检索结果-南通市图书馆

International Journal of Automation and computing 2016年第3期13卷 285-295页

作者： Jia-Can Geng Zhe Cui xing-sheng gu Key Laboratory of Advanced Control and Optimization for Chemical Process Ministry of EducationEast China University of Science and Technology

Considering the imprecise nature of the data in real-world problems, the earliness/tardiness （E/T） fiowshop scheduling problem with uncertain processing time and distinct due windows is concerned in this paper. A fuzzy scheduling model is established and then transformed into a deterministic one by employing the method of maximizing the membership function of middle value. Moreover, an effective scatter search based particle swarm optimization （SSPSO） algorithm is proposed to minimize the sum of total earliness and tardiness penalties. The proposed SSPSO algorithm incorporates the scatter search （SS） algorithm into the frame of particle swarm optimization （PSO） algorithm and gives full play to their characteristics of fast convergence and high diversity. Besides, a differential evolution （DE） scheme is used to generate solutions in the SS. In addition, the dynamic update strategy and critical conditions are adopted to improve the performance of SSPSO. The simulation results indicate the superiority of SSPSO in terms of effectiveness and efficiency.

关键词： Earliness/tardiness (E/T) scheduling fuzzy modeling scatter search (SS) particle swarm optimization (PSO).

Intelligent Welding Robot Path Planning

在线全文

学校读者我要写书评

暂无评论

Intelligent Welding Robot Path Planning

Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

2015年中国智能自动化学术会议

作者： Xue Wu Wang Ying Pan Shi Rui Yu xing sheng gu School of Information Science and Engineering East China University of Science and Technology

Spot welding robots are now widely used in manufacturing industry,and usually many welding joints have to be traversed in welding *** path planning for welding robot is based on engineering experiments where teaching and playback were applied in most *** usually takes the engineer much time to obtain desired welding path,and sometimes,it is difficult to find an optimal path for spot welding robot especially when the number of welding joints is ***,welding robot path planning has become one key technology in this *** optimization algorithm is beneficial for realizing effective welding robot path *** this end,particle swarm optimization(PSO) algorithm was improved ***,the improved PSO algorithm was applied for path planning of welding robot,and the simulation results show the effectiveness of the method.

关键词： Welding robot Path planning Particle swarm optimization Genetic algorithm

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 281-292页

作者： xing Wang Wei Pi sheng Hu Haifeng Bao Na Yao Wei Luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

CT与MRI增强扫描诊断肝细胞癌的对比分析

在线全文

学校读者我要写书评

暂无评论

中国医学影像技术 2010年第1期26卷 1-4页

作者：邢古生王爽欧阳汉马霄虹周纯武中国医学科学院北京协和医学院肿瘤医院影像诊断科北京100021

目的比较多排螺旋CT三期增强及3.0T MR多期动态增强扫描对肝细胞肝癌（HCC）的诊断价值。方法60例临床疑似HCC患者接受CT及MR检查,39例确诊为HCC,共59个病灶。CT采用平扫加三期增强,MR采用LA-VA技术双动脉期、双门脉期、双静脉期及延迟... 详细信息

目的比较多排螺旋CT三期增强及3.0T MR多期动态增强扫描对肝细胞肝癌（HCC）的诊断价值。方法60例临床疑似HCC患者接受CT及MR检查,39例确诊为HCC,共59个病灶。CT采用平扫加三期增强,MR采用LA-VA技术双动脉期、双门脉期、双静脉期及延迟期共7期动态增强扫描。对观测数据行Alternative-free-response ROC（AFROC）曲线分析,并计算曲线下面积（Az）,比较两种方法的诊断价值。结果CT增强扫描的Az平均值为0.8120±0.0118,MR多期动态增强扫描的Az平均值为0.9093±0.0072,差异无统计学意义。在〈1cm的HCC病灶组,CT和MR增强扫描的平均灵敏度分别为63.89%和80.55%。在1～3cm组和〉3cm组,CT和MR增强扫描诊断的灵敏度差异均无统计学意义。在所有病灶中,CT多期增强扫描的灵敏度低于MR动态增强扫描（83.62%vs88.70%）,差异无统计学意义,CT阳性预测值（PPV）也低于MR扫描（93.07%vs96.31%）,差异无统计学意义。结论在诊断HCC病灶方面,MR动态增强扫描与CT增强扫描相比差异无统计学意义;但对于小于1cm病灶,MR动态增强扫描诊断的灵敏度显著高于CT增强扫描。

