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新疆维吾尔族与汉族初诊1型糖尿病患儿血清25-羟维生素D_3水平和相关抗体检出情况以及多个指标的相互关系

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中国医药 2018年第12期13卷 1844-1848页

作者：郭红余亮米克拉依.加帕尔程云仙冯瑞华李奇凤罗新辉新疆维吾尔自治区人民医院儿科乌鲁木齐830001

目的观察新疆维吾尔族与汉族初诊1型糖尿病(T_1DM)患儿血清25-羟维生素D_3水平和相关抗体[谷氨酸脱羧酶抗体(GADA)、抗酪氨酸磷酸酶抗体(IA2)、抗胰岛细胞抗体(ICA)、抗胰岛素自身抗体(IAA)、锌转运8自身抗体(ZnT-8)]检出情况以及多个... 详细信息

目的观察新疆维吾尔族与汉族初诊1型糖尿病(T_1DM)患儿血清25-羟维生素D_3水平和相关抗体[谷氨酸脱羧酶抗体(GADA)、抗酪氨酸磷酸酶抗体(IA2)、抗胰岛细胞抗体(ICA)、抗胰岛素自身抗体(IAA)、锌转运8自身抗体(ZnT-8)]检出情况以及多个指标的临床关系。方法选取2015年6月至2018年6月于新疆维吾尔自治区人民医院儿科初次诊断的T_1DM患儿88例作为T_1DM组,选取同期健康查体的体重指数、空腹血糖、C肽水平正常的儿童100名作为正常对照组。比较2组临床资料及常规生化指标、血清25-羟维生素D_3水平、糖尿病相关抗体检出情况及C肽水平。结果 T_1DM组的血清25-羟维生素D_3浓度低于正常对照组[(15±8)μg/L比(39±13)μg/L],差异有统计学意义(P 0.05)。88例T_1DM患儿糖尿病相关抗体阳性59例,阳性率为67.0%,汉族患儿糖尿病相关抗体阳性率明显高于维吾尔族患儿[94. 3%(33/35)比49.0%(26/53)],差异有统计学意义(P <0.05)。T_1DM患儿ICA及IAA的检出率高。T_1DM患儿25-羟维生素D_3缺乏组的GADA、IA2、ICA、IAA、ZnT-8阳性率明显高于不足组和充足组,差异均有统计学意义(均P <0.01)。抗体数量的分布以携带3种抗体的患儿例数最多,差异有统计学意义(P <0. 05);携带3、4种抗体患儿空腹C肽水平明显低于携带0、2种抗体患儿,差异有统计学意义(P <0. 05)。结论 T_1DM患儿血清25-羟维生素D_3缺乏,胰岛自身抗体ICA及IAA的检出率高,25-羟维生素D_3可能会影响ICA及IAA的产生及检出率。汉族患儿抗体总检出率高于维吾尔族,提示T_1DM的发生除自身免疫主要因素外,尚存在其他原因。胰岛自身抗体种类的数量与C肽水平呈负相关。

关键词： 1型糖尿病 25-羟维生素D3 胰岛自身抗体 C肽

不同品种猪PBD-119基因的克隆与差异表达研究

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延边大学农学学报 2020年第2期42卷 75-82页

作者：刘艳光张珈溯罗新惠柳检强金海国夏广军曹阳张立春延边大学农学院吉林延吉133002 吉林省农业科学院畜牧分院吉林公主岭136100

为获得猪β防御素-119(PBD-119)基因mRNA序列以及在不同品种猪体内组织表达量模式,该试验以民猪、大白猪和野杂猪为试验动物,采用RT-PCR方法扩增PBD-119基因mRNA并进行生物信息学分析,利用qRT-PCR的方法检测该基因在不同品种猪组织中的... 详细信息

