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Model informed precision medicine of Chinese herbal medicines formulas-A multi-scale mechanistic intelligent model

Journal of Pharmaceutical Analysis 2024年第4期14卷 585-600页

作者： Yuanyuan Qian xiting wang Lulu Cai Jiangxue Han Zhu Huang Yahui Lou Bingyue Zhang Yanjie wang Xiaoning Sun Yan Zhang Aisong Zhu Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome Zhejiang Chinese Medical UniversityHangzhou310000China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing100190China Zhejiang Engineering Research Center for“Preventive Treatment”Smart Health of Traditional Chinese Medicine Zhejiang Chinese Medical UniversityHangzhou310000China College of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou310000China Affiliated Hospital of Liaoning University of Traditional Chinese Medicine Shenyang110032China Academy of Chinese Medical Science Zhejiang Chinese Medical UniversityHangzhou310000China

Recent trends suggest that Chinese herbal medicine formulas(CHM formulas)are promising treatments for complex *** characterize the precise syndromes,precise diseases and precise targets of the precise targets between complex diseases and CHM formulas,we developed an artificial intelligence-based quantitative predictive algorithm(DeepTCM).DeepTCM has gone through multilevel model calibration and validation against a comprehensive set of herb and disease data so that it accurately captures the complex cellular signaling,molecular and theoretical levels of traditional Chinese medicine(TCM).As an example,our model simulated the optimal CHM formulas for the treatment of coronary heart disease(CHD)with depression,and through model sensitivity analysis,we calculated the balanced scoring of the ***,we constructed a biological knowledge graph representing interactions by associating herb-target and gene-disease ***,we experimentally confirmed the therapeutic effect and pharmacological mechanism of a novel model-predicted intervention in humans and *** novel multiscale model opened up a new avenue to combine“disease syndrome”and“macro micro”system modeling to facilitate translational research in CHM formulas.

关键词： Chinese herbal medicine formulas Precision medicine Mathematical modeling Systems biology Coronary heart disease Depression Ischemia-reperfusion Inflammation

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时间变革:学生核心素养发展需要什么样的教学时间观?

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中国教育学刊 2024年第5期 7-11页

作者：王永明亓玉慧王禧婷山东师范大学教育学部山东济南250014 青岛大学师范学院山东青岛266071

传统的教学时间观主要服务于知识掌握的目标,形成了外在指向的、线性累积的和工具理性的教学时间观,这使学生的生命常常处于被动、机械、空洞的状态,制约了学生核心素养发展的更大可能性。辨清教学时间、生命、核心素养之间的本真关系... 详细信息

传统的教学时间观主要服务于知识掌握的目标,形成了外在指向的、线性累积的和工具理性的教学时间观,这使学生的生命常常处于被动、机械、空洞的状态,制约了学生核心素养发展的更大可能性。辨清教学时间、生命、核心素养之间的本真关系具有重要的意义,有利于揭示素养发展的时间意蕴、机理和现实基础,有利于确立以核心素养发展为目标的新的教学时间观。为此,应探索转变教学时间观,使传统教学时间观转向主体本位、立体综合、意义生成的新教学时间观。

关键词：教学时间观核心素养生命主体

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Towards better analysis of machine learning models:A visual analytics perspective

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Visual Informatics 2017年第1期1卷 48-56页

作者： Shixia Liu xiting wang Mengchen Liu Jun Zhu Tsinghua University BeijingChina

Interactive model analysis,the process of understanding,diagnosing,and refining a machine learning model with the help of interactive visualization,is very important for users to efficiently solve real-world artificial intelligence and data mining *** advances in big data analytics have led to a wide variety of interactive model analysis *** this paper,we present a comprehensive analysis and interpretation of this rapidly developing ***,we classify the relevant work into three categories:understanding,diagnosis,and *** category is exemplified by recent influential *** future research opportunities are also explored and discussed.

关键词： Interactive modelanalysis Interactive visualization Machine learning Understanding Diagnosis Refinement

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服务新疆能源化工产业发展的“3+1”订单式人才培养模式改革

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化工管理 2024年第13期 29-33页

作者：郭勤王西亭马信宋俊丽葛磊新疆理工学院新疆阿克苏843000 新疆西部合盛硅业有限公司新疆石河子832061

构建能源强国,人才与科技是至关重要的一个环节。新疆作为中国能源资源禀赋突出的地区,将丰富的能源潜力转变成发展的强劲动能离不开懂工艺、懂设备,具有团队协作意识、创新精神和扎根边疆的高水平应用型人才。新疆理工学院在校企深度... 详细信息

