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Rice Chitin Receptor OsCEBiP Is Not a Transmembrane Protein but Targets the Plasma Membrane via a GPI Anchor

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Molecular Plant 2017年第5期10卷 767-770页

作者： Gong, Ben-Qiang Xue, Jiao Zhang, Nannan Xu, Lahong yao, xinran Yang, Qiu-Jiao Yu, Yang Wang, Hong-Bin Zhang, Dandan Li, Jian-Feng Sun Yat Sen Univ Sch Life Sci State Key Lab Biocontrol Guangzhou 510275 Guangdong Peoples R China Sun Yat Sen Univ Sch Life Sci Guangdong Prov Key Lab Plant Resources Guangzhou 510275 Guangdong Peoples R China

Dear Editor,Plants are sessile organisms that are constantly challenged by microbial pathogens from the habitat. The key for plants to survive is to perceive pathogens in a timely and precise manner and subsequently l... 详细信息

关键词： Rice Chitin Receptor OsCEBiP Transmembrane Protein

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数据驱动的风电场全工况非线性调频动态建模

电力系统自动化 2023年第15期47卷 162-169页

作者：胡阳姚欣然房方宋子秋郭强刘吉臻电站能量传递转化与系统教育部重点实验室(华北电力大学) 北京市102206 华北电力大学控制与计算机工程学院北京市102206 国网山西省电力公司电力科学研究院山西省太原市030001

当前风电场级并网调频面临较大挑战。为降低建模复杂度,采用风电场并网点实际运行数据,提出了风电场出力范围内全工况一次调频特性时域差分动态建模方法。首先,进行机理分析并确定输入输出变量,完成数据采样和处理。然后,提出离散工况... 详细信息

当前风电场级并网调频面临较大挑战。为降低建模复杂度,采用风电场并网点实际运行数据,提出了风电场出力范围内全工况一次调频特性时域差分动态建模方法。首先,进行机理分析并确定输入输出变量,完成数据采样和处理。然后,提出离散工况抽样和非线性评估方法,建立了单工况子空间模型,并进行间隙测度评估全工况调频响应动态非线性度。此后,为高效逼近全工况复杂非线性调频特性,构建混杂有限差分回归向量,并对其张成的差分动态空间进行凸划分,在各子工作域均匀选取建模样本并采用带注意力机制的长短期记忆神经网络进行全工况建模。最后,经过某风电场并网点调频运行数据进行验证,表明所提出的全工况有限差分动态建模方法具有任意精度逼近能力,可有效表征风电场一次调频复杂非线性响应特性。

关键词：风电场一次调频有限差分域划分神经网络子空间辨识间隙测度

Active switching multiple model method for tracking a noncooperative gliding flight vehicle

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Science China(Information Sciences) 2020年第9期63卷 156-174页

作者： Tianyu ZHENG Yu yao Fenghua HE Denggao JI xinran ZHANG School of Astronautics Harbin Institute of Technology Beijing Institute of Nearspace Vehicle's Systems Engineering

The study investigates the trajectory estimation problem of a noncooperative gliding flight vehicle with complex and atypical maneuvers. An active switching multiple model(ASMM) method is *** method employs a motion behavior model set(MBMS), a motion behavior recognition algorithm, and an active switching estimation and fusion algorithm. First, a recognizable MBMS, which can capture all the motion behaviors of a gliding flight vehicle, is established. Then, a motion behavior recognition algorithm based on recurrent neural networks(RNNs) is developed to obtain the current probability of each motion behavior. Then, an active switching estimation and fusion algorithm is proposed, in which the adopted models are actively chosen at each time instant according to a model selection strategy. Last, the proposed ASMM method is applied to a noncooperative gliding flight vehicle. The simulation results show that the proposed method has higher estimation precision and better dynamic performance.

