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Reconstituted high-density lipoproteins: novel biomimetic nanocarriers for drug delivery

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Acta Pharmaceutica Sinica B 2018年第1期8卷 51-63页

作者： xinyi ma Qingxiang Song Xiaoling Gao Department of Pharmacology and Chemical Biology Faculty of Basic Medicine Shanghai Jiao Tong University School of Medicine

High-density lipoproteins(HDL) are naturally-occurring nanoparticles that are biocompatible,non-immunogenic and completely biodegradable. These endogenous particles can circulate for an extended period of time and transport lipids, proteins and micro RNA from donor cells to recipient *** on their intrinsic targeting properties, HDL are regarded as promising drug delivery systems. In order to produce on a large scale and to avoid blood borne pollution, reconstituted high-density lipoproteins(rHDL) possessing the biological properties of HDL have been developed. This review summarizes the biological properties and biomedical applications of rHDL as drug delivery platforms. It focuses on the emerging approaches that have been developed for the generation of biomimetic nanoparticles rHDL to overcome the biological barriers to drug delivery, aiming to provide an alternative,promising avenue for efficient targeting transport of nanomedicine.

关键词： Biomimetic nanocarrier Reconstituted high-density lipoprotein Biological barriers Efficient targeting Nanodrug delivery systems

Role-based Bayesian decision framework for autonomous unmanned systems

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Journal of Systems Engineering and Electronics 2023年第6期34卷 1397-1408页

作者： PANG Weijian ma xinyi LIANG Xueming LIU Xiaogang DONG Erwa Beijing Aeronautical Engineering Research Center Beijing 100076China Academy of Military Sciences Beijing 100091China Air Forces Command College of PLA Beijing 100097China

In the process of performing a task,autonomous unmanned systems face the problem of scene changing,which requires the ability of real-time decision-making under dynamically changing ***,taking the unmanned system coordinative region control operation as an example,this paper combines knowledge representation with probabilistic decisionmaking and proposes a role-based Bayesian decision model for autonomous unmanned systems that integrates scene cognition and individual ***,according to utility value decision theory,the role-based utility value decision model is proposed to realize task coordination according to the preference of the role that individual is ***,multi-entity Bayesian network is introduced for situation assessment,by which scenes and their uncertainty related to the operation are semantically described,so that the unmanned systems can conduct situation awareness in a set of scenes with ***,the effectiveness of the proposed method is verified in a virtual task *** research has important reference value for realizing scene cognition,improving cooperative decision-making ability under dynamic scenes,and achieving swarm level autonomy of unmanned systems.

关键词： autonomous unmanned systems multi-entity Bayesian network(MEBN) situation awareness decision modeling.

Auxin regulation involved in gynoecium morphogenesis of papaya flowers

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Horticulture Research 2019年第1期6卷 237-247页

作者： Ping Zhou mahpara Fatima xinyi ma Juan Liu Ray Ming College of Life Sciences FAFU and UIUC Joint Center for Genomics and BiotechnologyFujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyFujian Agriculture and Forestry UniversityFuzhou 350002 FujianChina Fruit Research Institute Fujian Academy of Agricultural SciencesFuzhou 350013 FujianChina College of Agriculture Fujian Agriculture and Forestry UniversityFuzhou 350002 FujianChina Department of Plant Biology University of Illinois at Urbana-ChampaignUrbanaIL 61801USA

The morphogenesis of gynoecium is crucial for propagation and productivity of fruit *** trioecious papaya(Carica papaya),highly differentiated morphology of gynoecium in flowers of different sex types is controlled by gene networks and influenced by environmental factors,but the regulatory mechanism in gynoecium morphogenesis is *** and dioecious papaya varieties were used for analysis of differentially expressed genes followed by experiments using auxin and an auxin transporter *** first compared differential gene expression in functional and rudimentary gynoecium at early stage of their development and detected significant difference in phytohormone modulating and transduction processes,particularly *** auxin signal transduction in rudimentary gynoecium was *** determine the role auxin plays in the papaya gynoecium,auxin transport inhibitor(N-1-Naphthylphthalamic acid,NPA)and synthetic auxin analogs with different concentrations gradient were sprayed to the trunk apex of male and female plants of dioecious *** of auxin transport by 10 mg/L NPA treatment resulted in female fertility restoration in male flowers,while female flowers did not show *** treatment with higher concentration(30 and 50 mg/L)caused deformed flowers in both male and female *** hypothesize that the occurrence of rudimentary gynoecium patterning might associate with auxin homeostasis *** auxin concentration and auxin homeostasis might be crucial for functional gynoecium morphogenesis in papaya *** results will lead to further investigation on the auxin homeostasis and gynoecium morphogenesis in papaya.