为获得猪β防御素-119(PBD-119)基因mRNA序列以及在不同品种猪体内组织表达量模式,该试验以民猪、大白猪和野杂猪为试验动物,采用RT-PCR方法扩增PBD-119基因mRNA并进行生物信息学分析,利用qRT-PCR的方法检测该基因在不同品种猪组织中的差异表达情况。RT-PCR扩增结果表明:在3个群体猪3种类型组织(肝脏,脾脏和血液)中均能扩增出特异性片段,测序结果显示片段长度为408bp,通过对PBD-119基因序列的比对分析,该基因在第263位碱基上存在多肽位点的改变(C263T),并在第53氨基酸位点发生改变,由脯氨酸变为丝氨酸(P-S),但并不影响二硫键结构;进化树分析表明,猪与人、倭黑猩猩和马的亲缘关系较近,与羊驼和双峰驼亲缘关系较远。qRT-PCR结果显示,PBD-119基因在3个品种猪的各组织中均有表达,且表达存在差异,以品种为研究对象比较相同组织的差异表达,PBD-119基因在肝脏中的表达为野杂猪>民猪>大白猪,在脾脏中表达为大白猪>民猪>野杂猪,而在血液中的表达为民猪>野杂猪>大白猪;以相同品种为目标,考察不同组织间PBD-119基因差异表达,结果发现大白猪不同于民猪和野杂猪在肝脏、脾脏和血液中的表达,表现为脾脏最高,其次为肝脏、血液,而民猪和野杂猪的表达为肝脏和血液中较高,脾脏最低。该试验结果为进一步探究PBD-119基因的生物学功能及免疫防御相关的候选基因提供基础依据。

关键词：民猪大白猪野杂猪 PBD-119基因克隆差异表达

基于芬顿反应的核桃初加工洗果污水无害化处理技术研究

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云南化工 2024年第6期51卷 60-62页

作者：杨婷杨映礼许新辉阮伋罗映铅只红美漾濞彝族自治县漾濞核桃品牌发展服务中心云南漾濞672500 漾濞彝族自治县林业和草原局云南漾濞672500

以某核桃加工企业的核桃洗果污水为研究对象,采用芬顿反应进行无害化处理。结果表明,最佳的处理工艺为在酸性条件下,加入3.50 g七水合硫酸亚铁,搅拌至完全溶解,然后加入30%的过氧化氢溶液200 mL,反应4 h;再然后加0.70 g氧化钙,调节pH值... 详细信息

以某核桃加工企业的核桃洗果污水为研究对象,采用芬顿反应进行无害化处理。结果表明,最佳的处理工艺为在酸性条件下,加入3.50 g七水合硫酸亚铁,搅拌至完全溶解,然后加入30%的过氧化氢溶液200 mL,反应4 h;再然后加0.70 g氧化钙,调节pH值至8左右。该技术具有成本低廉、达标处理时间短、效率高、无害化等特点,适用于不同规模核桃初加工过程洗果水无害化处理环节。

关键词：芬顿反应核桃洗果污水无害化

儿童耐碳青霉烯类肠杆菌科细菌耐药机制及治疗进展

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儿科药学杂志 2023年第3期29卷 59-63页

作者：法吾丹·阿布都阿卜力克木·阿卜杜杰力力罗新辉依帕古力·斯米江北京儿童医院新疆医院新疆维吾尔自治区儿童医院乌鲁木齐830091

随着碳青霉烯类抗菌药物在感染性疾病中的广泛应用,近年来文献报道耐碳青霉烯类肠杆菌科细菌(carbapenem-resistant Enterobacteriaceae bacteria,CRE)检出率日趋增多。中国儿童细菌耐药监测数据显示,儿童为CRE感染的高发人群[1]。多个... 详细信息

