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Multi-layer hierarchical cellulose nanofibers/carbon nanotubes/vinasse activated carbon composite materials for supercapacitors and electromagnetic interference shielding

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Nano Research 2024年第3期17卷 904-912页

作者： Tianxu Wang Chuanyin xiong Yongkang Zhang Bo Wang Qing xiong Meng{2. Zhao Yonghao Ni College of Bioresources Chemical&Materials Engineering Shaanxi University of Science and TechnologyXi’an 710021China department of Chemical and biomedical Engineering The University of MaineOronoME 04469USA University of New Brunswick Limerick Pulp&Paper CtrFrederictonNB E3B 5A3Canada

Developing porous self-supporting electrodes with excellent conductivity,good mechanical properties,and high electrochemical activity is crucial for constructing electrode materials with lightweight,ultra-thin,flexible,and high capacitance *** this work,we prepared a cellulose nanofibers(CNFs)/carbon nanotubes(CNTs)/vinasse activated carbon(VAC)(CCV)composite material with a multi-layer hierarchical conductive structure through simple vacuum filtration and *** this composite material,the self-assembly of CNF provides the main skeleton structure of a multi-layer hierarchical *** provides a fast path for the rapid transfer of electrons and is beneficial for the loss of electromagnetic *** provides sufficient double layer *** synergistic effect of the above three endows CCV composite materials with excellent energy storage performance and electromagnetic interference(EMI)shielding *** addition,we endowed the CCV composite with a certain shape and performance by introducing a vitrimer polymer with a dynamic cross-linked network *** summary,thanks to the synergistic effect of various components in the multi-layer hierarchical structure,CCV composite materials exhibit excellent integration performance,especially stable energy storage performance and EMI shielding *** significant properties make CCV composite materials have great application prospects in the fields of energy storage and intelligent EMI shielding.

关键词： self-supporting electrodes multi-layer hierarchical structure supercapacitors electromagnetic interference shielding

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Endoscopic ultrasound-guided lauromacrogol injection for treatment of colorectal cavernous hemangioma:Two case reports

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 966-973页

作者： Hua-Tuo Zhu Wen-Guo Chen Jing-jie Wang Jia-Nan Guo fen-Ming Zhang Guo-Qiang Xu Hong-Tan Chen department of Gastroenterology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Colorectal cavernous hemangioma is a rare vascular malformation resulting in recurrent lower gastrointestinal hemorrhage,and can be misinterpreted as *** resection is currently the mainstay of treatment,with an emphasis on sphincter *** SUMMARY We present details of two young patients with a history of persistent hematochezia diagnosed with colorectal cavernous hemangioma by endoscopic ultrasound(EUS).Cavernous hemangioma was relieved by several EUS-guided lauromacrogol injections and the patients achieved favorable clinical *** Multiple sequential EUS-guided injections of lauromacrogol is a safe,effective,cost-efficient,and minimally invasive alternative for colorectal cavernous hemangioma.

关键词： Endoscopic ultrasound Lauromacrogol injection Colorectal cavernous hemangioma Case report

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Single cell analysis unveils B cell-dominated immune subtypes in HNSCC for enhanced prognostic and therapeutic stratification

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International Journal of Oral Science 2024年第3期16卷 448-459页

作者： Kang Li Caihua Zhang Ruoxing Zhou Maosheng Cheng Rongsong Ling Gan xiong jieyi Ma Yan Zhu Shuang Chen jie Chen Demeng Chen Liang Peng State Key Laboratory of Oncology in South China Department of Oral and Maxillofacial SurgeryInstitute of Precision MedicineCenter for Translational MedicineThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Institute for Advanced Study Shenzhen UniversityShenzhenChina Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-Sen UniversityGuangzhouChina Senior department of Oncology The Fifth Medical Center of PLA General HospitalBeijingChina

Head and neck squamous cell carcinoma(HNSCC)is characterized by high recurrence or distant metastases rate and the prognosis is *** is mounting evidence that tumor-infiltrating B cells(TIL-Bs)have a crucial,synergistic role in tumor ***,little is known about the role TIL-Bs play in immune microenvironment and the way TIL-Bs affect the outcome of immune checkpoint *** single-cell RNA sequencing(scRNA-seq)data from the Gene Expression Omnibus(GEO)database,the study identified distinct gene expression patterns in *** samples were categorized into TIL-Bs inhibition and TIL-Bs activation groups using unsupervised *** classification was further validated with TCGA HNSCC data,correlating with patient prognosis,immune cell infiltration,and response to *** found that the B cells activation group exhibited a better prognosis,higher immune cell infiltration,and distinct immune checkpoint levels,including elevated PD-L1.A prognostic model was also developed and validated,highlighting four genes as potential biomarkers for predicting survival outcomes in HNSCC ***,this study provides a foundational approach for B cells-based tumor classification in HNSCC,offering insights into targeted treatment and immunotherapy strategies.

