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Numerical Simulation of the Mass Movement Process of the 2018 Sedongpu Glacial Debris Flow by Using the Fluid-Solid Coupling Method

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Journal of Earth Science 2024年第2期35卷 583-596页

作者： xing-yu long yu-Xiang Hu Bin-Rui Gan Jia-Wen Zhou State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu610065China College of Water Resource and Hydropower Sichuan UniversityChengdu610065China

In the context of global warming and intensified human activities,glacier instability in plateau regions has increased,and glacier debris flows have become active,which poses a significant threat to the lives and property of people and socioeconomic *** mass movement process of glacier debris flows is extremely complex,so this paper uses the 2018 Sedongpu glacier debris flow event on the Qinghai-Tibet Plateau as an example and applies a numerical simulation method to invert the whole process of mass *** view of the interaction between phases in the process of motion,we use the fluid-solid coupling method to describe the mass *** granular-flow model and drift-flux model are employed in FLOW3D software to study the mass movement process of glacier debris flows and explore their dynamic *** results indicate that the glacier debris flow lasted for 700 s,and the movement process was roughly divided into four stages,including initiation,scraping,surging and deposition;the depositional characteristics calculated by the fluid-solid coupling model are consistent with the actual survey results and have good reliability;strong erosion occurs during the mass movement,the clear volume amplification effect,and the first wave climbs 17.8 m across the *** fluid-solid coupling method can better simulate glacier debris flows in plateau regions,which is helpful for the study of the mechanism and dynamic characteristics of such disasters.

关键词： glacial debris flow Qinghai-Tibet Plateau fluid-solid coupling FLOW3D mass movement depositional characteristics disasters engineering geology

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Micra无导线起搏系统的临床应用研究

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中国心脏起搏与心电生理杂志 2024年第4期38卷 268-272页

作者：邢建东徐伟邢玉龙南京市高淳人民医院心血管内科江苏南京210008 南京鼓楼医院心血管内科江苏南京210008

目的探讨Micra无导线起搏器系统临床应用的安全性及有效性。方法连续入选2020年1月至2022年12月在南京鼓楼医院住院治疗且具备Micra无导线起搏器系统植入适应证的心律失常患者41例。其中因囊袋感染电极导线拔除后再植入无导线起搏器21... 详细信息

目的探讨Micra无导线起搏器系统临床应用的安全性及有效性。方法连续入选2020年1月至2022年12月在南京鼓楼医院住院治疗且具备Micra无导线起搏器系统植入适应证的心律失常患者41例。其中因囊袋感染电极导线拔除后再植入无导线起搏器21例(再植入LP组),首次植入无导线起搏器20例(首次植入LP组)。对比分析两组的手术时间、释放次数、X线曝光时间、起搏参数、并发症等数据。随访两组植入1、3、6及12个月时起搏参数情况。结果所有患者均成功植入Micra无导线起搏器,起搏器植入部位为中高位室间隔。再植入LP组男性15例(71.4%),平均年龄(72.5±19.1)岁。首次植入LP组男性12例(60%),平均年龄(60.8±8.4)岁。再植入LP组与首次植入LP组相比,在手术时间、释放≤2次比例、X线曝光时间、起搏阈值、感知、阻抗之间均无差异(P均>0.05),两组均未发生手术及起搏器相关并发症和严重不良事件。两组患者在1、3、6及12个月随访时的起搏阈值、感知、阻抗均无差异(P均>0.05)。结论 Micra无导线起搏器植入安全可行,传统起搏器因感染并发症移除后更换无导线起搏器亦同样安全有效。

关键词：心血管病学无导线起搏器心脏起搏器感染导线拔除

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Male fecundity prognosis and infertility diagnosis in the era of personalised medicine

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Asian Journal of Andrology 2010年第4期12卷 463-467页

作者： Wen-Bing Zhu xing-yu long Li-Qing Fan Institute of Reproductive and Stem Cell Engineering Central South University Reproductive and Genetic Hospital of CITIC- Xiangya Central South University Changsha 410078 China

In daily clinical practice, we attempt to classify diseases according to patients＇ symptoms and reference values for certain tests. A minimal evaluation is performed following the diagnostic standard, and the patient is treated according to the diagnosis. In this ＇classification medicine＇ model, a patient＇s individual characteristics are more or less ignored.

