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Effects of lighting conditions and accommodation on the three-dimensional position of Visian implantable collamer lens

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Eye and Vision 2024年第3期10卷 31-40页

作者： Lingling Niu Zhe Zhang Huamao Miao Jing Zhao Xiaoying Wang Ji C.He xingtao zhou Department of Ophthalmology and Optometry Eye&ENT HospitalFudan UniversityShanghaiChina NHC Key Laboratory of Myopia(Fudan University) ShanghaiChina Key Laboratory of Myopia Chinese Academy of Medical SciencesShanghaiChina Shanghai Research Center of Ophthalmology and Optometry ShanghaiChina New England College of Optometry MABostonUSA

Background To investigate the effects of lighting conditions and accommodation on the three-dimensional position of Visian implantable collamer lens(ICL V4c).Methods This observational study recruited 62 eyes of 31 myopia patients underwent ICL V4c *** segment optical coherence tomography(AS-OCT)assessed the anterior chamber depth(ACD),ACD-ICL(distance from the corneal endothelium to anterior surface of the ICL V4c),vault(distance between the posterior ICL V4c surface and anterior crystalline lens surface),and crystalline lens tilt under various lighting conditions and accommodation relative to the corneal topographic axis at one year after ICL V4c *** was defined as the scotopic condition,which was also the non-accommodative stimulus *** ICL V4c tilt was analyzed using *** significance level was set at P<*** The ACD-ICL values were similar under various lighting conditions(P=0.978)but decreased during accommodation(P<0.001).The vault was significantly smaller under mesopic and photopic conditions than the baseline(P=0.044 and P<0.001,respectively)but remained unchanged during accommodation(P=0.058).The inferotemporal proportion of ICL V4c(88.7%,55 eyes)and crystalline lens(74.2%,46 eyes)tilts were not significantly different(P=0.063).Crystalline lens under various lighting conditions and accommodation exhibited similar *** vertical tilt of ICL V4c was significantly larger under photopic conditions than the baseline(P=0.038).The horizontal and total tilts were significantly decreased during accommodation(P=0.043 and 0.013,respectively).Conclusions The axial position of ICL V4c in the anterior chamber was stable under various lighting *** conditions and accommodation may influence vertical,horizontal and total tilts of ICL V4c.

关键词： Implantable collamer lens Anterior segment optical coherence tomography Myopia Tilt

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云南武庙:边疆内地化的侧影

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学术探索 2024年第7期 84-96页

作者：周兴涛西昌学院文化传媒学院四川西昌610152

全面梳理云南武庙历代建修情况,重点考察建修主体、目的、选址及依托于武庙的社会活动,发现云南武庙与内地差异并不太大。云南武庙有社区组织性质,是官方与民间社会生活紧密衔接的公共空间,是内地社会组织与文化习俗向边疆移植的产物。... 详细信息

全面梳理云南武庙历代建修情况,重点考察建修主体、目的、选址及依托于武庙的社会活动,发现云南武庙与内地差异并不太大。云南武庙有社区组织性质,是官方与民间社会生活紧密衔接的公共空间,是内地社会组织与文化习俗向边疆移植的产物。它由武到文,从军事到社会生活的各层面深刻地影响着云南地区各族人民,是汉族与其他少数民族交融的公共空间,是不同宗教力量与世俗力量妥协共生的空间,它展示的中央权力与文化统领程度成正比,也是边疆内地化的一个侧影,云南各地民族群众在集体参与的事件和经历中形成共同的家园感。

关键词：云南武庙公共空间边疆内地化

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宫保鸡丁菜肴的呈味特性研究

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食品与发酵工业 2024年第2期50卷 224-231页

作者：赵金梅周兴桃李娜林盛超刘平西华大学食品与生物工程学院四川成都610039

该研究采用高效液相色谱、电感耦合等离子发射光谱法等技术对宫保鸡丁中有机酸、呈味核苷酸及游离氨基酸等进行定性定量分析,并结合滋味活性值(taste active value,TAV)探究宫保鸡丁的特征滋味物质。结果显示,5种宫保鸡丁(A1~A5)中均检... 详细信息

该研究采用高效液相色谱、电感耦合等离子发射光谱法等技术对宫保鸡丁中有机酸、呈味核苷酸及游离氨基酸等进行定性定量分析,并结合滋味活性值(taste active value,TAV)探究宫保鸡丁的特征滋味物质。结果显示,5种宫保鸡丁(A1~A5)中均检出6种有机酸、3种呈味核苷酸、6种无机离子、17种游离氨基酸及辣椒素,且均未检出二氢辣椒素。其中,A4样含有较高的有机酸和无机离子,其呈味核苷酸及游离氨基酸含量均高于其他4种样品,含量分别为1392.65 mg/kg和10567.80 mg/kg,滋味更浓厚。另外,富马酸、苹果酸、琥珀酸、乙酸、5′-肌苷酸、辣椒素、钠离子、钾离子、氯离子、磷酸根离子、谷氨酸及组氨酸12种呈味组分的TAV均大于1,表明其为宫保鸡丁的特征滋味物质,对产品整体滋味呈现至关重要。

