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Efficacy and safety of transvaginal mesh repair in a cohort with a minimum of 10-year follow-up

Science China(Life Sciences) 2024年第5期67卷 1061-1068页

作者： Zhibo Zhang Jianbin Guo Weijie Tian Ye Zhang Yuelun Zhang Tianshu Sun Jiali Duan xinmiao bao Yuan Wang Yang Ye Qianqian Gao Honghui Shi Abraham Nick Morse Juan Chen Lan Zhu Departmentof Obstetrics and Gynecology Peking Union MedicalCollege HospitalChinese Academyof Medical Sciences&Peking Union MedicalCollegeNational Clinical Research Center for Obstetricand Gynecologic DiseasesBeijing 100730China Department of Gynecology Guizhou Provincial People’s HospitalMedical College of Guizhou UniversityGuiyang 550002China Department of Obstetrics and Gynecology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Medical Doctor Program Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Pathology Peking Union Medical College HospitalBeijing 100730China Tufts University School of Medicine Boston MA 02111USA

Although transvaginal mesh(TVM)repair is no longer used in some countries,long-term outcomes after TVM surgery are of great importance ***,reports with follow-up>10 years are ***,this study aimed to report outcomes in a prospective cohort with at least 10 years of *** with stageⅢ–Ⅳsymptomatic prolapse were approached consecutively from 2008 to 2013 at one tertiary *** main outcome measure was symptomatic *** outcomes included anatomic failure,recurrence,patient satisfaction,complications,and *** Kaplan-Meier curve was used to estimate the cumulative failure *** the 121 patients enrolled in the study,103(85.1%)completed a median follow-up of 11 *** estimated probability rates of symptomatic and anatomic failure were 17.6%and 8.8%in 11 years,*** estimated incidence of symptomatic failure increased by 8.2%between 5 and 11 years;however,the corresponding rate for anatomic failure was 3.7%.The most common complication was vaginal mesh exposure,and its estimated probability increased from 19.3%to 28.4%from 5 to 11 years,*** trimming resolved 80.0%of vaginal *** patients did not report decreased overall *** with vaginal mesh exposure requiring>3 office procedures or mesh removal in the operating room(5.8%by 11 years)had lower satisfaction rates(P<0.01)and were defined as having severe mesh *** rates of postoperative pain,reoperation,and Patient Global Impression of Improvement≥2 were 2.5%,3.3%,and 94.2%,*** results of this study implied that TVM treatment gradually increased the symptomatic failure rate but provided durable anatomical support of the vaginal *** mesh exposure was common in women who were largely not sexually active;however,80%of the cases could be managed in the outpatient clinic,which did not affect patient satisfaction.

关键词： complication efficacy long-term follow-up pelvic organ prolapse safety transvaginal mesh

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Update on Mayer—Rokitansky—Küster—Hauser syndrome

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Frontiers of Medicine 2022年第6期16卷 859-872页

作者： Na Chen Shuang Song xinmiao bao Lan Zhu National Clinical Research Center for Obstetric and Gynecologic Diseases Department of Obstetrics and GynecologyState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing100730China Peking Union Medical College M.D.ProgramBeijing100730China

This review presents an update of Mayer—Rokitansky—Küster—Hauser(MRKH)syndrome on its etiologic,clinical,diagnostic,psychological,therapeutic,and reproductive *** etiology of MRKH syndrome remains unclear due to its intrinsic *** and genetic causes that may interact during the embryonic development have been proposed with no definitive etiopathogenesis *** proportion of concomitant extragenital malformations varies in different studies,and the discrepancies may be explained by ethnic *** addition to physical examination and pelvic ultrasound,the performance of pelvic magnetic resonance imaging is crucial in detecting the presence of rudimentary uterine *** syndrome has long-lasting psychological effects on patients,resulting in low esteem,poor coping strategies,depression,and anxiety *** psychological counseling and peer support to diagnosed patients is *** and timely psychological intervention could significantly improve a patient’s *** nonsurgical and surgical methods have been suggested for treatment of MRKH *** to the high success rate and minimal risk of complications,vaginal dilation has been proven to be the first-line *** is the second-line option for patients experiencing dilation *** transplantation and gestational surrogacy are options for women with MRKH syndrome to achieve biological motherhood.

