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Genes & Diseases 2024年第1期11卷 53-56页

作者： Ye Cheng Lei Zhang xiaolong Wu Hiroaki Wakimoto Haoming Geng Yukui Wei Geng Xu xinru xiao Jie Bai Yaming Wang Zeliang Hu Leiming Wang Qingtang Lian Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Brain Tumor Research Center Massachusetts General HospitalDepartment of NeurosurgeryHarvard Medical SchoolBostonMA02134USA Department of Pathology Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Gliomas originating from anatomically and developmentally distinct brain regions have different clinical ***,the molecular landscape underlying this difference remains *** analyzed key molecular mutations via sequencing and correlated them with clinical characteristics in 180 adult patients with gliomas originating from the neocortex,mesocortex,and *** of cerebellar origin had significantly longer survival than those of supratentorial origin,consistent with higher rates of mutation in key genes associated with supratentorial gliomas.

关键词： clinical cortex glioma

数字孪生何以破解黄河流域数字化治理的“碎片化”困境——基于整体性治理的运行框架

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学习论坛 2024年第1期 58-66页

作者：司林波萧欣茹西北大学公共管理学院陕西西安710127

当前,黄河流域数字化治理面临数据获取不全面、信息集成难度大、省级共享水平落后以及新旧技术间应用壁垒等“碎片化”困境。数字孪生黄河是以数字化的虚拟映射来模拟黄河全要素和时空全过程,具有高度还原性、即时同步性、闭环协同性以... 详细信息

当前,黄河流域数字化治理面临数据获取不全面、信息集成难度大、省级共享水平落后以及新旧技术间应用壁垒等“碎片化”困境。数字孪生黄河是以数字化的虚拟映射来模拟黄河全要素和时空全过程,具有高度还原性、即时同步性、闭环协同性以及优化革新性特征,可以有效破解黄河流域数字化治理的“碎片化”问题。基于整体性治理理论,结合数字孪生黄河整体性建设目标,从协同感知、集成整合、应用融合、反馈优化四个维度构建数字孪生黄河整体性建设运行框架,推动数字孪生黄河建设从加强整体规划、整合数据资源、完善全域智慧水利平台、推动技术更新与升级等方面采取因应之策。

关键词：数字技术数字孪生黄河数字化治理碎片化整体性治理

A2M在慢性阻塞性肺疾病中的表达及其与免疫细胞浸润的相关性

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南京医科大学学报（自然科学版） 2024年第1期44卷 1-11,59页

作者：肖心儒范亮施宇佳张倩南京医科大学附属常州市第二人民医院呼吸与危重症医学科江苏常州213003 南京医科大学常州医学中心江苏常州213003

目的:研究慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者外周血α2巨球蛋白(alpha 2 macroglobulin,A2M)与免疫细胞浸润的相关性。方法:对GSE38974数据集进行综合分析。GO富集、KEGG分析和GSVA分析用于探索潜在的... 详细信息

目的:研究慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者外周血α2巨球蛋白(alpha 2 macroglobulin,A2M)与免疫细胞浸润的相关性。方法:对GSE38974数据集进行综合分析。GO富集、KEGG分析和GSVA分析用于探索潜在的功能和通路。CIBERSORT用于评估组织浸润性免疫细胞。收集25例稳定期COPD患者和26例健康对照,分析外周血A2M水平与免疫细胞计数的相关性。ELISA检测血浆中A2M的浓度。RT-qPCR检测细胞和外周血中A2M mRNA的表达水平。Western blot法检测M2型巨噬细胞表面标志物精氨酸酶(arginase-1,Arg-1)的表达水平。采用Pearson相关分析进行相关性分析。ROC曲线判断A2M的诊断灵敏度与特异度。结果:对GSE38974数据集的差异表达基因进行生物信息学分析发现,A2M在COPD患者肺组织中表达下降,且与COPD患者肺组织的免疫细胞浸润相关。RT-qPCR和ELISA结果显示,A2M水平在COPD患者外周血中下调,与COPD患者淋巴细胞、单核细胞具有相关性。ROC曲线提示A2M具有诊断COPD的价值。进一步的通路分析提示A2M可能与巨噬细胞等调节免疫途径相关。在M2巨噬细胞中敲低A2M后Arg-1的表达降低。结论:A2M在COPD患者肺组织与外周血中表达降低,与COPD患者免疫细胞计数、免疫细胞浸润等密切相关,A2M可能在巨噬细胞向M2型极化的过程中发挥了重要作用。

