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Innovative design and optimization of a two-dimensional deployable nine-grid planar antenna mechanism with a flat reflection surface

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Chinese Journal of Aeronautics 2023年第11期36卷 529-550页

作者： Bo CHEN Ze JIANG xinlu wei Luyao GUO Xin ZHOU Yundou XU Junjie QIAN Yongsheng ZHAO Parallel Robot and Mechatronic System Laboratory of Hebei Province Yanshan UniversityQinhuangdao 066004China Key Laboratory of Advanced Forging&Stamping Technology and Science of Ministry of National Education Yanshan UniversityQinhuangdao 066004China Space Structure and Mechanism Technology Laboratory of China Aerospace Science and Technology Group Co.Ltd Shanghai 201109China Aerospace System Engineering Shanghai Shanghai 201109China

With the development of the aerospace industry,space missions are becoming more complicated and diversified,and there is a demand for antenna mechanisms with a larger physical *** this paper,a planar deployable mechanism is proposed,which can form a flat reflection surface with a small gap between *** this end,a novel large-scale two-dimensional deployable nine-grid planar antenna mechanism is ***,two antenna folding schemes and four supporting mechanism schemes are *** comparison analysis,the antenna configuration scheme with the best comprehensive performance is selected.A kinematic model of the deployable mechanism is established,and its kinematic characteristics are ***,the correctness of the kinematic model is verified by comparing the analytical and simulation results of the kinematic ***,a finite element model of the antenna is *** on the response surface method,the structural parameters of the support rods of the antenna are optimized,and a set of optimized solutions with lightweight and high fundamental frequency characteristics are ***,a prototype of the proposed nine-grid planar antenna is *** feasibility of the deployment principle and the rationality of the designed mechanism are verified by deployment experiments.

关键词： Design optimization Kinematics Planar antenna Structural design Two-dimensional expansion

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超声引导下腹直肌鞘神经阻滞在腹膜透析管植入术中的应用

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临床麻醉学杂志 2018年第3期34卷 217-221页

作者：高玮杨歆璐魏昕柴小青中国科学技术大学附属第一医院安徽省立医院麻醉科合肥市230000

目的观察超声引导下腹直肌鞘神经阻滞在终末期肾病患者腹膜透析管植入术中的麻醉效果。方法选择择期行腹膜透析管置入术终末期肾病患者75例,男38例,女37例,年龄18~65岁,BMI 18.5~24.0 kg/m2,ASAⅢ级,采用随机数字法分为三组,A组:全身麻... 详细信息

目的观察超声引导下腹直肌鞘神经阻滞在终末期肾病患者腹膜透析管植入术中的麻醉效果。方法选择择期行腹膜透析管置入术终末期肾病患者75例,男38例,女37例,年龄18~65岁,BMI 18.5~24.0 kg/m2,ASAⅢ级,采用随机数字法分为三组,A组:全身麻醉组,麻醉方法为全凭静脉麻醉;B组:腹直肌鞘神经阻滞组,手术侧腹直肌鞘内注射0.5%罗哌卡因15 ml;C组:局部浸润麻醉组,1%利多卡因+0.5%罗哌卡因在手术切口和手术路径进行局部浸润麻醉。记录入室时(T0)、麻醉诱导后10 min(T1)、手术开始即刻(T2)、手术开始后20 min(T3)、手术结束时(T4)的HR和MAP。记录患者术后2、4、8、12、24 h运动VAS评分、Ramsay镇静评分,记录手术时间和不良反应。结果与T0时比较,T1~T3时A组HR明显减慢、MAP明显降低(P<0.05);T2、T3时C组HR明显增快、MAP明显升高(P<0.05);B组不同时点HR和MAP差异无统计学意义。与T1时比较,T2、T3时C组HR明显增快、MAP明显升高(P<0.05),与T2、T3时比较,T4时C组HR明显减慢、MAP明显降低(P<0.05)。术后2、4、8、12、24 h B组运动VAS评分明显低于A组和C组(P<0.05)。C组术中总体补救镇痛次数明显多于B组(P<0.05)。A组和B组手术时间明显短于C组(P<0.05)。三组均未发生不良反应。结论超声引导下腹直肌鞘神经阻滞在终末期肾病患者腹膜透析管植入术中麻醉效果确切、无不良反应,值得在临床推广。