随着碳青霉烯类抗菌药物在感染性疾病中的广泛应用,近年来文献报道耐碳青霉烯类肠杆菌科细菌(carbapenem-resistant Enterobacteriaceae bacteria,CRE)检出率日趋增多。中国儿童细菌耐药监测数据显示,儿童为CRE感染的高发人群[1]。多个国家儿童细菌耐药监测数据显示,儿童CRE感染现状与不良临床结局有关,给临床治疗带来严峻的挑战,引起了医学界的高度关注[2-5]。为迫切解决这一难题,全世界范围内对其耐药机制及治疗方案进行了深入的研究,显示儿童CRE耐药机制不同于成人,并提出了治疗建议策略及新型抗菌药物。因此,本文就儿童CRE耐药机制及治疗进展作一综述,为指导临床掌握CRE的耐药机制及选择合理治疗方案提供参考。

关键词：细菌耐药监测耐碳青霉烯类肠杆菌科细菌碳青霉烯类抗菌药物感染现状耐药机制感染性疾病临床结局数据显示

Investigating the crucial roles of aliphatic tails in disulfide bond-linked docetaxel prodrug nanoassemblies

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Asian Journal of Pharmaceutical Sciences 2021年第5期16卷 643-652页

作者： Yuequan Wang Cong luo Shuang Zhou xinhui Wang Xuanbo Zhang Shumeng Li Shenwu Zhang Shuo Wang Bingjun Sun Zhonggui He Jin Sun Shenyang Pharmaceutical University Shenyang 110016China

Disulfide bond-bridging strategy has been extensively utilized to construct tumor specificity-responsive aliphatic prodrug nanoparticles(PNPs) for precise cancer therapy. Yet, there is no research shedding light on the impacts of the saturation and cis-trans configuration of aliphatic tails on the self-assembly capacity of disulfide bond-linked prodrugs and the in vivo delivery fate of PNPs. Herein, five disulfide bond-linked docetaxelfatty acid prodrugs are designed and synthesized by using stearic acid, elaidic acid, oleic acid, linoleic acid and linolenic acid as the aliphatic tails, respectively. Interestingly, the cistrans configuration of aliphatic tails significantly influences the self-assembly features of prodrugs, and elaidic acid-linked prodrug with a trans double bond show poor self-assembly capacity. Although the aliphatic tails have almost no effect on the redox-sensitive drug release and cytotoxicity, different aliphatic tails significantly influence the chemical stability of prodrugs and the colloidal stability of PNPs, thus affecting the in vivo pharmacokinetics, biodistribution and antitumor efficacy of PNPs. Our findings illustrate how aliphatic tails affect the assembly characteristic of disulfide bond-linked aliphatic prodrugs and the in vivo delivery fate of PNPs, and thus provide theoretical basis for future development of disulfide bond-bridged aliphatic prodrugs.

关键词： Docetaxel Aliphatic prodrug Disulfide bond Self-assembly capacity In vivo drug delivery fate

Over 18% binary organic solar cells enabled by isomerization of non-fullerene acceptors with alkylthiophene side chains

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Science China Chemistry 2022年第9期65卷 1758-1766页

作者： Ao Shang Siwei luo Jianquan Zhang Heng Zhao Xinxin Xia Mingao Pan Chao Li Yuzhong Chen Jicheng Yi xinhui Lu Wei Ma He Yan Huawei Hu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Department of Chemistry Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsEnergy Institute and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionHong Kong University of Science and TechnologyClear Water BayKowloonHong Kong 999077China State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China Department of Physics Chinese University of Hong KongNew TerritoriesHong Kong 999077China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

Side-chain engineering has been demonstrated as an effective method for fine-tuning the optical,electrical,and morphological properties of organic semiconductors toward efficient organic solar cells(OSCs).In this work,three isomeric non-fullerene small molecule acceptors(SMAs),named as BTP-4F-T2C8,BTP-4F-T2EH and BTP-4F-T3EH,with linear and branched alkyl chains substituted on the α or β positions of thiophene as the side chains,were synthesized and systematically *** results demonstrate that the size and substitution position of alkyl side chains can greatly affect the electronic properties,molecular packing as well as crystallinity of the *** blending with donor polymer D18-Cl,the prominent device performance of 18.25% was achieved by the BTP-4F-T3EH-based solar cells,which is higher than those of the BTP-4F-T2EH-based(17.41%)and BTP-4F-T2C8-based(15.92%)*** enhanced performance of the BTP-4F-T3EH-based devices is attributed to its stronger crystallinity,higher electron mobility,suppressed bimolecular recombination,and the appropriate intermolecular interaction with the donor *** work reveals that the side chain isomerization strategy can be a practical way in tuning the molecular packing and blend morphology for improving the performance of organic solar cells.

