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Combined MELD and blood lipid level in evaluating the prognosis of decompensated cirrhosis

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World Journal of Gastroenterology 2010年第11期16卷 1397-1401页

作者： Jiang, Ming liu, Fei xiong, Wu-jun Zhong, Lan Xu, Wen Xu, Fei liu, Yan-Bing Tongji Univ Shanghai E Hosp Affiliated Dept Gastroenterol Shanghai 200120 Peoples R China

AIM: To evaluate the prognostic value of the combined model for end-stage liver disease (MELD) and blood lipid level in patients with decompensated cirrhosis. METHODS: A total of 198 patients with decompensated cirrhosis were enrolled into the study. The values of triglyceride (TG), cholesterol (TC), high density lipoproteins (HDL) and low density lipoprotein (LDL) of each patient on the fi rst day of admission were retrieved from the medical records, and MELD was calculated. All the patients were followed up for 1 year. The relationship between the change of blood lipid level and the value of MELD score was studied by analysis of variance. The prognostic factors were screened by multivariate Cox proportional hazard model. Draw Kaplan-Meier survival curves were drawn. RESULTS: Forty-f ive patients died within 3 mo and 83 patients died within 1 year. The levels of TG, TC, HDL and LDL of the death group were all lower than those of the survivors. The serum TG, TC, HDL and LDL levels were lowered with the increase of the MELD score. Multivariate Cox proportional hazard model showed that MELD ≥18 and TC ≤2.8 mmol/L were independent risk factors for prognosis of decompensated cirrhosis. Survival analysis showed that MELD ≥18 combined with TC ≤ 2.8 mmol/L can clearly discriminate between the patients who would survive and die in 1 year. CONCLUSION: MELD ≥18 and TC ≤2.8 mmol/L are two important indexes to predict the prognosis of patients with decompensated cirrhosis. Their combination can effectively predict the long-term prognosis of patients with decompensated cirrhosis.

关键词： Cirrhosis Model of end-stage liver disease Blood lipid Prognosis Survival time

椎间骨桥对骨质疏松性椎体压缩骨折愈合的影响

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局解手术学杂志 2017年第6期26卷 427-430页

作者：李青松王亚楠孟令志朴美慧马俊雄刘军项良碧王琪沈阳军区总医院骨科辽宁沈阳110016

目的分析椎间骨桥对骨质疏松性椎体压缩骨折(OVCF)愈合的影响。方法选取2010年3月至2015年6月我科收治的部分胸腰椎椎体上终板骨折的患者170例,将其中行保守治疗3个月后仍表现为椎体上终板骨皮质不连的患者60例作为观察组,保守治疗3个... 详细信息

目的分析椎间骨桥对骨质疏松性椎体压缩骨折(OVCF)愈合的影响。方法选取2010年3月至2015年6月我科收治的部分胸腰椎椎体上终板骨折的患者170例,将其中行保守治疗3个月后仍表现为椎体上终板骨皮质不连的患者60例作为观察组,保守治疗3个月后伤椎愈合良好患者110例作为对照组,对比分析2组患者在伤后3周内伤椎周围骨桥的分布情况。结果观察组分布在T_9~T_(10)、T_(10)~T_(11)及T_(11)~T_(12)节段的椎间骨桥数量及伤椎上方第2个椎间隙骨桥的数量明显高于对照组,与对照组相比,观察组存在较大的伤椎楔形角。结论新发的骨质疏松性椎体压缩骨折上方第2个椎间隙存在完整骨桥时或者矢状位伤椎楔形角度大于14.2°时,采取保守治疗可能增加伤椎不愈合的风险,采取保守治疗还是外科手术干预,应慎重选择。

关键词：椎间骨桥椎体压缩骨折骨皮质不连续愈合不良

Recruitment and reinforcement: maintaining epigenetic silencing

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Science China(Life Sciences) 2018年第5期61卷 515-522页

作者： Chengzhi Wang Bing Zhu jun xiong National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of BiophysicsChinese Academy of Sciences College of Life Sciences University of Chinese Academy of Sciences