关键词： gliding flight vehicle target tracking multiple model estimation and fusion motion behavior recurrent neural networks

Improving acarbose production and eliminating the by-product component C with an efficient genetic manipulation system of Actinoplanes ***50/110

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Synthetic and Systems Biotechnology 2017年第4期2卷 302-309页

作者： Qinqin Zhao Huixin Xie yao Peng xinran Wang Linquan Bai State Key Laboratory of Microbial Metabolism School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China

Theα-glucosidase inhibitor acarbose is commercially produced by Actinoplanes *** used as a potent drug in the treatment of type-2 *** order to improve the yield of acarbose,an efficient genetic manipulation system for Actinoplanes *** *** conjugation system between *** carryingØC31-derived integrative plasmids and the mycelia of Actinoplanes ***50/110 was optimized by adjusting the parameters of incubation time of mixed culture(mycelia and ***),quantity of recipient cells,donor-to-recipient ratio and the concentration of MgCl2,which resulted in a high conjugation efficiency of 29.4%.Using this integrative system,a cloned acarbose biosynthetic gene cluster was introduced into SE50/110,resulting in a 35%increase of acarbose titer from 2.35 to 3.18 g/***,a pIJ101-derived replicating plasmid combined with the counter-selection system CodA(sm)was constructed for gene inactivation,which has a conjugation frequency as high as 0.52%.Meanwhile,almost all 5-flucytosine-resistant colonies were sensitive to apramycin,among which 75%harbored the successful deletion of targeted *** this replicating vector,the maltooligosyltrehalose synthase gene treY responsible for the accumulation of component C was inactivated,and component C was eliminated as detected by *** on an efficient genetic manipulation system,improved acarbose production and the elimination of component C in our work paved a way for future rational engineering of the acarbose-producing strains.

关键词： Actinoplanes sp. Acarbose Genetic manipulation Conjugation Component C

Increasing stiffness promotes pulmonary retention of ligand-directed dexamethasone-loaded nanoparticle for enhanced acute lung inflammation therapy

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Bioactive Materials 2023年第2期20卷 539-547页

作者： Yinglan Yu Shujie Li Yuan yao xinran Shen Lian Li Yuan Huang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu610041China

Inhaled nanoparticles(NPs)need to penetrate the bronchial mucosa to deliver drug payloads deeply in the lung for amplified local ***,the bronchial mucociliary barrier eliminates NPs rapidly,which considerably limits their mucosal *** this study,we find that surface ligand modification and stiffness adjustment of NPs contribute to the significantly enhanced bronchial mucosal absorption and pulmonary retention of inhaled *** utilize neonatal Fc receptor ligand(FcBP)to modify the rationally designed low stiffness NPs(Soft-NP)and high stiffness NPs(Stiff-NP)to target bronchial *** an acute lung inflammation rat model,after intranasal administration with dexamethasone-loaded NPs,Stiff-NP endowed with FcBP displays superior therapeutic *** in vitro data demonstrate that the promotion effect of FcBP to bronchial mucosal absorption of Stiff-NP dominates over *** could be attributed to the higher affinity between ligand-receptor when incorporating FcBP on the Stiff-NP ***,high stiffness modulates more actin filaments aggregation to mediate endocytosis,along with strengthened Ca2+signal to enhance ***,we highlight that FcBP-modified NPs with higher stiffness would be a potential pulmonary drug delivery system.

关键词： Pulmonary drug delivery Mucus barrier Epithelial barrier Stiffness Ligand modification Acute lung inflammation

High photoelectric conversion efficiency and fast relaxation time of FA_(0.4)MA_(0.6)PbI_(3) applied in ultrafast modulation of terahertz waves

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Journal of Energy Chemistry 2024年第4期91卷 299-305页

作者： Zhibo Xu Ying Zeng xinran Zhao Xiaoyin Chen Aoyu Fan Furi Ling Jiang Li Jianquan yao School of Optics and Electronic Information Huazhong University of Science and TechnologyWuhan 430074HubeiChina College of Precision Instrument and Optoelectronics Engineering Tianjin UniversityTianjin 300072China Institute of Fluid Physics China Academy of Engineering PhysicsMianyang 621900SichuanChina School of Information Engineering Wuhan University of TechnologyWuhan 430070HubeiChina National Engineering Research Center of Fiber Optic Sensing Technology and Networks Wuhan University of TechnologyWuhan 430070HubeiChina Hubei Key Laboratory of Broadband Wireless Communication and Sensor Networks Wuhan 430070HubeiChina

