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A highly sensitive fluorescent probe RN-NA reveals peroxynitrite as a novel biomarker for primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 219-227页

作者： Bo Qin Yuan lei Luo Bao You-Jia Zhang Ke-yin Liu Yu-Hong Chen Department of Ophthalmology&Visual Science Eye&ENT HospitalShanghai Medical CollegeFudan UniversityShanghai 200031China Key Laboratory of Myopia NHFPC(Fudan University)Shanghai Key Laboratory of Visual Impairment and Restoration(Fudan University)Shanghai 200031China State Key Laboratory of Biobased Material and Green Papermaking Key Laboratory of Pulp&Paper Science and Technology of Shandong Province/Ministry of EducationQilu University of TechnologyShandong Academy of SciencesJinan 250353Shandong ProvinceChina

AIM:To directly quantify peroxynitrite(ONOO-)using a highly sensitive fluorescence resonance energy transfer probe RN-NA,investigate the association between ONOOand primary open angle glaucoma(POAG),and clarify whether RN-NA could be used as a potential tool for POAG ***:Plasma and aqueous humor(AH)samples were collected from POAG patients(n=100,age:59.70±6.87y)and age-related cataract(ARC)patients(n=100,age:61.15±4.60y)admitted to our ***,RN-NA was used to detect ONOO-in plasma and AH samples,and the relationship between ONOO-level and POAG was analyzed using binary logistic ***,Pearson correlation analysis was applied to characterize the correlation of the levels of ONOO-with the patients’age,intraocular pressure(IOP),and mean deviation of visual field *** ONOO-scavenger MnTMPyP was employed to treat the 3-morpholinosyndnomine(SIN-1)-induced ocular hypertension in mice(n=7,6-8wk).Finally,the IOP and ONOO-in both eyes were measured 30min after the last drug ***:ONOO-levels of AH and plasma were significantly higher in the POAG group than in the ARC group(P<0.01).Additionally,ONOO-levels were closely correlated with POAG in a binary logistic regression analysis[odds ratio(OR)=1.008,95%confidence interval(CI):1.002-1.013,P<0.01 for AH;OR=1.004,95%CI:1.002-1.006,P<0.001 for plasma].Pearson correlation analysis showed that ONOO-levels in AH or plasma were positively associated with visual field defects(R=0.51,P<0.01 for AH;R=0.45,P<0.001 for plasma),and ONOO-levels in plasma and AH were correlated in the POAG group(R=0.69,P<0.001).However,administering MnTMPyP to mouse eyes reversed the elevated IOP caused by SIN-1(P<0.05).CONCLUSION:ONOO-levels in AH and plasma,detected by RN-NA,are significantly related to POAG and positively correlated with visual field defects in POAG ***,ONOO-is a potential biomarker of POAG,especially advanced ***,anti-nitration compounds may be novel ocular hypotens

关键词： peroxynitrite fluorescent probe RN-NA primary open angle glaucoma 3-morpholinosyndnomine

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Comparison of Statistical Signal Detection Methods in Adverse Events Following Immunization — China, 2011–2015

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China CDC weekly 2024年第16期6卷 350-356,I0001页

作者： Lanfang Xia Keli Li Yan Li Zhijie An Quanwei Song lei Wang Zundong yin Huaqing Wang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina

Introduction:The current study aims to assess the performance of data mining techniques in detecting safety signals for adverse events following immunization(AEFI)using routinely obtained data in *** different methods for detecting vaccine safety signals were ***:The AEFI data from 2011 to 2015 was collected for our *** analyzed the data using four different methods to detect signals:the proportional reporting ratio(PRR),reporting odds ratio(ROR),Bayesian confidence propagation neural network(BCPNN),and multi-item gamma Poisson shrinker(MGPS).Each method was evaluated at 1–3 thresholds for *** assess the performance of these methods,we used the published signal rates as gold standards to determine the sensitivity and ***:The number of identified signals varied from 602 for PRR1(with a threshold of 1)to 127 for *** considering the common reactions as the reference standard,the sensitivity ranged from 0.9%for MGPS1/2 to 38.2%for PRR1/2,and the specificity ranged from 85.2%for PRR1 and ROR1 to 96.7%for *** considering the rare reactions as the reference standard,PRR1,PRR2,ROR1,ROR2,and BCPNN exhibited the highest sensitivity(73.3%),while MGPS1 exhibited the highest specificity(96.9%).Discussion:For common reactions,the sensitivities were modest and the specificities were *** rare reactions,both the sensitivities and specificities were *** study provides valuable insights into the selection of signal detection methods and thresholds for AEFI data in China.