Cells need to appropriately balance transcriptional stability and adaptability in order to maintain their identities while responding robustly to various stimuli. Eukaryotic cells use an elegant "epigenetic" system to achieve this functionality. "Epigenetics" is referred to as heritable information beyond the DNA sequence, including histone and DNA modifications, nc RNAs and other chromatin-related components. Here, we review the mechanisms of the epigenetic inheritance of a repressive chromatin state,with an emphasis on recent progress in the field. We emphasize that(i) epigenetic information is inherited in a relatively stable but imprecise fashion;(ii) multiple cis and trans factors are involved in the maintenance of epigenetic information during mitosis; and(iii) the maintenance of a repressive epigenetic state requires both recruitment and self-reinforcement *** mechanisms crosstalk with each other and form interconnected feedback loops to shape a stable epigenetic system while maintaining certain degrees of flexibility.

关键词： heterochromatin heterochromatin maintenance polycomb H3K27me3 H3K9me2/3

Effect of solute atom adsorption on heterogeneous nucleation by in-situ MgO particles:Experimental and theoretical studies

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Journal of Magnesium and Alloys 2023年第10期11卷 3642-3656页

作者： Liling Mo Hengbin Liao xiong Zhou Yu-jun Zhao jun Du Department of Metallic Materials School of Materials Science and EngineeringSouth China University of Technology381 Wushan RdGuangzhouGuangdong 510640China Department of Physics South China University of Technology381 Wushan RdGuangzhouGuangdong 510640China

The introduction of oxide inclusions during the smelting process has a clear promising heterogeneous nucleation potency on Mg-based alloys, but the mechanism has not been explored clearly yet. In the present work, the grain refinement mechanism of MgO in pure Mg,Mg-3Al and AZ31(Mg-2.9Al-0.9Zn-0.3Mn) alloys is investigated by combing first-principles calculations and experiments. The theoretical results show that solute atoms adsorption will affect the nucleation and the subsequent growth process, which is an important factor affecting the refinement efficiency. A contradiction between the experimental results and the grain growth restriction factor(GRF) theory is observed,that is the refinement ratio of AZ31 is worse than Mg-3Al alloy. This is explained by an adsorption model which reveals that Al promotes the adsorption of Mg on MgO surface so as to stimulate more particles available as nucleating sites. Meanwhile, Fe and Mn also have favorable effects on the adsorption of Mg, Zn may play the opposite role compared to Al. The theoretical analyzes provide a strong support to the experiments that Al benefits the initial nucleation of α-Mg on MgO to promote the grain refining effect of Mg-3Al prior to AZ31 alloy.

关键词： Magnesium alloy First-principles calculation MgO Grain refinement Adsorption

Editorial:Celebrating the 30 Wonderful Year Journey of Chinese Physics B

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Chinese Physics B 2022年第12期31卷 10-12页

作者： Hong-jun Gao Qihua xiong Institute of Physics and University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100190China State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China

The year 2022 marks the 30^(th)anniversary of Chinese Physics *** editorial provides a brief history of the journal and introduces the anniversary theme collection comprising over 30 invited reviews and perspective ar... 详细信息

关键词： editorial 30^(th)anniversary

EFFECTS OF DIFFERENT FUNCTIONALIZATION SCHEMES ON THE INTERFACIAL STRENGTH OF CARBON NANOTUBE POLYETHYLENE COMPOSITE

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Acta Mechanica Solida Sinica 2015年第3期28卷 277-284页

作者： Tan Xiao Juqing liu Huifang xiong Architecture and Civil Engineering Institute Guangdong University of Petrochemical Technology Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM)Nanjing Tech University (NanjingTech) School of Computer and Electronic Information Guangdong University of Petrochemical Technology

The mechanical performance of carbon nanotube （CNT） reinforced polymer com- posites is primarily controlled by the dispersive capacity and interracial shear strength of CNTs in polymer matrices. CNT functionalizations will improve dispersion and strengthen interracial bonding of CNTs in matrices. To understand the effects of different functionalization schemes on the interracial strength of CNT-polymer composites, pullout of the covalent, noncovalent, and mixed functionalized single-walled carbon nanotube （SWCNT） from polyethylene （PE） matrix was simulated by using molecular dynamics, respectively. The results show that the SWCNT-PE interracial shear strength is significantly improved by SWCNT functionalizations, particularly by mixed functionalization.

