Al_(2)O_(3) film is observed on its *** Al_(2)O_(3) film with dense structure formed on the surface provides protection for the *** characterization results show that A1 is aggregated in theγ’phase,while Re is aggregated in the y phase during the formation of oxide *** that Re can inhibit the diffusion of A1 in the nickel matrix,it is inferred that Re can inhibit the outward diffusion of A1 and prevent the decrease of Al concentration in theγ’*** concentration of Al hinders the decomposition of Al_(2)O_(3) due to the reaction of acid and basic ***_(2)O_(3) keeps its structure intact and provides protection for the matrix.

关键词： Single-crystal superalloy Hot corrosion Rhenium Al_(2)O_(3)film Element diffusion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：