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Imperfection sensitivity of mechanical properties in soft network materials with horseshoe microstructures

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Acta Mechanica Sinica 2021年第7期37卷 1050-1062,I0001页

作者： Jianxing Liu xinyuan zhu Zhangming Shen Yihui Zhang AML Department of Engineering MechanicsCenter for Flexible Electronics TechnologyTsinghua UniversityBeijing 100084China

Developments of soft network materials with rationally distributed wavy microstructures have enabled many promising applications in bio-integrated electronic devices,due to their abilities to reproduce precisely nonlinear mechanical properties of human tissues/*** practical applications,the soft network materials usually serve as the encapsulation layer and/or substrate of bio-integrated electronic devices,where deterministic holes can be utilized to accommodate hard chips,thereby increasing the filling ratio of the device ***,it is essential to understand how the hole-type imperfection affects the stretchability of soft network materialswith various geometric *** presents a systematic investigation of the imperfection sensitivity of mechanical properties in soft network materials consisting of horseshoe microstructures,through combined computational and experimental studies.A factor of imperfection insensitivity of stretchability is introduced to quantify the influence of hole imperfections,as compared to the case of perfect soft network *** factor is shown to have different dependences on the arc angle and normalized width of horseshoe microstructures for triangular network *** soft triangular and Kagome network materials,especially with the arc angle in the range of(30?,60?),are found to be much more imperfection insensitive than corresponding traditional lattice materials with straight ***,the soft honeycomb network materials are not as imperfection insensitive as traditional honeycomb lattice materials.

关键词： Imperfect network material Imperfection insensitivity Microstructure shape Lattice topology Stretchability

Supramolecular nanoscale drug-delivery system with ordered structure

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National Science Review 2019年第6期6卷 1128-1137页

作者： Xin Jin Lijuan zhu Bai Xue xinyuan zhu Deyue Yan School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University

Supramolecular chemistry provides a means to integrate multi-type molecules leading to a dynamic organization. The study of functional nanoscale drug-delivery systems based on supramolecular interactions is a recent trend. Much work has focused on the design of supramolecular building blocks and the engineering of supramolecular integration, with the goal of optimized delivery behavior and enhanced therapeutic effect. This review introduces recent advances in supramolecular designs of nanoscale drug delivery. Supramolecular affinity can act as a main driving force either in the self-assembly of carriers or in the loading of drugs. It is also possible to employ strong recognitions to achieve self-delivery of drugs. Due to dynamic controllable drug-release properties, the supramolecular nanoscale drug-delivery system provides a promising platform for precision medicine.

关键词： supramolecular chemistry drug-delivery system host–guest recognition self-delivery system precision medicine

Planet-satellite cage hybrids:covalent organic cages encircling metal organic cage

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Science China Chemistry 2022年第5期65卷 858-862页

作者： Chenjuan Yu Pan Yang xinyuan zhu Youfu Wang School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China School of Materials Engineering Shanghai University of Engineering ScienceShanghai 201620China

As a rising type of precisely molecular nanoobjects,porous molecular cages,including covalent organic cages(COCs) and metal organic cages(MOCs),have attracted much more *** is fascinating to construct well-defined cage hybrids combining COCs and MOCs to further rich their types,properties,and ***,it is a big challenge due to the isotropy of the porous molecular *** this article,an anisotropic COC ligand based on aryl ether bonds and bearing one isophthalate moiety has been designed and *** planet-satellite cage hybrids(PSCHs),MOC@COCs,have been constructed through the coordination of the anisotropic COC ligand and copper ions with or without the help of extra dicarboxylic ligands in an almost quantitative manner for the first *** PSCHs with one different topological MOC(heteroleptic bipolar,distorted cuboctahedral or homoleptic cuboctahedral) as the planet and different numbers of COCs(6,12 or 24) as satellites are *** structural and thermal properties of these PSCHs have also been *** obtained PSCHs exhibit discrete,uniform and stable structures,good solubility and strong film-forming property.

关键词： cage hybrid planet-satellite covalent organic cage metal organic cage giant molecule

EGFR-targeted and gemcitabine-incorporated chemogene for combinatorial pancreatic cancer treatment

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Nano Research 2024年第2期17卷 848-857页

