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白芍总苷与甲氨蝶呤联合应用对幼年特发性关节炎的治疗效果及安全性评估

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世界复合医学 2024年第4期10卷 83-86页

作者：杭守伟徐达良沈杨何孝亮陈登环高雨彤王欣荣李娜陈定赟安徽省儿童医院儿童风湿科安徽合肥230041

目的评估白芍总苷与甲氨蝶呤联合应用治疗幼年特发性关节炎(juvenile idiopathic arthritis,JIA)的疗效及安全性。方法回顾性选取2021年10月—2023年12月在安徽省儿童医院就诊的88例JIA患儿的临床资料,以不同治疗方式分为两组,每组44... 详细信息

目的评估白芍总苷与甲氨蝶呤联合应用治疗幼年特发性关节炎(juvenile idiopathic arthritis,JIA)的疗效及安全性。方法回顾性选取2021年10月—2023年12月在安徽省儿童医院就诊的88例JIA患儿的临床资料,以不同治疗方式分为两组,每组44例。对照组采用甲氨蝶呤治疗,联合组采用白芍总苷与甲氨蝶呤联合治疗。对比两组的治疗效果。结果治疗后,联合组治疗总有效率(95.45%)高于对照组(79.54%),差异有统计学意义(χ^(2)=5.091,P<0.05)。治疗后,联合组炎症因子水平低于对照组,差异有统计学意义(P均<0.05)。联合组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论白芍总苷与甲氨蝶呤联合应用治疗JIA显示出优越的疗效和较好的安全性,能更有效地降低炎症因子水平,减少不良反应的发生。

关键词：幼年特发性关节炎白芍总苷甲氨蝶呤治疗效果安全性评估

基于工作过程的“机械图样识读与绘制”学习领域课程开发与设计

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图学学报 2013年第2期34卷 141-147页

作者：王新荣张家界航空工业职业技术学院湖南张家界427000

基于工作过程教学模式成为目前适应高职教育的有效模式。以机械设计与制造专业基础课程"机械制图"与"计算机辅助设计与绘图"的整合为例,探讨对该课程学科体系下的知识解构和基于工作过程导向重组,开发与设计、基于工作过程的"机械图样... 详细信息

基于工作过程教学模式成为目前适应高职教育的有效模式。以机械设计与制造专业基础课程"机械制图"与"计算机辅助设计与绘图"的整合为例,探讨对该课程学科体系下的知识解构和基于工作过程导向重组,开发与设计、基于工作过程的"机械图样识读与绘制"学习领域课程,使课程学习内容与工作内容良好对接,实现上岗工作"零适应期"。

关键词：工程制图领域课程学习基于工作过程课程开发与设计

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厦门会议产业综合竞争力的评价研究

科技管理研究 2013年第13期33卷 214-218页

作者：王欣荣集美大学诚毅学院福建厦门361021

会议产业作为新兴的第三产业,属于朝阳产业,为社会各界关注。通过运用波特钻石理论模型,对厦门会议产业竞争力的影响因素进行分析,并运用层次分析法对各影响因素进行评价,旨在正确评价会议产业的价值,找到提升厦门会议产业综合竞争力的... 详细信息

会议产业作为新兴的第三产业,属于朝阳产业,为社会各界关注。通过运用波特钻石理论模型,对厦门会议产业竞争力的影响因素进行分析,并运用层次分析法对各影响因素进行评价,旨在正确评价会议产业的价值,找到提升厦门会议产业综合竞争力的途径。

关键词：会议产业竞争力钻石模型层次分析法

P2X7受体在乳腺浸润性导管癌中的表达水平及临床意义

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肿瘤 2021年第2期41卷 100-109页

作者：王鑫蓉王哲杨向红中国医科大学附属盛京医院病理科辽宁沈阳110000

目的:检测P2X7受体(P2X7 purinergic receptor,P2X7R)在乳腺浸润性导管癌中的表达水平,并探讨其表达水平与乳腺浸润性导管癌患者临床病理参数及预后的关系。方法:采用免疫组织化学法检测P2X7R在170例乳腺浸润性导管癌、50例乳腺导管原... 详细信息

