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自铸雄奇瑰丽词一洗万古凡马空——毛泽东诗词创作综览及赏析

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毛泽东思想研究 2024年第4期 28-34页

作者：王幸生军事科学院原军队建设研究部北京1100091

毛泽东是伟大的马克思主义者,是伟大的无产阶级革命家、战略家、理论家,同时还是一位才华横溢的诗人。目前已正式发表以及从种种史料中钩沉的可以认定的毛泽东诗词有百余首,这些诗作既继承了中华民族优秀的诗词文化传统,又展示了旧诗词... 详细信息

毛泽东是伟大的马克思主义者,是伟大的无产阶级革命家、战略家、理论家,同时还是一位才华横溢的诗人。目前已正式发表以及从种种史料中钩沉的可以认定的毛泽东诗词有百余首,这些诗作既继承了中华民族优秀的诗词文化传统,又展示了旧诗词所不曾有的文化品格和风貌,为中华诗词园地增添了瑰宝。学习毛泽东诗词,不仅可以提高我们的诗词文化素养,还可以涵养共产党人、革命军人的精神世界。

关键词：毛泽东诗词中华优秀传统文化

中药单体及有效成分抗肿瘤作用机制的研究进展

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中华中医药杂志 2024年第6期39卷 3002-3009页

作者：赵军王小强谢兴文王兴盛徐世红姜朝阳甘肃省中医院创伤中心兰州730050 甘肃中医药大学附属医院老年骨科兰州730000

文章根据抗肿瘤药物的不同作用机制进行分类,对抗肿瘤中药进行归纳总结,旨在为中医药抗肿瘤提供理论基础及科学依据。肿瘤细胞的自我复制、增殖、免疫逃逸、耐药及后期多器官的转移是该疾病致死致残的主要原因,针对肿瘤的治疗,目前临床... 详细信息

文章根据抗肿瘤药物的不同作用机制进行分类,对抗肿瘤中药进行归纳总结,旨在为中医药抗肿瘤提供理论基础及科学依据。肿瘤细胞的自我复制、增殖、免疫逃逸、耐药及后期多器官的转移是该疾病致死致残的主要原因,针对肿瘤的治疗,目前临床采用联合用药的方式,能够发挥抗肿瘤治疗作用,但随着用药时间的延长及频率的增加,表现出对药物的敏感性降低、耐药、免疫逃逸等恶性生物学行为。近年来,中药、中药单体及有效成分被用于抗肿瘤治疗,中药的使用抑制了肿瘤细胞的自我繁殖,同时促进肿瘤细胞凋亡,除此以外,中药的干预,提高了肿瘤细胞对药物的敏感性及机体的免疫、降低了肿瘤细胞的耐药、降低了机体的炎症反应、抑制肿瘤血管化进程,中医药的干预提高了患者的生活质量,较好地弥补了目前抗肿瘤治疗中的不足。

关键词：中药单体有效成分抗肿瘤作用机制研究进展

YAP调控Notch信号通路影响小鼠NASH肝纤维化的机制及慈菇消脂方的干预作用

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中国医科大学学报 2024年第5期53卷 392-400页

作者：王莉王兴胜赵秀萍王爱娣屈红梅马燕花甘肃中医药大学第一临床医学院消化内科兰州730000 甘肃中医药大学第三附属医院·白银市第一人民医院消化二部甘肃白银730900

目的探讨Yes相关蛋白(YAP)调控Notch信号通路影响非酒精性脂肪性肝炎(NASH)肝纤维化的机制及解毒化痰法中药慈菇消脂方的干预作用。方法将小鼠随机分为正常组、NASH肝纤维化模型组、维替泊芬(VP)组、VP+中药低剂量组、VP+中药高剂量组和... 详细信息

目的探讨Yes相关蛋白(YAP)调控Notch信号通路影响非酒精性脂肪性肝炎(NASH)肝纤维化的机制及解毒化痰法中药慈菇消脂方的干预作用。方法将小鼠随机分为正常组、NASH肝纤维化模型组、维替泊芬(VP)组、VP+中药低剂量组、VP+中药高剂量组和DMSO对照组。采用蛋氨酸-胆碱缺乏(MCD)饮食联合小剂量CCl4建立小鼠NASH相关肝纤维化模型,采用HE、Masson染色观察肝脏纤维化程度,ELISA法检测肝纤维化四项,碱水法测定小鼠肝脏中羟脯氨酸含量,免疫组织化学法检测α-SMA、ColⅠ、YAP、Notch1蛋白在肝脏中的定位,Western blotting及实时定量PCR检测Notch信号通路中Notch1/2、Jagged1和DLL4蛋白及mRNA表达。结果NASH肝纤维化组小鼠肝细胞肿胀、胞质透明,肝小叶、门管区以及窦周均存在明显纤维化,并伴有大量炎症细胞浸润及多量脂肪小滴,局部出现肝细胞坏死、溶解以及肝硬化;肝纤维化四项指标显著升高(P<0.01);肝细胞中α-SMA、ColⅠ、YAP以及Notch1定位于细胞质中;肝脏中YAP、Notch1/2及Jagged1均呈高表达(P<0.01)。经VP及VP联合高、低剂量中药慈菇消脂方分别干预后,小鼠肝脏中YAP、Notch1/2及Jagged1均呈低表达(P<0.05),DLL4因子在VP联合中药高剂量组上调(P<0.05)。结论YAP可能通过下调Notch1/2、Jagged1及上调DLL4,抑制Notch通路活化,干预NASH肝纤维化发生。中药慈菇消脂方通过多成分、多靶点下调YAP、Notch1/2、Jagged1、上调DLL4,抑制Notch信号通路活化,改善NASH肝纤维化进展。