关键词： Male fecundity prongosis infertility diagnosi era of personalised medicina

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Giant cellular leiomyoma in the broad ligament of the uterus:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12696-12702页

作者： Jiao Yan yu Li xing-yu long Dao-Cheng Li Si-Jin Li The First Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina The Sixth Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Department of Obstetrics and Gynecology The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina

BACKGROUND The treatment of large pelvic masses in postmenopausal women is a challenge in clinical *** ultrasound or magnetic resonance imaging can be used to determine the size and location of the mass,it is still difficult to achieve a preoperative *** majority of cellular leiomyomas are diagnosed by histopathology after *** report the differential diagnosis and surgical management of a rare case of cellular leiomyoma in the broad ligament of the *** SUMMARY A 52-year-old Chinese woman without sexual history was admitted to the First Affiliated Hospital of Guangzhou University of Chinese Medicine for the first *** patient had a 1-year history of progressive abdominal enlargement as well as a 2-year history of menopause,and complained of frequent abdominal pain and low-grade *** tomography of the abdomen showed a solid cystic mass(29.4 cm×18.8 cm×37.7 cm)in the pelvis and ***,routine blood test results indicated a baseline cancer antigen 125(CA-125)level of 187.7 U/mL and C-reactive protein of 109.58 mg/***,retrograde hysterectomy and bilateral adnexectomy were performed in this *** histopathologic examination of the surgical specimen,a rare cellular leiomyoma in the broad ligament was *** Clinicians need to constantly improve diagnosis and treatment for the challenges posed during clinical assessment,differential diagnosis,and surgical management.

关键词： Surgical oncology Cellular leiomyoma in the broad ligament Uterine leiomyoma Retrograde abdominal hysterectomy Case report

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猪肺炎支原体P46-P65重组蛋白的表达及间接ELISA抗体检测方法的建立

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中国预防兽医学报 2024年第7期46卷 709-715页

作者：杨振宇李璇刘一宁谢邵波郑金刘春燕林美婷刘腾唐红剑余兴龙湖南农业大学动物医学院湖南长沙410128 湖南康保特生物科技有限公司湖南长沙410128

为建立猪肺炎支原体(Mhp)血清学调查及免疫评估方法,本研究利用DNAStar生物学软件对Mhp的P46和P65进行抗原表位分析,利用重叠延伸PCR(SOE-PCR)获得P46-P65融合基因,构建重组表达质粒pETP46-P65,将其转化大肠杆菌BL21(DE3)感受态细胞,经... 详细信息

为建立猪肺炎支原体(Mhp)血清学调查及免疫评估方法,本研究利用DNAStar生物学软件对Mhp的P46和P65进行抗原表位分析,利用重叠延伸PCR(SOE-PCR)获得P46-P65融合基因,构建重组表达质粒pETP46-P65,将其转化大肠杆菌BL21(DE3)感受态细胞,经诱导后获得了可溶性表达的重组P46(aa33~aa419)-P65(aa307~aa627)蛋白(rP46-P65)。以纯化的r P46-P65为包被抗原,经优化各反应条件后建立了检测Mhp抗体的间接ELISA方法。特异性试验结果显示所建立的方法与CSFV、FMDV、PEDV、PCV2、PRV、PRRSV和APP等阳性血清均无交叉反应。该方法可检测到最高稀释至6 400倍的Mhp阳性血清,批内和批间变异系数均小于5%。利用IDEXX试剂盒和本研究建立的方法同时检测298份临床血清样品,前者的检测阳性率为62.4%(186/298),后者的检测阳性率为73.8%(220/298),两者检测结果的总符合率为88.6%。IDEXX检测为阳性的血清,采用本研究建立的ELISA方法检测也均为阳性;而部分Mhp阳性猪经IDEXX试剂盒检测为阴性的血清,该ELISA方法检测结果却为阳性,其中79.4%(27/34)检测结果有差异的血清经Mhp颜色变化试验证明均为阳性,表明本研究建立的ELISA方法的敏感性明显高于IDEXX方法。本研究建立的检测猪Mhp抗体的间接ELISA方法与目前广泛使用的方法相比优势明显,为临床血清流行病学调查及血清抗体水平评估提供了可行方法。

关键词：猪肺炎支原体重组融合蛋白P46-P65 间接ELISA

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Improving flangeability of multiphase steel by increasing microstructural homogeneity

