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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao jun liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

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Rupture Process of the M_s 7.0 Lushan Earthquake Determined by Joint Inversion of Local Static GPS Records, Strong Motion Data, and Teleseismograms

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Journal of Earth Science 2017年第2期28卷 404-410页

作者： jun Li Chengli liu Yong Zheng xiong xiong State Key Laboratory of Geodesy and Earth's Dynamics Institute of Geodesy and Geophysics CAS Hubei Subsurface Multi-Scale Imaging Key Laboratory Institute of Geophysics and Geomatics China University of Geosciences

On April 20, 2013, an M_s 7.0 earthquake struck Lushan County in Sichuan Province, China, and caused serious damage to the source region. We investigated the rupture process of the M_s7.0 Lushan earthquake by jointly inverting waveforms of teleseismic P waveforms and local strong motion records as well as static GPS observations. The inverted results indicate that the rupture of this earthquake was dominated by the failure of an asperity with a triangular shape and that the main shock was dominated by thrust slip. The earthquake released a total seismic moment of 1.01× 10^（19）Nm, with 92% of it being released during the first 11 s. The rupture had an average slip of 0.9 m and produced an average stress drop of 1.8 MPa. Compared with our previous work that was based mainly on a unique dataset, this joint inversion result is more consistent with field observations and the distribution of aftershock zones.

关键词： GPS Longmenshan Lushan earthquake rupture process strong motion

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南黄海西部2007年4月的逆温跃层

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海岸工程 2017年第1期36卷 1-11页

作者：苏劼熊学军刘浩卢德杰国家海洋局第一海洋研究所山东青岛266061 青岛海洋科学与技术国家实验室区域海洋动力学与数值模拟功能实验室山东青岛266237 中海石油深海开发有限公司广东深圳518067

利用南黄海西部2007-04的温盐实测资料,采用海洋层结谱表达法及自适应识别,得到逆温跃层的"五点三要素",形成强度要素平面分布图。分析表明,逆温跃层的存在与黄海暖流水有直接的关系:1)4月份,黄海暖流水受到的海面冷却仍是产生逆温跃层... 详细信息

利用南黄海西部2007-04的温盐实测资料,采用海洋层结谱表达法及自适应识别,得到逆温跃层的"五点三要素",形成强度要素平面分布图。分析表明,逆温跃层的存在与黄海暖流水有直接的关系:1)4月份,黄海暖流水受到的海面冷却仍是产生逆温跃层的普遍原因,在该海区黄海暖流向北延伸和向两侧拓展的区域都有该种类型的逆温跃层存在,位置相对较浅;2)但在偏南的黄海暖流主干区,海面冷却产生的效应被主流区的热量补充所抵消,逆温跃层很弱甚至消失,这是该月份逆温跃层分布区向北退缩并在南部中心附近呈现缺失区的主要原因;3)南下的鲁北沿岸流水的冷水叠加在黄海暖流水的暖水上方,使逆温跃层加强,使得冷暖水的作用区成为强逆温跃层区;4)黄海暖流左侧冷沿岸流水及右侧冷水的前端向黄海暖流楔入,其前端往往覆盖在底层高温高盐的黄海暖流水上方形成下逆温跃层,从而形成双逆温跃层。这些特点,较以前认知更加客观、全面、细致和准确。

关键词：海洋层结谱表达法及自适应识别逆温跃层黄海暖流强逆温跃层双逆温跃层

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基于T-S模型的液压缸模糊故障树分析方法研究

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湖南城市学院学报（自然科学版） 2017年第4期26卷 47-51页

作者：熊志宏刘君范彬陈昶殷赳湖南城市学院机械与电气工程学院湖南益阳413000

针对液压油缸故障树分析时存在的故障数据获取不足以及传统分析方法的限制,提出了基于T-S模型的液压油缸模糊故障树分析方法,对已建立的液压油缸T-S模糊故障树进行分析﹒分析过程中,采取将底事件的模糊失效率替代为其故障概率的方法,同... 详细信息

