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Cascade equilibrium stage relaxation method by introducing equilibrium efficiency parameter

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Chinese Journal of Chemical Engineering 2024年第2期66卷 145-156页

作者： Xuepu Cao Shengkun Jia xing qian Yiqing Luo Xigang Yuan College of Chemical and Pharmaceutical Hebei University of Science&TechnologyShijiazhuang 050018China School of Chemical Engineering and Technology State Key Laboratory of Chemical EngineeringTianjin UniversityTianjin 300072China College of Information Science and Technology Beijing University of Chemical TechnologyBeijing 100029China

Optimizing multistage processes,such as distillation or absorption,is a complex mixed-integer nonlinear programming(MINLP)*** integer into continuous variables and solving the easier nonlinear programming(NLP)problem is an optimization idea for the multistage *** this article,we propose a relaxation method based on the efficiency *** the efficiency parameter is 1or 0,the proposed model is equivalent to the complete existence or inexistence of the equilibrium *** non-integer efficiency represents partial existence.A multi-component absorption case shows a natural penalty for non-integer efficiency,which can assist the efficiency parameter converging to 0 or ***,its penalty is weaker than the existing relaxation models,such as the bypass efficiency *** a simple distillation case,we show that this property can weaken the nonconvexity of the optimization problem and increase the probability of obtaining better optimization results.

关键词： Mathematical modeling Absorption Distillation Optimization

Evaluating the tumor stratification with a lysosomal pH sensitive-probe by fluorescence lifetime imaging

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Chinese Chemical Letters 2024年第3期35卷 262-267页

作者： Jun Yan xing Liang qian Zhang Luolin Wang Weiying Lin Guangxi Key Laboratory of Electrochemical Energy Materials Institute of Optical Materials and Chemical BiologySchool of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004China

Owing to the anaerobic metabolism in the tumor,abundant acidic metabolites are produced and accumulated in the ***,the cells in different tumor layers are directly linked to the pH ***,due to the lack of robust tools,the high-efficient evaluation of the acidic micro-environment of tumor stratification faces the challenge of accurate *** designed a new pH sensitive fluorescent lifetime probe target to *** we expected,the fluorescence lifetime of PLN possesses a good linear fit to the pH value,which could detect the pH change at a single lysosome level in real time,and then evaluate the different acidity of tumor *** probe PLN is successfully used to evaluate the tumor stratification by fluorescence lifetime imaging microscopy(FLIM)for the first time,which is of great significance in the preoperative diagnosis of clinical tumor treatment or evaluation of drug delivery effect.

关键词： FLIM pH Fluorescence imaging Lysosome Tumor imaging

Effects of combustion temperature on the optical properties of brown carbon from biomass burning

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Journal of Environmental Sciences 2024年第3期137卷 302-309页

作者： Peng Gao Rule Deng Song Jia Yue Li Xuefei Wang qian xing School of Chemistry Sciences University of Chinese Academy of SciencesBeijing 100049China College of Chemistry and Materials Engineering Beijing Technology and Business UniversityBeijing 100048China

Biomass burning has been known as one of main sources of Brown Carbon(BrC)in *** this study,by controlling the combustion temperature at 250℃,350℃,and 450℃,the methanol soluble organic carbon(MSOC)and methanol insoluble carbon(MISC)from pine wood burning was collected by ***–Vis,excitation emission matrix(EEM),TEM and FTIR spectra were applied to investigate the properties of BrC *** MSOC at 250℃ and 350℃,all the spectral profiles of UV–Vis absorption and excitation emission matrix are almost the same,while the EEM of MSOC at 450℃ are different from that of the other *** MISC fuorescence was observed only in the case of 450℃.In the FTIR spectra,with the temperature increasing the peaks associated to the oxygen-contained functions was weakened,indicating the formation of the fuorophores with larger conjugated system,especially aromatic *** results show that biomass combustion at low temperature produces more oxygen-riched BrC,which possesses relatively lower light absorption,while at high temperature produces more aromatics hydrocarbons with relatively strong light *** results of this work are helpful to trace the source of brown carbon and optimize biomass energy utilization.