Active control of terahertz(THz)waves is attracting tremendous attentions in terahertz communications and active photonic ***,due to its excellent photoelectric conversion performance and simple manufacturing process,has emerged as a promising candidate for optoelectronic ***,the exploration of perovskites in optically controlled THz modulators is still *** this work,the photoelectric properties and carrier dynamics of FA_(0.4)MA_(0.6)PbI_(3)perovskite films were investigated by optical pumped terahertz probe(OPTP)*** ultrafast carrier dynamics reveal that FA_(0.4)MA_(0.6)PbI_(3)thin film exhibits rapid switching and relaxation time within picosecond level,suggesting that FA_(0.4)MA_(0.6)PbI_(3)is an ideal candidate for active THz devices with ultrafast ***,as a proof of concept,a FA_(0.4)MA_(0.6)PbI_(3)-based metadevice with integrating plasma-induced transparency(PIT)effect was fabricated to achieve ultrafast modulation of THz *** experimental results demonstrated that the switching time of FA_(0.4)MA_(0.6)PbI_(3)-based THz modulator is near to 3.5 ps,and the threshold of optical pump is as low as 12.7μJ cm^(-2).The simulation results attribute the mechanism of ultrafast THz modulation to photo-induced free carriers in the FA_(0.4)MA_(0.6)PbI_(3)layer,which progressively shorten the capacitive gap of PIT *** study not only illuminates the potential of FA_(0.4)MA_(0.6)PbI_(3)in THz modulation,but also contributes to the field of ultrafast photonic devices.

关键词： Terahertz modulation Perovskites Metamaterials Plasmon-induced transparency

The regulation of the Treg/Th 17 balance by mesenchyma stem cells in human systemic lupus erythematosus

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Cellular & Molecular Immunology 2017年第5期14卷 423-431页

作者： Dandan Wang Saisai Huang xinran Yuan Jun Liang Renju Xu Genhong yao Xuebing Feng Lingyun Sun Department of Rheumatology and Immunology The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing China

Background and objective： Umbilical cord （UC）-derived mesenchymal stem cells （MSCs） have shown immunoregulation of various immune cells. The aim of this study was to investigate the mechanism of UC MSCs in the regulation of peripheral regulatory T cells （Treg） and T helper 17 （Th17） cells in patients with systemic lupus erythematosus （SLE）. Methods： Thirty patients with active SLE, refractory to conventional therapies, were given UC MSCs infusions. The percentages of peripheral blood CD4＋CD25＋Foxp3＋ regulatory T cells （Treg） and CD3＋CD8-1L17A＋ Th17 cells and the mean fluorescence intensities （MFI） of Foxp3 and IL- 17 were measured at I week, I month, 3 months, 6 months, and 12 months after MSCs transplantation （MSCT）. Serum cytokines, including transforming growth factor beta （TGF-β）, tumor necrosis factor alpha （TNF-α）, interleukin 6 （IL-6）, and IL-17A were detected using ELISA. Peripheral blood mononuclear cells from patients were collected and co-cultured with UC MSCs at ratios of 1：1, 10：1, and 50：1, respectively, for 72 h to detect the proportions of Treg and Th17 cells and the MFIs of Foxp3 and IL-17 were determined by flow cytometry. The cytokines in the supernatant solution were detected using ELISA. Inhibitors targeting TGF-β, IL-6, indoleamine 2,3-dioxygenase （IDO）, and prostaglandin E2 were added to the co-culture system, and the percentages of Treg and Th17 cells were observed. Results： The percentage of peripheral Treg and Foxp3 MFI increased 1 week, 1 month, and 3 months after UC MSCs transplantation, while the Th17 proportion and MFI of IL-17 decreased 3 months, 6 months, and 12 months after the treatment, along with an increase in serum TGF-β at I week, 3 months, and 12 months and a decrease in serum TNF-a beginning at I week. There were no alterations in serums IL-6 and IL-17A before or after MSCT. In vitro studies showed that the UC MSCs dose-dependently up-regulated peripheral Treg proportion in SLE patients, which was not depended on cell-cell co

关键词： mesenchymal stem cells regulatory T cells systemic lupus erythematosus T helper 17 cells umbilical cord

Protective effects of ginsenosides Rg1 and Rb1 against cognitive impairment induced by simulated microgravity in rats

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中国药理学与毒理学杂志 2023年第7期37卷 490-491页

作者： JIANG Ning LYU Jingwei ZHANG Yiwen SUN xinran yao Caihong WANG Qiong HE Qinghu LIU Xinmin Research Center for Pharmacology and Toxicology Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical College Institute of Food Science and Technology Chinese Academy of Agricultural Sciences Sino-Pakistan Center on Traditional Chinese Medicine Hunan University of Medicine

