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POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation

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Protein & Cell 2021年第4期12卷 279-296页

作者： Jian Xiao Yanni xiong Liu-Ting Yang Ju-Qiong Wang Zi-Mu Zhou Le-Wei Dong xiong-jie shi Xiaolu Zhao jie Luo Bao-Liang Song Hubei Key Laboratory of Cell Homeostasis College of Life SciencesFrontier Science Center for Immunology and MetabolismWuhan UniversityWuhan 430072China

Sterol-regulatory element binding proteins(SREBPs)are the key transcriptional regulators of lipid *** activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi,where it is sequentially cleaved by site-1 protease(S1P)and site-2 protease and releases a nuclear form to modulate gene *** search for new genes regulating cholesterol metabolism,we perform a genome-wide CRISPR/Cas9 knockout screen and find that partner of site-1 protease(POSH),encoded by C120RF49,is critically involved in the SREBP *** of POSH decreases the generation of nuclear SREBP and reduces the expression of SREBP target *** binds S1P,which is synthesized as an inactive protease(form A)and becomes fully mature via a two-step autocatalytic process involving forms B/B and C/*** promotes the generation of the functional S1P-C/C from S1P-B/B(canonical cleavage)and,notably,from S1P-A directly(non-canonical cleavage)as *** POSH-mediated S1P activation is also essential for the cleavages of other S1P substrates including ATF6,CREB3 family members and the a/p-subunit precursor of ***,we demonstrate that POSH is a cofactor controlling S1P maturation and plays important roles in lipid homeostasis,unfolded protein response,lipoprotein metabolism and lysosome biogenesis.

关键词： SREBP site-1 protease proteolytic activation unfolded protein response activating transcription factor 6 mannose-6-phosphate

A MODEL OF INTERDIFFUSION IN COMPOSITIONALLY MODULATED ALLOYS

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Chinese Physics Letters 1985年第8期2卷 357-360页

作者： xiong shi-jie Institute of Solid State Physics Nanjing UniversityNanjing

We propose a model to describe the microscopic processes of interdiffusion in compositionally modulated alloys,taking into account not only the short range interaction between the migrating atoms and their environments,but also the long range Coulomb's forces arising from the charge transfer due to *** results for relations between the interdiffusivities and the modulation wavelengths,obtained by neglecting the correlation effect,show the behaviour observed in experimental works.

关键词： alloys behaviour diffusion

Construction of Genetic Linkage Map Based on SSR Markers in Peanut(Arachis hypogaea L.)

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Agricultural Sciences in China 2008年第8期7卷 915-921页

作者： HONG Yan-bin LIANG Xuan-qiang CHEN Xiao-ping LIU Hai-yan ZHOU Gui-yuan LI Shao-xiong WEN shi-jie Crops Research Institute Guangdong Academy of Agricultural Sciences Guangzhou 510640 P.R.China

Molecular genetic maps of crop species can be used in a variety of ways in breeding and genomic research such as identification and mapping of genes and quantitative trait loci （QTLs） for morphological, physiological and economic traits of crop species. However, a comprehensive genetic linkage map for cultivated peanut has not yet been developed due to the extremely low frequency of DNA polymorphism in cultivated peanut. In this study, 142 recombinant inbred lines （RILs） derived from a cross between Yueyou 13 and Zhenzhuhei were used as mapping population in peanut （Arachis hypogaea L.）. A total 652 pairs of genomic-SSR primer and 392 pairs of EST-SSR primer were used to detect the polymorphisms between the two parents. 141 SSR primer pairs, 127 genomic-SSR and 14 EST-SSR ones, which can be used to detect polymorphisms between the two parents, were selected to analyze the RILs population. Thus, a linkage genetic map which consists of 131 SSR loci in 20 linkage groups, with a coverage of 679 cM and an average of 6.12 cM of inter-maker distance was constructed. The putative functions of 12 EST-SSR markers located on the map were analyzed. Eleven showed homology to gene sequences deposited in GenBank. This is the first report of construction of a comprehensive genetic map with SSR markers in peanut （Arachis hypogaea L.）. The map presented here will provide a genetic framework for mapping the qualitative and quantitative trait in peanut.