关键词： specificity routine vaccine

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Observation of the failure mechanism in Ag_(10)Ge_(15)Te_(75)-based memristor induced by ion transport

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Nano Research 2024年第9期17卷 8431-8437页

作者： Yuwei Xiong Kuibo yin Weiwei Sun Jingcang Li Shangyang Shang lei Xin Qiyun Wu Xiaoran Gong Yidong Xia Litao Sun SEU-FEI Nano-Pico Center Key Laboratory of MEMS of Ministry of EducationSoutheast UniversityNanjing 210096China College of Engineering and Applied Sciences Nanjing UniversityNanjing 210093China

The solid-electrolyte-based memristors have attracted tremendous attention for the next-generation nonvolatile memory for both logic and neuromorphic ***,they encounter variability performance challenges which originated from the random ionic transport and conductive filaments ***,the electrochemical metallized mechanism associated with ion transport has been ***,the failure mechanism caused by ion transport during cycles is rarely ***,the five stages of failure in the Ag/Ag_(10)Ge_(15)Te_(75)/W memristor are elucidated through ex-situ current-voltage measurements combined with in-situ transmission electron microscopy *** investigation reveals that the migration and enrichment of Ag ions result in the precipitation of Ag_(2)*** formation of Ag_(2)Te hinders the device's ability to maintain its bipolar characteristics and also decreases the resistance value of the high resistance state,thereby reducing the device's switching *** promising results provide important guidance for the future design of structures and the manipulation of ion transport for high-performance memristors.

关键词： Ag10Ge15Te75 in-situ transmission electron microscopy(TEM) failure mechanism

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Mpox(formerly monkeypox):pathogenesis,prevention,and treatment

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Signal Transduction and Targeted Therapy 2024年第1期9卷 234-248页

作者： Junjie Lu Hui xing Chunhua Wang Mengjun Tang Changcheng Wu Fan Ye Lijuan yin Yang Yang Wenjie Tan Liang Shen Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and ScienceHubei ProvinceXiangyang 441021China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China College of Biotechnology Tianjin University of Science&TechnologyTianjin 300457China Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for infectious diseaseState Key Discipline of Infectious DiseaseShenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China

In 2022,a global outbreak of Mpox(formerly monkeypox)occurred in various countries across Europe and America and rapidly spread to more than 100 countries and *** World Health Organization declared the outbreak to be a public health emergency of international concern due to the rapid spread of the Mpox ***,nations intensified their efforts to explore treatment strategies aimed at combating the infection and its ***,the available therapeutic options for Mpox virus infection remain *** far,only a few numbers of antiviral compounds have been approved by regulatory *** the high mutability of the Mpox virus,certain mutant strains have shown resistance to existing pharmaceutical *** highlights the urgent need to develop novel antiviral drugs that can combat both drug resistance and the potential threat of ***,there is a lack of comprehensive literature on the pathophysiology and treatment of *** address this issue,we conducted a review covering the physiological and pathological processes of Mpox infection,summarizing the latest progress of anti-Mpox *** analysis encompasses approved drugs currently employed in clinical settings,as well as newly identified small-molecule compounds and antibody drugs displaying potential antiviral efficacy against ***,we have gained valuable insights from the process of Mpox drug development,including strategies for repurposing drugs,the discovery of drug targets driven by artificial intelligence,and preclinical drug *** purpose of this review is to provide readers with a comprehensive overview of the current knowledge on Mpox.