关键词：宫保鸡丁滋味物质有机酸游离氨基酸呈味核苷酸

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关注有晶状体眼后房型人工晶状体植入术后白内障手术要点

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中华实验眼科杂志 2024年第3期42卷 219-223页

作者：王晓瑛周行涛竺向佳蒋永祥陈珣复旦大学附属眼耳鼻喉科医院上海200031

随着年龄的增长,越来越多有晶状体眼后房型人工晶状体(ICL)植入患者面临白内障对视力的威胁。此类患者白内障术前眼部检查时应该关注角膜内皮细胞密度是否大于2000个/mm^(2)、前房角的开放状态以及是否有视网膜脱离、脉络膜新生血管等... 详细信息

随着年龄的增长,越来越多有晶状体眼后房型人工晶状体(ICL)植入患者面临白内障对视力的威胁。此类患者白内障术前眼部检查时应该关注角膜内皮细胞密度是否大于2000个/mm^(2)、前房角的开放状态以及是否有视网膜脱离、脉络膜新生血管等眼底异常;眼部生物测量时应该关注前房深度和晶状体厚度的测量起止线,若行ICL联合角膜屈光手术的患者要按照角膜激光手术后的检查要求使用2种以上设备测量角膜屈光力;人工晶状体类型选择时要考虑高度近视眼的组织结构特点,相较于C形与L形襻,平板襻在高度近视伴有大囊袋以及较大的撕囊直径患者中相对更为稳定;Kane、Barrett UniversalⅡ、Olsen、Hill-RBF等人工晶状体屈光度计算公式在长眼轴人群中相对准确;推荐ICL取出与白内障超声乳化和人工晶状体植入术同时进行,手术切口宜大于2.6 mm。飞秒激光辅助的白内障摘除手术,虽然在减少角膜内皮细胞丢失、减轻角膜水肿、高质量撕囊等方面优于传统超声乳化白内障吸除术,但因ICL的存在会引起飞秒切削气泡聚积、需要手动调整激光扫描定位以及较低拱高,可造成撕囊和碎核的不完全,建议谨慎使用。眼科医师应充分认识和关注ICL术后白内障手术的特点和设计的难点,与患者充分沟通交流,个性化选择,以期获得更佳的视觉效果。

关键词：有晶状体眼后房型人工晶状体高度近视白内障人工晶状体手术要点

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自体散光透镜重塑转位术矫正超高度散光1例

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中国眼耳鼻喉科杂志 2024年第S1期24卷 47-52页

作者：尚建慜黄佳王晓瑛周行涛复旦大学附属眼耳鼻喉科医院眼科上海200031

18岁男性,因“双眼散光”,要求行手术矫正就诊。患者诉自幼高度散光,无戴镜史。裸眼视力:右眼0.05,左眼0.15。主觉验光:右眼-4.00/-6.75×175°→1.0-,左眼+1.00/-11.00×175°→0.8。外观双眼睑裂狭长。裂隙灯检查未见明显异常。诊断... 详细信息

18岁男性,因“双眼散光”,要求行手术矫正就诊。患者诉自幼高度散光,无戴镜史。裸眼视力:右眼0.05,左眼0.15。主觉验光:右眼-4.00/-6.75×175°→1.0-,左眼+1.00/-11.00×175°→0.8。外观双眼睑裂狭长。裂隙灯检查未见明显异常。诊断为双眼超高度散光,双眼屈光参差,圆锥角膜待排;予配框架镜,定期随访。1年后,双眼角膜曲率较前略增加,予双眼跨上皮角膜交联手术。2年后,患者再次随访,要求手术矫正。检查发现角膜情况稳定,决定采用首创的自体散光透镜重塑转位术进行矫正:首先应用飞秒激光进行散光透镜制作,之后采用准分子激光重塑透镜,再对透镜进行90°转位,最后将角膜瓣复位完成矫正。术后裸眼视力在术后1个月起稳定在0.8,最佳矫正视力与术前保持稳定。主觉验光:右眼0/-1.25×100°→1.0,左眼+1.50/-1.50×150°→0.8。对于高度散光寻求手术矫正的患者,首先需要通过全面的检查和必要的随访判断是否有圆锥角膜的可能,是否有术后发生角膜扩张性疾病的风险,对于存疑的,可尝试跨上皮角膜交联手术稳定角膜情况,对于常规手术方式难以矫正的超高度散光,在角膜条件稳定的情况下,可尝试自体散光透镜重塑转位术,可获得较为满意的视觉效果,且能最大限度保留角膜组织,安全性高。