关键词： MRKH(Mayer-Rokitansky-Küster-Hauser)syndrome etiology clinical characteristic diagnosis treatment psychological effect

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Clinical characteristics and offspring developmental malformation of 126 patients with septate uterus

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Chinese Medical Journal 2023年第6期136卷 749-751页

作者： Zichen Zhao Yiran Shou xinmiao bao Jiashen Shao Lan Zhu Department of Obstetrics and Gynecology National Clinical Research Center for Obstetric&Gynecologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Orthopedic Surgery Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

To the Editor:Septate uterus is a uterine malformation caused by abnormal resorption of the midline septum after fusion of the Müllerian ducts and it can be classified into the complete and incomplete *** affects2%ofwomen of reproductive age,leading to poor fertility outcomes.[1]However,the adverse effects of this malformed uterine environment,especially the postmetroplasty uterine environment,on fetal development are unclear.

关键词： malformation uterus fetal

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女性生殖器官畸形的伴发畸形特点——北京协和医院444例病例分析

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中华妇产科杂志 2024年第5期59卷 346-352页

作者：苏思鲍欣淼王姝陈娜刘珠凤孙大为冷金花樊庆泊史宏晖孙智晶陈娟刘海元于昕张俊吉戴毅郎景和朱兰中国医学科学院北京协和医学院北京协和医院妇产科、国家妇产疾病临床医学研究中心、疑难重症及罕见病全国重点实验室北京100730

目的分析女性生殖器官畸形中其他系统伴发畸形的发生率和临床表型。方法回顾性分析2003年1月至2022年12月期间于北京协和医院诊断子宫、子宫颈或阴道畸形的住院患者的临床资料,以美国生殖医学学会2021年分类标准为基础进行生殖器官畸形... 详细信息

目的分析女性生殖器官畸形中其他系统伴发畸形的发生率和临床表型。方法回顾性分析2003年1月至2022年12月期间于北京协和医院诊断子宫、子宫颈或阴道畸形的住院患者的临床资料,以美国生殖医学学会2021年分类标准为基础进行生殖器官畸形的分类,统计各类生殖器官畸形的伴发畸形发生率和伴发畸形的具体表现。结果总计纳入444例生殖器官畸形患者,泌尿系统、骨骼系统等生殖器官外伴发畸形的总体发生率为43.5%(193/444)。阴道斜隔综合征患者均有梗阻侧的肾脏畸形(100.0%,78/78),双子宫患者的伴发畸形发生率高达8/11,单角子宫为43.5%(10/23),Mayer-Rokitansky-Küster-Hauser综合征为33.6%(79/235),纵隔子宫为18.8%(6/32),子宫颈发育不良为18.5%(12/65)。泌尿系统伴发畸形(30.6%,136/444)和骨骼系统伴发畸形(13.5%,60/444)在各个类型生殖器官畸形中均为最常见的伴发畸形,其中尤以单肾缺如和脊柱侧凸常见。结论伴发泌尿系统和骨骼系统畸形是女性生殖器官畸形的重要特点,推荐对所有女性生殖器官畸形患者行泌尿系统超声和全脊柱正侧位X线片筛查。

关键词：畸形,多发性生殖器,女(雌)性泌尿生殖系统畸形肌肉骨骼畸形

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Effects of NaCl and NaHCO3 Stress on Photosynthesis and Chlorophyll Fluorescence Characteristics of Hemerocallis fulva ‘Golden Doll’

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Agricultural Biotechnology 2020年第3期9卷 18-25,28页

作者： Ying bao Jiaxin WANG Chao CHEN xinmiao YU Tangshan Normal University Tangshan 063000China

