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An analytical transient coal permeability model:Sorption non-equilibrium index-based swelling switch

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1175-1191页

作者： xingxing Liu Jishan Liu Liang chen Jinchang Sheng Huimin Wang College of Civil and Transportation Engineering Hohai UniversityNanjing210098China School of Engineering The University of Western Australia35 Stirling HighwayCrawleyWA6009Australia College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210098China

Long-term permeability experiments have indicated that sorption-induced swelling can switch from internal to bulk depending on the evolutive sorption ***,this sorption swelling switch mechanism has not been considered in current analytical permeability *** study introduces a normalized sorption non-equilibrium index(SNEI)to characterize the sorption status,quantify the dynamical variations of matrix swelling accumulation and internal swelling partition,and formulate the sorption swelling switch *** incorporation of this index into the extended total effective stress concept leads to an analytical transient coal permeability *** results show that the sorption swelling switch itself results in the permeability switch under stress-constrained conditions,while the confined bulk swelling suppresses the permeability recovery to the continuous reduction under displacement-constrained *** verifications show that current experimental observations correspond to the early stages of the transient process,and they could be extended to the whole process with these *** study demonstrates the importance of the sorption swelling switch in determining permeability evolution using simple boundary *** provides new insights into experimentally revealing the sorption swelling switch in the future,and underscores the requirement of a rigorous model for complex coupled processes in large-scale coal seams.

关键词： Coal permeability Sorption swelling switch Sorption non-equilibrium Boundary conditions

脐血间充质干细胞外泌体在小儿脑损伤中的应用研究

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中国临床研究 2024年第8期37卷 1278-1283页

作者：吴世丽赛依帕陈星星胡筱霞赵海燕甘肃中医药大学甘肃兰州730000 甘肃省人民医院儿科甘肃兰州730000

常见的小儿脑损伤主要包括新生儿缺血缺氧性脑病、创伤性脑损伤、脑瘫、脑出血等,这类疾病在临床上较难治疗,可引起不可逆的损伤,导致严重的后遗症。脑损伤发病机制复杂,普遍认为神经炎症、缺血、细胞凋亡是引起脑损伤的关键因素。基于... 详细信息

常见的小儿脑损伤主要包括新生儿缺血缺氧性脑病、创伤性脑损伤、脑瘫、脑出血等,这类疾病在临床上较难治疗,可引起不可逆的损伤,导致严重的后遗症。脑损伤发病机制复杂,普遍认为神经炎症、缺血、细胞凋亡是引起脑损伤的关键因素。基于小儿大脑未成熟时有强大的神经重塑性,故小儿脑损伤已成为再生医学上有吸引力且有发展前景的研究方向。来自人脐血间充质干细胞来源的外泌体(hUMSC-Exos)在无细胞治疗方面隐藏着巨大的潜能,在不久的将来是替代细胞和药物治疗的新策略和新突破。本文将以hUMSC-Exos通过介导不同的信号通路及表达因子等分子机制减少神经炎症、促进神经再生、刺激血管生成、抗细胞凋亡修复脑损伤的过程展开综述。

关键词：脑损伤人脐血间充质干细胞外泌体小儿无细胞治疗

化工综合实验设计探究——以胆碱类低共熔溶剂预处理杨木制备生物质基碳纳米管为例

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山东化工 2024年第8期53卷 70-74页

作者：窦金孝田露李先春陈星星余江龙辽宁科技大学化学工程学院辽宁鞍山114051

针对辽宁科技大学化学工程与工艺专业实验部分教学内容更新不及时,无法与目前专业前沿知识和先进分析表征技术同步的现状,设计开发了生物质基碳纳米管的制备、结构表征及性能研究的综合设计性实验项目。通过文献查阅、实验方案设计、样... 详细信息

针对辽宁科技大学化学工程与工艺专业实验部分教学内容更新不及时,无法与目前专业前沿知识和先进分析表征技术同步的现状,设计开发了生物质基碳纳米管的制备、结构表征及性能研究的综合设计性实验项目。通过文献查阅、实验方案设计、样品制备和检测、数据分析等教学环节,培养学生运用专业理论知识和基础实验技能来解决煤化工和化工相关领域中实际问题的能力。全面提升学生的动手能力、思辨能力和综合问题分析能力,从而满足工程教育专业认证背景下对于人才培养的要求。