关键词：非酒精性脂肪性肝炎肝纤维化 Yes相关蛋白 Notch信号通路慈菇消脂方

Development of a correlation equation between the diesterification of maleic anhydride and the acidic ionic liquids nature

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Green Chemical Engineering 2023年第1期4卷 57-63页

作者： Yumei Liu Shengxin Chen Ran An xingsheng wang Ruixia Liu Beijing Key Laboratory of Ionic Liquids Clean Process CAS Key Laboratory of Green Process and EngineeringState Key Laboratory of Multiphase Complex SystemsInstitute of Process EngineeringInnovation Academy for Green ManufactureChinese Academy of SciencesBeijing100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing100190China School of Chemical Engineering and Energy Zhengzhou UniversityZhengzhou450001China Department of Chemistry School of Chemical EngineeringDalian University of TechnologyDalian116023China

The sustainable synthesis of dimethyl maleate via diesterification through the utilization of ionic liquid(IL)is of great ***,the relationship between the ILs nature and the reactivity of diesterification is still ***,a series of ILs with different structures were selected for the comprehensive investigation of *** acidity(H_(0))and Kamlet-Taft solvent parameters(hydrogen bond donor ability(α),hydrogen bond acceptor ability(β),and polarizability(π^(*)))of ILs were measured by UV–Visible spectroscopy,and the effects of them on the diesterification of maleic anhydride were also studied in *** results indicated that not only H0of the IL-based catalysis system,but also itsα,β,andπ^(*)influenced the reaction activity of ***,a quantifiable correlation was fitted between the natural logarithm of the rate constant and multiple parameters of ILs,indicating that the diesterification rate had a positive correlation with the H0,α,andπ^(*),and inverse correlation with theβof the IL.A plausible synergetic reaction mechanism for the excellent performance of[(HSO_(3))PMim][HSO_(4)]has been ***,this work thoroughly explored the relationship between the nature of ILs on diesterification in-depth,which will reveal the nature of diesterification in detail.

关键词： Multiparameter correlation equation Diesterification Maleic anhydride Ionic liquids Kamlet-Taft solvent parameters

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雌激素与特发性脊柱侧弯相关性的研究进展

临床小儿外科杂志 2024年第5期23卷 493-495页

作者：王培鑫赵军王兴盛徐世红姜朝阳王小强杨红娟甘肃中医药大学中医临床学院，兰州730000 甘肃省中医院创伤中心，兰州730050

特发性脊柱侧弯(idiopathic scoliosis,IS)作为儿童青少年常见的脊柱疾病之一,影响因素复杂,给儿童青少年的生活质量和身心健康带来严重影响。雌激素作为影响特发性脊柱侧弯发生、发展的一个重要因素,可通过异常调节骨代谢、经受体作用... 详细信息

特发性脊柱侧弯(idiopathic scoliosis,IS)作为儿童青少年常见的脊柱疾病之一,影响因素复杂,给儿童青少年的生活质量和身心健康带来严重影响。雌激素作为影响特发性脊柱侧弯发生、发展的一个重要因素,可通过异常调节骨代谢、经受体作用于椎旁肌肉等直接或间接影响脊柱侧弯的发生、发展。研究雌激素对脊柱侧弯进展的影响,可为脊柱侧弯病因研究和治疗提供新的策略。本文就雌激素与特发性脊柱侧弯相关性的研究进展进行综述。

关键词：雌激素脊柱疾病外科手术儿童

A comprehensive study of device variability of sub-5 nm nanosheet transistors and interplay with quantum confinement variation

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Science China(Information Sciences) 2023年第2期66卷 287-288页

作者： Haowen LUO Ruihan LI Xiangshui MIAO xingsheng wang School of Optical and Electronic Information Huazhong University of Science and Technology Hubei Yangtze Memory Laboratories School of Integrated Circuits Huazhong University of Science and Technology Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology

Dear editor,Gate-all-around(GAA) nanosheet transistor(NST) is one of the most promising candidates to replace Fin FET as the next generation because of its best electrostatic integrity and gate control over the channel [1]. However, statistical variability induced by traditional statistical variation sources including random discrete dopants(RDD), line edge roughness(LER), metal gate granularity(MGG), and strong quantum confinement effect has severely limited the performance improvement of NST, which requires a comprehensive study.