关键词：超声引导终末期肾病腹直肌鞘神经阻滞腹膜透析管植入术

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斜井各向异性地层随钻侧向测井响应规律及快速校正方法

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岩性油气藏 2023年第3期35卷 161-168页

作者：李丰丰倪小威徐思慧魏新路刘迪仁长江大学油气资源与勘探技术教育部重点实验室武汉430100 中国石油塔里木油田公司产能建设事业部新疆库尔勒841000 中国石油集团测井有限公司辽河分公司辽宁盘锦124000

采用有限元数值模拟方法与参数敏感性函数,模拟了螺绕环式随钻侧向测井仪在斜井各向异性地层中的响应特性;通过分析仪器对层厚/围岩、各向异性、井斜角的响应敏感程度,并基于正演结果分段拟合,针对不同的井斜角,提出一种井斜/各向异性... 详细信息

采用有限元数值模拟方法与参数敏感性函数,模拟了螺绕环式随钻侧向测井仪在斜井各向异性地层中的响应特性;通过分析仪器对层厚/围岩、各向异性、井斜角的响应敏感程度,并基于正演结果分段拟合,针对不同的井斜角,提出一种井斜/各向异性快速校正的计算方法。研究结果表明:①当目的层厚度小于0.5 m时,仪器的响应受围岩影响严重;当目的层厚度为0.5~5.0 m时,仪器的响应同时受围岩和各向异性的影响;当目的层厚度大于5.0 m时,各向异性对仪器响应的影响占主导。②当井斜角小于30°时,测井响应受各向异性系数影响较小,视电阻率相差最大为2.5Ω·m;当井斜角大于30°时,仪器响应受各向异性影响严重,不能反映地层水平电阻率。③井斜/各向异性校正法在电导性地层与厚度较大的电阻性地层中具有更好的校正效果。

关键词：斜井各向异性随钻侧向测井探测深度分辨率敏感性有限元数值模拟

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Expression of YB-1 enhances production of murine leukemia virus vectors by stabilizing genomic viral RNA

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Protein & Cell 2012年第12期3卷 943-949页

作者： wei Li xinlu Wang Guangxia Gao Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Murine leukemia virus(MLV)-based retroviral vectors is widely used for gene transfer and basic research,and production of high-titer retroviral vectors is very *** we report that expression of the Y-box binding protein 1(YB-1)enhanced the production of infectious MLV ***-1 specifically increased the stability of viral genomic RNA in virus-producing cells,and thus increasing viral RNA levels in both producer cells and virion *** viral element responsive to YB-1 was mapped to the repeat sequence(R region)in MLV genomic *** results identified YB-1 as a MLV mRNA stabilizer,which can be used for improving production of MLV vectors.

关键词： Y-box binding protein 1 retroviral vector RNA stability

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YB-1 stabilizes HIV-1 genomic RNA and enhances viral production

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Protein & Cell 2013年第8期4卷 591-597页

作者： Xin Mu wei Li xinlu Wang Guangxia Gao Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

HIV-1 utilizes cellular factors for effi cient *** viral RNA is different from cellular mRNAs in many aspects,and is prone to attacks by cellular RNA quality control *** establish effective infection,the virus has evolved multiple mechanisms to protect its ***,we show that expression of the Y-box binding protein 1(YB-1)enhanced the production of *** of endogenous YB-1 in producer cells decreased viral ***-1 increased viral protein expression by stabilizing HIV-1 *** stem loop 2 in the HIV-1 RNA packaging signal was mapped to be the YB-1-responsive *** together,these results indicate that YB-1 stabilizes HIV-1 genomic RNA and thereby enhances HIV-1 gene expression and viral production.