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Journal of Iron and Steel Research International 2024年第7期31卷 1736-1745页

作者： Xiao-yu Yang Yong-gang Yang xing Fang Han-long Zhang Zhen-li Mi Beijing Advanced Innovation Center for Materials Genome Engineering Institute of Engineering TechnologyUniversity of Science and Technology BeijingBeijing 100083China Shanghai Baosteel Group Corp.Technology Center Shanghai 201900China

Multiphase microstructure significantly increases the strength,usually at the expense of flangeability because of lacking microstructure *** further improve the strength-flangeability of multiphase steel,the microstructural homogeneity was advanced by adjusting the hard martensite/austenite(M/A)*** strength-flangeability was measured via uniaxial tensile tests and hole expansion *** microstructures were characterized using a scanning electron microscope equipped with an electron backscatter diffraction detector and a transmission electron *** tests were supplementally used to quantitatively reveal the microstructural homogeneity of the *** show that the adjusted multiphase steel achieves an excellent ultimate tensile strength(~800 MPa)and flangeability(~135%hole expansion ratio).A promising homogeneous multiphase microstructure was obtained by controlling undercooled austenite transformed at about 600℃.This microstructure consists of soft polygonal ferrite,blocky bainitic ferrite,and hard M/A *** volume fraction of M/A islands is around 5%,and the average size is less than l *** nanoindentation analysis indicated that the participation of M/A islands impressively influenced the microstructural *** strain partition and better mechanical compatibility were present in the adjusted multiphase steel since the plasticity initiation started late,which resulted in a positive ***,avoiding M/A islands distributed in the chain along the rolling direction on the matrix hindered the possibility of voids coalescing into cracks and stabilized the flanging performance.

关键词： Multiphase steel Flangeability Martensite/austenite island-Microstructural homogeneity-Microstructure Compact strip production process

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A semantic vector map-based approach for aircraft positioning in GNSS/GPS denied large-scale environment

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Defence Technology（防务技术） 2024年第4期34卷 1-10页

作者： Chenguang Ouyang Suxing Hu Fengqi long Shuai Shi Zhichao yu Kaichun Zhao Zheng You Junyin Pi Bowen xing State Key Laboratory of Precision Measurement Technology and Instruments Tsinghua UniversityBeijing 100084China School of Mechanical and Information Engineering China University of Mining and Technology(Beijing)Beijing 100083China

Accurate positioning is one of the essential requirements for numerous applications of remote sensing data,especially in the event of a noisy or unreliable satellite *** this end,we present a novel framework for aircraft geo-localization in a large range that only requires a downward-facing monocular camera,an altimeter,a compass,and an open-source Vector Map(VMAP).The algorithm combines the matching and particle filter *** vector and correlation between two building contour vectors are defined,and a coarse-to-fine building vector matching(CFBVM)method is proposed in the matching stage,for which the original matching results are described by the Gaussian mixture model(GMM).Subsequently,an improved resampling strategy is designed to reduce computing expenses with a huge number of initial particles,and a credibility indicator is designed to avoid location mistakes in the particle filter *** experimental evaluation of the approach based on flight data is *** a flight at a height of 0.2 km over a flight distance of 2 km,the aircraft is geo-localized in a reference map of 11,025 km~2using 0.09 km~2aerial images without any prior *** absolute localization error is less than 10 m.

关键词： Large-scale positioning Building vector matching Improved particle filter GPS-Denied Vector map

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Surface diffraction beamline at the SSRF

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Nuclear Science and Techniques 2024年第7期35卷 47-57页

作者： yue-Liang Gu Xu Zheng xing-Min Zhang Bin Zhao Guang-Zhi Yin Da-Ming Zhu yuan-He Sun xing-yu Gao Xiao-long Li Shanghai Advanced Research Institute Chinese Academy of Sciences239 Zhangheng RoadPudong DistrictShanghai201204China

BL02U2 of the Shanghai Synchrotron Radiation Facility is a surface diffraction beamline with a photon flux of 5.5×10^(12) photons/s at 10 keV and a beam size of 160µm×80µm at the sample *** is dedicated to studying surfaces(solid-vacuum,solid-gas)and interfaces(solid-solid,solid-liquid,and liquid-liquid)in nanoscience,condensed matter,and soft matter systems using various surface scattering techniques over an energy range of 4.8-28 keV with transmission and reflection ***,BL02U2 has a high energy resolution,high angular resolution,and low beam divergence,which can provide excellent properties for X-ray diffraction experiments,such as grazing incident X-ray diffraction,X-ray reflectivity,crystal truncation rods,and liquid X-ray *** of in situ environments can also be provided for the samples *** paper describes the setup of the new beamline and its applications in various fields.