关键词：高度散光圆锥角膜透镜重塑透镜转位

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青稞β葡聚糖恢复Th17/Treg细胞平衡维持小鼠肠道功能

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南昌大学学报（理科版） 2024年第3期48卷 241-250页

作者：余永康陈坤英冯汝婷周兴涛谢明勇南昌大学食品科学资源挖掘全国重点实验室江西南昌330047

肠道免疫系统需要执行复杂的任务,如提供快速、特异性的免疫反应以防御病原微生物并维持对肠道内容物的免疫耐受性。维持肠道免疫平衡对肠道稳态至关重要,而溃疡性结肠炎会导致连续的肠道炎症反应,从而使肠道免疫失衡。为探究青稞β葡聚... 详细信息

肠道免疫系统需要执行复杂的任务,如提供快速、特异性的免疫反应以防御病原微生物并维持对肠道内容物的免疫耐受性。维持肠道免疫平衡对肠道稳态至关重要,而溃疡性结肠炎会导致连续的肠道炎症反应,从而使肠道免疫失衡。为探究青稞β葡聚糖(HBG)通过调节Th17/Treg细胞平衡恢复小鼠肠道屏障功能,从而缓解小鼠结肠炎症状,构建了DSS诱导的小鼠结肠炎模型并口服不同浓度的HBG。小鼠处死后,观察小鼠结肠组织形态,测定Occludin、Claudin-1蛋白、Th17细胞、Treg细胞和M1、M2巨噬细胞的含量,流式细胞术检测小鼠脾脏Th17和Treg细胞的分化情况。发现HBG能够缓解小鼠结肠炎病理症状,恢复肠道屏障功能,恢复小鼠结肠组织和脾脏组织的Th17/Treg细胞平衡。结果表明HBG通过调控小鼠Th17/Treg细胞平衡从而恢复结肠炎小鼠免疫稳态、促进肠道屏障功能的恢复,为多糖维持肠道免疫的功能性食品开发上提供一定的理论依据。

关键词：青稞β葡聚糖 Th17细胞 Treg细胞肠道屏障

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A“T.E.S.T.”hydrogel bioadhesive assisted by corneal cross-linking for in situ sutureless corneal repair

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Bioactive Materials 2023年第7期25卷 333-346页

作者： Meiyan Li Ruoyan Wei Chang Liu Haowei Fang Weiming Yang Yunzhe Wang Yiyong Xian Kunxi Zhang Yong He xingtao zhou Department of Ophthalmology EYE&ENT Hospital of Fudan University ShanghaiChina NHC Key Laboratory of Myopia(Fudan University) ShanghaiChina State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhouChina Shanghai Research Center of Ophthalmology and Optometry ShanghaiChina Department of Ophthalmology Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Polymer Materials School of Materials Science and EngineeringShanghai UniversityShanghaiChina

Corneal transplantation is an effective clinical treatment for corneal diseases,which,however,is limited by donor *** is of great clinical value to develop bioadhesive corneal patches with functions of“Transparency”and“Epithelium&Stroma generation”,as well as“Suturelessness”and“Toughness”.To simultaneously meet the“T.E.S.T.”requirements,a light-curable hydrogel is designed based on methacryloylated gelatin(GelMA),Pluronic F127 diacrylate(F127DA)&Aldehyded Pluronic F127(AF127)co-assembled bi-functional micelles and collagen type I(COL I),combined with clinically applied corneal cross-linking(CXL)technology for repairing damaged *** patch formed after 5 min of ultraviolet irradiation possesses transparent,highly tough,and strongly bio-adhesive *** cross-linking makes the patch withstand deformation near 600%and exhibit a burst pressure larger than 400 mmHg,significantly higher than normal intraocular pressure(10-21 mmHg).Besides,the slower degradation than GelMA-F127DA&AF127 hydrogel without COL I makes hydrogel patch stable on stromal beds in vivo,supporting the regrowth of corneal epithelium and *** hydrogel patch can replace deep corneal stromal defects and well bio-integrate into the corneal tissue in rabbit models within 4 weeks,showing great potential in surgeries for keratoconus and other corneal diseases by combining with CXL.