关键词：慢性阻塞性肺疾病 α2巨球蛋白免疫细胞浸润

MicroRNA-21/PARP-1作为生物标志物在AR和CARAS中的诊断价值分析

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南京医科大学学报（自然科学版） 2024年第6期44卷 860-867页

作者：肖心儒丁紫琪刘志光毛正道张倩南京医科大学附属常州市第二人民医院呼吸与危重症医学科南京医科大学常州医学中心江苏常州213003

目的:评估外周血microRNA(miR)-21、血浆聚腺苷二磷酸核糖聚合酶1[poly(ADP-ribose)polymerase-1,PARP-1]在过敏性鼻炎(allergic rhinitis,AR)和过敏性鼻炎-哮喘综合征(combined allergic rhinitis and asthma syndrome,CARAS)中的诊断价值。方法:收集44例CARAS患者、31例AR患者和42例健康对照的外周血,采用RT-qPCR法检测外周血中miR-21的表达水平,采用ELISA法检测血浆中PARP-1蛋白水平。应用Pearson进行相关性分析。受试者工作特征(receiver operating characteristic,ROC)曲线判断miR-21和PARP-1的诊断灵敏度与特异度。结果:CARAS组患者外周血miR-21的表达较健康对照组升高。AR组患者血浆PARP-1的水平较CARAS组和健康对照组升高。Pearson相关性分析结果显示,外周血miR-21的表达水平在AR患者中与嗜酸性粒细胞计数相关,在CARAS患者中与鼻呼出气一氧化氮(fractional nasal nitric oxide,FnNO)水平相关;血浆PARP-1在AR患者中与1秒钟用力呼气量占预计值百分比(forced expiratory volume in onesecond percent predicted,FEV_(1)%_(pred))相关,在CARAS患者中与FEV_(1)%_(pred)及1秒钟用力呼气量(forced expiratory volume in one second,FEV_(1))/用力肺活量(forced vital capacity,FVC)(FEV_(1)/FVC)相关。ROC曲线分析显示,外周血miR-21作为CARAS的诊断标志物时,灵敏度为51.35%,特异度为80.95%。血浆PARP-1作为AR的诊断标志物时,灵敏度为90.32%,特异度为54.76%。血浆PARP-1作为AR进展为CARAS的诊断标志物时,灵敏度为45.45%,特异度为90.32%。结论:AR和CARAS患者外周血miR-21、PARP-1存在差异表达,外周血miR-21可作为CARAS的诊断标志物,PARP-1可作为AR的诊断标志物及AR进展为CARAS的生物标志物。这对寻求AR和CARAS的诊治靶点有十分重要的价值。

关键词：过敏性鼻炎-哮喘综合征 microRNA-21 PARP-1 生物标志物

Galectin 2 regulates JAK/STAT3 signaling activity to modulate oral squamous cell carcinoma proliferation and migration in vitro

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BIOCELL 2024年第5期48卷 793-801页

作者： xinru FENG LI xiao Medical School University of Electronic Science and Technology of ChinaChengdu610072China Department of Stomatology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu610072China

Background:Galectin 2(LGALS2)is a protein previously reported to serve as a mediator of disease progression in a range of *** function of LGALS2 in oral squamous cell carcinoma(OSCC),however,has yet to be explored,prompting the present study to address this literature ***:Overall,144 paired malignant tumor tissues and paracancerous OSCC patient samples were harvested and the LGALS2 expression levels were examined through qPCR and western *** LGALS2 coding sequence was introduced into the pcDNA3.0 vector,to enable the overexpression of this gene,while an LGALS2-specific shRNA and corresponding controls were also *** functionality of LGALS2 as a regulator of the ability of OSCC cells to grow and undergo apoptotic death in vitro was assessed through EdU uptake and CCK-8 assays,and flow cytometer,whereas a Transwell system was used to assess migratory activity and *** agonist of the Janus Kinase 2(JAK2)/Signal Transducer and Activator of Transcription 3(STAT3)pathway was also used to assess the role of this pathway in the context of LGALS2 ***:Here,we found that lower LGALS2 protein and mRNA expression were evident in OSCC tumor tissue samples,and these expression levels were associated with clinicopathological characteristics and patient survival *** LGALS2 enhanced proliferation in OSCC cells while rendering these cells better able to resist *** opposite was instead observed after LGALS2 was ***,the ability of LGALS2 to suppress the progression of OSCC was related to its ability to activate the JAK/STAT3 signaling ***:Those results suggest a role for LGALS2 as a suppressor of OSCC progression through its ability to modulate JAK/STAT3 signaling,supporting the potential utility of LGALS2 as a target for efforts aimed at treating OSCC patients.