作者： Miao Xie Qiushuang Zhang Yuanyuan Guo Lijuan zhu xinyuan zhu Chuan Zhang School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesInstitute of Molecular MedicineSixth people’s HospitalSchool of MedicineShanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai 200240China Department of Radiology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200233China Institute of Molecular Medicine Shanghai Jiao Tong University Affiliated Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Pancreatic cancer stands out as a recognized intractable tumor due to its high malignancy and mortality rates,which are largely attributed to the insensitivity of current clinical chemotherapies or *** chemo and gene therapy that integrates different therapeutic targets,may increase the chemosensitivity of pancreatic cancer and synergistically enhance the antitumor ***,conventional co-delivery of gene and chemo drugs is intensively dependent on complex nanoparticle delivery systems,thus would be limited by unstable drug packaging,nonspecific biodistribution,and biosafety ***,we rationally designed an epidermal growth factor-receptor(EGFR)-targeted and gemcitabine-incorporated oligonucleotide(termed as chemogene)with anti-Bcl-2 sequence,which achieves simple and precise integration of gemcitabine into a gene regulative agent,as well as the EGFR-targeted delivery for pancreatic cancer *** solid-phase synthesis,gemcitabine,as the first-line chemodrug for pancreatic cancer,is introduced to the antisense oligonucleotide to replace all cytosine nucleosides to obtain the gemcitabine-integrated chemogene(Ge-ASO^(Bcl-2)).Thereafter,Ge-ASO^(Bcl-2)is covalently coupled with EGFR nanobody to construct the final targeted chemogene without any exogenous ***,this nanobody-conjugated chemogene exhibits remarkable tumor targeting capability and antitumor effects both in vitro and in vivo,which initiates a first step toward the application of combinatorial chemo and gene therapy for future pancreatic cancer treatment.

关键词： antisense oligonucleotide chemogene nanobody drug delivery system pancreatic cancer

Recent advances in carbon monoxide-releasing nanomaterials

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Bioactive Materials 2024年第7期37卷 30-50页

作者： Xiaomei Ning xinyuan zhu Youfu Wang Jinghui Yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai200240China Department of Organ Transplantation Shanghai Changzheng HospitalNaval Medical UniversityShanghai200003China School of Resources Environment and MaterialsGuangxi UniversityNanning530004China

As an endogenous signaling molecule,carbon monoxide(CO)has emerged as an increasingly promising option regarding as gas therapy due to its positive pharmacological effects in various *** to the gaseous nature and potential toxicity,it is particularly important to modulate the CO release dosages and targeted locations to elucidate the biological mechanisms of CO and facilitate its clinical *** on these,diverse CO-releasing molecules(CORMs)have been developed for controlled release of CO in biological ***,practical applications of these CORMs are limited by several disadvantages including low stability,poor solubility,weak releasing controllability,random diffusion,and potential *** light of rapid developments and diverse advantages of nanomedicine,abundant nanomaterials releasing CO in controlled ways have been developed for therapeutic purposes across various *** to their nanoscale sizes,diversified compositions and modified surfaces,vast CO-releasing nanomaterials(CORNMs)have been constructed and exhibited controlled CO release in specific locations under various stimuli with better pharmacokinetics and *** this review,we present the recent progress in CORNMs according to their *** a concise introduction to CO therapy,CORMs and CORNMs,the representative research progress of CORNMs constructed from organic nanostructures,hybrid nanomaterials,inorganic nanomaterials,and nanocomposites is *** basic properties of these CORNMs,such as active components,CO releasing mechanisms,detection methods,and therapeutic applications,are discussed in detail and listed in a ***,we explore and discuss the prospects and challenges associated with utilizing nanomaterials for biological CO release.

关键词： monoxide release listed

Using 2D NMR to determine the degree of branching of complicated hyperbranched polymers

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Science China Chemistry 2008年第11期51卷 1057-1065页

作者： zhu xinyuan CHEN Liang CHEN Yan YAN DeYue School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China Instrumental Analysis Center Shanghai Jiao Tong UniversityShanghai 200240China

Degree of branching (DB) is a crucial structure parameter of hyperbranched polymers, which can be determined by 1H NMR, quantitative 13C NMR, degradative method, etc. However, for complicated hy-perbranched polymers, intricate structure and severe overlap of spectral signals hinder the determina-tion of DB using traditional methods. In this work, the architecture of complicated hyperbranched polymers has been elucidated with the help of 2D NMR techniques. Using such a method, overlapped NMR signals can be well separated into a two-dimensional space, and additional structural information is also available. Correspondingly, quantitative analysis for complicated systems can be realized. De-termination of DBs for three types of complicated hyperbranched polymers synthesized from step-polymerization, self-condensation vinyl polymerization and self-condensation ring-opening po-lymerization is shown as examples.

