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黄连温胆汤研究热点和前沿可视化分析

中国中医药信息杂志 2023年第3期30卷 20-24页

作者：朱爽刘文娜李新龙赵欣然吕行张瑜北京中医药大学东方医院北京100078 北京中医药大学东直门医院北京100700

目的梳理黄连温胆汤方剂研究现状及热点,为后续研究提供思路和参考。方法计算机检索中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、中国生物医学文献数据库(CBM)建库至2021年12月31日发表的黄连温... 详细信息

目的梳理黄连温胆汤方剂研究现状及热点,为后续研究提供思路和参考。方法计算机检索中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、中国生物医学文献数据库(CBM)建库至2021年12月31日发表的黄连温胆汤相关文献。提取文献发表时间、作者、作者单位及关键词等信息,并对作者单位、关键词进行预处理,采用VOSviewer软件进行关键词共现研究、聚类分析,构建关键词时间叠加网络。结果初检得到文献4323篇,经筛选,最终纳入1664篇。涉及2665位作者,来自黑龙江中医药大学、南京中医药大学、河南中医药大学等864家研究机构;纳入文献包含关键词1226个,共出现5242次,研究涉及3个主要临床研究方向:神经-精神系统疾病(失眠、抑郁)、消化系统疾病(慢性胃炎、胆汁反流)、循环代谢系统疾病(高血压病、2型糖尿病、代谢综合征、冠心病),涉及1个主要基础研究方向:经验传承(名医经验、医案研究)。研究前沿包括高血压病、半夏白术天麻汤、高脂血症、网络药理学、信号通路、同型半胱氨酸等方面。结论黄连温胆汤的研究集中于神经-精神系统、消化系统、循环代谢系统等内科疾病临床研究和名医经验传承方面,其中循环代谢疾病是近年研究热点。网络药理学、信号通路等方面可能成为黄连温胆汤方剂研究新热点。

关键词：黄连温胆汤研究热点可视化 VOSviewer 文献计量学

Improving acarbose production and eliminating the by-product component C with an efficient genetic manipulation system of Actinoplanes ***50/110

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Synthetic and Systems Biotechnology 2017年第4期2卷 302-309页

作者： Qinqin zhao Huixin Xie Yao Peng xinran Wang Linquan Bai State Key Laboratory of Microbial Metabolism School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China

Theα-glucosidase inhibitor acarbose is commercially produced by Actinoplanes *** used as a potent drug in the treatment of type-2 *** order to improve the yield of acarbose,an efficient genetic manipulation system for Actinoplanes *** *** conjugation system between *** carryingØC31-derived integrative plasmids and the mycelia of Actinoplanes ***50/110 was optimized by adjusting the parameters of incubation time of mixed culture(mycelia and ***),quantity of recipient cells,donor-to-recipient ratio and the concentration of MgCl2,which resulted in a high conjugation efficiency of 29.4%.Using this integrative system,a cloned acarbose biosynthetic gene cluster was introduced into SE50/110,resulting in a 35%increase of acarbose titer from 2.35 to 3.18 g/***,a pIJ101-derived replicating plasmid combined with the counter-selection system CodA(sm)was constructed for gene inactivation,which has a conjugation frequency as high as 0.52%.Meanwhile,almost all 5-flucytosine-resistant colonies were sensitive to apramycin,among which 75%harbored the successful deletion of targeted *** this replicating vector,the maltooligosyltrehalose synthase gene treY responsible for the accumulation of component C was inactivated,and component C was eliminated as detected by *** on an efficient genetic manipulation system,improved acarbose production and the elimination of component C in our work paved a way for future rational engineering of the acarbose-producing strains.

关键词： Actinoplanes sp. Acarbose Genetic manipulation Conjugation Component C

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某市放射工作人员外周血淋巴细胞微核率

中华劳动卫生职业病杂志 2018年第7期36卷 527-529页

作者：郝建秀王彦徐畅李旭光王晓光赵欣然于程程江波刘强中国医学科学院北京协和医学院放射医学研究所、天津市放射医学与分子核医学重点实验室天津300192

目的对长期接触低剂量电离辐射的放射工作人员进行淋巴细胞微核率检测，评价放射工作人员的健康状况，为加强对放射工作人员的健康监护提供依据。方法2013年1月1日至2016年12月21日，对4年间在中国医学科学院放射医学研究所进行职工健... 详细信息

目的对长期接触低剂量电离辐射的放射工作人员进行淋巴细胞微核率检测，评价放射工作人员的健康状况，为加强对放射工作人员的健康监护提供依据。方法2013年1月1日至2016年12月21日，对4年间在中国医学科学院放射医学研究所进行职工健康检查的5901名放射工作人员，其外周血淋巴细胞微核率进行统计分析和评价。结果与岗前组相比较岗中组微核率均高，差异有统计学意义（P〈0．01）；不同性别（t=5．97）、不同工种（Х2=378．69）、不同级别工作单位（Х2=115．48），微核率差异有统计学意义（P〈0．01）。将岗中组中672名放射工作人员2013～2016年的微核结果进行分析（Х2=92．57），差异有统计学意义（P〈0．01）。放射工作人员微核率明显高于非接触人员，其中从事介入治疗的放射工作人员其微核率最高。不同虽然医院比较，民营医院放射工作人员微核率最高，随着工龄的增加微核率呈上升趋势。结论放射工作人员微核率明显高于非接触人员，并且随着工龄微核率呈上升趋势。其中从事介入治疗的放射工作人员微核率最高。此现象需引起重视，需加强防护以保障放射工作人员的健康。