目的:检测P2X7受体(P2X7 purinergic receptor,P2X7R)在乳腺浸润性导管癌中的表达水平,并探讨其表达水平与乳腺浸润性导管癌患者临床病理参数及预后的关系。方法:采用免疫组织化学法检测P2X7R在170例乳腺浸润性导管癌、50例乳腺导管原位癌和34例乳腺癌旁正常组织中的表达水平。采用χ~2检验分析P2X7R表达与乳腺癌患者临床病理指参数的关系,并用Kaplan-Meier法和COX风险回归模型分析P2X7R表达水平与患者预后的相关性。结果:P2X7R在浸润性导管癌和导管原位癌组织中均高表达,且明显高于乳腺癌旁正常组织(P<0.01);P2X7R表达水平与患者淋巴结转移(P=0.039)、TNM分期(P=0.045)、雌激素受体(estrogen receptor,ER)(P=0.024)和孕激素受体(progesterone receptor,PR)(P=0.033)的表达水平存在相关性,且P2X7R在淋巴结转移患者、TNMⅢ期患者、ER阳性患者和PR阳性患者中高表达率更高。P2X7R与患者年龄、肿瘤大小、组织学分级、人类表皮生长因子受体2(human epidermal growth factor receptor-2,HER-2)、p53和Ki-67无相关性。P2X7R高表达乳腺浸润性导管癌患者的无病生存(disease-free survival,DFS)时间较低表达者短(P=0.013)。单因素分析结果显示,乳腺浸润性导管癌患者的DFS与肿瘤大小(P=0.002)、淋巴结转移(P=0.009)、TNM分期(P<0.001)、Ki-67(P=0.026)和P2X7R(P=0.013)相关;多因素分析结果显示,TNM分期(P=0.033)和P2X7R(P=0.043)是影响乳腺浸润性导管癌患者DFS的独立危险因素。结论:P2X7R在乳腺癌中高表达,并且P2X7R高表达的乳腺癌患者预后更差,提示其可以作为一种乳腺癌的潜在预后标志物。

关键词：乳腺肿瘤受体,嘌呤能P2X7 免疫组织化学预后

Alternating current heating techniques for lithium-ion batteries in electric vehicles:Recent advances and perspectives

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Journal of Energy Chemistry 2024年第9期96卷 679-697页

作者： xinrong Huang Jinhao Meng Wei Jiang Wenjie Liu Kailong Liu Yipu Zhang Daniel-Ioan Stroe Remus Teodorescu School of Energy and Electrical Engineering Chang’an UniversityXi’an 710018ShaanxiChina School of Electrical Engineering Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina School of Highway Chang’an UniversityXi’an 710018ShaanxiChina School of Automation Northwestern Polytechnical UniversityXi’an 710072ShaanxiChina School of Control Science and Engineering Shandong UniversityJinan 250100ShandongChina Department of Energy Aalborg UniversityAalborg 9220Denmark

The significant decrease in battery performance at low temperatures is one of the critical challenges that electric vehicles(EVs)face,thereby affecting the penetration rate in cold *** current(AC)heating has attracted widespread attention due to its low energy consumption and uniform heating *** paper introduces the recent advances in AC heating from the perspective of practical EV ***,the performance degradation of EVs in low-temperature environments is introduced *** concept of AC heating and its research methods are ***,the effects of various AC heating methods on battery heating performance are *** on existing studies,the main factors that affect AC heating performance are ***,various heating circuits based on EVs are categorized,and their cost,size,complexity,efficiency,reliability,and heating rate are elaborated and *** evolution of AC heaters is presented,and the heaters used in brand vehicles are sorted ***,the perspectives and challenges of AC heating are *** paper can guide the selection of heater implementation methods and the optimization of heating effects for future EV applications.

关键词： Lithium-ion battery Low temperature Alternating current heating Heater Electric vehicle

Topological pseudospin switcher:Mechanism and acoustic realization

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 46-53页

作者： Jia-He Chen Yiyin Chen Yaoqieyu Song Yongxu Xu xinrong Li Jingsong wang Jiawei He Jiaxu Qu Zheng Li Xiaofei Li Wenqiang Lin Jiannan Chen Caixing Fu Zhi Hong Hang School of Physical Science and Technology&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhou 215006China Institute for Advanced Study Soochow UniversitySuzhou 215006China Provincial Key Lab of Thin Films Soochow UniversitySuzhou 215006China

The control of the pseudospin of sound wave has attracted increasing attention in recent *** the finite-size effect of topological acoustics,we successfully construct an H-shaped acoustic topological pseudospin switcher that sound wave energy can be easily switched through different *** interesting phenomenon of pseudospin flipping is numerically and experimentally demonstrated.A quantitative interference theory is proposed that the constructive and destructive interference of pseudospin states leads to pseudospin flipping and preserving in multiple *** verify the key parameters of the design,including the length of the passage and its interface state dispersion,and the theory can be extended to other topology acoustics and photonics ***,the tunable topological sonic crystal we use provides adjustable convenience to pseudospin switcher *** pseudospin switching behavior offers an efficient method to control the acoustic topological edge state transport,which has great potential in versatile applications,such as integrated acoustics,acoustic security,and information processing.