关键词： peanut (Arachis hypogaea L.) SSR genetic linkage map

基于离子液体萃取体系宏观超分子组装的锶分离

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核化学与放射化学 2022年第1期44卷 52-60页

作者：史策熊世杰沈兴海北京分子科学国家研究中心放射化学与辐射化学重点学科实验室应用物理与技术研究中心北京大学化学与分子工程学院北京100871

Sr的分离在放射性资源的回收利用领域有着重要意义。离子液体萃取Sr的体系得到了极大的拓展,但是很难实现Sr、Cs之间的完全分离。放射性废液的问题也关系着离子液体体系在乏燃料后处理领域的应用。本工作研究了Sr在离子液体萃取体系中... 详细信息

Sr的分离在放射性资源的回收利用领域有着重要意义。离子液体萃取Sr的体系得到了极大的拓展,但是很难实现Sr、Cs之间的完全分离。放射性废液的问题也关系着离子液体体系在乏燃料后处理领域的应用。本工作研究了Sr在离子液体萃取体系中的界面宏观超分子组装,并开展了其在锶铯分离领域的应用基础研究。首先发现并研究了Sr^(2+)在离子液体萃取体系中界面上的宏观超分子组装(MSA)行为,可实现宏观超分子组装的离子液体为C_(n) OHmimNTf_(2)(n=2、3),萃取剂为正辛基苯基-N,N-二异丁基胺基甲酰基甲基氧化膦(CMPO)和N,N,N′,N′-四辛基-3-氧戊二酰胺(TODGA)。通过质谱、核磁、红外、理论计算等方法分析了Sr宏观超分子组装体(Sr-MSA)的结构,提出了形成Sr-MSA过程的三级组装机理,即Sr^(2+)与CMPO配体形成配合物并与C_(2)OHmim^(+)发生阳离子交换,进入离子液体相;配合物通过相互间的静电吸引、氢键、疏水作用、长碳链等非共价作用形成纳米尺度组装体,并可生长至介观;介观组装体逐渐转移至界面并进一步生长至宏观尺度的中间体;多个宏观中间体在Marangoni效应产生的界面牵引作用下发生MSA,最终组装为单个Sr-MSA。最后,开发了Sr的选择性分离方法,成功实现了水溶液中Sr^(2+)的一步法选择性提取和固化。形成的Sr-MSA可用镊子夹出从而简单实现Sr^(2+)从水溶液中的选择性分离。该法在高酸度环境下仍可适用,在高酸度场景如乏燃料后处理中有潜在应用价值。

关键词：锶宏观超分子组装萃取离子液体 Marangoni效应

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第1期68卷 201-208页

作者： Hui-Feng Wang Wen-jie shi Yu-Xin Yang Bao-Xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO2 reduction photocatalysis

Industrial solid wastes to environmental protection materials for removal of gaseous pollutants:A review

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Green Energy & Environment 2025年第1期10卷 34-83页

作者： Jiacheng Bao Xin Sun Ping Ning Kai Li jie Yang Fei Wang Lei shi Maohong Fan Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming650500China College of Engineering and Physical Sciences and School of Energy ResourcesUniversity of WyomingLaramieWY82071USA College of Engineering Georgia Institute of TechnologyAtlantaGA30332USA

The application of industrial solid wastes as environmentally functional materials for air pollutants control has gained much attention in recent years due to its potential to reduce air pollution in a cost-effective *** this review,we investigate the development of industrialwaste-based functional materials for various gas pollutant removal and consider the relevant reaction mechanism according to different types of industrial solid *** see a recent effort towards achieving high-performance environmental functional materials via chemical or physical modification,in which the active components,pore size,and phase structure can be *** review will discuss the potential of using industrial solid wastes,these modified materials,or synthesized materials from raw waste precursors for the removal of air pollutants,including SO_(2),NO_(x),Hg^(0),H_(2)S,VOCs,and CO_(2).The challenges still need to be addressed to realize this potential and the prospects for future research *** suggestions for future directions include determining the optimal composition of these materials,calculating the real reaction rate and turnover frequency,developing effective treatment methods,and establishing chemical component databases of raw industrial solid waste for catalysts/adsorbent preparation.

关键词： Industrial solid waste Reaction mechanism Modification method Air pollutants

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石墨炔基本性能及其在放射化学领域的应用

核化学与放射化学 2020年第6期42卷 423-432页

作者：袁天宇熊世杰沈兴海北京分子科学国家研究中心放射化学与辐射化学重点学科实验室应用物理与技术研究中心北京大学化学与分子工程学院北京100871

石墨炔作为一种新型的二维碳材料,自2010年首次合成后即得到了广泛的关注和研究。目前石墨炔在储能、催化、电化学、医药和吸附等领域已经展现出广阔的应用前景。石墨炔具有特殊三角孔洞结构和大π键特性,对不同离子具有选择性吸附潜力... 详细信息

