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Value of whole body diffusion weighted imaging in diagnostic and therapeutic evaluation of malignant lymphoma

The Chinese-German Journal of Clinical Oncology 2011年第2期10卷 111-115页

作者： xingrong hu ruizhi ran jiaquan zhang shunzhen li Department of Imaging The Central Hospital of Enshi Autonomous Prefecture Enshi 445000 China

Objective:The aim was to evaluate the role of whole body diffusion weighted imaging(WB-DWI) of magnetic resonance in the diagnosis and efficacy evaluation of malignant ***:The clinical manifestation of whole body diffusion weighted imaging of 47 patients with malignant lymphoma being pathologically proved were carried on by retrospective analysis and to compare with 10 healthy *** were 8 cases of Hodgkin's lymphoma(HD) patients,of which WB-DWI examination of 5 cases were carried out before and after treatment and 3 cases were done after *** were 39 cases of non-Hodgkin's lymphoma(NHL) patients,of which WB-DWI examination in 19 cases were acted before treatment,11 cases were done before and after treatment and 9 cases done after *** apparent diffusion coefficient(ADC) diagram the ADC values of lymph nodes in patients with malignant lymphoma and healthy volunteers were measured respectively,among 16 patients the ADC values of parts of lymph node being consistent with the initial inspection were determined again and compared the values before and after,and compared with healthy ***:Whole body magnetic resonance diffusion weighted imaging(MR-DWI) showed more sensitive to lymphoma,and 372 lymph nodes greater than 1 cm were detected with *** treatment,mean ADC value of 35 patients with malignant lymphoma was(0.86 ± 0.21) × 10-3 mm2/s,of which an average ADC values of 28 cases after treatment was(1.22 ± 0.31) × 10-3 mm2/s,before and after treatment difference of the average ADC values of patients was statistically significant(P lignant lymphoma before treatment was statistically significant(P 0.05).Conclusion:WB-DWI and ADC values being measured in the

关键词： lymphoma magnetic resonance imaging diffusion weighted imaging apparent diffusion coefficient

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Dietary ferulic acid and vanillic acid on inflammation,gut barrier function and growth performance in lipopolysaccharide-challenged piglets

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Animal Nutrition 2022年第1期8卷 144-152页

作者： ruizhi hu Shusong Wu Baizhen li Jijun Tan Jiahao Yan Ying Wang Zhiyi Tang Ming liu Chenxing Fu Hongfu zhang Jianhua He hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients College of Animal Science and TechnologyHunan Agricultural UniversityChangsha410128China Beijing China-Agri HongKe Bio-Technology Co. Ltd.Beijing102206China State Key Laboratory of Animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing100193China

Ferulic acid(FA)and vanillic acid(VA)are considered as major phenolic metabolites of cyanidin 3-glucoside,a polyphenol that widely exists in plants that possess a protective effect against oxidative stress and inflammation in our previous *** study aimed to investigate the effect of FA and VA on inflammation,gut barrier function,and growth performance in a weaned piglet model challenged with lipopolysaccharide(LPS).Thirty-six piglets(PIC 337×C48,28 d of age)were randomly allocated into 3 treatments with 6 replicate pens(2 piglets per pen).They were fed with a basal diet or a diet containing 4,000 mg/kg of FA or *** supplementation of VA significantly increased average daily gain(ADG)(Pligens group,and Eubacterium xylanophilum group(Plimited effect on these *** results demonstrated that both VA and FA could alleviate inflammation and oxidative stress,but only VA has a significant positive effect on the growth performance of LPS-challenged piglets potentially through modulating gut microbiota.