关键词： prognosis elevated offering

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Curcumin modulates oxidative stress to inhibit pyroptosis and improve the inflammatory microenvironment to treat endometriosis

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Genes & Diseases 2024年第3期11卷 102-105页

作者： jie Ding Shanshan Mei Kaili Wang Wen Cheng Shuai Sun Zhexin Ni Xiaoqiu Wang Chaoqin yu department of Gynecology of Traditional Chinese Medicine Changhai Hospital Affiliated to Naval Medical UniversityShanghai 200433China Obstetrics and Gynecology department The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhouZhejiang 310006China department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Obstetrics and Gynecology Hospital of fudan University Shanghai 200433China

Endometriosis(EM)is a common disease that affects approximately 10%-15%of women of childbearing *** pathogenesis of EM is unclear,but studies have shown a strong association between EM and inflammation,as well as oxidative stress.^(1) Pyroptosis is also called inflammatory cell *** pyroptosis occurs,it activates a strong inflammatory *** is associated with oxidative stress,and Ros act as intermediate triggers to activate pyroptosi.

关键词： inflammatory death oxidative

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Reinfection and Risk Factors of SARS-CoV-2.during an Omicron Wave 2.2. in shanghai

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Biomedical and Environmental Sciences 2024年第2期37卷 204-209页

作者： WANG Pei Qin WANG Xiao Hang WANG Jian SHI Zhi Wen CHU Dong Mei WANG Zhi Fei ZHANG Mu Bai LIU Wei ZHOU Zi jie XIE Wei fen department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghai 200003China Health examination center Changzheng HospitalNaval Medical UniversityShanghai 200003China

Multiple waves of coronavirus disease 2.19(COVID-19) outbreaks have affected numerous countries worldwide. The first case of SARS-CoV-2.reinfection was reported in Hong Kong in August 2.2.^([1]), leading to increased interest in the effectiveness of natural immunity acquired from primary infection. While data reports vary across countries, all findings indicate that prior SARS-CoV-2.infection provides substantial protection against reinfection^([2.). However, natural immunity from infection with previous non-Omicron or early Omicron sub-lineages offers lower levels of protection against Omicron reinfection, with rates below 60%^([3]) and approximately 75%[4], respectively.

关键词： immunity infection Omi

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Identification of differentially expressed mRNAs as novel predictive biomarkers for gastric cancer diagnosis and prognosis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1947-1964页

作者： Jian-Wei Zhou Yi-Bing Zhang Zhi-Yang Huang yu-Ping yuan {2. Jin department of Gastroenterology Wenzhou Central HospitalDingli Clinical College of Wenzhou Medical UniversityThe Second Affiliated Hospital of Shanghai UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Gastric cancer(GC)has a high mortality rate *** significant progress in GC diagnosis and treatment,the prognosis for affected patients still remains *** To identify important candidate genes related to the development of GC and iden-tify potential pathogenic mechanisms through comprehensive bioinformatics *** The Gene Expression Omnibus database was used to obtain the GSE183136 dataset,which includes a total of 135 GC *** limma package in R software was employed to identify differentially expressed genes(DEGs).Thereafter,enrichment analyses of Gene Ontology(GO)terms and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways were performed for the gene modules using the clusterProfile package in R *** protein-protein interaction(PPI)networks of target genes were constructed using STRING and visualized by Cytoscape *** common hub genes that emerged in the cohort of DEGs that was retrieved from the GEPIA database were then screened using a Venn *** expression levels of these overlapping genes in stomach adenocarcinoma samples and non-tumor samples and their association with prognosis in GC patients were also obtained from the GEPIA database and Kaplan-Meier ***,real-time quantitative polymerase chain reaction(RT-qPCR)and western blotting were performed to determine the mRNA and protein levels of glutamic-pyruvic transaminase(GPT)in GC and normal immortalized cell *** addition,cell viability,cell cycle distribution,migration and invasion were evaluated by cell counting kit-8,flow cytometry and transwell ***,we also conducted a retrospective analysis on 70 GC patients diagnosed and surgically treated in Wenzhou Central Hospital,Dingli Clinical College of Wenzhou Medical University,The Second Affiliated Hospital of shanghai University between January 2017 to December *** tumor and adjacent normal samples were collected from the patients to determine the