With Hemerocallis fulva‘Golden Doll'as an experimental material,the effects of different concentrations of neutral salt( NaCl) and alkaline salt( NaHCO3) stresses on photosynthesis and chlorophyll fluorescence characteristics in H. fulva seedlings were studied. The results showed that salt stress treatment significantly reduced the photosynthetic capacity of H. fulva. Under the NaCl and NaHCO3 stresses,the photosynthetic characteristics and chlorophyll fluorescence parameters of H. fulva seedlings were basically the same,but the photosynthetic characteristics and chlorophyll fluorescence parameter values of H. fulva seedlings were significantly different under different salt types and salt concentrations. With the extension of days of salt stress and the increase of salt concentration,the initial fluorescence yield( Fo) and non-photochemical quenching coefficient( NPQ) increased;the maximum fluorescence yield( Fm),maximum photochemical efficiency( Fv/Fm),PSII actual photosynthetic quantum yield( Y) and apparent quantum efficiency( AQY) all showed a downward trend;and moreover,with the extension of days of salt stress and the increase of salt concentration,the net photosynthetic rate( Pn) decreased and the intercellular CO2 concentration( Ci) increased. It was speculated that under salt stress,the photosynthetic characteristics of H. fulva leaves were inhibited. On the one hand,the non-stomatal limiting factor,i. e.,the chlorophyll content decreased,which led to the inhibition of photosynthetic characteristics. On the other hand,the decrease in the photosynthetic performance of mesophyll cells led to a decrease in the net photosynthetic rate of H. fulva. The changes of photosynthetic characteristics and chlorophyll fluorescence parameters in H. fulva caused by salt stress were closely related to the types of salts and salt concentration. High salt stress significantly inhibited the photosynthetic capacity of H. fulva‘Golden Doll',and the effect of NaHCO3 on H. fulva

关键词： Hemerocallis fulva‘Golden Doll’ Salt stress Photosynthetic characteristics Chlorophyll fluorescence

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不同材料的中子透射Monte Carlo模拟计算

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核技术 2011年第3期34卷 188-192页

作者：曾心苗周鹏秦培中鲍矛郭广水许自炎北京市射线应用研究中心北京市科学技术研究院辐射新材料重点实验室北京100012

用Monte Carlo粒子输运计算程序(M-C程序)对入射能量从0.025eV到20MeV的中子及入射厚度1–40cm的多种材料进行了中子透射性能计算。这些屏蔽材料有主体材料聚乙烯、水和混凝土、铁、铜,铅和聚乙烯-碳化硼复合材料,以及功能添加剂碳化硼... 详细信息

用Monte Carlo粒子输运计算程序(M-C程序)对入射能量从0.025eV到20MeV的中子及入射厚度1–40cm的多种材料进行了中子透射性能计算。这些屏蔽材料有主体材料聚乙烯、水和混凝土、铁、铜,铅和聚乙烯-碳化硼复合材料,以及功能添加剂碳化硼和氧化钆。结果显示,随着材料厚度的增加,中子透射系数降低;同一种材料,随入射中子能量的降低透射系数降低的幅度呈增大趋势,但聚乙烯和水的透射系数较小且下降幅度与能量低于0.1MeV的中子基本相同,有些材料随厚度增加出现能量较高中子的透射系数低于能量较低中子透射系数的现象;不同材料的中子透射系数随厚度增加而降低的幅度在能量较低时差别明显,能量高时差别减小。主体材料与功能添加剂组合有利于提高材料的屏蔽能力。

关键词：中子透射系数 Monte Carlo方法屏蔽材料功能添加剂

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Metabolic rate and evaporative water loss in the silky starling （Sturnus sericeus）

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Zoological Research 2014年第4期35卷 280-286页

作者： Huan-Huan bao Qing-Jian LIANG Hong-Lei ZHU Xiao-Qiu ZHOU Wei-Hong ZHENG Jin-Song LIU College of Chemistry and Life Sciences Zhejiang Normal University Jinhua 321004 China College of Life and Environmental Sciences Wenzhou University Wenzhou 325035 China

To better understand the physiological characteristics of the silky starling(Sturnus sericeus), its body temperature(Tb), basal metabolic rate(BMR), evaporative water loss(EWL) and thermal conductance(C) elicited by different ambient temperatures(Ta)(5-30 °C) were determined in the present study. Our results showed that they have a high Tb(41.6±0.1 °C), a wide thermal neutral zone(TNZ)(20-27.5 °C) and a relatively low BMR within the TNZ(3.37±0.17 mL O2/g·h). The EWL was nearly stable below the TNZ(0.91±0.07 mg H2O/g·h) but increased remarkably within and above the TNZ. The C was constant below the TNZ, with a minimum value of 0.14±0.01 mL O2/g·h·°C. These findings indicate that the BMR, Tb and EWL of the silky starling were all affected by Ta, especially when Ta was below 20 °C and the EWL plays an important role in thermal regulation.