关键词：电离辐射微核率放射工作人员

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羊水过少的中医辨证论治

中国医药导报 2012年第7期9卷 101-102页

作者：曾倩张红霞崔潇华赵新然孙敬之孙秋玲河北省沧州中西医结合医院河北沧州061000

羊水过少是对围生期结局有重要影响,而目前西医治疗方法局限的产科疾病。已有不少中医治疗羊水过少的临床研究见诸报道,但有关本病的中医理论与临床尚不系统、不完善。本文就羊水过少的病因病机及辨证论治作一初步探讨。

关键词：羊水过少中医辨证论治

Defining newly formed and tissue-resident bone marrow-derived macrophages in adult mice based on lysozyme expression

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Cellular & Molecular Immunology 2022年第12期19卷 1333-1346页

作者： Tong Lei Jiayu Zhang Qian Zhang xinran Ma Yanan Xu Yang zhao Lianfeng Zhang Zhongbing Lu Yong zhao State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina College of Life Science University of Chinese Academy of SciencesBeijingChina Cunji Medical School University of Chinese Academy of SciencesBeijingChina Key Laboratory of Human Diseases Comparative Medicine Ministry of HealthInstitute of Laboratory Animal ScienceChinese Academy of Medical SciencesPeking Union Medical CollegeBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

Tissue-resident macrophages are derived from different precursor cells and display different *** of the tissue-resident macrophages of inflamed or damaged tissues in adults can be achieved by bone marrow-derived monocytes/*** lysozyme(Lysm)-GFP-reporter mice,we found that alveolar macrophages(AMs),Kupffer cells,red pulp macrophages(RpMacs),and kidney-resident macrophages were Lysm-GFP^(−),whereas all monocytes in the fetal liver,adult bone marrow,and blood were Lysm-GFP^(+).Donor-derived Lysm-GFP^(+)resident macrophages gradually became Lysm-GFP−in recipients and developed gene expression profiles characteristic of tissue-resident ***,Lysm may be used to distinguish newly formed and long-term surviving tissue-resident macrophages that were derived from bone marrow precursor cells in adult mice under pathological ***,we found that Irf4 might be essential for resident macrophage differentiation in all tissues,while cytokine and receptor pathways,mTOR signaling pathways,and fatty acid metabolic processes predominantly regulated the differentiation of RpMacs,Kupffer cells,and kidney macrophages,*** in ST2,mechanistic target of rapamycin(mTOR)and fatty acid-binding protein 5(FABP5)differentially impaired the differentiation of tissue-resident macrophages from bone marrow-derived monocytes/macrophages in the lungs,liver,and *** results indicate that a combination of shared and unique signaling pathways coordinately shape tissue-resident macrophage differentiation in various tissues.

关键词： Tissue-resident macrophages Kupffer cells Lysozyme Inflammation Metabolism Cytokine

Detection and recognition of veterinary drug residues in beef using hyperspectral discrete wavelet transform and deep learning

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International Journal of Agricultural and Biological Engineering 2022年第1期15卷 224-232页

作者： Rongchang Jiang Jingxin Shen xinran Li Rui Gao Qinghe zhao Zhongbin Su College of Electrical and Information Northeast Agricultural UniversityHarbin 150030China Shandong Academy of Agricultural Machinery Sciences Jinan 250100China Harbin Big Data Center Harbin 150030China

A fast,non-destructive recognition method for veterinary drug residues in beef was proposed to mitigate the laborious sample preparation and long detection times associated with conventional chemical detection *** beef samples free of veterinary drug residues and four groups of beef sprayed with relevant concentrations of metronidazole,ofloxacin,salbutamol,and dexamethasone under ambient conditions were analyzed by 400-1000 nm hyperspectral imaging followed by multiplicative scatter correction *** dimension reduction was performed using Competitive Adaptive Reweighted Sampling(CARS),Principal Component Analysis(PCA),and Discrete Wavelet Transform(DWT)based on Haar,db3,bior1.5,sym5,and rbio1.3 wavelet basis *** data were subjected to Convolutional Neural Network(CNN),Multilayer Perceptron(MLP),Random Forest(RF),and Support Vector Machine(SVM)***,MLP,SVM,and RF algorithms achieved overall accuracies of 91.6%,88.6%,87.6%,and 86.2%,respectively,when combined with DWT(wavelet basis functions and numbers of transform layers being Haar-4,db3-2,bior1.5-4,and sym5-3,respectively).The algorithm Kappa coefficients(0.89,0.86,0.85,and 0.83,respectively)and time consumption for prediction(140.60 ms,57.85 ms,70.67 ms,and 87.16 ms,respectively)were also superior to models based on CARS and *** combined with deep learning can shorten prediction times,considerably improve the accuracy of classification and recognition,and alleviate the Hughes phenomenon,thus providing a new method for the fast,non-destructive detection and recognition of veterinary drug residues in beef.