关键词： Gastric cancer Differentially expressed genes Bioinformatics Hub genes Prognosis

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The lactylation index predicts the immune microenvironment and prognosis of pan-cancer patients

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BIOCELL 2024年第8期48卷 1223-1239页

作者： XUEJIA ZHAI jie LIU JINWEI XIAO TAO ZHANG JUN WANG JIANJUN LI SHICANG yu department of Oncology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing400038China department of Stem Cell and Regenerative Medicine Institute of Pathology and Southwest Cancer CenterSouthwest HospitalThird Military Medical University(Army Medical University)Chongqing400038China Key Laboratory of Cancer Immunopathology Ministry of EducationChongqing400038China International Joint Research Center for Precision Biotherapy Ministry of Science and TechnologyChongqing400038China Jin-feng Laboratory Chongqing401329China

Background:Protein lactylation is a new way for the“metabolic waste”lactic acid to perform novel ***,our understanding of the contribution of protein lactylation to both tumor progression and therapeutic interventions remains *** construction of a scoring system for lactylation to predict the prognosis of pancancer patients and to evaluate the tumor immune microenvironment(TIME)would improve our understanding of the clinical significance of ***:Consensus clustering analysis of lactylation-related genes was used to cluster 177 pancreatic adenocarcinoma(PAAD)***,a scoring system was developed using the least absolute shrinkage and selection operator(LASSO)*** validation and external validation were both conducted to assess and confirm the predictive accuracy of the scoring ***,leucine rich repeat containing 1(LRRC1),a newly discovered lactylation-related gene,was analyzed in PAAD in ***:Utilizing the profiles of 332.lactylation-related genes,a total of 177 patients with PAAD were segregated into two distinct ***^(high) patients had a poorer prognosis than LacCluster^(low) *** the differential analysis between the LacCluster^(high) and LacCluster^(low) groups,we identified additional genes associated with *** genes were then integrated to construct the LacCluster-enhanced system,which enabled more accurate prognosis prediction for patients with ***,a lactylation index containing three genes(LacI-3)was constructed using LASSO *** was done to enhance the usability of the LacCluster-enhanced system in the *** to those in the LacI-3^(high) subgroup,patients in the LacI-3^(low) subgroup exhibited increased expression of immune checkpoint-related genes,more immune cell infiltration,lower tumor mutation burdens,and better prognoses,indicating a“hot tumor”***,knocking down the expression of LRRC1,

关键词： Pancreatic adenocarcinoma Pan-cancer Lactylation Prognosis Tumor immune microenvironment LRRC1

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Computed tomography-based multi-organ radiomics nomogram model for predicting the risk of esophagogastric variceal bleeding in cirrhosis

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World Journal of Gastroenterology 2024年第36期30卷 4044-4056页

作者： yu-jie Peng Xin Liu Ying Liu Xue Tang Qi-Peng Zhao Yong Du department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina department of Radiology The People’s Hospital of Chongqing Liang Jiang New AreaChongqing 401121China

BACKGROUND Radiomics has been used in the diagnosis of cirrhosis and prediction of its associated ***,most current studies predict the risk of esophageal variceal bleeding(EVB)based on image features at a single level,which results in incomplete *** studies have explored the use of global multi-organ radiomics for non-invasive prediction of EVB secondary to *** To develop a model based on clinical and multi-organ radiomic features to predict the risk of first-instance secondary EVB in patients with *** In this study,2.8 patients with cirrhosis were retrospectively evaluated and randomly split into training(n=145)and validation(n=63)*** areas were chosen as regions of interest for extraction of multi-organ radiomic features:The whole liver,whole spleen,and lower esophagus–gastric fundus *** the training cohort,radiomic score(Rad-score)was created by screening radiomic features using the inter-observer and intra-observer correlation coefficients and the least absolute shrinkage and selection operator *** clinical risk factors were selected using multivariate logistic regression *** radiomic features and clinical risk variables were combined to create a new radiomics-clinical model(RC model).The established models were validated using the validation *** Radiomics has been used in the diagnosis of cirrhosis and prediction of its associated ***,most current studies predict the risk of esophageal variceal bleeding(EVB)based on image features at a single level,which results in incomplete *** studies have explored the use of global multi-organ radiomics for non-invasive prediction of EVB secondary to *** To develop a model based on clinical and multi-organ radiomic features to predict the risk of first-instance secondary EVB in patients with *** In this study,2.8 patients with cirrhosis were retrospectively evaluated and randoml