关键词： Ferulic acid Vanillic acid Inflammation Gut barrier function Growth performance Piglet

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Taking the pulse of COVID-19:a spatiotemporal perspective

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International Journal of Digital Earth 2020年第10期13卷 1186-1211页

作者： Chaowei Yang Dexuan Sha Qian liu Yun li Hai Lan Weihe Wendy Guan Tao hu Zhenlong li Zhiran zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao zhang ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei liu Dieter Pfoser Shuming Bao Mei li Haoyuan zhang Chunbo liu Jie Jiang Shihong Du liang Zhao Mingyue Lu lin li huan Zhou Andrew Ding NSF Spatiotemporal Innovation Center George Mason Univ.FairfaxVAUSA Department of Geography and GeoInformation Science George Mason Univ.FairfaxVAUSA Department of Geographical Sciences University of MarylandCollege ParkMDUSA Center for Geographic Analysis Harvard UniversityCambridgeMAUSA Geoinformation and Big Data Research Lab Department of GeographyUniversity of South CarolinaColumbiaSCUSA Chinese Academy of Surveying and Mapping BeijingPeople’s Republic of China School of Resource and Environmental Sciences Wuhan UniversityWuhanPeople’s Republic of China Cloud Computeand Storage OperationsInformation Technology ServicesGeorge Mason UniversityFairfaxVAUSA Department of Geography Pennsylvania State UniversityState CollegePAUSA School of Business Management East China Normal UniversityShanghaiPeople’s Republic of China School of Mathematical Sciences East China Normal UniversityShanghaiPeople’s Republic of China Department of Psychology George Mason UniversityFairfaxVAUSA mDepartment of Computer Science George Mason UniversityFairfaxVAUSA Department of Information Technology George Mason UniversityFairfaxVAUSA Department of Biology George Mason UniversityFairfaxVAUSA College of Land Science and Technology China Agricultural UniversityBeijingPeople’s Republic of China China Data Institute Ann ArborMIUSA Institute of Remote Sensing and GIS Peking UniversityBeijingPeople’s Republic of China Aerospace Information Research Institute Chinese Academy of SciencesBeijingPeople’s Republic of China School of Geomatics and Urban Spatial Informatics Beijing University of Civil Engineering and ArchitectureBeijingPeople’s Republic of China School of Geographical Sciences Nanjing University of Information Science&TechnologyNanjingPeople’s Republic of China School of Geodesy and Geomatics Wuhan UniversityWuhanPeople’s Republic of China wFaculty of Environment University of WaterlooWaterlooCanada

The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the *** transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and *** response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global *** perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies.

关键词： Big Data Earth system emergency geospatial sciences epidemics applications

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青年肺癌肺内弥漫转移的CT表现与误诊分析

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中国现代医生 2008年第27期46卷 124-125,F0003页

作者：胡兴荣张俊邱妮妮李顺振李祚雯湖北省恩施自治州中心医院影像科湖北恩施445000

目的探讨青年肺癌肺内弥漫性转移的CT表现,并对其误诊原因进行分析。方法回顾性分析4例经穿刺活检、支气管镜检查及病理证实的青年肺癌伴肺内弥漫性转移的CT表现及误诊原因的病历资料。结果4例青年肺癌肺内弥漫性转移伴有淋巴结转移和... 详细信息

目的探讨青年肺癌肺内弥漫性转移的CT表现,并对其误诊原因进行分析。方法回顾性分析4例经穿刺活检、支气管镜检查及病理证实的青年肺癌伴肺内弥漫性转移的CT表现及误诊原因的病历资料。结果4例青年肺癌肺内弥漫性转移伴有淋巴结转移和远处转移,均被误诊为结核。结论青年肺癌肺内弥漫性转移临床表现无特异性,恶性程度高、转移早,容易误诊,CT扫描具有重要的临床诊断价值,值得临床医生予以重视。

关键词：肺肿瘤转移瘤误诊结核 CT

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Exploring age and gender disparities in cardiometabolic phenotypes and lipidomic signatures among Chinese adults: a nationwide cohort study

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life Metabolism 2024年第5期3卷 61-74页