关键词： hyperspectral beef veterinary drug residues discrete wavelet transform convolutional neural network deep learning

Activating sulfur oxidation reaction via six-electron redox mesocrystal NiS2 for sulfur-based aqueous batteries

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National Science Review 2023年第6期10卷 64-74页

作者： Zhoudong Yang Boya Wang Yongjin Chen Wanhai Zhou Hongpeng Li Ruizheng zhao xinran Li Tengsheng Zhang Fanxing Bu Zaiwang zhao Wei Li Dongliang Chao Dongyuan zhao Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials College of Chemistry and Materials Fudan University Center for High Pressure Science and Technology Advanced Research

Sulfur-based aqueous batteries(SABs) are deemed promising candidates for safe,low-cost,and high-capacity energy ***,despite their high theoretical capacity,achieving high reversible value remains a great challenge due to the thermodynamic and kinetics problems of elemental ***,the reversible six-electron redox electrochemistry is constructed by activating the sulfur oxidation reaction(SOR) process of the elaborate mesocrystal NiS2(M-NiS2).Through the unique 6e-solid-to-solid conversion mechanism,SOR efficiency can reach an unprecedented degree of ca.96.0%.The SOR efficiency is further reve aled to be closely associated with the kinetics feasibility and thermodynamic stability of the M-NiS2intermedium in the formation of elemental *** from the boosted SOR,compared with the bulk electrode, the M-NiS2electrode exhibits a high reversible capacity(1258 mAh g-1),ultrafast reaction kinetics(932 mAh g-1at 12 A g-1),and long-term cyclability(2000 cycles at 20 A g-1).As a proof of concept,a new M-NiS2‖ Zn hybrid aqueous battery exhibits an output voltage of 1.60 V and an energy density of 722.4 Wh kgcath-1,which opens a new opportunity for the development of high-energy aqueous batteries.

关键词： sulfur-based aqueous battery mesocrystal material sulfur oxidation reaction high-energy aqueous battery six-electron redox

基于分形结构的天线设计及天线-芯片一体化射频组件制造工艺

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电子与封装 2023年第8期23卷 77-86页

作者：王刚赵心然尹宇航夏晨辉周超杰袁渊王成迁中科芯集成电路有限公司江苏无锡214072

实现了一种基于分形结构的天线-芯片一体化射频组件的设计与制造,设计了基于4阶Hilbert曲线的分形电感和基于2阶Sierpinski三角形的天线结构,有效提高了集成模组中的空间利用率,实现了电子器件的小型化。天线结构可以通过馈电位置的变... 详细信息

实现了一种基于分形结构的天线-芯片一体化射频组件的设计与制造,设计了基于4阶Hilbert曲线的分形电感和基于2阶Sierpinski三角形的天线结构,有效提高了集成模组中的空间利用率,实现了电子器件的小型化。天线结构可以通过馈电位置的变化实现辐射频点可调,最多可实现36GHz、50GHz、70.6GHz3个辐射频点,有助于实现灵活的应用场景。各辐射频点上的回波损耗大于25dB,最大辐射方向增益为11.93dB。为了实现分形天线和射频芯片的一体化集成,设计和实现了天线-芯片一体化射频组件架构与12英寸晶圆级嵌入式基板工艺。与现有的射频组件集成工艺相比,利用光刻工艺实现了天线-芯片垂直高密度互连,同时改善了系统的射频性能。

关键词：分形结构天线封装一体化有机基板再布线晶圆级封装

YAP抑制剂Verteporfin对食管癌细胞存活和同质黏附能力的影响

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生命的化学 2023年第2期43卷 296-302页

作者：王秀丽李婷杨子怡李鑫婷赵蓉赵欣冉杨佳程李晓钟王晓霞山西医科大学生物化学与分子生物学教研室晋中030600 山西省人民医院感染科太原030012

为探讨Yes相关蛋白(Yes-associated protein,YAP)抑制剂Verteporfin(VP)对食管癌细胞存活和同质黏附(即细胞间黏附)能力的影响,采用噻唑蓝(thiazolyl blue tetrazolium bromide,MTT)比色法检测了不同浓度的VP对食管癌细胞KYSE150和KYSE30存活率的影响。利用细胞聚集实验、细胞分离实验检测了VP处理后对KYSE150和KYSE30细胞同质黏附能力的影响。MTT比色法实验结果显示,VP对食管癌细胞生存有抑制作用,且抑制作用随药物浓度增大而增强;细胞聚集实验和细胞分离实验结果显示,与未经药物处理的细胞相比,VP处理后的细胞聚集的团块数量较少、体积较大、细胞的分离程度小,且浓度越大越显著。以上结果提示,细胞同质黏附能力显著增强,且呈浓度依赖性。VP能抑制食管癌细胞存活,增强食管癌细胞同质黏附能力,为VP可能成为治疗食管癌的新型药物奠定了理论基础。

关键词： Yes相关蛋白抑制剂 Verteporfin 同质黏附能力食管癌

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