关键词：碳纳米管专业实验工程教育专业认证综合实验设计

Efficacy and safety of high-dose esomeprazole–amoxicillin dual therapy for Helicobacter pylori rescue treatment:a multicenter,prospective,randomized,controlled trial

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Chinese Medical Journal 2022年第14期135卷 1707-1715页

作者： Hanxin Bi xingxing chen Yuxin chen Xin Zhao Shasha Wang Jiehong Wang Ting Lyu Shuang Han Tao Lin Mingquan Li Donghong Yuan Junye Liu Yongquan Shi Xi’an Medical University Xi’anShaanxi 710021China State Key Laboratory of Cancer Biology National Clinical Research Center for Digestive Diseases and Xijing HospitalAir Force Medical UniversityXi’anShaanxi 710032China Department of Gastroenterology Xianyang Central HospitalXianyangShaanxi 712000China Department of Gastroenterology Affiliated Hospital of Shaanxi University of Chinese MedicineXianyangShaanxi 712000China Department of Gastroenterology Shaanxi Nuclear Industry 215 HospitalXianyangShaanxi 712000China Department of Gastroenterology Xi’an Red Cross HospitalXi’anShaanxi 710054China Department of Gastroenterology Xi’an Daxing HospitalXi’anShaanxi 710082China Department of Gastroenterology Yan’an People’s HospitalYan’anShaanxi 716000China Department of Gastroenterology Yan’an University Affiliated HospitalYan’anShaanxi 716000China Department of Radiation Protective Medicine Air Force Medical UniversityXi’anShaanxi 710032China

Background:High-dose dual therapy(HDDT)with proton pump inhibitors(PPIs)and amoxicillin has attracted widespread attention due to its favorable efficacy in eradicating Helicobacter pylori(***).This study aimed to compare the efficacy and safety of high-dose PPI-amoxicillin dual therapy and bismuth-containing quadruple therapy for *** rescue ***:This was a prospective,randomized,multicenter,non-inferiority *** recruited from eight centers who had failed previous treatment were randomly(1:1)allocated to two eradication groups:HDDT(esomeprazole 40 mg and amoxicillin 1000 mg three times daily;theHDDTgroup)and bismuth-containing quadruple therapy(esomeprazole 40 mg,bismuth potassium citrate 220 mg,and furazolidone 100 mg twice daily,combined with tetracycline 500 mg three times daily;the tetracycline,furazolidone,esomeprazole,and bismuth[TFEB]group)for 14 *** primary endpoint was the *** eradication *** secondary endpoints were adverse effects,symptom improvement rates,and patient ***:A total of 658 patients who met the criteria were enrolled in this *** HDDT group achieved eradication rates of 75.4%(248/329),81.0%(248/306),and 81.3%(248/305)asdetermined by the intention-to-treat(ITT),modified intention-totreat(MITT),and per-protocol(PP)analyses,*** eradication rates were similar to those in the TFEB group:78.1%(257/329),84.2%(257/305),and 85.1%(257/302).The lower 95%confidence interval boundary(9.19%in the ITT analysis,9.21%in the MITT analysis,and9.73%in the PP analysis)was greater than the predefined non-inferiority margin of10%,establishing a non-inferiority of the HDDT group *** TFEB *** incidence of adverse events in the HDDT group was significantly lower than that in the TFEB group(11.1%vs.26.8%,P<0.001).Symptom improvement rates and patients’compliance were similar between the two ***:Fourteen-day HDDT is non-inferior to bismuth-containing quadruple the

关键词： Bismuth-containing quadruple therapy Helicobacter pylori High-dose dual therapy Rescue treatment

围产期前后奶牛血清糖脂代谢参数的差异性研究

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天津农学院学报 2024年第4期31卷 45-48页

作者：赵欣雅田雨佳陈星星魏勇跃潘振亮天津农学院动物科学与动物医学学院天津300392 天津市武清区农业发展服务中心天津301700 北京凰宏畜牧科技有限公司北京100020