关键词： Artificial intelligence Cirrhosis Radiomics Esophagogastric variceal bleeding

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Spin transport of half-metal Mn_(2.X_(3) with high Curie temperature:An ideal giant magnetoresistance device from electrical and thermal drives

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Frontiers of physics 2024年第4期19卷 125-135页

作者： Bin Liu Xiaolin Zhang Jingxian xiong Xiuyang Pang Sheng Liu Zixin Yang Qiang yu Honggen Li Sicong Zhu Jian Wu Hubei Province Key Laboratory of Systems Science in Metallurgical Process The State Key Laboratory for Refractories and MetallurgyCollaborative Innovation Center for Advanced SteelsInternational Research Institute for Steel TechnologyWuhan University of Science and TechnologyWuhan 430081China Key Laboratory of Artificial Micro-and Nano-structures of Ministry of Education and School of Physical and Technology Wuhan UniversityWuhan 430072China College of Advanced Interdisciplinary Studies Nanhu Laser LaboratoryNational University of Defense TechnologyChangsha 410073China department of Mechanical Engineering National University of SingaporeSingapore 117575Singapore i-Lab&Key Laboratory of Nanodevices and Applications&Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and NanoBionicsChinese Academy of SciencesSuzhou 215123China Institute of Optical Science and Technology School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China

Currently,magnetic storage devices are encountering the problem of achieving lightweight and high integration in mobile computing devices during the information *** a result,there is a growing urgency for twodimensional half-metallic materials with a high Curie temperature(TC).This study presents a theoretical investigation of the fundamental electromagnetic properties of the monolayer hexagonal lattice of Mn_(2.X_(3)(X=S,Se,Te).Additionally,the potential application of Mn_(2.X_(3) as magneto-resistive components is *** three of them fall into the category of ferromagnetic *** particular,the Monte Carlo simulations indicate that the TC of Mn2.3 reachs 381 K,noticeably greater than room *** findings present notable advantages for the application of Mn2.3 in spintronic ***,a prominent spin filtering effect is apparent when employing non-equilibrium Green’s function simulations to examine the transport *** resulting current magnitude is approximately 2.10^(4) nA,while the peak gigantic magnetoresistance exhibits a substantial value of 8.36×10^(16)%.It is noteworthy that the device demonstrates a substantial spin Seebeck effect when the temperature differential between the electrodes is *** brief,Mn_(2.X_(3) exhibits outstanding features as a highTC half-metal,exhibiting exceptional capabilities in electrical and thermal drives spin ***,it holds great potential for usage in spintronics applications.

关键词： half-metals Mn_(2.X_(3) high Curie temperature electrical and thermal GMR

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Design,synthesis,and biological evaluation of 1,2.4-triazole derivatives as potent antitubercular agents

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Chinese Chemical Letters 2024年第3期35卷 326-331页

作者： yu Wen Shichun Lun yuxue Jiao Wei Zhang Tianyu Hu Ting Liu Fan Yang jie Tang Bing Zhang William R.Bishai Li-Fang yu shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China Center for Tuberculosis Research Department of MedicineDivision of Infectious DiseaseJohns Hopkins School of MedicineBaltimoreMD21231-1044United States shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China shanghai Key Laboratory of Green chemistry and Chemical Process School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China

Inhibition of mycobacterial membrane protein large 3(MmpL3)thereby affecting the mycolic acid biosynthetic pathway has been proven to be an effective strategy for developing antitubercular *** on the X-ray crystal structure of MmpL3 inhibitor complexes,a series of novel 1,2.4-triazole derivatives were designed,synthesized and evaluated antitubercular activity against Mtb strain *** structure–activity relationship exploration resulted in the identification of compounds 2. and 2.,which possess potent antitubercular activity against Mtb strain H37Rv[minimum inhibitory concentration(MIC)=0.03–0.13μg/mL]and the clinical isolates of multidrug resistance(MDR)and extensive drug resistance(XDR)tuberculosis(MIC=0.06–1.0μg/mL).Moreover,compounds 2. and 2. showed neglectable cytotoxicity(IC_(50)≥32.g/mL)to the mammalian Vero cells and favorable physicochemical and pharmacokinetic properties according to the in silico absorption,distribution,metabolism and excretion(ADME)***,the potential target of representative 1,2.4-triazole 2. was identified to be MmpL3 using a microscale thermophoresis(MST)assay.

关键词： Tuberculosis MDR and XDR-TB MmpL3 inhibitor 1 2 4-Triazole Structure-based drug design

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