关键词： Y-box binding protein 1 HIV-1 RNA stability

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Influence of temperature and diffusive entropy on the capture radius of fly-casting binding

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Science China(Physics,Mechanics & Astronomy) 2011年第12期54卷 2237-2242页

作者： CHANG Le GUO xinlu ZHANG Jian WANG Jun WANG wei National Laboratory of Solid State Microstructure and Department of Physics Nanjing University Nanjing 210093 China

The recognition and binding of proteins through the "fly-casting" mechanism are important biological processes. In this paper, a physical model for fly-casting binding is described based on the capillarity theory for protein chains. It is found that the capture radius for the fly-casting binding process is maximized at the transition temperature at which the free energy of the monomeric extended state of the protein equals that of the folded state. The factors related to the folding barrier or binding affinity do not change the condition needed to realize the optimization for fly-casting processes. These results will aid in the comprehensive understanding of binding processes.

关键词： protein binding fly-casting mechanism protein folding

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BP神经网络算法在页岩气饱和度评价的应用

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工程地球物理学报 2022年第2期19卷 216-222页

作者：王志豪周明顺魏新路刘迪仁孙康申威赵桠松长江大学地球物理与石油资源学院湖北武汉430100 中石油华北油田分公司勘探开发研究院河北任丘062500 中国石油集团测井有限公司辽河分公司辽宁盘锦124000

页岩气储层中高含量的有机质和黏土矿物会对饱和度的计算会产生影响,常规油气储层建立的饱和度计算模型在页岩气储层饱和度评价中存在较大误差,亟需寻求新的途径与思路。本文分析总结了页岩气储层性质及其与含水饱和度的关系机理。利用... 详细信息

页岩气储层中高含量的有机质和黏土矿物会对饱和度的计算会产生影响,常规油气储层建立的饱和度计算模型在页岩气储层饱和度评价中存在较大误差,亟需寻求新的途径与思路。本文分析总结了页岩气储层性质及其与含水饱和度的关系机理。利用井中地层密度和铀含量与岩心分析含水饱和度有较好的相关性,通过BP神经网络训练建立新的非电性测井饱和度评价模型。在以往饱和度计算模型基础上,考虑总有机碳含量对页岩储层含水饱和度的影响,建立新的含水饱和度计算公式。研究结果表明,此模型通过铀含量和地层密度计算得出的含水饱和度与岩心分析数据具有更高的吻合度。本次研究基于岩心分析数据,建立基于BP神经网络的含水饱和度计算模型,为页岩气含水饱和度的评价提供了新的方法与思路。

关键词：页岩气含水饱和度地层密度铀含量 BP神经网络总有机碳含量

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One-step growth of ultrathin CoSe_(2)nanobelts on N-doped MXene nanosheets for dendrite-inhibited and kinetic-accelerated lithium-sulfur chemistry

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Science Bulletin 2024年第13期69卷 2059-2070页

作者： Chuanliang wei Zhengran Wang Peng Wang xinlu Zhang Xuguang An Jinkui Feng Baojuan Xi Shenglin Xiong School of Chemistry and Chemical Engineering School of Materials Science and EngineeringShandong UniversityJinan 250100China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

The practical application of lithium–sulfur(Li–S)batteries is inhibited by the shuttle effect of lithium polysulfides(LiPSs)and slow polysulfide redox kinetics on the S cathode as well as the uncontrollable growth of dendrites on the Li metal ***,both cathode and anode sides must be considered when modifying LiS ***,two-dimensional(2D)ultrathin CoSe_(2)nanobelts are in situ grown on 2D N-doped MXene nanosheets(CoSe_(2)@N-MXene)via one-step solvothermal process for the first *** to its unique 2D/2D structure,CoSe_(2)@N-MXene can be processed to crumpled nanosheets by freeze-drying and flexible and freestanding films by vacuum *** crumpled CoSe_(2)@NMXene nanosheets with abundant active sites and inner spaces can act as S hosts to accelerate polysulfide redox kinetics and suppress the shuttle effect of LiPSs owing to their strong adsorption ability and catalytic conversion effect with ***,the CoSe_(2)@N-MXene film(CoSe_(2)@NMF)can act as a current collector to promote uniform Li deposition because it contains lithiophilic CoSe_(2)and N *** the systematic effect of CoSe_(2)@N-MXene on S cathode and Li metal anode,the electrochemical and safety performance of Li–S batteries are ***_(2)@NMF also shows excellent storage performances in flexible energy storage devices.