石墨炔作为一种新型的二维碳材料,自2010年首次合成后即得到了广泛的关注和研究。目前石墨炔在储能、催化、电化学、医药和吸附等领域已经展现出广阔的应用前景。石墨炔具有特殊三角孔洞结构和大π键特性,对不同离子具有选择性吸附潜力,在放射化学领域有着潜在的应用价值。之前的工作表明,石墨炔在镧锕分离、钍铀分离、锶铯分离中具有显著的效果。与此同时,锕系离子被石墨炔吸附后呈现单离子态。石墨炔的π体系与锕系单离子的5f电子之间发生强烈的键合作用。而5f电子的反馈作用对锕系离子的选择性分离至关重要。本文首先对石墨炔的合成、性质、应用进行简短的综述,进而对石墨炔在放射化学领域中的初步结果进行介绍,最后对石墨炔在放射化学领域的应用进行了展望。

关键词：石墨炔放射化学离子选择性分离锕系单离子

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半羟化的碳化硅片的第一性原理研究

南京大学学报（自然科学版） 2011年第1期47卷 25-31页

作者：高本领王宝林熊诗杰淮阴工学院数理学院淮安223003 南京大学物理系南京210093 盐城工学院物理系盐城224003

通过密度泛函理论,研究了碳化硅片被羟化时的电磁特性.所研究的碳化硅片为六角蜂窝状结构,碳硅原子之比为1∶1,相间排列.由于碳化硅片中含碳、硅两种元素;为此,分别考虑了全部的碳原子以及全部的硅原子分别被羟化的情形,结果发现了丰富... 详细信息

通过密度泛函理论,研究了碳化硅片被羟化时的电磁特性.所研究的碳化硅片为六角蜂窝状结构,碳硅原子之比为1∶1,相间排列.由于碳化硅片中含碳、硅两种元素;为此,分别考虑了全部的碳原子以及全部的硅原子分别被羟化的情形,结果发现了丰富的电磁特性.由于羟基对羟化原子的吸引作用,碳硅原子出现分层,对应于碳、硅原子被羟化时的碳硅层间距分别为0.671、0.390,碳硅键长度也分别伸长为1.904、1.861,而对应的键角C-O-H与Si-O-H分别为107.8°、114.1°,表现了新奇的几何结构特点.由形成能计算发现羟化是放热的,说明此过程易实现.为寻找到最稳定的磁状态,分别考察了铁磁、反铁磁以及非磁三种构型,结果发现,当所有碳原子被羟化时,材料为非磁性的正常金属;而当其中所有的硅原子被羟化时,是直接带隙为1.12 eV的反铁磁半导体.其中,硅被羟化时的结构更稳定.这些说明通过调节碳化硅片中羟化的不同位置,可以有效地调节碳化硅片的电磁特性,预示着在未来的纳米功能材料中可能的应用.

关键词：密度泛函理论羟化反铁磁半导体

衡重式挡墙土体破裂面及土压力特性离心模型试验

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岩土工程学报 2022年第11期44卷 1968-1977,I0003页

作者：罗强黄豫赵嘉伟郭增瑞熊诗杰张良西南交通大学土木工程学院四川成都610031 西南交通大学高速铁路线路工程教育部重点实验室四川成都610031

掌握墙背形状复杂的衡重式挡墙土体破裂面及土压力特性,对完善结构设计具有重要意义。研制了一套墙体位移实时控制装置,开展了3种路堤填土高度的衡重式挡墙土工离心模型试验,分析了平动位移模式下墙背土体变形破裂特征及土压力变化规律... 详细信息

掌握墙背形状复杂的衡重式挡墙土体破裂面及土压力特性,对完善结构设计具有重要意义。研制了一套墙体位移实时控制装置,开展了3种路堤填土高度的衡重式挡墙土工离心模型试验,分析了平动位移模式下墙背土体变形破裂特征及土压力变化规律,对比了测试值与规范计算值差异,提出了基于破裂面剪切状态的土压力计算模式修正方法。试验表明:达到主动极限状态时墙背土体仅形成下墙破裂面和上墙第二破裂面,可划分为平移土体、滑动棱体及稳定土体3区域;上墙第一破裂面剪应力未达到极限,是造成土压力试验值较设计计算值在上墙显著偏大而下墙偏小的关键因素;引入上墙第一破裂面内摩擦角φ发挥系数η(η≤1),建立的衡重式挡墙土压力计算修正模式,能较好反映应力偏角φ_(η)(φ_(η)=ηφ)对土体破裂角及上、下墙背土压力影响,计算修正值与试验数据吻合良好。

关键词：衡重式挡墙破裂面土压力离心模型试验应力偏角

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