试验旨在探究奶牛围产期不同时间血清糖脂代谢参数的变化规律,按照体况(3.25±0.5,5分制)、体重((570±50)kg)随机选取13头青年中国荷斯坦奶牛,分别在产前14 d(ap14)、7 d(ap7)和产后1 d(pp1)、7 d(pp7)、14 d(pp14)、21 d(pp21)采集血... 详细信息

试验旨在探究奶牛围产期不同时间血清糖脂代谢参数的变化规律,按照体况(3.25±0.5,5分制)、体重((570±50)kg)随机选取13头青年中国荷斯坦奶牛,分别在产前14 d(ap14)、7 d(ap7)和产后1 d(pp1)、7 d(pp7)、14 d(pp14)、21 d(pp21)采集血清,检测糖代谢参数(胰高血糖素、糖化血红蛋白、胰岛素、血糖)和脂代谢参数(血酮、低密度脂蛋白、胆碱酯酶、低密度脂蛋白胆固醇、高度脂蛋白胆固醇、甘油三酯、总胆固醇、游离脂肪酸)。结果表明:奶牛在pp14血液中的胰高血糖素浓度显著低于ap7和pp1中的浓度(P<0.05);ap7奶牛血液中的胰岛素水平显著高于pp7、pp14、pp21中的浓度,且在pp1奶牛血液中的胰岛素水平显著高于pp14和pp21中的浓度(P<0.05);pp7、pp14、pp21奶牛血液中的BHBA水平显著高于ap14中的水平,pp14奶牛血液中的BHBA水平显著高于pp1的水平(P<0.05);ap7、pp1、pp7血液中的HDL-C浓度显著低于pp14、pp21的浓度(P<0.05);奶牛血液中的CHO水平在pp1、pp7中显著低于pp14、pp21中的浓度,且在ap7中显著低于pp21中的浓度(P<0.05)。结果说明:围产期奶牛血液糖脂代谢参数的改变反映了奶牛产后糖代谢和体脂动员发生明显变化。

关键词：围产期奶牛糖脂代谢脂肪动员能量负平衡酮病预防

Calibrating SECCM measurements by means of a nanoelectrode *** intrinsic oxygen reduction activity of PtNi catalyst nanoparticles

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Nano Research 2022年第2期15卷 1564-1569页

作者： Emmanuel Batsa Tetteh Tobias Loffler Tsvetan Tarnev Thomas Quast Patrick Wilde Harshitha Barike Aiyappa Simon Schumacher Corina Andronescu Richard D.Tilley xingxing chen Wolfgang Schuhmann Analytical Chemistry-Center for Electrochemical Sciences Faculty of Chemistry and BiochemistryRuhr University BochumUniversitatsstr.150D-44780 BochumGermany Chemical Technology III Faculty of Chemistry and CENIDE-Center for NanointegrationUniversity Duisburg EssenCarl Benz Str.199D-47057 DuisburgGermany School of Chemistry and Australian Centre for NanoMedicine University of New South WalesSydney 2052Australia Research Group of Functional Materials for El

Scanning electrochemical cell microscopy(SECCM)is increasingly applied to determine the intrinsic catalytic activity of single electrocatalyst *** is especially feasible if the catalyst nanoparticles are large enough that they can be found and counted in post-SECCM scanning electron microscopy ***,this becomes impossible for very small nanoparticles and hence,a catalytic current measured in one landing zone of the SECCM droplet cannot be correlated to the exact number of catalyst *** show,that by introducing a ruler method employing a carbon nanoelectrode decorated with a countable number of the same catalyst particles from which the catalytic activity can be determined,the activity determined using SECCM from many spots can be converted in the intrinsic catalytic activity of a certain number of catalyst nanoparticles.