关键词：肝肿瘤体层摄影术,X线计算机磁共振成像诊断显像

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min xing Hai-Dong Qian Qiao Gao sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

CT动脉单期与MR双动脉期诊断肝细胞癌对比分析

在线全文

学校读者我要写书评

暂无评论

中国介入影像与治疗学 2010年第1期7卷 1-4页

作者：邢古生王爽欧阳汉马霄虹周纯武中国医学科学院北京协和医学院肿瘤医院影像诊断科北京100021

目的以螺旋CT、3．0TMR对肝细胞癌（HCC）患者行增强扫描，对比CT单动脉期与MR双动脉期扫描对HCC病灶的显示能力。方法39例HCC患者59个病灶纳入本研究，并完成CT及MR检查。根据病灶大小，分为〉3cm组（n=20）、1～3cm组（n=27）及〈1cm... 详细信息

目的以螺旋CT、3．0TMR对肝细胞癌（HCC）患者行增强扫描，对比CT单动脉期与MR双动脉期扫描对HCC病灶的显示能力。方法39例HCC患者59个病灶纳入本研究，并完成CT及MR检查。根据病灶大小，分为〉3cm组（n=20）、1～3cm组（n=27）及〈1cm组（n=12）。CT单动脉期采用25S延迟扫描；MR双动脉期采用肝脏加速容积采集（LAVA）技术，延迟时间分别相当于第17秒和24秒。比较CT动脉期和MR双动脉期对HCC病灶的显示能力。结果CT动脉期和MR双动脉期对小于〈1cm组HCC病灶的敏感度分别为50．00％（6／12）和75．00％（9／12），MR双动脉期的敏感度显著高于CT动脉期（P=0．04）；在1～3cm组，CT动脉期与MR双动脉期的敏感度分别为66．67％（18／27）、81．48％（22／27）（P〉0．05）；在〉3cm组，CT动脉期与MR双动脉期的敏感度均为95．00％（19／20）。结论对小于1cm的HCC灶，MR双动脉期扫描对病灶的检出效能高于CT单动脉期扫描。

关键词：肝肿瘤体层摄影术 X线计算机磁共振成像诊断显像

Single-cell omics: experimental workflow, data analyses and applications

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

肝内胆管细胞癌患者的预后影响因素分析

中华肿瘤杂志 2009年第11期31卷 845-848页

作者：张磊蔡建强毕新宇赵建军邢古生阎涛付玉霞赵平中国医学科学院北京协和医学院肿瘤医院腹部外科 100021

目的分析影响肝内胆管细胞癌（ICC）患者预后的相关临床病理因素，并对ICC的外科治疗方式进行探讨。方法回顾性分析43例经病理证实为ICC患者的临床病理资料。43例ICC患者中，40例行肝切除术，2例在剖腹探查时行无水酒精注射，1例仅行剖... 详细信息

目的分析影响肝内胆管细胞癌（ICC）患者预后的相关临床病理因素，并对ICC的外科治疗方式进行探讨。方法回顾性分析43例经病理证实为ICC患者的临床病理资料。43例ICC患者中，40例行肝切除术，2例在剖腹探查时行无水酒精注射，1例仅行剖腹探查。采用单因素和Cox回归模型对可能影响ICC患者术后生存的因素进行分析。结果全组43例患者的1、3和5年生存率分别为64．4％、30．9％和25．8％。40例行肝切除患者的术后1、3和5年生存率分别为74．7％、33．3％和27．8％。单因素分析结果显示，肿瘤直径、有无淋巴结转移、癌胚抗原（CEA）水平和TNM分期与ICC患者的术后生存显著相关（均P〈0．05）。Cox多因素分析结果显示，肿瘤直径和有无淋巴结转移是影响ICC患者术后生存的独立因素（均P〈0．05）。结论肿瘤直径和有无淋巴结转移是影响ICC患者术后生存的独立因素，CEA水平和TNM分期是影响ICC患者术后生存的重要因素。对ICC患者应选择行根治性肝切除术。