关键词： Nanosheets

Progress of vanadium phosphorous oxide catalyst for n-butane selective oxidation

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Chinese Journal of Chemical Engineering 2022年第3期35卷 297-315页

作者： Muhammad Faizan Yingwei Li Ruirui Zhang xingsheng wang Piao Song Ruixia Liu Beijing Key Laboratory of Ionic Liquids Clean Process State Key Laboratory of Multiphase Complex SystemInstitute of Process Engineering Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The utilization of lighter alkanes into useful chemical products is essential for modern chemistry and reducing the CO_(2)***,n-butane has gained special attention across the globe due to the abundant production of maleic anhydride(MA).Vanadium phosphorous oxide(VPO)is the most effective catalyst for selective oxidation of n-butane to MA so ***,the VPO complex exists in more or less fifteen different structures,each one having distinct phase composition and exclusive surface morphology and physiochemical properties such as valence state,lattice oxygen,acidity etc.,which relies on precursor preparation method and the activation conditions of *** catalytic performance of VPO catalyst is improved by adding different promoters or co-catalyst such as various metals dopants,or either introducing template or structural-directing ***,new preparation strategies such as electrospinning,ball milling,hydrothermal,barothermal,ultrasound,microwave irradiation,calcination,sol-gel method and solvothermal synthesis are also employed for introducing improvement in catalytic *** in above-mentioned different aspects will be ascribed in current review in addition to summarizing overall catalysis activity and final *** analyze the performance of the catalytic precursor,the reaction mechanism and reaction kinetics both are discussed in this review to help clarify the key issues such as strong exothermic reaction,phosphorus supplement,water supplement,deactivation,and air/n-butane pretreatment *** to the various industrial applications of VPO.

关键词： N-butane selective oxidation Oxidation of light alkanes Vanadium phosphorus oxide(VPO) Maleic anhydride

Modeling and physical mechanism analysis of the effect of a polycrystalline-ferroelectric gate on FE-FinFETs

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Science China(Information Sciences) 2023年第5期66卷 305-306页

作者： Chengxu wang Hao YU Yichen wang Zichong ZHANG Xiangshui MIAO xingsheng wang School of Optical and Electronic Information Huazhong University of Science and Technology Hubei Yangtze Memory Laboratories School of Integrated Circuits Huazhong University of Science and Technology Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology

Due to its potential in low-power computing or storage applications, the Hf O2-based ferroelectric (FE) field-efect transistor (FET), which consists of a MOSFET and an FE gate dielectric stack on the top of the original gate, has attracted massive research interest in the past decade [1].Taking advantage of the scalability of FE Hf O2-based film [2], FE-FETs have been developing high-performance computing and high-density memory at advanced process nodes [3]. However, significant variations in state-of-the-art FE-Fin FETs are also caused by polycrystalline FE gates.

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Rare earth metal based DES assisted the VPO synthesis for n-butane selective oxidation toward maleic anhydride

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Green Energy & Environment 2023年第6期8卷 1737-1752页

作者： Muhammad Faizan Yingwei Li xingsheng wang Piao Song Ruirui Zhang Ruixia Liu Beijing Key Laboratory of Ionic Liquids Clean Process CAS Key Laboratory of Green Process and EngineeringState Key Laboratory of Multiphase Complex SystemInstitute of Process Engineering Chinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China Zhengzhou Institute of Emerging Industrial Technology Zhengzhou450000China

Deep eutectic solvents(DESs) are now considered a new class of ionic liquid analogs that have been generously used in various ***, vanadium phosphorus oxide(VPO) catalysts are synthesized in combination with a deep eutectic solvent containing rare earth metal(rE-DES), and their catalytic performance in n-butane selective oxidation to produce maleic anhydride(MA) is evaluated. The rE-DES is produced from the interaction of choline chloride(ChCl) and rare earth metal salts(Cerium, Europium, Lanthanum, and Samarium metal salt)(ChCl:rE = 1:0.5–1:3) under mild conditions. It was found that DESs served as structural modifiers and electronic promoters during VPO synthesis. It regulated the chemical state of the catalyst surface, such as the vanadium valence state, acid-base properties, and ratios of V^(4+)/V^(5+),Lat–O/Sur–O and P/V. Various characterization techniques, such as FT-IR, DSC, XRD, SEM, EDS, TEM, Raman, TGA, NH3-TPD, and XPS,were used to examine its physical and chemical characteristics. These characteristics were correlated with the catalytic performance. The VPO catalyst modified by rE-DES showed a significant enhancement of n-butane conversion and MA selectivity while suppressing the selectivity of CO and CO_(2)as well as the CO/CO_(2)ratio compared to the unpromoted VPO catalyst. Especially for Ce-DES-VPO, it increased the n-butane conversion and MA mass yield up to approximately 11% and 10%, respectively. In addition, we evaluated the catalytic performance under different activation atmospheres.

关键词： earth anhydride vanadium