关键词： LGALS2 Oral squamous cell carcinoma(OSCC) Janus Kinase 2/Signal Transducer and Activator of Transcription 3(JAK2-STAT3) Progression

Cognitive Navigation for Intelligent Mobile Robots:A Learning-Based Approach With Topological Memory Configuration

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1933-1943页

作者： Qiming Liu xinru Cui Zhe Liu Hesheng Wang Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China MoE Key Laboratory of Artificial Intelligence AI InstituteShanghai Jiao Tong UniversityShanghai 200240China Department of Automation Key Laboratory of System Control and Information Processing of Ministry of EducationKey Laboratory of Marine Intelligent Equipment and System of Ministry of EducationShanghai Engineering Research Center of Intelligent Control and ManagementShanghai Jiao Tong UniversityShanghai 200240China

Autonomous navigation for intelligent mobile robots has gained significant attention,with a focus on enabling robots to generate reliable policies based on maintenance of spatial *** this paper,we propose a learning-based visual navigation pipeline that uses topological maps as memory *** introduce a unique online topology construction approach that fuses odometry pose estimation and perceptual similarity *** tackles the issues of topological node redundancy and incorrect edge connections,which stem from the distribution gap between the spatial and perceptual ***,we propose a differentiable graph extraction structure,the topology multi-factor transformer(TMFT).This structure utilizes graph neural networks to integrate global memory and incorporates a multi-factor attention mechanism to underscore elements closely related to relevant target cues for policy *** from photorealistic simulations on image-goal navigation tasks highlight the superior navigation performance of our proposed pipeline compared to existing memory *** validation through behavior visualization,interpretability tests,and real-world deployment further underscore the adapt-ability and efficacy of our method.

关键词： Graph neural networks(GNNs) spatial memory topological map visual navigation

Eutectogel-based self-powered wearable sensor for health monitoring in harsh environments

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Nano Research 2024年第6期17卷 5559-5568页

作者： Junpeng Wu xinru Teng Lu Liu Hongzhi Cui xiaoyi Li College of Materials Science and Engineering Ocean University of ChinaQingdao 266100China Key Lab for Special Functional Materials of Ministry of Education School of Materials Science and EngineeringHenan UniversityKaifeng 475004China

Triboelectric nanogenerators(TENG)have emerged as a highly promising energy harvesting technology,attracting significant attention in recent years for their broad ***-based TENGs,with superior stretchability and sensitivity,have been widely reported as wearable ***,the traditional hydrogel-based TENGs suffer from freezing at low temperatures and drying at high temperatures,resulting in *** this study,we introduce an anti-freezing eutectogel,which uses a deep eutectic solvent(DES),to improve the stability and electrical conductivity of TENGs in harsh environmental *** eutectogel-based TENG(E-TENG)produces an open-circuit voltage of 776 V,a short-circuit current of 1.54μA,and a maximum peak power of 1.1 ***,the E-TENG exhibits exceptional mechanical properties with an elongation at a break of 476%under ***,it maintains impressive performances across a wide temperature range from−18 to 60℃,with conductivities of 2.15 S/m at−10℃and 1.75 S/m at−18℃.Based on the excellent weight stability of the E-TENG sensor,motion sensing can be achieved in the air,and even ***,the versatility of the E-TENG can serve as a wearable sensor,by integrating it with Bluetooth *** self-powered E-TENG can monitor various human motion signals in real-time and send the health signals directly to mobile *** research paves a new road for the applications of TENGs in harsh environments,offering wireless flexible sensors with real-time health signal monitoring capabilities.

