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基于油基钻屑制备压裂支撑剂的室内研究

西南石油大学学报（自然科学版） 2024年第1期46卷 76-88页

作者：白杨常爽刘宇程柳新国罗平亚油气藏地质及开发工程全国重点实验室西南石油大学四川成都610500 西南石油大学化学化工学院四川成都610500 西南石油大学石油与天然气工程学院四川成都610500

针对热解析后脱油钻屑处理难和处理方式单一的问题,开展了将油基钻屑残渣制备成免烧压裂支撑剂的研究,研究了钻屑与水泥比、CMC添加量、石膏添加量和养护天数共4个因素对免烧压裂支撑剂性能影响。结果表明,在原料配比较优的情况下,制备... 详细信息

针对热解析后脱油钻屑处理难和处理方式单一的问题,开展了将油基钻屑残渣制备成免烧压裂支撑剂的研究,研究了钻屑与水泥比、CMC添加量、石膏添加量和养护天数共4个因素对免烧压裂支撑剂性能影响。结果表明,在原料配比较优的情况下,制备工艺为钻屑水泥比0.67(质量比),石膏添加量为6%(质量分数),CMC添加量为4%(质量分数),养护时间28 d。该条件下制得的压裂支撑剂颗粒体积密度为1.47 g/cm^(3),视密度为2.52 g/cm^(3),35 MPa下颗粒破碎率为1.57%。经扫描电子显微镜与X射线衍射仪分析发现,此时压裂支撑剂内部结构致密,孔隙封闭,水化产物CaO·SiO_(2)·nH_(2)O凝胶和钙长石类物质有利于提高压裂支撑剂的综合物理性能。为脱油钻屑残渣利用提供新的方向。

关键词：免烧支撑剂水力压裂油基钻屑水化硬化资源化利用

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白芥子涂方对哮喘治疗中的免疫调节作用研究

中国医院药学杂志 2024年第13期44卷 1541-1547页

作者：刘敏黄鹤归徐宏峰刘新国武汉市第一医院药学部湖北武汉430022

目的:探讨白芥子涂方在哮喘治疗中的免疫调剂作用机制。方法:构建SD大鼠哮喘模型,随机分为正常对照组、模型组、白芥子涂方敷贴非穴位组、白芥子涂方敷贴肺俞穴组、阳性对照组(氨茶碱敷贴肺俞穴),给药14 d,收集血清、肺、脾、胸腺、肝... 详细信息

目的:探讨白芥子涂方在哮喘治疗中的免疫调剂作用机制。方法:构建SD大鼠哮喘模型,随机分为正常对照组、模型组、白芥子涂方敷贴非穴位组、白芥子涂方敷贴肺俞穴组、阳性对照组(氨茶碱敷贴肺俞穴),给药14 d,收集血清、肺、脾、胸腺、肝脏及肾脏组织。评估淋巴细胞增殖及巨噬细胞活化,检测血清细胞因子水平,分析器官指数、形态学及皮肤树突状细胞(dendritic cells,CD)细胞数,检测CD90及H2-Ab1表达改变。结果:与模型组相比,白芥子涂方敷贴穴位组及氨茶碱敷贴可以诱导T淋巴细胞增殖(P<0.01),增加IgA、IgG、IgM、IFN-γ及IL-2(P<0.01),但降低IL-4及MBP水平(P<0.01)。此外,白芥子涂方敷贴肺俞穴组贴及氨茶碱敷贴肺俞穴组皮肤组织中淋巴细胞浸润减少,细胞肿胀数降低,支气管管腔内黏液分泌降低,气道水肿及闭塞减少,肺间质炎性浸润伴充血情况减少。皮肤组织中CD1a^(+)CD83^(-)未成熟DC细胞减少,而CD1a^(+)CD83^(+)成熟DC细胞增加,皮肤组织中CD90及H2-Ab1表达显著性增加。结论:白芥子涂方穴位敷贴治疗可促进皮肤组织中髓系树突状细胞发生形变、迁移,并促进抗原的呈递作用,可以激活机体免疫功能,且对机体不良反应低,能发挥调节机体Th1/Th2的失衡的作用。

关键词：白芥子涂方穴位敷贴支气管哮喘免疫调节

Progress in heavy ion cancer therapy at IMP and future development

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Malignancy Spectrum 2024年第2期1卷 91-98页

作者： Qiang Li xinguo liu Zhongying Dai Pengbo He Yuanyuan Ma Guosheng Shen Xiaodong Jin Fei Ye Xiaogang Zheng Ting Zhao Hui Zhang Zheng Li Bingwen Zou Yuehu Pu Weiqiang Chen Institute of Modern Physics Chinese Academy of SciencesLanzhouGansuChina Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences LanzhouGansuChina Gansu Provincial Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine LanzhouGansuChina University of Chinese Academy of Sciences BeijingChina Division of Thoracic Tumor Multimodality Treatment and Department of Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuanChina Medical Equipment Innovation Research Center West China HospitalSichuan UniversityChengduSichuanChina