作者： Xiaojing Jia Hong lin ruizhi Zheng Shuangyuan Wang Yilan Ding Chunyan hu Mian li Yu Xu Min Xu Guixia Wang Lulu Chen Tianshu Zeng Ruying hu Zhen Ye lixin Shi Qing Su Yuhong Chen Xuefeng Yu li Yan Tiange Wang Zhiyun Zhao Guijun Qin Qin Wan Gang Chen Meng Dai Di zhang Bihan Qiu Xiaoyan Zhu Jie Zheng Xulei Tang Zhengnan Gao Feixia Shen Xuejiang Gu Zuojie Luo Yingfen Qin li Chen Xinguo Hou Yanan huo Qiang li Yinfei zhang Chao liu Youmin Wang Shengli Wu Tao Yang huacong Deng Jiajun Zhao Yiming Mu Shenghan Lai Donghui li Weiguo hu Guang Ning Weiqing Wang Yufang Bi Jieli Lu for theC Study Group Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People's Republic of ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Endocrine and Metabolic Diseases The First Hospital of Jilin UniversityChangchunJilin 130021China Department of Endocrine and Metabolic Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Zhejiang Provincial Center for Disease Control and Prevention HangzhouZhejiang 310051China Department of Endocrine and Metabolic Diseases Affiliated Hospital of Guiyang Medical CollegeGuiyangGuizhou 550004China Department of Endocrine and Metabolic Diseases Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Endocrine and Metabolic Diseases Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Endocrine and Metabolic Diseases Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120China Department of Endocrine and Metabolic Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Endocrine and Metabolic Diseases The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Department of Endocrine and Metabolic Diseases Fujian Provincial HospitalFujian Medical UniversityFuzhouFujian 350003China Department of Endocrine and Metabolic Diseases The First Hospital of Lanzhou UniversityLanzhouGansu 730000China Department of Endocrine and Metabolic Diseases Dalian Municipal Central HospitalDalianLiao

Understanding sex disparities in modifiable risk factors across the lifespan is essential for crafting individualized intervention *** aim to investigate age-related sex disparity in cardiometabolic phenotypes in a large nationwide Chinese cohort.A total of 254,670 adults aged 40 years or older were selected from a population-based cohort in *** sex disparities in the prevalence of metabolic diseases were observed across different age strata,particularly for dyslipidemia and its com*** additive models were employed to characterize phenotype features,elucidating how gender differences evolve with advancing *** of the 16 phenotypes consistently exhibited no sex differences,while four(high-density lipoprotein[HDL]cholesterol,apolipoprotein A1,diastolic blood pressure,and fasting insulin)displayed significant sex differences across all age ***,apolipoprotein B,non-HDL cholesterol,and total cholesterol demonstrated significant age-dependent sex dis***,premenopausal females exhibited significant age-related differences in lipid levels around the age of 40-50 years,contrasting with the relatively stable associations observed in males and postmenopausal *** played an important but not sole role in age-related sex differences in blood *** duration also had an age-and sex-dependent impact on *** analysis and K-means clustering further revealed that 58.6%of the 263 measured lipids varied with sex and age,with sphingomyelins,cholesteryl esters,and triacylglycerols being the most profoundly influenced lipid species by the combined effects of age,sex,and their *** findings underscore the importance of age consideration when addressing gender disparities in metabolic diseases and advocate for personalized,age-specific prevention and management.

关键词： sex difference aging metabolic diseases modifiable risk factors lipidomics

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Guidelines for burn rehabilitation in China

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Burns & Trauma 2015年第3期3卷 133-142页