关键词： interracial shear strength carbon nanotubes nano composites molecular dynamics

Credit Rationing and the Simulation of Bank-Small and Medium Sized Firm Artificial Credit Market

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Journal of Systems Science & Complexity 2016年第4期29卷 991-1017页

作者： liu Xuefeng ZHANG Wei xiong xiong SHEN Dehua ZHANG Yongjie College of Management and Economics Tianjin UniversityTianjin 300072China Key Laboratory of Computation and Analytics of Complex Management Systems(CA CMS) Tianjin UniversityTianjin 300072China Departament d'Economia Universitat Jaume ICastellSn de la Plana12071Spain.

By analyzing the financing difficulties faced by the small and medium-sized firms, the paper built an artificial credit markets with the agent-based computational modeling to simulate the real world credit transactions. There are firms, banks, different risk-type projects as well as legal and supervision environments in which debt contracts constitute the financial instruments. The simulation results show that the number of collateral, average success probability of projects, and the prime interest rate have materially impact on bank's average profit, bank's capital, the overall interest rate,the number of borrowing firms, loan size, and the degree of credit rationing. These results in line with those of the classical S-W model in the sense that the relationship between bank profits and interest rates is non-monotonic as well as the relationship between credit rationing and interest rates. And thus there is an adverse selection effect in credit rationing theory.

关键词： Agent-based computational finance artificial credit market credit rationing small- and medium-sized firms.

Rapid Hydrogen Transportation Along Grain Boundary in Nickel

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Acta Metallurgica Sinica(English Letters) 2014年第4期27卷 615-620页

作者： Yongli Wang Liangyin xiong Shi liu Department of Special Environment Materials Institute of Metal ResearchChinese Academy of Sciences

The permeability and diffusivity of hydrogen in directionally solidified polycrystalline and single crystal nickel foils were measured by gas permeation *** results showed that both hydrogen diffusivity and permeability were higher in directionally solidified nickel specimen than those in single crystal one at the temperature ranging from 300 to480 °C,and confirmed the existence of short-circuit diffusion along the grain boundaries（GBs） in the directionally solidified *** results suggested that the rapid diffusion along GBs was more obviously characterized in terms of higher permeability rather than higher *** contribution of grain boundary to hydrogen transportation was represented by the differences of diffusivity（and permeability） in single crystal nickel and directionally solidified *** modifying the Fick＇s first diffusion law and counting the grain boundary density,the hydrogen diffusivity and permeability of rapid diffusion along GBs were *** results suggested both the diffusivity and permeability fit the Arrhenius relationship well at different temperature.

关键词： Hydrogen trapping Hydrogen embrittlement Grain boundary diffusion Nickel

CO_(2) hydrogenation to methanol over Rh/In_(2)O_(3)–ZrO_(2)catalyst with improved activity

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Green Chemical Engineering 2022年第2期3卷 165-170页

作者： Zhe Lu Jing Wang Kaihang Sun Shilong xiong Zhitao Zhang Chang-jun liu School of Chemical Engineering and Technology Tianjin UniversityTianjin300072China

The In_(2)O_(3)supported rhodium catalyst has been previously confirmed to be active for CO_(2)hydrogenation to *** this work,the In_(2)O_(3)–ZrO_(2)solid solution was prepared and employed to support the rhodium *** deposition-precipitation method was applied to make the Rh catalyst highly *** catalyst characterization confirms that the use of ZrO_(2)optimizes and stabilizes the oxygen vacancies of In_(2)O_(3),which causes the enhanced adsorption and activation of CO_(2).The highly dispersed Rh catalyst remarkably improves the hydrogenation ability of the In_(2)O_(3)–ZrO_(2)*** to Rh/In_(2)O_(3),the In_(2)O_(3)–ZrO_(2)supported Rh catalyst shows significantly higher activity with high methanol *** instance,at 300℃ and 5 MPa,the methanol selectivity over Rh/In_(2)O_(3)–ZrO_(2)reaches 66.5%with a space-time yield(STY)of methanol of 0.684 g MeOH h^(-1) g cat-1 and a CO_(2)conversion of 18.1%.The methanol selectivity and methanol STY at 300℃ is 19% and 26% higher than that of the Rh/In_(2)O_(3)catalyst.

关键词： Rh In_(2)O_(3) ZrO_(2) CO_(2) Hydrogenation Methanol