关键词： topological acoustics realization

Changes of grain size from peat profile in eastern mountainous area over past 2000 years,Jilin Province,Northeast China

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Global Geology 2024年第3期27卷 132-144页

作者： ZHANG xinrong wang Jiayu PING Shuaifei LI Yaran College of Earth Sciences Jilin UniversityChangchun 130061China Key Laboratory of Mineral Resources Evaluation in Northeast Asia Ministry of Natural ResourcesJilin UniversityChangchun 130061China Key Laboratory for Oil Shale and Coexisting Minerals Jilin UniversityChangchun 130061China Standing Committee of the People's Congress of Ninghe District Tianjin CityTianjin 301574China

Plenty of high-resolution paleoclimate investigations of the last thousand years were carried out to potentially predict future climate *** ombrotrophic peatland is one of the best recorders for high-resolution paleoclimate studies in the forest *** size analysis was carried out on ombrotrophic peat profile in the eastern mountainous region of Jilin Province,Northeast *** peat profile lasts the past 2000 a by four radiocarbon(AMS14C)*** results showed that the inorganic minerals in the peat profile are mainly silt,with some contribution from clay and a minor amount of sand,which are mainly due to wind dust and suspended *** paleoclimate stages are found in this peat profile by phytolith analysis,peat cellulose isotope research and historical documents:ca.45–1550 AD,relatively cold period;ca.1550 AD–present,relatively warm *** finding is important for the initial study of paleoclimatic changes over the last 2000 a in the mountainous area of eastern mountainous area,Jilin Province,Northeast China.

关键词： peat sediments grain size analysis paleoclimate

Changes of grain size from peat profile in eastern mountainous area over past 2000 years, Jilin Province, NE China

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Global Geology 2024年

作者： Zhang xinrong wang Jiayu Ping Shuaifei Li Yaran College of Earth Science Jilin University Key-Laboratory for Oil Shale and Coexisting Minerals Jilin University Ninghe District of Banqiao Town People's Government Key Laboratory of Mineral Resources Evaluation in Northeast Asia Ministry of Natural Resources

Plenty of high-resolution paleoclimate investigations of the last thousand years were carried out to potentially predict future climate changes. Mountainous ombrotrophic peatland is one of the best recorders for high-resolution paleoclimate studies in the forest area. Grain size analysis was carried out on ombrotrophic peat profile in the eastern mountainous region of Jilin Province, NE China. The peat profile lasts the past 2 000 a by four radiocarbon (AMS 14C) ages. The results showed that the inorganic minerals in the peat profile are mainly silt, with some contribution from clay and a minor amount of sand, which are mainly due to wind dust and suspended transportation. Two paleoclimate stages are found in this peat profile by phytolith analysis, peat cellulose isotope research and historical documents,ca. 45–1550 AD., a relative cold period; ca. 1550 AD-present, warm. This finding is important for the initialstudyofpaleoclimaticchangesoverthelast2000ainthemountainousareaofeatern mountainous area, Jilin Province, NE China.

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Forcing mechanism of the Pleistocene east Asian monsoon variations in a phase perspective

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Science China Earth Sciences 2005年第10期48卷 1708-1717页

作者： TIAN Jun1,2, wang Pinxian1, CHENG xinrong1, wang Rujian1 & SUN Xiangjun1,3 1. State Key Laboratory of Marine Geology, Tongji University, Shanghai 200092, China 2. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 3. Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China Tongji University Chinese Academy of Sciences

The deep sea records from the ODP Sites 1143 and 1144 in the northern and southern South China Sea (SCS), including foraminiferal δ 18O and δ 13C, Opal% and pollen percentage, reveal that the variations of the east Asian monsoon have been closely correlated with the variations of the Earth’s orbital parameters (eccentricity, obliquity and precession) and the global ice volume on orbital scale. All the monsoonal proxies show strong 100 ka, 41 ka and 23 ka cycles. Although G. ruber δ 13C of Site 1143 is coherent with the ETP (ETP= normalized (eccentricity + obliquity-precession) at eccentricity, obliquity and precession bands, most of the coherent relationship focuses on the precession band, and the other monsoonal proxies are coherent with the ETP only at the precession band, which indicate that precession dominates the Pleistocene tropical climate changes. The phase relationship of the monsoonal proxies with the foraminiferal δ 18O implies that the global ice volume changes have played a significant role in modulating the east Asian monsoon climate, at least dominating the winter monsoon. This forcing mechanism of the east Asian monsoon is apparently different from that of the Indian ocean mon-soon. The variations of the east Asian monsoon at the precession band, at least that of the winter monsoon, have been controlled not only by the sensible heating but also by the latent heating of the surface water in the South China Sea.

关键词： South China Sea, ODP, east Asian monsoon, orbital forcing, global ice volume.