构建能源强国,人才与科技是至关重要的一个环节。新疆作为中国能源资源禀赋突出的地区,将丰富的能源潜力转变成发展的强劲动能离不开懂工艺、懂设备,具有团队协作意识、创新精神和扎根边疆的高水平应用型人才。新疆理工学院在校企深度合作基础上,以能源化学工程专业和过程装备与控制工程专业为试点,开展校企协同“3+1”订单式人才培养模式的改革与实践。历经三年的实证研究与实践检验后,实现了对学生创新实践能力、工程素养以及团队协作精神的全方位培育,学生和用人单位的满意度不断提高,同时在能源化工行业就业的学生比例也显著增长。面向新疆能源化工产业发展的“3+1”订单式人才培养模式有助于推动创新性、工程性高水平应用型人才培养,从而实现产业升级与发展。

关键词： “3+1”订单式人才培养校企协同育人能源化工产业

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Chiral carbon dots from glucose by room temperature alkaliassisted synthesis for electrocatalytic oxidation of tryptophan enantiomers

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Nano Research 2023年第7期16卷 8929-8936页

作者： Mengling Zhang Xing Fan Xin Du Yurong Ma xiting wang Hui Huang Yang Liu Youyong Li Zhenhui Kang Macao Institute of Materials Science and Engineering(MIMSE) MUST-SUDA Joint Research Center for Advanced Functional MaterialsMacao University of Science and TechnologyTaipaMacao 999078China Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and DevicesJoint International Research Laboratory of Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Research Center for Carbon-based Electronics and Key Laboratory for the Physics and Chemistry of Nanodevices School of ElectronicsPeking UniversityBeijing 100871China

Chiral catalysis is one of the most direct and effective approach to obtain pure optical *** carbon dots(CDs)as carbon-based chiral catalysts show great potential in chiral ***,we report a facile one step base-catalyzed aldol condensation to fabricate the chiral CDs from glucose at ambient temperature and *** formation of chiral CDs involves the processes of isomerization and aldol *** chiral CDs have been demonstrated that they have selective capacity for electrocatalytic oxidization of tryptophan enantiomers.L type of CDs(LCDs)is more likely to catalyze L-tryptophan(Trp)than D-Trp with the selective factor(I_(L)/I_(D))of 1.60,whereas the D type of CDs(DCDs)tends to catalyze D-Trp(I_(L)/I_(D):0.63).Theoretical calculations combined with various contrast experiments(temperature and pH)demonstrate that the selectively electrocatalytic capacity of chiral CDs toward Trp isomers is due to the different hydrogen-bond interactions between chiral CDs and Trp.

关键词： chiral carbon dots synthesis mechanism electrocatalysis chiral catalysis

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Microbial Sulfate Reduction and Its Role in Carbon Sequestration in Marine Sediments

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Journal of Earth Science 2024年第4期35卷 1378-1381页

作者： xiting Liu Houjie wang Jiarui Liu Guang-Chao Zhuang Key Laboratory of Submarine Geosciences and Prospecting Technology College of Marine GeosciencesOcean University of ChinaQingdao266100China Qingdao Marine Science and Technology Center Laboratory for Marine GeologyQingdao266237China Department of Earth Planetaryand Space SciencesUniversity of CaliforniaLos Angeles90095USA Frontiers Science Center for Deep Ocean Multispheres and Earth System(FDOMES)and Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao266100China

0 INTRODUCTION The carbon buried in marine sediments in the form of organic carbon or carbonate minerals represents the largest pathway for carbon removal from Earth's surface environments(Sun and Turchyn,2014).Microbial sulfate reduction(MSR)is a fundamental biogeochemical process occurring in marine sediments,where sulfate-reducing bacteria(SRB)reduce sulfate(SO42-)to sulfide(S2-)using organic matter or methane as electron donors(Jorgensen,2021).

关键词： buried carbonate environments

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阿司匹林反应性检测方法与影响因素的研究进展

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中国医药 2024年第2期19卷 293-296页

作者：张嘉祺王茜婷陈夏欢刘梅林北京大学第一医院老年病内科北京100034

阿司匹林是一种常用的抗血小板治疗药物,广泛应用于心血管疾病的预防。尽管阿司匹林已被证实能显著改善心血管疾病患者的临床结局,但临床实践中始终有部分患者服用阿司匹林后仍发生血栓事件,无法达到预期的抗血小板治疗效果,提示阿司匹... 详细信息

阿司匹林是一种常用的抗血小板治疗药物,广泛应用于心血管疾病的预防。尽管阿司匹林已被证实能显著改善心血管疾病患者的临床结局,但临床实践中始终有部分患者服用阿司匹林后仍发生血栓事件,无法达到预期的抗血小板治疗效果,提示阿司匹林反应性存在个体差异。近年来研究发现,阿司匹林反应性调控受多种因素影响,且阿司匹林反应性的检测方法逐步完善。本文综述了阿司匹林反应性的定义、检测方法、影响因素以及相关基因的研究进展,对进一步探索阿司匹林反应性的调控机制,实现阿司匹林的个体化、精准化治疗,提高心血管疾病的预防效果具有重要意义。