关键词： intrinsic electrocatalytic activity nanoelectrochemistry scanning electrochemical cell microscopy(SECCM) PtNi nanoparticles single entity electrochemistry alkaline medium

Orthogonal Combinatorial Raman Codes Enable Rapid High-Throughput-Out Library Screening of Cell-Targeting Ligands

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Research 2024年第1期2023卷 199-208页

作者： Yuchen Tang xingxing Zheng Tingjuan Gao China Key Laboratory of Pesticide and Chemical Biology of Ministry of Education College of ChemistryCentral China Normal UniversityWuhan 430079China

High-throughput assays play an important role in the fields of drug discovery,genetic analysis,and clinical *** super-capacity coding strategies may facilitate labeling and detecting large numbers of targets in a single assay,practically,the constructed large-capacity codes have to be decoded with complicated procedures or are lack of survivability under the required reaction *** challenge results in either inaccurate or insufficient decoding ***,we identified chemical-resistant Raman compounds to build a combinatorial coding system for the high-throughput screening of cell-targeting ligands from a focused 8-mer cyclic peptide *** accurate in situ decoding results proved the signal,synthetic,and functional orthogonality for this Raman coding *** orthogonal Raman codes allowed for a rapid identification of 63 positive hits at one time,evidencing a high-throughput-out capability in the screening *** anticipate this orthogonal Raman coding strategy being generalized to enable efficient high-throughput-out screening of more useful ligands for cell targeting and drug discovery.

关键词： enable throughput allowed

Boosting solar hydrogen production via electrostatic interaction mediated ***-TiO_(2−x)biohybrid system

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Nano Research 2024年第6期17卷 5390-5398页

作者： xingxing Lv Weicheng Huang Ya Gao Rui chen Xiaowei chen Danqing Liu Ling Weng Liangcan He Shaoqin Liu School of Material Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150040China School of Medicine and Health and Key Laboratory of Micro-systems and Micro-structures Manufacturing of Ministry of EducationHarbin Institute of TechnologyHarbin 150001China Department of Physics School of ScienceJimei UniversityXiamen 361021China Zhengzhou Research Institute Harbin Institute of TechnologyZhengzhou 450046China

Hydrogen is garnering growing attention as a green energy source with zero carbon ***,most hydrogen production technologies still rely on the consumption of fossil fuels and are therefore *** has driven the search for more environmentally friendly methods of hydrogen *** this work,we present an innovative approach to enhance hydrogen generation via electrostatic interaction in the Escherichia coli and defective titanium dioxide(TiO_(2−x))*** method involves narrowing the forbidden bandwidth of TiO2 while introducing defect bands into its conduction band to facilitate visible light absorption and efficient charge *** biohybrid system,consisting of *** and TiO_(2−x),demonstrates a remarkable capability to produce 1.25 mmol of hydrogen within a 3-h timeframe under visible light *** accomplishment signifies a 3.31-fold rise in hydrogen production in comparison to ***,signifying a substantial enhancement in hydrogen production ***,we delve into the alterations in biological metabolites associated with hydrogen production and the changes in electron transfer in different biohybrid *** provides valuable insights into the understanding of the intrinsic mechanisms that drive the *** work introduces a novel and promising avenue for achieving this exciting goal.

关键词： Escherichia coli TiO_(2−x)nanoparticles biohybrid system hydrogen production

专业学位研究生“政产学研用”一体化培养体系建构

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中国冶金教育 2024年第1期 16-18,22页

作者：李先春高云安百钢李胜利樊增广陈星星辽宁科技大学化学工程学院辽宁鞍山114051 辽宁科技大学材料与冶金学院辽宁鞍山114051 辽宁科技大学教务处辽宁鞍山114051 辽宁科技大学研究生院辽宁鞍山114051

通过文献梳理分析专业学位研究生培养研究态势,认为中国专业学位研究生的教育质量与国家创新体系建设和产业发展需求仍然存在较大差距,学术型人才培养的印记依然存在,以“政产学研用‘一体化’培养专业学位研究生”为主题的理念创新和... 详细信息

通过文献梳理分析专业学位研究生培养研究态势,认为中国专业学位研究生的教育质量与国家创新体系建设和产业发展需求仍然存在较大差距,学术型人才培养的印记依然存在,以“政产学研用‘一体化’培养专业学位研究生”为主题的理念创新和实践探索亟待重点强化。从“组织决策、规章制度、教学管理、资源保障、成果产出”五个维度,对“一体化”体系建构进行了阐释。

关键词：专业学位研究生培养体系建构政产学研用