关键词：肝内胆管细胞癌肝切除术预后

在线全文

学校读者我要写书评

暂无评论

文明叙事:习近平文化思想的方法论审视

新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 34-42页

作者：张明谷生秀南京大学马克思主义学院江苏南京210023

文明是中国共产党百余年推进马克思主义中国化时代化的核心线索,文明叙事是中国共产党历史叙事的重要维度,也是习近平文化思想的重要方法论。习近平文化思想的深厚文明意蕴体现在四个方面:一是从历史纵深出发把握“走自己的路”的文明基... 详细信息

文明是中国共产党百余年推进马克思主义中国化时代化的核心线索,文明叙事是中国共产党历史叙事的重要维度,也是习近平文化思想的重要方法论。习近平文化思想的深厚文明意蕴体现在四个方面:一是从历史纵深出发把握“走自己的路”的文明基因,即从中华5000多年文明的历史传承中把握中国道路的来龙去脉及其内在逻辑必然;二是以“第二个结合”为根本方法,重塑发展中华文明的使命担当,不断推动建设中华民族现代文明实现传统文明的现代新生;三是坚守文明超越理念,将新文明的建构与中国式现代化的现实实践相互关联,以中国式现代化创造人类文明新形态,打破西方以资本逻辑为核心的形而上学抽象文明观的历史困境;四是坚持文明交流互鉴,推动落实全球文明倡议,构建人类文明交往新范式。

关键词：习近平文化思想文明叙事 “走自己的路” “第二个结合” 文明交流互鉴

盆底筋膜保护与重建对腹腔镜下前列腺癌根治术后早期控尿的影响

在线全文

学校读者我要写书评

暂无评论

现代泌尿生殖肿瘤杂志 2016年第3期8卷 145-149页

作者：汤桂兴王树声古炽明李源甘澍广东省中医院泌尿外科广州510105

目的了解采用盆底筋膜保护与重建法对腹腔镜下前列腺癌根治术后患者早期控尿的影响。方法回顾性分析自同一术者2013年1月至2015年12月在广东省中医院泌尿外科行腹腔镜下前列腺癌根治术的40例患者资料,其中采用盆底筋膜保护与重建技术的... 详细信息

目的了解采用盆底筋膜保护与重建法对腹腔镜下前列腺癌根治术后患者早期控尿的影响。方法回顾性分析自同一术者2013年1月至2015年12月在广东省中医院泌尿外科行腹腔镜下前列腺癌根治术的40例患者资料,其中采用盆底筋膜保护与重建技术的前列腺癌患者17例（治疗组）,采用常规腹腔镜下治疗的前列腺癌患者23例（对照组）,对两组患者的年龄、术前BMI、术前前列腺体积、术前临床分期、术前Gleason评分、手术时间、术中出血量、术后吻合口漏尿率、术后病理切缘阳性率、术后病理分期、术后Gleason评分及早期尿控功能恢复的情况等临床指标进行统计学分析。结果 40例腹腔镜下前列腺癌根治术均经腹膜外完成,术中无中转开放,无术中输血病例,术后吻合口无漏尿,两组均有1例术后病理切缘阳性。两组在年龄、术前BMI、术前前列腺体积、术前临床分期、术前Gleason评分、手术时间、术中出血量、术后病理分期及术后Gleason评分方面差异均无统计学意义（P〉0.05）;40例患者均在术后12~16d拔除尿管,治疗组拔除尿管后3d内、1个月内和3个月内的累积完全控尿比例分别为52.9%、64.7%和82.4%,显著高于对照组（分别为8.7%、26.1%和34.8%）,两组差异有统计学意义（P〈0.05）。结论在腹腔镜前列腺癌根治术中使用盆底筋膜保护与重建技术可显著提高患者术后早期的控尿能力。

关键词：腹腔镜前列腺癌根治术盆底筋膜保护盆底筋膜重建控尿