关键词： Ultrathin CoSe_(2)nanobelts N-doped MXene nanosheets In situ growth Flexible MXene-based films Li-S batteries

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Isoflurane preserves energy balance in isolated hepatocytes during in vitro anoxia/reoxygenation

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World Journal of Gastroenterology 2005年第25期11卷 3920-3924页

作者： QuanLi wei-FengYu Mai-TaoZhou xinlu Li-QunYang MingZhu Jian-GangSong Jun-HuaLu DepartmentofAnesthesiology EasternHepatobiliarySurgeryHospitaltheSecondMilitaryMedicalUniversityShanghai200438China DepartmentofClinicalSurgery EasternHepatobiliarySurgeryHospitaltheSecondMilitaryMedicalUniversityShanghai200438China

AIM: To investigate the protective effect of isoflurane on energy balance in isolated hepatocytes during in vitro anoxia/reoxygenation, and to compare isoflurane with halothane. METHODS: Hepatocytes freshly isolated from fed rats were suspended in Krebs-Henseleit buffer, and incubated in sealed flasks under O2/CO2 or N2/CO2 (95%/5%, V/V) for 30 or 60 min, followed by 5 or 10 min of reoxygenation, with an added volatile anesthetic or not. ATP, ADP, and adenosine monophosphate in hepatocytes were determined by high performance liquid chromatography, and energy charge was calculated. RESULTS: During 30 min of anoxia, the energy charge and total adenine nudeotide steadily increased with the isoflurane dose from 0 to 2 minimum alveolar anesthetic concentration (MAC), then decreased from 2 to 3 MAC. In short incubations (30-35 min) at 1 MAC isoflurane, energy charge modestly decreased during anoxia, which was partially prevented by isoflurane and completely reversed by reoxygenation, and total adenine nudeotide did not decrease. In long incubations (60-70 min), both energy charge and total adenine nudeotide greatly decreased during anoxia, with partial and no reversal by reoxygenation, respectively. Isoflurane partly prevented decreases in both energy charge and total adenine nudeotide during anoxia and reoxygenation. In addition, 1 MAC isoflurane obviously increased ATP/ADP, which could not be changed by 1 MAC halothane. CONCLUSION: Isoflurane partially protects isolated hepatocytes against decreases in both energy charge and total adenine nudeotide during short (reversible) or long (irreversible) anoxia.

关键词： Isoflurane Hepatocytes Anoxia Energy balance

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Identification of new type I interferon- stimulated genes and investigation of their involvement in IFN-β activation

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Protein & Cell 2018年第9期9卷 799-807页

作者： Xiaolin Zhang wei Yang xinlu Wang Xuyuan Zhang Huabin Tian Hongyu Deng Liguo Zhang Guangxia Gao CAS Key Laboratory of Infection and Immunity CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China

Virus infection induces the production of type I interferons （IFNs）. IFNs bind to their heterodimeric receptors to initiate downstream cascade of signaling, leading to the up-regulation of interferon-stimulated genes （ISGs）. ISGs play very important roles in innate immunity through a variety of mechanisms. Although hundreds of ISGs have been identified, it is commonly recognized that more ISGs await to be discovered. The aim of this study was to identify new ISGs and to probe their roles in regulating virus-induced type I IFN production. We used consensus interferon （Con-IFN）, an artificial alpha IFN that was shown to be more potent than naturally existing type I IFN, to treat three human immune cell lines, CEM, U937 and Daudi cells. Microarray analysis was employed to identify those genes whose expres- sions were up-regulated. Six hundred and seventeen genes were up-regulated more than 3-fold. Out of these 617 genes, 138 were not previously reported as ISGs and thus were further pursued. Validation of these 138 genes using quantitative reverse transcription PCR （qRT-PCR） confirmed 91 genes. We screened 89 genes for those involved in Sendal virus （SeV）-induced IFN-13 promoter activation, and PIM1 was identified as one whose expression inhibited SeV-mediated IFN-β activation. We provide evidence indicating that PIM1 specifically inhibits RIG-I- and MDA5-mediated IFN-β signaling. Our results expand the ISG library and iden- tify PIM1 as an ISG that participates in the regulation of virus-induced type I interferon production.

关键词： interferon-stimulated genes IFN-β signaling PIM1 RIG-I MDA5

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