关键词：基础代谢率蒸发失水八哥生理特点环境温度热导率最小值热调节

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新型放射性气溶胶取样过滤膜的研制

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膜科学与技术 2009年第6期29卷 10-15页

作者：曾心苗黄子瀚张龙王红杰鲍矛叶仕有刘茂林北京市射线应用研究中心北京100012 中国工程物理研究院绵阳621900 清华大学化工系北京100084

制备了用于放射性气溶胶取样监测的增强微孔滤膜,讨论了铸膜液配方、制膜工艺参数和添加剂对膜结构和性能的影响.实验结果表明,以PVP为致孔添加剂,以面密度较低的无纺布为支撑层,控制铸膜液浓度和成膜工艺,可得到表面收集特性好,过滤效... 详细信息

制备了用于放射性气溶胶取样监测的增强微孔滤膜,讨论了铸膜液配方、制膜工艺参数和添加剂对膜结构和性能的影响.实验结果表明,以PVP为致孔添加剂,以面密度较低的无纺布为支撑层,控制铸膜液浓度和成膜工艺,可得到表面收集特性好,过滤效率高的PVDF双功能层增强微孔滤膜.该增强微孔滤膜取样阻力小,流量大,强度高,配合人工核素气溶胶快速监测装置,可进行高氡浓度环境下α放射性气溶胶的实时连续监测.

关键词：放射性气溶胶表面收集特性增强微孔膜添加剂制膜条件

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电子束辐射预硫化天然橡胶/丁苯橡胶并用体系的研究

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辐射研究与辐射工艺学报 2008年第1期26卷 19-22页

作者：鲍矛矫阳康兴川陆永俊李淑凤曾心苗北京市射线应用研究中心北京100012

以天然橡胶/丁苯橡胶(Natural rubber/styrene butadiene rubber,NR/SBR)并用体系为基材,采用电子束辐照技术对其进行辐射预硫化,研究了不同吸收剂量下,材料交联度、硫化速度及格林强度的变化趋势,并评价了电子束辐射预硫化对材料最终... 详细信息

以天然橡胶/丁苯橡胶(Natural rubber/styrene butadiene rubber,NR/SBR)并用体系为基材,采用电子束辐照技术对其进行辐射预硫化,研究了不同吸收剂量下,材料交联度、硫化速度及格林强度的变化趋势,并评价了电子束辐射预硫化对材料最终力学性能的影响。结果表明:NR/SBR并用体系的交联度和格林强度随吸收剂量的增加而提高,热硫化速度基本不受吸收剂量的影响,可实现NR/SBR并用体系的辐射预硫化;辐射预硫化与未辐射预硫化的NR/SBR相比,完全硫化后材料的力学性能相差不大。

关键词：天然橡胶/丁苯橡胶并用体系电子束辐射预硫化吸收剂量格林强度

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L(+)-酒石酸生产菌株扩展青霉WH-3的筛选

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第10期21卷 835-840页

作者： Wen-na bao Yi CHEN Hong-xiu LIAO Hang CHEN Shi-wang LIU Yong LIU School of Biological and Chemical Engineering Zhejiang University of Science and TechnologyHangzhou 310023China Zhejiang Provincial Key Laboratory for Chemical and Biological Processing Technology of Farm Products Hangzhou 310023China1

L(+)-酒石酸生产菌株扩展青霉WH-3的筛选目的:筛选产L(+)-酒石酸的新真菌菌株。创新点:首次筛选获得能同时在酸性和高底物浓度下转化生产L(+)-酒石酸的菌株。方法:利用电镜、内转录间隔区(ITS)序列、核磁共振、质谱和旋光度对筛选菌株... 详细信息

L(+)-酒石酸生产菌株扩展青霉WH-3的筛选目的:筛选产L(+)-酒石酸的新真菌菌株。创新点:首次筛选获得能同时在酸性和高底物浓度下转化生产L(+)-酒石酸的菌株。方法:利用电镜、内转录间隔区(ITS)序列、核磁共振、质谱和旋光度对筛选菌株进行鉴定,并优化其发酵条件,研究其酶学性质。结论:扩展青霉WH-3的60%活性位于菌丝体中,且该菌丝体能在酸性(pH4.5)、高浓度底物中转化,具有高转化率和高立体特异性,为L(+)-酒石酸的生产提供新的催化剂。

关键词： L(+)-酒石酸:扩展青霉顺式环氧琥珀酸水解酶:筛菌

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