Basic research on heavy ion cancer therapy such as radiobiology, medicalphysics, and therapeutic technique has been conducted at the Institute ofModern Physics (IMP), Chinese Academy of Sciences since 1995. Based on theachievements acquired in the basic research and the requirements for a heavyion accelerator for radiotherapy purposes, a dedicated heavy ion therapy facilitynamed Heavy Ion Medical Machine (HIMM) was designed at IMP andconstructed in Wuwei, China. The HIMM facility consists of two electroncyclotron resonance ion sources, one cyclotron as the injector and onesynchrotron as the main accelerator, and four different treatment roomsequipped with passive or active beam delivery systems, and accelerates carbonions up to 400 MeV/u. After the performance inspection of HIMM organized bythe National Medical Device Inspection Center, preclinical tests like cell andanimal radiobiological experiments and dosimetric verification using anthropomorphicphantoms for elucidating the biophysical properties of the carbon ionbeams provided by HIMM were carried out. According to the Chinese medicaldevice regulations, a clinical trial in which 46 tumor patients were recruited andtwo hospitals participated was conducted in the HIMM facility, aiming atevaluating the treatment safety and short-term efficacy of the medical *** success of the clinical trial helped the HIMM facility be authorized by theChinese government as a class III medical device. In this paper, all the aspectsmentioned above are introduced and discussed, and implications for futureimprovements are also given.

关键词： heavy ion cancer therapy clinical trial performance inspection dosimetric verification medical device

3D hypothesis clustering for cross-view matching in multiperson motion capture

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Computational Visual Media 2020年第2期6卷 147-156页

作者： Miaopeng Li Zimeng Zhou xinguo liu State Key Lab of CAD&CG Zhejiang UniversityHangzhou310058China

We present a multiview method for markerless motion capture of multiple people. The main challenge in this problem is to determine crossview correspondences for the 2 D joints in the presence of noise. We propose a 3 D hypothesis clustering technique to solve this problem. The core idea is to transform joint matching in 2 D space into a clustering problem in a 3 D hypothesis space. In this way, evidence from photometric appearance, multiview geometry, and bone length can be integrated to solve the clustering problem efficiently and robustly. Each cluster encodes a set of matched 2 D joints for the same person across different views, from which the 3 D joints can be effectively inferred. We then assemble the inferred 3 D joints to form full-body skeletons for all persons in a bottom–up way. Our experiments demonstrate the robustness of our approach even in challenging cases with heavy occlusion,closely interacting people, and few cameras. We have evaluated our method on many datasets, and our results show that it has significantly lower estimation errors than many state-of-the-art methods.

关键词： multi-person motion capture cross-view matching clustering human pose estimation

A detailed study on stereodynamics of He+H_2^(+)(v=1,j=1) reaction with quasi-classical trajectory calculations

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Science China(Physics,Mechanics & Astronomy) 2012年第3期55卷 436-442页

作者： liu xinguo ZHAO LianQing ZHANG QingGang School of Physics and Electronics Shandong Normal UniversityJinan 250014China

Calculations of He+H2+ (v=l,j=l) reaction system are carded out on a new potential energy surface (PES) at different collision energies with the quasi-classical trajectory (QCT) method. The results of the reaction probability and the cross section curves show an obvious oscillatory structure attributed to the resonances caused by the potential well of the Hell2+ complex. The three angular distributions P(θr), P(φr) and P(θr,(φr) as well as four polarization dependent differential cross sections (PDDCSs) are calculated, respectively. Results indicate that the collision energy has great influence on both the vector correlation of k-k', k-j', k-k'-j' and the PDDCSs of the title reaction. The rotational polarization of product Hell+ presents diverse characteristics at dif- ferent collision energies. The rotational angular momentum vectorsj' of product are both aligned and oriented. Furthermore, the product Hell+ tends to scatter forward correspondingly as the collision energy increases.

关键词： QCT PDDCS vector correlation rotational polarization

Semirigid vibrating rotor target calculation for reaction O(^(3)P)+CH_(4)→CH_(3)+OH

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Science China(Physics,Mechanics & Astronomy) 2004年第2期47卷 223-230页

作者： liu xinguo BAI Lihua ZHANG Qinggang Department of Physics Shandong Normal University Jinan 250014 China Department of Physics Shandong Normal University Jinan 250014 China Department of Physics Shandong Normal University Jinan 250014 China

The time-dependent quantum dynamics calculation for reaction O(3P)+CH4 →CH3+OH is made, using of the semirigid vibrating rotor target (SVRT) model and the time-dependent wave packet (TDWP) method. The corresponding reaction probabilities of different initial states are provided. From the calculation of initial rovibrational statej=0,v=0, 1, we can see that the excitation of the H-CH3 stretching vibration gives significant enhancement of reaction probability and the reaction threshold decreases dramatically with the enhancement of the vibrating excitation, which indicates that the vibrating energy of reagent molecules contributes a lot to the molecular collision. As for the calculation of reaction probability of statev=0,j=0,1,2,3, the results show that the reaction probability rises significantly with the enhancement of rotational quantum numberj while the reaction threshold has no changes. The spatial steric effect of the title reaction is studied and analyzed too after the calculation of reaction probability of statesj=5,k=0–2,n=0 andj=5,k=2,n=0–2 is made.