针对液压油缸故障树分析时存在的故障数据获取不足以及传统分析方法的限制,提出了基于T-S模型的液压油缸模糊故障树分析方法,对已建立的液压油缸T-S模糊故障树进行分析﹒分析过程中,采取将底事件的模糊失效率替代为其故障概率的方法,同时将其故障程度用模糊数来表示﹒对液压油缸T-S模糊故障子树进行实例分析,计算并分析所建立的液压油缸模糊故障子树的各故障分析数据﹒

关键词：模糊故障树分析故障数据 T-S模型故障子树

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PVP-Assisted Synthesis of Self-Supported Ni_(2)P@Carbon for High-Performance Supercapacitor

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Research 2019年第1期2019卷 200-209页

作者： Qian He xiong xiong liu Rui Wu jun Song Chen School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Center for Applied Chemistry University of Electronic Science and Technology of ChinaNo.2006Xiyuan Ave.West Hi-Tech ZoneChengduChina

Highly conductive and stable electrode materials are usually the focus of high-performance *** this work,a unique design of Ni_(2)P@carbon self-supported composite nanowires directly grown on Ni foam was applied for a *** Co3O4 nanowire array was first synthesized on the Ni foam substrate,and the resulting Ni_(2)P@carbon nanocomposite was obtained by hydrothermally coating Co_(3)O_(4) with the Ni-ethylene glycol complex followed by gaseous *** have discovered that the molecular weight of surfactant polyvinylpyrrolidone(PVP)used in the hydrothermal step,as well as the temperature for phosphorization,played very important roles in determining the electrochemical properties of the ***,the sample synthesized using PVP with 10 k molecular weight and phosphorized at 300℃ demonstrated the best supercapacitive performance among the different samples,with the highest capacitance and most stable cyclic *** an asymmetric supercapacitor(ASC)was assembled with this Ni_(2)P@carbon sample as the cathode and activated carbon(AC)as the anode,the ASC device showed excellent capacitances of 3.7 and 1.6 F cm^(-2) at 2 and 50 mA cm^(-2),respectively,and it kept a high capacitance of 1.2 F cm^(-2) after 5000 cycles at a current rate of 25 mA cm^(-2).In addition,the ASC could reach a high energy density of about 122.8 Wh kg^(-1) at a power density of 0.15 kW kg^(-1) and 53.3 Wh kg^(-1) at the highest power density of 3.78 kW kg^(-1).Additionally,this device also had the ability to power up 16 red LEDs effortlessly,making it a strong candidate in electrochemical energy storage for practical usage.

关键词： composite nanowires capacitance

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Linear angular dispersion compensation of cleaned self-diffraction light with a single prism

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High Power Laser Science and Engineering 2018年第2期6卷 69-73页

作者： xiong Shen Peng Wang jun liu Ruxin Li State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China IFSA Collaborative Innovation Center Shanghai Jiao Tong UniversityShanghai 200240China

The linear angular dispersion of a self-diffraction(SD) pulse, from a femtosecond laser pulse cleaning device, is compensated for by the use of a single prism. More than 500 μJ first-order SD pulse has a contrast of 1012, which is about five orders of magnitude improvement from the input fundamental pulse. The wings of the distribution away from the main pulse in ±1 ps are cleaned with a contrast improvement of about 107, which verifies the pulse cleaning ability of the SD process.

关键词： angular dispersion femtosecond self-diffraction temporal contrast

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Understanding the phenomenon of capacity increasing along cycles: In the case of an ultralong-life and high-rate SnSe-Mo-C anode for lithium storage

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Journal of Energy Chemistry 2022年第9期31卷 133-142,I0005页

作者： Xin Wu Xingyu xiong Bin Yuan jun liu Renzong Hu School of Materials Science and Engineering.Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials South China University of TechnologyGuangzhou 510640GuangdongChina