作者： Chinese Burn Association Chinese Association of Burn Surgeons Ying Cen Jiake Chai huade Chen Jian Chen Guanghua Guo Chunmao Han Dahai hu Jingning huan Xiaoyuan huang Chiyu Jia Cecilia WP li-Tsang Jianan li Zongyu li Qun liu Yi liu Gaoxing Luo Guozhong Lv Xihua Niu Daizhi Peng Yizhi Peng Hongyan Qi shunzhen Qi Zhiyong Sheng Dan Tang Yibing Wang Jun Wu Zhaofan Xia Weiguo Xie Hongming Yang Xianfeng Yi Lehua Yu Guoan zhang The Chinese Burn Care and Rehabilitation Association Department of Burn and Plastic Surgery West China School of MedicineWest China HospitalSichuan UniversityChengduSichuanChina Department of Burn&Plastic Surgery the First Hospital Affiliated to General Hospital of PLABeijingChina Department of Burns General Hospital of Guangdong ProvinceGuangzhouGuangdongChina State Key Laboratory of Trauma Burns and Combined InjuryInstitute of Burn ResearchSouthwest Hospitalthe Third Military Medical UniversityChongqingChina Department of Burns the First Affiliated Hospital of Nanchang UniverisityResearch Center of Technology of Wound Repair Engineering in Jiangxi ProvinceNanchangJiangxiChina Department of Burns and Wound Center The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangChina Department of Burns and Cutaneous Surgery Xijing HospitalFourth Military Medical UniversityXi’anShanxiChina Department of Burn and Plastic Surgery Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Burns and Plastic Surgery Central South UniversityChangshaHunanChina Plastic Beauty and Burn Repair Center the 309th Hospital of the Chinese PLABeijingChina Department of Rehabilitation Sciences the Hong Kong Polytechnic UniversityHung HomHong KongChina Department of Rehabilitation Medicine the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Burns and Plastic Surgery the Fifth Hospital of HarbinHarbinHeilongjiang ProvinceChina Department of Burn and Plastic Surgery the Fourth Hospital of TianjinBurn Institution of TianjinTianjinChina Burns and Plastic Surgery Center PLA Lanzhou General Hospital of Lanzhou CommandLanzhouGansuChina Department of Burn Surgery the Third People’s Hospital of WuxiJiangsuChina Department of Burn Surgery the First People’s Hospital of ZhengZhouZhengzhouHenanChina Department of Burn Surgery Beijing Children’s HospitalBeijingChina The Center of Burn and Plastic of Hebei Province Bethune International Peace Hospita

Quality of life and functional recovery after burn injury is the final goal of burn care,especially as most of burn patients survive the injury due to advanced medical ***,dysfunction,disfigurement,contractures,psychological problems and other discomforts due to burns and the consequent scars are common,and physical therapy and occupational therapy provide alternative treatments for these problems of burn *** guideline,organized by the Chinese Burn Association and Chinese Association of Burn Surgeons aims to emphasize the importance of team work in burn care and provide a brief introduction of the outlines of physical and occupational therapies during burn treatment,which is suitable for the current medical circumstances of *** can be used as the start of the tools for burn rehabilitation.

关键词： Burn Rehabilitation Physical therapy Occupational Therapy Scar

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复合微生态制剂对肉鸡生产性能、肠道菌群、抗氧化指标和免疫功能的影响

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动物营养学报 2012年第2期24卷 334-341页

作者：胡顺珍张建梅谢全喜李晓颖山东宝来利来生物工程股份有限公司泰安271000

本试验旨在探讨复合微生态制剂对肉鸡生产性能、肠道菌群、抗氧化指标和免疫功能的影响。将240只1日龄雌性健康肉鸡随机分为4组,每组3个重复,每个重复20只。试验预试期5 d,Ⅰ组为对照组,饲喂基础饲粮;Ⅱ、Ⅲ、Ⅳ组为试验组,在饲喂基础... 详细信息

本试验旨在探讨复合微生态制剂对肉鸡生产性能、肠道菌群、抗氧化指标和免疫功能的影响。将240只1日龄雌性健康肉鸡随机分为4组,每组3个重复,每个重复20只。试验预试期5 d,Ⅰ组为对照组,饲喂基础饲粮;Ⅱ、Ⅲ、Ⅳ组为试验组,在饲喂基础饲粮同时,分别定时在饮水中添加复合微生态制剂A及其佐剂B,其中复合微生态制剂A的添加水平为饲粮的2.0‰,6日龄时开始添加,每周2次,每次饮用量为周采食量2.0‰的1/2;复合微生态制剂佐剂B在7、14和21日龄免疫后分别连续使用3 d,每天1次,每次饮用量为日采食量的0.5‰、1.0‰和2.0‰。正试期为37 d。测定各组生产性能、肠道菌群数量、抗氧化指标和免疫指标。结果表明:1)在每个试验阶段,Ⅱ组肉鸡平均日增重均显著高于对照组(P0.05)。4)14日龄和42日龄时,Ⅳ组肉鸡的脾脏指数最高,均显著高于对照组(P<0.05);14、28和42日龄时,Ⅲ组肉鸡的法氏囊指数均较高,显著高于对照组(P<0.05)。由此可知,2.0‰复合微生态制剂A和0.5‰复合微生态制剂佐剂B能够提高肉鸡生产性能,改善其肠道微生态环境,提高其抗氧化能力。同时,复合微生态制剂及其佐剂的添加可在一定程度上增强肉鸡免疫功能。