关键词： SVRT model, time-dependent wave packet, reaction probability, steric effect.

支撑喉镜下低温等离子射频消融术与传统喉裂开术治疗早期声门型喉癌的疗效比较

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癌症进展 2024年第14期22卷 1601-1604页

作者：邢金燕谭建成刘鑫国驻马店市中心医院耳鼻咽喉科河南驻马店463000

目的比较支撑喉镜下低温等离子射频消融术(LPRFA)与传统喉裂开术治疗早期声门型喉癌(GC)的疗效。方法根据手术方法的不同将66例早期GC患者分为对照组(n=33,传统喉裂开术)和观察组(n=33,支撑喉镜下LPRFA)。比较两组患者的手术相关指标、... 详细信息

目的比较支撑喉镜下低温等离子射频消融术(LPRFA)与传统喉裂开术治疗早期声门型喉癌(GC)的疗效。方法根据手术方法的不同将66例早期GC患者分为对照组(n=33,传统喉裂开术)和观察组(n=33,支撑喉镜下LPRFA)。比较两组患者的手术相关指标、疼痛程度[视觉模拟评分法(VAS)]、临床疗效、术后并发症发生情况、生活质量[欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQ-C30)]及复发情况。结果观察组患者的手术时间和住院时间均明显短于对照组,术中出血量明显少于对照组,差异均有统计学意义(P﹤0.01)。术后1、3天,观察组患者VAS评分均明显低于对照组,差异均有统计学意义(P﹤0.01)。观察组患者的总有效率高于对照组,术后并发症总发生率低于对照组,差异均有统计学意义(P﹤0.05)。术后3、6个月,两组患者EORTC QLQ-C30评分均高于本组术前,观察组患者EORTC QLQ-C30评分均高于对照组,差异均有统计学意义(P﹤0.05)。术后6个月,两组患者复发率比较,差异无统计学意义(P﹥0.05)。结论支撑喉镜下LPRFA治疗早期GC患者的临床疗效较好,可加快患者术后恢复,减轻术后疼痛,降低术后并发症发生率,提高生活质量。

关键词：早期声门型喉癌传统喉裂开术支撑喉镜下低温等离子射频消融术疗效术后并发症

黄河三角洲非遗展览的“两创”发展实践——以滨州市为例

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滨州学院学报 2024年第3期40卷 78-82页

作者：马海真刘新国顾红红赵冉滨州市博物馆山东滨州256600 滨州市文化馆山东滨州256600 淄博市博物总馆山东淄博255000

如何用展览讲好非遗“两创”故事,推动非遗保护“见人、见物、见生活”,是当前非遗保护传承面临的重大课题。宏大叙事展览是推广非遗的重要方式,为破解非遗的传播与传承难题提供了可能和实施路径。滨州市地处黄河三角洲腹地,非遗资源丰... 详细信息

如何用展览讲好非遗“两创”故事,推动非遗保护“见人、见物、见生活”,是当前非遗保护传承面临的重大课题。宏大叙事展览是推广非遗的重要方式,为破解非遗的传播与传承难题提供了可能和实施路径。滨州市地处黄河三角洲腹地,非遗资源丰富,在非遗保护传承上进行了积极探索和“两创”实践。从滨州市非遗保护传承现状入手,以该地区典型的非遗载体为展示对象,以“做好非遗的保护传承”为策展理念构建宏大叙事展览,“透物见精神”,可以更好地推动非遗的保护与传承。

关键词：非遗展览宏大叙事黄河三角洲 “两创”

A NOTE ON THE BACKWARD ERRORS FOR INVERSE EIGENVALUE PROBLEMS

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Journal of Computational Mathematics 2003年第2期21卷 201-206页

作者： xinguo liu Zhengjian Bai (Department of Mathematics, Ocean University of China, Qingdao 266071) Departmenl of Mathematics Ocean University of China Qingdao 266071

In this note, we consider the backward errors for more general inverse eigenvalue problems by extending Sun's approach. The optimal backward errors are defined for diagonal-ization matrix inverse eigenvalue problem with respect to an approximate solution, and the upper and lower bounds are derived for the optimal backward errors. The results may be useful for testing the stability of practical algorithms.

关键词： Inverse eigenvalue problem Optimal backward error Upper bound Lower bound