A good cycling stability is a prerequisite for the application of metal-based materials in lithium-ion batteries(LIBs). However, an abnormal increase in capacity is often observed, which has rarely been focused on in many studies. In our SnSe-Mo-C composite anode, a high reversible capacity of 737.4 mAh g^(-1)remained after 5000 cycles at 5 A g^(-1)between 0.01 and 3.0 V versus Li/Li+. However, a continuous capacity increase occurred in the initial cycles, with 1086.9 mAh g^(-1)after 1000 cycles and 1216.9 mAh g^(-1)after 1500 cycles, respectively. Further studies revealed that the electrolyte decomposed at high potentials(2.5–3.0 V) and provided additional capacities. The cut-off voltage and electrolyte filling were controlled, which eliminated the impact of electrolyte decomposition, prevented rapid capacity decay, and provided a stable cycling performance for SnSe-Mo-C anodes in LIBs. This work shows that the composite anode is promising for lithium storage and the findings provide new insights into understanding and controlling the phenomenon of capacity increase with cycling in metal-based anode materials.

关键词： Lithium-ion battery SnSe Capacity increase Electrolyte decomposition

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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Approach from the laboratory to the field: New strategies in the control of mosquito-borne infectious diseases

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Science China Life Sciences 2025年第1期 303-305页

作者： Ziqian Xu Lianpan Dai jun liu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID) National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences

Vector-borne viruses, transmitted among humans and animal hosts through bites of vectors such as mosquitoes and ticks,pose a great and ongoing threat to public health and biosafety(Yang et al., 2022).Among them, dengue virus-induced epidemics, have dramatically increased worldwide in recent decades. The report released by the World Health Organization(WHO) at the end of 2023 showed that dengue epidemic globally surged in2023, with the number of reported cases nearing a historical peak.

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Clinical significance and prognostic value of tumor necrosis factor-α and dickkopf related protein-1 in ankylosing spondylitis

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World Journal of Clinical Cases 2020年第7期8卷 1213-1222页

作者： jun-Hui xiong Jian liu Jian Chen Department of Rheumatology Lishui People’s HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND Ankylosing spondylitis(AS)frequently occurs in people aged 30-45 years,and its prevalence is generally believed to be between 0.1%and 1.4%*** present,the“gold standard”for diagnosis of AS requires the provision of pelvic X-rays,which makes it more difficult to perform in population-based epidemiological ***,the identification of serological indicators related to the diagnosis,treatment,and prognosis of AS patients is of great *** To analyze the therapeutic,diagnostic significance and prognostic value of dickkopf-related protein-1(DKK-1)and tumor necrosis factor-α(TNF-α)in *** A total of 113 patients with active AS were selected as the research group,and 100 healthy subjects who underwent physical examination were selected as the control *** levels of DKK-1 and TNF-α in peripheral blood in the two groups were *** diagnostic and predictive values of DKK-1 and TNF-α for AS were analyzed with ROC curves,and the factors influencing AS recurrence were analyzed with COX *** Before treatment,the research group showed lower DKK-1 levels but higher TNF-αlevels than the control group(both aP<0.05).In the research group,DKK-1 was up-regulated and TNF-αwas down-regulated after 12 wk of treatment(aP<0.05).The area under the curve,sensitivity and specificity of DKK-1 combined with TNF-αfor diagnosing AS were 0.934,82.30%and 97.00%,*** treatment,the area under the curve,cutoff value,sensitivity and specificity of DKK-1 for predicting the curative effect were 0.825,68.42 pg/mL,73.68%and 80.00%,respectively,and those of TNF-αwere 0.863,32.79 ng/L,92.11%and 77.33%,***-1 and TNF-αlevels after treatment were closely related to the curative effect(aP<0.05).C-reactive protein,the Bath Ankylosing Spondylitis Disease Activity Index,DKK-1,and TNF-αwere risk factors for AS recurrence(aP<0.05).CONCLUSION DKK-1 and TNF-αare effective in the diagnosis and treatment of AS and are risk f

关键词： Dickkopf-related protein-1 Tumor necrosis factor-α Ankylosing spondylitis Diagnosis Prognosis Peripheral blood

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