关键词：阿司匹林反应性血小板个体化治疗心血管疾病

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阿司匹林与高尿酸血症关系的研究进展

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中国医药 2024年第6期19卷 933-936页

作者：张嘉祺王茜婷李佳润刘甜刘梅林北京大学第一医院老年病内科北京100034

高尿酸血症(HUA)常见于心血管疾病的患者,阿司匹林是心血管疾病中应用最广泛的抗血小板药物。HUA与心血管疾病的发生发展密切相关,阿司匹林可能干扰尿酸生成与排泄的过程,从而影响血尿酸水平。本文综述了阿司匹林对HUA以及血尿酸水平的... 详细信息

高尿酸血症(HUA)常见于心血管疾病的患者,阿司匹林是心血管疾病中应用最广泛的抗血小板药物。HUA与心血管疾病的发生发展密切相关,阿司匹林可能干扰尿酸生成与排泄的过程,从而影响血尿酸水平。本文综述了阿司匹林对HUA以及血尿酸水平的影响,对进一步探索阿司匹林影响尿酸生成和排泄影响的作用机制,实现合并HUA的心血管疾病患者阿司匹林的个体化、精准化治疗,提高心血管疾病的预防效果具有重要意义。

关键词：高尿酸血症阿司匹林心血管疾病

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Surface engineering with ionic polymers on membranes for boron removal

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Frontiers of Chemical Science and Engineering 2024年第5期18卷 61-69页

作者： xiting Zhang Chenyi Fang J Paul Chen Sui Zhang Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117576Singapore Department of Civil and Environmental Engineering National University of SingaporeSingapore 119260Singapore College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

Removal of boric acid from seawater and wastewater using reverse osmosis membrane technologies is imperative and yet remains inadequately addressed by current commercial *** research efforts performed post-modification of reverse osmosis membranes to enhance boron rejection,which is usually accompanied by substantial sacrifice in water *** study delves into the surface engineering of low-pressure reverse osmosis membranes,aiming to elevate boron removal efficiency while maintaining optimal salt rejection and water *** were modified by the self-polymerization and co-deposition of dopamine and polystyrene sulfonate at varying ratios and *** surfaces became smoother and more hydrophilic after *** optimum membrane exhibited a water permeability of 9.2±0.1 L·m^(-2)·h^(-1)·bar^(-1),NaCl rejection of 95.8%±0.3%,and boron rejection of 49.7%±0.1% and 99.6%±0.3% at neutral and alkaline pH,*** water permeability is reduced by less than 15%,while the boron rejection is 3.7 times higher compared to the blank *** research provides a promising avenue for enhancing boron removal in reverse osmosis membranes and addressing water quality concerns in the desalination process.

关键词： membrane low-pressure reverse osmosis boron surface engineering

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Curcumin alleviates TGF-β1-induced fibrosis in NRK-49F cells via suppression of miR-21 expression,and regulation of the TGF-β1/smad3 signaling pathway

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Journal of Traditional Chinese Medical Sciences 2020年第1期7卷 68-74页

作者： Lan Zhang Yi Liu xiting wang Cheng Li Mengmeng Shen Liming Di Shuangshuang He Yu Li School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing100029China

Objective:Overexpression of microRNA-21(miR-21)has been well-recognized during fibrosis in a wide range of tissue types through regulation of fibrogenesis via diverse *** exhibits antifibrotic effects in various *** and others have previously demonstrated that curcumin has positive effects on the protection against ***,the effect of curcumin on miR-21 expression has not been ***:In this study,transforming growth factor-b1(TGF-b1)-stimulated rat renal fibroblast cells(NRK-49F)were transfected with miR-21 inhibitors,then the expression of Smad3,a-smooth muscle actin(a-SMA),type I collagen(COL1A1),and type III collagen(COL3A1)was determined using quantitative real-time-PCR(qRT-PCR)and western blot *** effect of curcumin on production of the extracellular matrix was evaluated using immunofluorescence,qRT-PCR,and western blot ***:TGF-b1 stimulation upregulated the expression of miR-21 and induced fibrogenesis in NRK-49F *** with miR-21 inhibitors selectively decreased smad3 activity,and noticeably reduced the expression of a-SMA,COL1A1,and *** treatment significantly inhibited the expressions of smad3,a-SMA,COL1A1,COL3A1,as well as miR-21 expression in NRK-49F cells in a dosedependent ***:Curcumin exerted its anti-fibrotic effects by targeting the TGF-b1/smad3 signaling pathway and suppressing miR-21 expression,thereby provides novel insight in the protective effects of curcumin against fibrosis in various organs.

关键词： Curcumin miR-21 NRK-49F Renal fibrosis TGF-b1/Smad3

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