关键词： triboelectric nanogenerators self-powered harsh environment health monitoring Eutectogel

Late Cenozoic uplift of the Liupan Mountains:Evidence from the Neogene loess deposits

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Science China Earth Sciences 2024年第5期67卷 1480-1488页

作者： Zhilin HE Yansong QIAO Zhengtang GUO Chaoqin CHEN Long CHEN Yang FU Ye YANG Yanxia LIANG xinru LIN Guoqiao xiao Tao ZHAN Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044China University of Chinese Academy of Sciences Beijing 100049China Institute of Ecological Geology Survey and Research of Heilongjiang Province Harbin 150030China School of Geography and Information Engineering China University of GeosciencesWuhan 430078China School of Earth Sciences China University of GeosciencesWuhan 430074China Natural Resources Survey Institute of Heilongjiang Province Harbin 150036China

The Liupan Mountains,one of the important mountain ranges in western China,are located on the boundary between the northeastern Tibetan Plateau and the Ordos *** uplift history of the Liupan Mountains remains *** deposits are good tracers of regional tectonic and geomorphic changes,because loess is sensitive to erosion and the formation and preservation of loess requires relatively flat highlands and relatively stable tectonic *** investigated the distribution of Neogene loess deposits on the western piedmont of the Liupan Mountains and examined a near-continuous loess section(Nanping section)on the piedmont alluvial *** of magnetic susceptibility stratigraphy with the QA-ⅠMiocene loess sequence dates this 56-m section covering the interval from~8.1 to 6.2 *** lower boundary age of this section,together with previously reported Zhuanglang red clay(sand-gravel layers with intercalated loess during~9–8 Ma and near-continuous loess during~8–4.8 Ma)and Chaona red clay(~8.1–2.58 Ma),indicates that the Liupan Mountains were uplifted in the late Miocene(~9–8 Ma)and basically formed by~8 Ma,attesting to no intense mountain building since that *** addition,based on the information from the Zhuanglang core and the QA-Ⅰsection,we infer that sizable parts of the Liupan Mountains were uplifted during the late Oligocene–early Miocene and did not experience intense uplift during~22–9 Ma.

关键词： Liupan Mountains Mountain building Neogene Loess Chinese Loess Plateau Late Miocene Late Oligocene–early Miocene

A Multi-Token Sector Antenna Neighbor Discovery Protocol for Directional Ad Hoc Networks

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China Communications 2024年第7期21卷 149-168页

作者： Zhang Hang Li Bo Yan Zhongjiang Yang Mao Li xinru School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710072China The 54th Research Institute of CETC Shijiazhuang 050081China

In this paper,we propose a Multi-token Sector Antenna Neighbor Discovery(M-SAND)protocol to enhance the efficiency of neighbor discovery in asynchronous directional ad hoc *** central concept of our work involves maintaining multiple tokens across the *** prevent mutual interference among multi-token holders,we introduce the time and space non-interference ***,we propose a master-slave strategy between *** the master token holder(MTH)performs the neighbor discovery,it decides which 1-hop neighbor is the next MTH and which 2-hop neighbors can be the new slave token holders(STHs).Using this approach,the MTH and multiple STHs can simultaneously discover their neighbors without causing interference with each *** on this foundation,we provide a comprehensive procedure for the M-SAND *** also conduct theoretical analyses on the maximum number of STHs and the lower bound of multi-token generation ***,simulation results demonstrate the time efficiency of the M-SAND *** compared to the QSAND protocol,which uses only one token,the total neighbor discovery time is reduced by 28% when 6beams and 112 nodes are employed.

关键词： multi-token neighbor discovery SAND protocol sector antenna ad hoc network

Trojan horses in tumor:engineered pyroelectric and photodynamic nanocomposites for NIR-induced cell apoptosis and tumor growth inhibition

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Science China Chemistry 2024年第9期67卷 3050-3062页

作者： Yanxi Yang xinru Kong Xueli Ren Yandai Lin Zhe Liu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjin 300072China

It is desirable but always challenging to develop a cutting-edge tumor treatment strategy with high therapeutic efficacy,lesiontargeted precision and mild *** to traditional treatment modalities,photodynamic therapy has been widely studied since the generation of reactive oxygen species(ROS)at cancerous lesions unprecedentedly offers a convenient approach for localized tumor ***,the consumption of oxygen for ROS production in a hypoxic tumor microenvironment has dramatically limited its feasibility and ***,the engineered nanocomposites of BTO@PDA-ICGHA with photodynamic and pyroelectric performances have been fabricated and applied to the photodynamic-pyroelectric dynamic *** continuing ROS production derived from intracellular oxygen(O_(2))and water(H_(2)O)by laser irradiation contributed to the superb tumor cell apoptosis and significant tumor growth ***,this study has validated a new concept by depositing the engineered nanocomposites at the tumor just like Trojan horses,facilitating ROS release as killers and exerting the NIR-induced cell apoptosis and tumor growth inhibition with high therapeutic efficiency and expectable translational perspectives.

关键词： nanocomposites pyroelectric effect photodynamic therapy cell apoptosis tumor growth inhibition

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