关键词： Surface and interface Beamline Surface diffraction Microstructure

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Biological factors driving colorectal cancer metastasis

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 259-272页

作者： Shuai-xing An Zhao-Jin yu Chen Fu Min-Jie Wei long-Hai Shen Department of Pharmacology School of PharmacyChina Medical UniversityShenyang 110122Liaoning ProvinceChina Liaoning Key Laboratory of Molecular Targeted Antitumor Drug Development and Evaluation Liaoning Cancer Immune Peptide Drug Engineering Technology Research CenterKey Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors(China Medical University)Ministry of EducationShenyang 110122Liaoning ProvinceChina BD Department Greenpine Pharma Group Co.LtdTianjin 300020China Center of Oncology Genertec Liaoyou Gem Flower HospitalPanJin 124010Liaoning ProvinceChina

Approximately 20%of colorectal cancer(CRC)patients present with metastasis at *** Stage I-III CRC patients who undergo surgical resection,18%typically suffer from distal metastasis within the first three years following initial *** median survival duration after the diagnosis of metastatic CRC(mCRC)is only 9 *** is traditionally considered to be an advanced stage malignancy or is thought to be caused by incomplete resection of tumor tissue,allowing cancer cells to spread from primary to distant organs;however,increa-sing evidence suggests that the mCRC process can begin early in tumor *** patients present with high heterogeneity and diverse cancer phenotypes that are classified on the basis of molecular and morphological *** genomic and nongenomic events can induce subclone diversity,which leads to cancer and *** the course of mCRC,metastatic cascades are associated with invasive cancer cell migration through the circulatory system,extravasation,distal seeding,dormancy,and reactivation,with each step requiring specific molecular ***,cancer cells presenting neoantigens can be recognized and eliminated by the immune *** this review,we explain the biological factors that drive CRC metastasis,namely,genomic instability,epigenetic instability,the metastatic cascade,the cancer-immunity cycle,and external lifestyle *** remarkable progress in CRC research,the role of molecular classification in therapeutic intervention remains *** review shows the driving factors of mCRC which may help in identifying potential candidate biomarkers that can improve the diagnosis and early detection of mCRC cases.

关键词： cancer Metastasis cascade Cancer immunity Genomic variation Epigenetic instability Lifestyle factor

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Numerical simulation study on the hygrothermal performance of building exterior walls under dynamic wind-driven rain condition

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Building Simulation 2024年第2期17卷 207-221页

作者： xing Hu Huibo Zhang Hui yu School of Design Shanghai Jiao Tong UniversityShanghai200240China

Wind-driven rain(WDR)has a significant influence on the hygrothermal performance,durability,and energy consumption of building *** calculation of WDR loads using semi-empirical models has been incorporated into the boundary conditions of coupled heat and moisture transfer ***,prior research often relied on fixed WDR absorption ratio,which fail to accurately capture the water absorption characteristics of porous building materials under rainfall ***,this study aims to investigate the coupled heat and moisture transfer of exterior walls under dynamic WDR boundary conditions,utilizing an empirically obtained WDR absorption ratio model based on field *** developed coupled heat and moisture transfer model is validated against the HAMSTAD *** findings reveal that the total WDR flux calculated with the dynamic WDR boundary is lower than that obtained with the fixed WDR boundary,with greater disparities observed in orientations experiencing higher WDR *** variations in moisture flow significantly impact the surface temperature and relative humidity of the walls,influencing the calculation of cooling and heating loads by different *** to the transient heat transfer model,the coupled heat and moisture transfer model incorporating dynamic WDR boundary exhibits maximum increases of 17.6%and 16.2%in cooling and heating loads,*** dynamic WDR boundary conditions provide more precise numerical values for surface moisture flux,offering valuable insights for the thermal design of building enclosures and load calculations for HVAC systems.

关键词： wind-driven rain building component hygrothermal model transient simulation cooling and heating loads

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