关键词： organic solar cells non-fullerene acceptors side chain isomerization morphology intermolecular interaction

Achieving 16.68% efficiency ternary as-cast organic solar cells

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Science China Chemistry 2021年第4期64卷 581-589页

作者： Ruijie Ma Yang Tao Yuzhong Chen Tao Liu Zhenghui luo Yuan Guo Yiqun Xiao Jin Fang Guangye Zhang Xiaojun Li Xia Guo Yuanping Yi Maojie Zhang xinhui Lu Yongfang Li He Yan Department of Chemistry and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration&Reconstruction Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina College of New Materials and New Energies Shenzhen Technology UniversityShenzhen 518118China School of Light Industry and Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Department of Physics Chinese University of Hong KongNew TerritoriesHong KongChina Laboratory of Advanced Optoelectronic Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China Beijing National Laboratory for Molecular Science Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China Hong Kong University of Science and Technology-Shenzhen Research Institute Shenzhen 518057China eFlexPV Limited Flat/RM B12/FHang Seng Causeway Bay BLDGCauseway BayHong KongChina Centre for Mechanical Technology and Automation Department of Mechanical EngineeringUniversity of AveiroAveiroPortugal

State-of-the-art organic solar cells(OSCs)often require the use of high-boiling point additive or post-treatment such as temperature annealing and solvent vapor annealing to achieve the best ***,additives are not desirable in largescale industrial printing process,while post-treatment also increases the production *** this article,we report highly efficient ternary OSCs based on PM6:BTP-Cl Br1:BTP-2O-4Cl-C12(weight ratio=1:1:0.2),with 16.68%power conversion efficiency(PCE)for as-cast device,relatively close to its annealed counterpart(17.19%).Apart from obvious energy tuning effect and complementary absorption spectra,the improved PCE of ternary device is mainly attributed to improved morphological properties including the more favorable materials miscibility,crystallinity,domain size and vertical phase separation,which endorse suppressed *** result of this work provides understanding and guidance for high-performance as-cast OSCs through the ternary strategy.

关键词： organic solar cells as-cast ternary morphology high-performance

Heteroheptacene-based acceptors with thieno[3,2-b]pyrrole yield high-performance polymer solar cells

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National Science Review 2022年第7期9卷 106-115页

作者： Zhenghui luo Ruijie Ma Jianwei Yu Heng Liu Tao Liu Fan Ni Jiahao Hu Yang Zou Anping Zeng Chun-Jen Su U-Ser Jeng xinhui Lu Feng Gao Chuluo Yang He Yan Shenzhen Key Laboratory of Polymer Science and Technology College of Materials Science and EngineeringShenzhen University Department of Chemistry and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration & Reconstruction Hong Kong University of Science and Technology (HKUST) Hong Kong University of Science and Technology-Shenzhen Research Institute Department of Physics Chemistry and Biology (IFM) Link?ping University Department of Physics Chinese University of Hong Kong Synchrotron Radiation Research Center Hsinchu Science Park Department of Chemical Engineering Tsing Hua University Hong Kong University of Science and Technology (HKUST) Light-Emitting Diode and Flat Panel Display Technology Research & Development Center Hong Kong University of Science and Technology (HKUST) Foshan Research Institute for Smart Manufacturing