关键词： papaya morphogenesis flowers

Ln-substituted polytungstates as efficient hetergeneous catalysts for Knoevenagel condensation reaction

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Chinese Chemical Letters 2023年第12期34卷 361-365页

作者： Baijie Xu Ruikun Zhao Zhen Jing xinyi ma Hui Zhao Pengtao ma Jingping Wang Jingyang Niu Henan Key Laboratory of Polyoxometalate Chemistry College of Chemistry and Chemical EngineeringHenan UniversityKaifeng 475004China

Three isomorphic polytungstates,CsgK_(18)H_(10){[Sm_(2)(H_(2)O)_(4)W_(4)O_(10)(AsW_(9)0_(33))3]_(2)(N(CH_(2)PO_(3))_(2))}:46.5H_(2)O(1),CS_(10)K_(9)H_(18){[Eu_(2)(H_(2)O)_(4)W_(4)O_(10)(AsW_(9)0_(33))_(3)]_(2)(N(CH_(2)PO_(3))_(2))}.41.5H_(2)O(2),Cs_(10)K_(9)H_(18){[Gd_(2)(H_(2)O)_(4)W_(4)O_(10)(AsW_(9)O_(33))_(3)]_(2)(N(CH_(2)PO_(3))_(2))}:46H_(2)O(_(3)),have been successfully synthesized and characterized by routine methods,and demonstrated excellent catalytic activities in Knoevenagel condensation reaction as heterogeneous ***,catalyst 1 achieved higher reaction activity than catalysts 2 and 3,where a satisfactory reaction yield(95%)and high TON value(6380)could be obtained at moderate reaction *** addition,in the scale-up experiment,with the help of catalyst 1,7.8g benzaldehyde and 5.7g ethyl cyanoacetate could transform into corresponding condensation product with a satisfactory yield(83%)and impressive TON value(13.883).

关键词： Polyoxometalates Polytungstates Lanthanide Lewis acid and base sites Knoevenagel condensation reaction

DNA methylome and transcriptome landscapes revealed differential characteristics of dioecious flowers in papaya

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Horticulture Research 2020年第1期7卷 1584-1598页

作者： Ping Zhou Xiaodan Zhang mahpara Fatima xinyi ma Hongkun Fang Hansong Yan Ray Ming College of Life Sciences FAFU and UIUC Joint Center for Genomics and BiotechnologyFujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyFujian Agriculture and Forestry University350002 FuzhouFujianChina Fruit Research Institute Fujian Academy of Agricultural Sciences350013 FuzhouFujianChina Department of Plant Biology University of Illinois at Urbana-ChampaignUrbanaIL 61801USA College of Agriculture Fujian Agriculture and Forestry University350002 FuzhouFujianChina

Separate sexes in dioecious plants display different morphology and physiological *** differences between the two sexes lie in their highly differentiated floral characteristics and in sex-related phenotype,which is genetically determined and epigenetically *** dioecious papaya(Carica papaya L.),global comparisons of epigenetic DNA methylation and gene expressions were still *** conducted bisulfite sequencing of early-stage flowers grown in three seasons(spring,summer and winter)and compared their methylome and transcriptome profiles to investigate the differential characteristics of male and female in *** variances between female and male papaya were conserved among three different ***,combined genome-scale transcriptomic evidence revealed that most methylation variances did not have influence on the expression profiles of neighboring genes,and the differentially expressed genes were most overrepresented in phytohormone signal transduction *** analyses showed diverse stress-responsive methylation alteration in male and female *** flower methylation was more responsive to stress whereas female flower methylation varied less under *** flowering of male papaya in spring might be associated with the variation in the transcription of CpSVP and CpAP1 coinciding with their gene-specific *** findings provide insights into the sex-specific DNA methylation and gene expression landscapes of dioecious papaya and a foundation to investigate the correlation between differentiated floral characteristics and their candidate genes.

关键词： papaya flowers landscape

Phosphorus incorporation-induced adsorption behavior modulation for carbon cathodes enables ultrastable and high-energy aqueous Zn-ion hybrid capacitors

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Science China Chemistry 2024年

作者： Lai Yu Xiaoyue He Rong Liu Guanglin Wan xinyi ma Anqiang Pan Liang Shi Genqiang Zhang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Material for Energy ConversionDepartment of Material Science and Engineering University of Science and Technology of China School of materials and Engineering Xinjiang University

The aqueous zinc ions hybrid capacitors(ZHCs) have great potential for future energy storage devices by their high safety and low cost merits, more importantly, it could combine the advantages of batteries and supercapacitors with high energy density and power output, respectively. However, the development of reliable cathodes is still a challenge with the unsatisfactory cycling stability and limited reaction kinetic, severely restricting its further commercial applications. Herein, we present phosphorus functionalized nitrogen-doped hierarchical porous carbon nanosheets(PN-HPCNS), where the P incorporation could effectively enhance the electronic transfer kinetics and ion adsorption capability to achieve superior zinc-ion storage properties. The asprepared PN-HPCNS cathode-based ZHC exhibits a high energy and power density(169.1 Wh kg–1/68 W kg–1, 15,840 W kg–1/30.8 Wh kg–1) and long cycling lifespans more than 20,000 cycles with 92.0% capacity retention. Systematic characterizations coupled with kinetics studies indicate that phosphorus modification is crucial to superior zinc ion storage, enabling PN-HPCNS with favorable reaction kinetics, promoting ion adsorption by providing more active sites. Moreover, the theoretical calculation reveals that the phosphorus modification could enhance the adsorption ability, contributing to the superior ZHCs performance of PN-HPCNS.