关键词：复合微生态制剂肉鸡生产性能肠道菌群抗氧化指标免疫功能

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基于“重要性-脆弱性-服务价值”的国土空间生态保护与修复管控

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农业工程学报 2022年第19期38卷 249-258页

作者：韦宝婧胡希军张亚丽汤佳康鹏李芮芝刘路云中南林业科技大学风景园林学院长沙410004 中南林业科技大学城乡景观生态研究所长沙410004 湖南省自然保护地风景资源大数据工程技术研究中心长沙410004 南方林业生态应用技术国家工程实验室长沙410004 中南林业科技大学生命科学与技术学院长沙410004

国土空间生态保护修复是维护国家生态安全格局的重要保障,科学划定与管控保护修复关键区对维持区域生态系统功能与可持续发展具有重要意义。该研究以福建上杭县作为典型研究案例区,在综合生态系统完整性、系统性与生态效益的基础上,构... 详细信息

国土空间生态保护修复是维护国家生态安全格局的重要保障,科学划定与管控保护修复关键区对维持区域生态系统功能与可持续发展具有重要意义。该研究以福建上杭县作为典型研究案例区,在综合生态系统完整性、系统性与生态效益的基础上,构建了“重要性-脆弱性-服务价值”(Ⅰ-F-Ⅴ)的多维生态系统测度框架,进而分析了区域生态系统的多维特征、测度因子间的权衡与协同关系,运用空间聚类(分组分析)划定了生态保护与修复空间,并基于各分区的空间分异性及生态系统结构特征,提出分区管控措施。结果表明:1)上杭县生态系统具有较强的空间异质性,整体上呈现重要性较高、脆弱性程度低、服务价值较高的空间分异格局;2)上杭县各生态系统测度因子间协同与权衡关系并存,综合重要性、脆弱性和服务价值之间均为协同关系,生态系统保护与修复区域可能存在高度重叠;3)上杭县可划分为Ⅲ-Ⅰ-Ⅴ(中等重要-一般脆弱-极高价值)、Ⅲ-Ⅲ-Ⅴ(中等重要-中等脆弱-极高价值)、Ⅲ-Ⅱ-Ⅴ(中等重要-较为脆弱-极高价值)、Ⅲ-Ⅲ-Ⅳ(中等重要-中等脆弱-较高价值)、Ⅱ-Ⅲ-Ⅰ(较为重要-中等脆弱-低价值)和Ⅳ-Ⅰ-Ⅰ(高度重要-一般脆弱-低价值)6个分区,其中,Ⅲ-Ⅰ-Ⅴ和Ⅲ-Ⅱ-Ⅴ两个分区面积较大,是区域发展的生态系统功能基底,各分区所在的土地覆被类型构成也存在明显的空间异质性,林地、灌丛、耕地和园地属于优势土地覆被类型;4)依据生态保护与修复措施将研究区进一步划分为生态保护区(生态保育区、绿色发展区、适度开发区)和生态修复区(生态修复区、保护修复统筹发展区)。研究结果可为区域国土空间生态保护修复规划与建设、生态安全格局维护提供较为科学、全面的研究思路和实践借鉴。

关键词：国土空间生态保护修复与管控生态系统测度空间分区上杭县

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纳米药物的构型调控用于自噬增强铁死亡和肿瘤免疫治疗

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Science Bulletin 2023年第1期68卷 77-94页