关键词： Biomass burning Combustion temperature Methanol-soluble brown carbon EEM Impinger

Diagnostic values of questionnaires of Convergence Insufficiency Symptom Survey and College of Optometrists Vision Development Quality of Life in the screening of convergence insufficiency

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 904-908页

作者： Ling Xiong qian Chen ye Wu Department of Ophthalmology West China HospitalSichuan University/Laboratory of Optometry and Vision ScienceWest China School of MedicineChengdu 610041Sichuan ProvinceChina Department of Clinical Research Management Center of BiostatisticsDesignMeasurement and EvaluationWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To compare and analyse the diagnostic efficacy of the College of Optometrists Vision Development Quality of Life Questionnaire(COVD-QOL)and the Convergence Insufficiency Symptom Survey(CISS)in detecting convergence insufficiency and to compare their diagnostic value in clinical ***:Using the diagnostic test method,62 adult patients with convergence insufficiency(age:24.74±3.75y)and 62 normal participants(age:23.61±3.13y)who visited the Optometry Clinic of West China Hospital of Sichuan University from April 2021 to January 2023 were *** subjects completed the CISS and *** analysis of the sensitivity and specificity of the CISS and COVD-QOL and comparison and joint experimental analysis of their diagnostic efficacy were ***:The sensitivity of the CISS and COVD-QOL for convergence insufficiency was 64.5%and 71.0%,respectively,while the specificity was 96.8%and 67.7%,*** to the CISS alone,the combination of the CISS and COVD-QOL demonstrated lower sensitivity and *** areas under the receiver operating characteristic curve of CISS,COVD-QOL and CISS combined with COVD-QOL were 0.806,0.694 and 0.782,***:Considering the low sensitivity of the CISS and the low specificity of the COVD-QOL,it is recommended to supplement these questionnaires with other screening tests for the detection of convergence insufficiency.

关键词： convergence insufficiency symptom survey College of Optometrists Vision Development Quality of Life Questionnaire convergence insufficiency asthenopia

Bilayer borophene:an efficient catalyst for hydrogen evolution reaction

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 13-23页

作者： Na xing Nan Gao Panbin ye Xiaowei Yang Haifeng Wang Jijun Zhao College of Sciences/Xinjiang Production&Construction Corps Key Laboratory of Advanced Energy Storage Materials and Technologies Shihezi UniversityShihezi832000China Key Laboratory of Materials Modification by Laser Ion and Electron Beams(Ministry of Education)Dalian University of TechnologyDalian116024China School of Materials Science and Engineering Taizhou UniversityTaizhou318000China

The electrocatalytic hydrogen evolution reaction is a crucial technique for green hydrogen ***,finding affordable,stable,and efficient catalyst materials to replace noble metal catalysts remains a significant *** experimental breakthroughs in the synthesis of two-dimensional bilayer borophene provide a theoretical framework for exploring their physical and chemical *** this study,we systematically considered nine types of bilayer borophenes as potential electrocatalysts for the hydrogen evolution *** first-principles calculations revealed that bilayer borophenes exhibit high stability and excellent conductivity,possessing a relatively large specific surface area with abundant active *** surface boron atoms and the bridge sites between two boron atoms can serve as active sites,displaying high activity for the hydrogen evolution ***,the Gibbs free energy change associated with adsorption for these bilayer borophenes can reach as low as−0.002 eV,and the Tafel reaction energy barriers are lower(0.70 eV)than those on ***,the hydrogen evolution reaction activity of these two-dimensional bilayer borophenes can be described by engineering their work ***,we considered the effect of pH on hydrogen evolution reaction activity,with significant activity observed in an acidic *** theoretical results reveal the excellent catalytic performance of two-dimensional bilayer borophenes and provide crucial guidance for the experimental exploration of multilayer boron for various energy applications.

关键词： bilayer borophene hydrogen evolution reaction work function pH effect

HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies

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Genes & Diseases 2024年第1期11卷 234-251页

作者： Yan Zhao Cheng xing Yating Deng Can ye Hongling Peng Department of Hematology The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Hunan Key Laboratory of Tumor Models and Individualized Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Hunan Engineering Research Center of Cell Immunotherapy for Hematopoietic Malignancies The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China

The hypoxic microenvironment is an essential characteristic of most malignant ***,hypoxia-inducible factor-1 alpha(HIF-1a)is a key regulatory factor of cellular adaptation to hypoxia,and many critical pathways are correlated with the biological activity of organisms via *** the intra-tumoral hypoxic environment,HIF-1αis highly expressed and contributes to the malignant progression of tumors,which in turn results in a poor prog-nosis in ***,it has been indicated that HiF-1αinvolves in various critical pro-cesses of life events and tumor development via regulating the expression of HiF-1a target genes,such as cell proliferation and apoptosis,angiogenesis,glucose metabolism,immune response,therapeutic resistance,*** from solid tumors,accumulating evidence has re-vealed that HiF-1αis also closely associated with the development and progression of hemato-logical malignancies,such as leukemia,lymphoma,and multiple *** inhibition of HiF-1a can facilitate an increased sensitivity of patients with malignancies to relevant ther-apeutic *** the review,we elaborated on the basic structure and biological functions of HIF-1a and summarized their current role in various *** is expected that they will have future potential fortargeted therapy.