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Synthesis and catalytic oxidation of organosilanes of a novel ruthenium-decorating polyoxomolybdate: Cs3Na6H[MoⅥ14RuⅣ2O50(OH)2]·24H2O

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Synthesis and catalytic oxidation of organosilanes of a nove...

Constructing heterointerface of Bi/Bi_(2)S_(3)with built-in electric field realizes superior sodium-ion storage capability

河南省化学会2018年学术年会

作者： Jingkun Lu xinyi ma Jingping Wang Jingyang Niu Henan Key Laboratory of Polyoxometalate Chemistry Institute of Molecular and Crystal EngineeringCollege of Chemistry and Chemical EngineeringHenan University

The first example of wholly inorganic ruthenium-containing polyoxomolybdate CsNaH[MoRuO(OH)]·24HO(1)has been successfully prepared via a conventional aqueous *** compound was structurally characterized by element analysis,infrared spectroscopy(IR),thermogravimetric analyses(TGA),X-ray photoelectron spectroscopy(XPS),energy dispersive X-ray spectroscopy(EDX)and single-crystal X-ray *** 1 is composed of an unprecedented{Mo14}-type isopolymolybdate with a di-ruthenium core precisely encapsulated in its center,exhibiting a three-tiered ladder-like ***,catalytic activity study of 1 has been investigated the heterogeneous catalysis reaction for the selective oxidation of *** 1 results in 98.7%yield at 85°C using tert-butyl hydroperoxide(TBHP)as an *** effects of various reaction parameters on the oxidation reaction were also investigated in detail and it could be recycled for three consecutive runs.

关键词： Ruthenium Polyoxomolybdate Heterogeneous catalysis Oxidation Silanols

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eScience 2023年第4期3卷 99-109页

作者： Rong Liu Lai Yu Xiaoyue He Huanhuan Liu xinyi ma Zongzhi Tao Guanglin Wan Nazir Ahmad Bo Peng Liang Shi Genqiang Zhang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Materials for Energy ConversionDepartment of Materials Science and EngineeringUniversity of Science and Technology of ChinaHefeiAnhui230026China School of materials Science and Engineering Anhui University of TechnologyMaanshanAnhui243002China

Bismuth sulfide(Bi_(2)S_(3))is a dominant anode material for sodium-ion batteries due to its high theoretical ***,extreme volume fluctuations as well as low electrical conductivity and reaction kinetics still limit its practical ***,we construct an abundant heterointerface of Bi/Bi_(2)S_(3)by engineering the structure of Bi nanoparticles embedded on Bi_(2)S_(3)nanorods(denoted as Bi-Bi_(2)S_(3)NRs)to effectively solve the above-mentioned *** and systematic characterization results reveal that the constructed hetero-interface of Bi/Bi_(2)S_(3)has a built-in electric field,significantly boosts the electrical conductivity,enhances the Na^(+)diffusion kinetics,and buffers the volume *** this modification,it can deliver long cycling life,with an ultra-high capacity of 500 mah g^(-1)over 500 cycles at 1 A g^(-1),and outstanding rate capability,with a capacity of 456 mah g^(-1)even at 15 A g^(-1).Moreover,a full cell can achieve a high energy density of 180 Wh kg^(-1)at a power density of 40 W kg^(-1).Our research opens up a fresh path for improving the dynamics and structural stability of metal sulfide-based electrode materials for SIBs.

关键词： Sodium-ion battery Anode materials Heterointerface Built-in electric field Energy band structure

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三维超声辅助平面磨削力研究

金刚石与磨料磨具工程 2016年第5期36卷 69-74,78页

作者：马新毅焦作神华重型机械制造有限公司河南焦作454000

三维超声辅助磨削力的研究一直是超声加工领域的空白,本研究首先以三维超声辅助平面磨削力为研究对象,从宏观力学角度进行分析,建立了三维超声辅助平面磨削力的数学模型,并分析在不同磨削参数下磨削力的变化情况,最后进行了试验验证。... 详细信息

三维超声辅助磨削力的研究一直是超声加工领域的空白,本研究首先以三维超声辅助平面磨削力为研究对象,从宏观力学角度进行分析,建立了三维超声辅助平面磨削力的数学模型,并分析在不同磨削参数下磨削力的变化情况,最后进行了试验验证。研究结果表明:在一定条件下,三维超声辅助平面磨削下的磨削力小于二维超声辅助平面磨削力,约下降20%;随砂轮转速的增大,磨削力下降,且当砂轮转速大于3000r/min时,磨削力下降明显;随着进给速度与磨削深度的增加,磨削力增加明显;实验验证同模型分析一致。

关键词：磨削力超声辅助加工陶瓷材料三维超声