关键词： Tough hydrogel Bioadhesives Corneal patch CXL Sutureless repair

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Ganoderma atrum polysaccharide relieves mitochondrial dysfunction to alleviate hydrogen peroxide-induced senescence via activating autophagy

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Journal of Future Foods 2022年第3期2卷 241-252页

作者： Mi Guo Ke Zhang Duoduo Zhang Yujia zhou Linyuan Liu Yu Wu xingtao zhou Shaoping Nie State Key Laboratory of Food Science and Technology China-Canada Joint Laboratory of Food Science and Technology(Nanchang)Key Laboratory of Bioactive Polysaccharides of Jiangxi ProvinceNanchang UniversityNanchang 330047China

Polysaccharides from genus Ganoderma have prominent anti-aging effect,but their mechanisms are incompletely *** our previous experiments,Ganoderma atrum polysaccharide(PSG)was exhibited to significantly alleviate senescence and DNA damage of A375 *** investigate its underlying mechanism,we conducted RNA-Seq analysis and found that PSG upregulated autophagy and mitochondria pathways compared to the model *** experiments showed that PSG relieved mitochondrial dysfunction via inhibiting the accumulation of reactive oxygen species(ROS)and loss of the mitochondrial membrane potential(MMP).Meanwhile,PSG activated autophagy and enhanced lysosomal function through transcription factor EB(TFEB).Interestingly,the pretreatment of autophagy inhibitors bafilomycin A1(Baf A1)reversed the ROS decline induced by PSG,which subsequently increased cellular senescence of *** addition,PSG had a similar anti-aging effect on normal fibroblast *** together,PSG might reduce ROS levels through activating autophagy,which in turn suppressed mitochondrial dysfunction and cellular senescence.

关键词： Ganoderma atrum polysaccharide Senescence Reactive oxygen species Autophagy Mitochondrial dysfunction

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Recent advances in small incision lenticule extraction(SMILE)-derived refractive lenticule preservation and clinical reuse

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再生工程(英文) 2023年第2期4卷 103-121页

作者： Xiaojun Hu Ruoyan Wei Chang Liu Yunzhe Wang Danjuan Yang Ling Sun Fei Xia Shengtao Liu Meiyan Li xingtao zhou Eye Institute and Department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghai 200031China Key Laboratory of Myopia NHC Key Laboratory of Myopia(Fudan University)Chinese Academy of Medical SciencesShanghai 200031China Shanghai Research Center of Ophthalmology and Optometry China Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care China

Small incision lenticule extraction(SMILE)has become one of the mainstream refractive surgeries in recent years,with satisfactory efficacy,safety,and ***-derived refractive lenticule,the byproduct of the surgery,holds great potential in clinical practice given its easy access and good *** studies have been published to describe its applications in refractive correction,corneal ectasia diseases,and corneal *** feasibility and safety were validated in both animal models and clinical ***,the preservation method is also crucial for its further promotion and *** techniques are also evaluated and applied in lenticule *** covered the recent advances in the preservation of corneal stromal lenticules and their clinical reuse in this review.

关键词： Small incision lenticule extraction Refractive lenticule Preservation Clinical reuse

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Study of preferred background luminance in watching computer screen in children

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Chinese Medical Journal 2014年第11期127卷 2073-2077页

作者： Shen Yang Kuai Shuguang zhou Weixi Peng Sheng Tian Mi Liu Kangjun zhou xingtao Department of Ophthalmology Eye and Ear Nose and Throat Hospital Fudan University Shanghai 200031 China Philips Research China Shanghai 200233 China

Background In recent years,computers have been intensively used at *** contrast to paper-based books and documents,computer screen is self-illuminated with larger screen-background luminance difference,which greatly induces visual *** compensate for that,one effective solution is to offer an additional background *** this study,we investigated whether and to what extent additional background lighting is needed in looking at a computer display *** In this study,60 healthy children aged from 9 to 12 years and 58 adults aged from 21 to 39 years participated in the *** were asked to choose their most preferred background luminance intensities at three screen luminance *** data were analyzed by Matlab （R2012b） and SPSS *** Both children and adult participants selected a non-dark background as their comfortable lighting condition when watching a computer display （children：t （59）=22.0,P 〈0.01,adults：t （57）=15.5,P 〈0.01）.Comparatively,children preferred brighter background in general （F （1,116）=7.0,P 〈0.01）.More importantly,participants＇ preferred background luminance levels were linearly correlated with screen luminance intensities （children：slope=0.97,R2=0.98; adults：slope=0.38,R2=1.00）.Conclusion These results indicate that varying background luminance to maintain screen-background luminance ratio is beneficial to human visual comfort.

关键词： eye fatigue antrast sensitivity myopia lighting

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