关键词： Angiogenesis Hematological malignancies Hypoxia-inducible factor-1 alpha(HIF-1α) Immune escape Targeted therapy

An investigation on topologies of hybrid manifold,impinging-jet nozzle and micro-pin-fin heat sinks

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Science China(Technological Sciences) 2024年第4期67卷 1061-1076页

作者： SHI qianLei YAO XiaoLe LIU qian QIN Le JU xing XU Chao Key Laboratory of Power Station Energy Transfer Conversion and System of MOE North China Electric Power UniversityBeijing 102206China

The hybrid manifold micro-pin-fin(MMPF)heat sink combined nozzle jets is an option for large-scale integrated circuits(LSI).The demond for uniform and ultra-high heat flux removal by MMPF heat sink has not been adequately *** work aims to solve the problem of fluid *** proposed basic tiling topologies,including square,regular hexagon,30°rhombus,and 60°rhombus topologies,provide different organized fluid flows and heat transfer *** present study focuses on comparing these topologies according to independent porous medium parameters,such as nozzle pore size D_(Z),flow pore size D_(X,Y),and porosityε.The results show that the square topology achieves the smallest total thermal resistance R_(tot)value of0.0975×10^(-4)K m^2/W,while the hexagon topology achieved the highest value of COP/?T,which was 2033.9 K^(-1).According to the sensitivity analysis results,the optimal total thermal resistance can be obtained by balancing the influences of nozzle pore size,flow pore size,and *** optimal pressure drop can be obtained by maximizing the porosity.

关键词： heat sink ultra-high heat flux manifold micro-pin-fin impinging-jet topology

Cross-species transmission and host range genes in poxviruses

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Virologica Sinica 2024年第2期39卷 177-193页

作者： Chen-Hui Yang A-Ling Song ye Qiu xing-Yi Ge College of Biology Hunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha410012China

The persistent epidemic of human mpox, caused by mpox virus (MPXV), raises concerns about the future spread ofMPXV and other poxviruses. MPXV is a typical zoonotic virus which can infect human and cause smallpox-likesymptoms. MPXV belongs to the Poxviridae family, which has a relatively broad host range from arthropods tovertebrates. Cross-species transmission of poxviruses among different hosts has been frequently reported andresulted in numerous epidemics. Poxviruses have a complex linear double-strand DNA genome that encodeshundreds of proteins. Genes related to the host range of poxvirus are called host range genes (HRGs). This reviewbriefly introduces the taxonomy, phylogeny and hosts of poxviruses, and then comprehensively summarizes thecurrent knowledge about the cross-species transmission of poxviruses. In particular, the HRGs of poxvirus aredescribed and their impacts on viral host range are discussed in depth. We hope that this review will provide acomprehensive perspective about the current progress of researches on cross-species transmission and HRGvariation of poxviruses, serving as a valuable reference for academic studies and disease control in the future.

关键词： Poxvirus Host range gene(HRG) Host spectrum Cross-species transmission

Unified deep learning model for predicting fundus fluorescein angiography image from fundus structure image

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Journal of Innovative Optical Health Sciences 2024年第3期17卷 105-113页

作者： Yiwei Chen Yi He Hong ye Lina xing Xin Zhang Guohua Shi Jiangsu Key Laboratory of Medical Optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163P.R.China School of Biomedical Engineering(Suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of China Hefei 230026P.R.China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031P.R.China

The prediction of fundus fluorescein angiography(FFA)images from fundus structural images is a cutting-edge research topic in ophthalmological image *** comprises estimating FFA from fundus camera imaging,single-phase FFA from scanning laser ophthalmoscopy(SLO),and three-phase FFA also from *** many deep learning models are available,a single model can only perform one or two of these prediction *** accomplish three prediction tasks using a unified method,we propose a unified deep learning model for predicting FFA images from fundus structure images using a supervised generative adversarial *** three prediction tasks are processed as follows:data preparation,network training under FFA supervision,and FFA image prediction from fundus structure images on a test *** comparing the FFA images predicted by our model,pix2pix,and CycleGAN,we demonstrate the remarkable progress achieved by our *** high performance of our model is validated in terms of the peak signal-to-noise ratio,structural similarity index,and mean squared error.

关键词： Fundus fluorescein angiography image fundus structure image image translation unified deep learning model generative adversarial networks