OBJECTIVE Microgravity exerts several negative effects on the learning and memory of astronauts during space flight. Rg1 and Rb1, the key steroidal components of ginseng, have shown potent neuroprotective effects with a high safety profile. The object of the current study is to investigate the influence of Rg1 and Rb1 on simulated microgravity-induced memory and learning dysfunction in the hindlimb suspension(HLS) rat model. METHODS The HLS rats were orally administered Rg1(30 and 60 μmol·kg-1) or Rb1(30 and 60 μmol·kg-1)for four weeks. The Morris water maze test(MWM) and reward operating conditioning reflex test(ROCR) were conducted to evaluate spatial and associative learning and memory. After the behavior tests, the serum and the prefrontal cortex(PFC)were dissected to measure the mechanism. RESULTS Rg1 and Rb1 treatment ameliorated the cognitive deficits of HLS-exposure rats in MWM and ROCR, reduced reactive oxygen species generation and increased antioxidant enzyme activity. Rg1 and Rb1also assisted in the recovery of mitochondrial complexⅠ(NADH dehydrogenase) activities and Mfn2, and decreased Drp-1 expression. Furthermore, Rg1 and Rb1 reduced the ratio of Bax/Bcl-2 and the expression of cleaved-caspase 3, cytochrome c, increased the levels of SYN, PSD95and activated BDNF-TrkB/PI3K-Akt pathway in the *** Rg1 and Rb1 treatment attenuated cognitive deficits induced by HLS, mitigated mitochondrial dysfunction, attenuated oxidative stress, inhibited apoptosis, and increased the synaptic plasticity, which was partly mediated by the modulation of the BDNF-TrkB/PI3K-Akt signaling.

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Deletion of CHD8 in cerebellar granule neuron progenitors leads to severe cerebellar hypoplasia,ataxia,and psychiatric behavior in mice

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Journal of Genetics and Genomics 2022年第9期49卷 859-869页

作者： Xiang Chen Tong Chen Chen Dong Huiyao Chen xinran Dong Lin Yang Liyuan Hu Huijun Wang Bingbing Wu Ye yao Yu Xiong Man Xiong Yifeng Lin Wenhao Zhou Departments of Neonatology Children's Hospital of Fudan UniversityNational Children's Medical CenterShanghai201102China Institutes of Biomedical Sciences Fudan UniversityShanghai200032China Key Laboratory of Birth Defects Children's Hospital of Fudan UniversityNational Children's Medical CenterShanghai201102China Department of Biostatistics School of Public HealthFudan UniversityShanghai200032China Department of Obstetrics Obstetrics and Gynecology Hospital of Fudan UniversityShanghai200090China Stem Cell Center Children's Hospital of Fudan UniversityShanghai201102China MOE Frontiers Center for Brain Science Fudan UniversityShanghai201102China

CHD8 is a candidate gene for autism spectrum disorders and neurological development *** has been reported to be essential for neurogenesis in the cerebral cortex,but the function of CHD8 in cerebellum has not been comprehensively *** potential relationship of cerebellum dysplasia with psychiatric disorders in patients with CHD8 mutations is still not *** this study,we establish different conditional knockout mouse models to investigate the roles of CHD8 in cerebellar *** with neural stem cell-specific Chd8 deletion exhibit significant reduction of cerebellum volume and no layering structure is *** deletion of Chd8 in cerebellar granule neuron progenitors(GNPs)leads to cerebellar hypoplasia,absent of proliferation layer and ectopic of Purkinje ***,no substantial cerebellar dysplasia is detected in mice with Purkinje neuron-or oligodendrocyte-specific Chd8 ***-cell RNA sequencing indicates that ribosome-related genes and pathways are most significantly disrupted in GNPs,indicating the potential ***,in addition to the ataxia phenotype,mice with GNPspecific Chd8 ablation present a neuropsychiatric phenotype in three-chamber and light/dark *** together,our results provide insights not only into the function of CHD8 in cerebellar development,but also the pathogenesis of neuropsychiatric disorders in patients with CHD8 mutations.

关键词： Cerebellum Granule neuron CHD8 Autism spectrum disorder