作者：胡睿智戴晨代新月董彩虹黄慧宋新然冯炜丁利陈雨张波 Department of Ultrasound Shanghai East HospitalTongji UniversityShanghai 200120China Materdicine Lab School of Life SciencesShanghai UniversityShanghai 200444China Department of Medical Ultrasound Shanghai Tenth People's HospitalUltrasound Research and Education InstituteShanghai Engineering Research Center of Ultrasound Diagnosis and TreatmentTongji University Cancer CenterSchool of MedicineTongji UniversityShanghai 200072China Department of Ultrasound Zhongshan HospitalFudan UniversityShanghai 200032China

设计合成了一种四足针尖状铁钯纳米颗粒(简称TFPs),分别通过诱导乳腺癌细胞自噬和巨噬细胞释放促炎因子,实现在光声成像引导下的乳腺肿瘤细胞铁死亡协同免疫治疗.首先,该新型TFPs具有优异的光学吸收和较高的光热转换效率,是良好的光声... 详细信息

设计合成了一种四足针尖状铁钯纳米颗粒(简称TFPs),分别通过诱导乳腺癌细胞自噬和巨噬细胞释放促炎因子,实现在光声成像引导下的乳腺肿瘤细胞铁死亡协同免疫治疗.首先,该新型TFPs具有优异的光学吸收和较高的光热转换效率,是良好的光声成像造影剂.其次,TFPs具有过氧化物酶/谷胱甘肽氧化酶模拟酶性能,能原位催化肿瘤区过表达过氧化氢,产生羟基自由基,并同时下调胞内谷胱甘肽水平,协同诱导细胞铁死亡.此外,其独特的针状形态可以进一步触发肿瘤细胞自噬,加快铁蛋白降解,释放铁离子,进而增效铁死亡;同时,特殊的尖状结构能触发巨噬细胞释放促炎细胞因子,增效放大免疫效应,在与PD-L1检查点抑制剂联合使用后,取得最强的抗肿瘤效果.这项工作不仅开发了一种高效的铁死亡诱导剂,也为在纳米尺度调控肿瘤细胞自噬/免疫功能提供了一种全新的策略.

关键词：肿瘤免疫治疗谷胱甘肽氧化酶细胞自噬光声成像巨噬细胞纳米药物造影剂模拟酶

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鸡源人葡萄球菌的分离鉴定及生物学特性分析

引用

中国家禽 2023年第3期45卷 52-58页

作者：张家浩邢潇月李虎刘祥杰杨睿智李莲瑞塔里木大学动物科学与技术学院新疆阿拉尔843300 塔里木畜牧科技兵团重点实验室新疆阿拉尔843300 新疆生产建设兵团塔里木动物疫病诊断与防控工程实验室新疆阿拉尔843300 塔里木大学生命科学与技术学院新疆阿拉尔843300

为确定新疆阿克苏地区某鸡场鸡精神不振、采食量减少和死亡的原因,试验对采集自该鸡场病死鸡内脏器官进行病原的分离鉴定,并进行动物致病性试验和药物敏感性试验,分析其致病力和耐药性。结果显示,从发病鸡内脏器官中分离到一株革兰氏阳... 详细信息

为确定新疆阿克苏地区某鸡场鸡精神不振、采食量减少和死亡的原因,试验对采集自该鸡场病死鸡内脏器官进行病原的分离鉴定,并进行动物致病性试验和药物敏感性试验,分析其致病力和耐药性。结果显示,从发病鸡内脏器官中分离到一株革兰氏阳性球菌,分离菌对复方新诺明、麦迪霉素、红霉素、诺氟沙星、环丙沙星、阿莫西林、青霉素、克林霉素、氨苄西林等药物表现为耐药,对部分头孢类、四环素类、氨基糖苷类、氯霉素类和多肽类药物表现为不同程度敏感;通过对分离菌进行形态学观察、生化试验、16S rRNA基因测序和同源性分析,确定该分离菌为人葡萄球菌。该分离菌可引起小鼠和雏鸡死亡,死亡雏鸡以肝脏肿大出血、胃黏膜出血等内脏器官出血为主要病理变化,与自然发病一致。研究首次在鸡上分离出人葡萄球菌,为鸡的人葡萄球菌病防治和合理用药提供依据。

关键词：人葡萄球菌耐药性分析分离与鉴定 16S rRNA 鸡源

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