Rationally utilizing and developing synthetic units is of particular significance for the design of high-performance non-fullerene small-mole cule acceptors(SMAs).Here,a thieno[3,2-b]pyrrole synthetic unit was employed to develop a set of SMAs(ThPy1,ThPy2,ThPy3 and ThPy4) by changing the number or the position of the pyrrole ring in the central core based on a standard SMA of IT-4 Cl,compared to which the four thieno[3,2-b] pyrrole-based acceptors exhibit bathochromic absorption and upshifted frontier orbital energy level due to the strong ele ctron-donating ability of *** a result,the polymer solar cells(PSCs) of the four thieno[3,2-b] pyrrole-based acceptors yield higher open-circuit voltage and lower energy loss relative to those of the IT-4 Cl-based *** is more,the ThPy3-based device achieves a power conversion efficiency(PCE)(15.3%) and an outstanding fill factor(FF)(0.771) that are superior to the IT-4 Cl-based device(PCE=12.6%,FF=0.758).The ThPy4-based device realizes the lowest energy loss and the smallest optical band gap,and the ternary PSC device based on PM6:BTP-eC9:ThPy4 exhibits a PCE of 18.43% and a FF of ***,this work sheds light on the great potential of thieno[3,2-b]pyrrole-based SMAs in realizing low energy loss and high PCE.

关键词： thieno[3,2-b]pyrrole small-molecule acceptors energy loss intramolecular non-covalent interactions polymer solar cells

Highly crystalline acceptor materials based on benzodithiophene with different amount of fluorine substitution on alkoxyphenyl conjugated side chains for organic photovoltaics

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Materials Reports(Energy) 2021年第4期1卷 45-53页

作者： Youdi Zhang Ruijie Ma Yong Wang Ying Wang Tao Liu Yiqun Xiao Yongjoon Cho Zhenghui luo xinhui Lu Lun Zhao Zhongyi Yuan Changduk Yang He Yan Yiwang Chen College of Chemistry Changchun Normal UniversityChangchun130032JilinChina College of Chemistry Nanchang UniversityNanchang330031China Department of Chemistry and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration&Reconstruction Hong Kong University of Science and Technology(HKUST)Hong KongChina Institute of Polymers and Energy Chemistry(IPEC) Nanchang UniversityNanchang330031China Department of Physics Chinese University of Hong KongHong KongChina Department of Energy Engineering School of Energy and Chemical EngineeringPerovtronics Research CenterLow Dimensional Carbon Materials CenterUlsan National Institute of Science and Technology(UNIST)Ulsan44919Republic of Korea

Organic solar cells based on narrow bandgap small-molecule acceptors(SMAs)with highly crystalline characteristics have attracted great attentions for their superiority in obtaining high photovoltaic *** highly crystalline SMAs to enhance power conversion efficiencies(PCEs)by regulating and controlling morphology and compatibility of donor and acceptor materials has turned out to be an effective *** this study,we synthesized three different crystalline SMAs by using fluorine substitution on alkoxyphenyl conjugated side chains to modulate the relationship of crystallinity and morphologies,namely ZY1(zero F atoms),ZY2(two F atoms),and ZY3(four F atoms).The three SMAs show the broad absorption edges and similar frontier orbital energy levels,generating the analogical(over 0.9 V)open circuit voltage(VOC)of the polymer solar cells(PSCs).As a result,the PM6:ZY2-based PSCs yield a PCE of 10.81%with a VOC of 0.95 V,a short-circuit current density(JSC)of 16.154 mA cm^(-2),and a fill factor(FF)of 0.71,which is higher than that of 9.17%(PM6:ZY1)and 6.37%(PM6:ZY3).And the PCE(17.23%)of the PM6:Y6:ZY2 based ternary PSCs is also higher than that of 16.32%PM6:Y6 based binary ***,the results demonstrate that adding fluorine atoms on the conjugated side chains to construct high crystalline materials is a positive strategy to effectively increase the efficiencies of binary and ternary PSCs.

关键词： Organic solar cells Small molecular acceptors Fluorine substitution Highly crystalline acceptors Nonfullerene polymer solar cells