关键词： hyperbranched polymer degree of branching 2D NMR

Fabrication of porous scaffolds with protein nanogels

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Science China Chemistry 2011年第6期54卷 961-967页

作者： zhu Qi YAN Ming HE Lin zhu xinyuan LU YunFeng YAN DeYue State Key Laboratory of Metal Matrix Composites: School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 China Department of Chemical & Biomolecular Engineering University of California Los Angeles 90055 USA Instrumental Analysis Center Shanghai Jiao Tong University Shanghai 200240 China

A novel type of porous scaffold was fabricated from single protein nanogels. The nanogels with single protein as core and crosslinked polymer network as shell were prepared through a two-step procedure including surface acryloylation and in situ radical polymerization. The formation of single protein nanogels was verified by matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometer, transmission electron microscopy (TEM) and dynamic light scattering (DLS) analyses. Subsequently, the porous scaffolds were fabricated through a solvent evaporating process of aqueous nanogel solutions. The porous scaffolds were characterized by Fourier transform infrared (FTIR), scanning electronic microscopy (SEM), atomic force microscopy (AFM), and fluorescence microscopy. Interestingly, the obtained porous nanogel scaffolds presented multi-level porous morphologies with macro and nano scale pores, providing better spaces and microenvironments than normal macro porous scaffolds. Cell proliferation assay of nanogels showed low cytotoxicity. Considering that both the protein species and polymer constitutes can be pre-designed and adjusted, these multi-level porous nanogel scaffolds are promising candidates for tissue culture applications.

关键词： protein nanogel porous scaffold tissue culture

Sulfanion-initiated open-vessel anionic ring-opening polymerization of N-sulfonyl aziridines

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Science China Chemistry 2021年第10期64卷 1778-1785页

作者： Meng Huo Yawen Bian Chunyang Yu Gansheng Tong Chongyin Zhang xinyuan zhu School of Chemistry'and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Key Laboratory of Electrical Insulation and Thermal AgingShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Surface&Interface Science of Polymer Materials of Zhejiang Province Department of ChemistryZhejiang Sci-Tech UniversityHangzhou 310018China Shanghai Aerospace Equipments Manufacturer Co. Ltd.Shanghai Engineering Research Center of Specialized Polymer Materials for AerospaceShanghai 200245China

Anionic ring-opening polymerization(AROP)of N-sulfonyl aziridines is an important synthetic route to linear polyethyleneimine(PEI)and its *** most cases,inert atmosphere and dry solvent were needed because of the oxygen-and water-sensitive initiators/catalysts ***,the AROP of N-sulfonyl aziridines that can be entirely operated in air atmosphere is still a challenging ***,we report a series of sulfanions,including xanthates,dithiocarbamates,dithiobenzoates,thioacetates,and thiolates,as the initiators for the AROP of N-sulfonyl *** to their good stability,openvessel polymerization was achieved with high livingness,affording a range of well-definedα-,ω-telechelic poly(N-sulfonyl aziridine)homopolymers and block copolymers with narrow dispersities and tunable molecular ***α-end group of these polyaziridines was readily converted to thiol group,which enabled further post-polymerization functionalization with benzyl acrylate and poly(ethylene glycol)via thiol-ene click *** establishment of open-vessel sulfanion-initiated AROP of N-sulfonyl aziridines thus lays a solid foundation for the bulk preparation and application of poly(N-sulfonyl aziridine)s and PEI derivatives.

关键词： anionic ring-opening polymerization sulfanion open-vessel N-sulfonyl aziridines

Preparation and Characterization of Paclitaxel/Chitosan Nanosuspensions for Drug Delivery System and Cytotoxicity Evaluation In Vitro

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Advanced Fiber Materials 2019年第2期1卷 152-162页

作者： Yongjia Liu Fengren Wu Yongle Ding Bangshang zhu Yue Su xinyuan zhu Instrumental Analysis Center National Infrastructures for Translation Medicine(Shanghai)State Key Laboratory of Metal Matrix CompositesSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua UniversityShanghai 201620China

In this study,we prepared paclitaxel/chitosan(PTX/CS)nanosuspensions(NSs)with different mass ratios of PTX and CS(1.5:2,2:2,and 2.5:2),for controlled drug delivery *** attachment and dispersion in water medium,a simple ultrasonic disruption technique was *** water-dispersed PTX/CS NSs exhibited a rod-shape morphology with an average diameter of 170-210 nm and average length of about 1-10μ*** electron microscopy,differential scan-ning calorimetry and X-ray diffraction indicated that the obtained PTX/CS NSs contain a nanocrystalline PTX *** was also inferred that presence of CS can promotes the crystalline nature of PTX up to 80%.In addition,efficiency of PTX loading reached over 85%in freeze-dried PTX/CS NSs,showing a slow rate of drug release in vitro for 8 *** MTT and LDH assessments revealed that PTX/CS NSs significantly inhibit the growth of tumor cells(HeLa),while it is slightly toxic for the normal cells(NIH/3T3).Therefore,PTX/CS NSs is suggested as a potential nanodrug delivery system for cancer therapy.

关键词： Paclitaxel Chitosan Nanosuspensions Drug release Cytotoxicity in vitro