关键词： prevention treatment intensified

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Photocatalytic seawater splitting by 2D heterostructure of ZnIn_(2)S_(4)/WO_(3) decorated with plasmonic Au for hydrogen evolution under visible light

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Journal of Energy Chemistry 2024年第6期93卷 55-63,I0003页

作者： Huiqin An Yanjun Wang xing Xiao Jiaxin Liu Zhiyao Ma Tianxin Gao Wanyu Hong Lizhi Zhao Hong Wang Qingjun Zhu Shanshan Chen Zhen yin School of Chemistry Tiangong UniversityTianjin 300387China School of Materials Science and Engineering Tiangong UniversityTianjin 300387China Deutsches Elektronen-Synchrotron DESY 15738 ZeuthenGermany Schoolof Materials Science and Engineering & National Institutefor Advanced Materials Nankai University Tianjin300350 China College of Chemical Engineering and Materials Science Tianjin University of Science and TechnologyTianjin 300457China

Photocatalytic H_(2) evolution from seawater splitting presents a promising approach to tackle the fossil energy crisis and mitigate carbon emission due to the abundant source of seawater and sunlight on the ***,the development of efficient photocatalysts for seawater splitting remains a formidable ***,a 2D/2D ZnIn_(2)S_(4)/WO_(3)(ZIS/WO_(3))heterojunction nanostructure is fabricated to efficiently separate the photoinduced carriers by steering electron transfer from the conduction band minimum of WO_(3) to the valence band maximum of ZIS via constructing internal electric ***,plasmonic Au nanoparticles(NPs)as a novel photosensitizer and a reduction cocatalyst are anchored on ZIS/WO_(3) surface to further enhance the optical absorption of ZIS/WO_(3) heterojunction and accelerate the catalytic *** obtained Au/ZIS/WO_(3) photocatalyst exhibits an outstanding H_(2) evolution rate of 2610.6 or 3566.3μmol g^(-1)h~(-1)from seawater splitting under visible or full-spectrum light irradiation,*** rates represent an impressive increase of approximately 7.3-and 6,6-fold compared to those of ZIS under the illumination of the same light *** unique 2D/2D structure,internal electric field,and plasmonic metal modification together boost the photocatalytic H_(2) evolution rate of Au/ZIS/WO_(3),making it even comparable to H_(2) evolution from pure water *** present work sheds light on the development of efficient photocatalysts for seawater splitting.

关键词： Photocatalytic seawater splitting 2D/2D ZnIn_(2)S_(4)/WO_(3) Surface plasmon resonance effect Interfacial electric field

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Status and developmental trends in recombinant collagen preparation technology

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Regenerative Biomaterials 2024年第2期3卷 17-36页

作者： Xiaolei Guo Yuan Ma Hang Wang Hongping yin Xinli Shi Yiqin Chen Guobiao Gao lei Sun Jiadao Wang Yunbing Wang Daidi Fan Center for Medical Device Evaluation National Medical Products AdministrationBeijing 100081China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China school of Life Science and Technology China Pharmaceutical UniversityNanjing 210009China National Engineering Research Center for Biomaterials&College of Biomedical Engineering Sichuan UniversityChengdu 610064China Biotech.&Biomed.Research Institute Northwest UniversityXi'an 710127China

Recombinant collagen is a pivotal topic in foundational biological research and epitomizes the application of critical bioengineer-ing *** technological advancements have pro-found implications across diverse areas such as regenerative medicine,organ replacement,tissue engineering,cosmetics and ***,recombinant collagen and its preparation methodologies rooted in genetically engineered celis mark pivotal milestones in medical product *** article pro-vides a comprehensive overview of the current genetic engi-neering technologies and methods used in the production of recombinant collagen,as well as the conventional production process and gquality control detection methods for this ***,the discussion extends to foresee the strides in physical transfection and magnetic control sorting studies,envisioning an enhanced preparation of recombinant collagen-seeded cells to further fuel recombinant collagen production.

关键词： recombinant collagen preparation genetic engineering collagen characterization physical transfection seed cell sorting

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Convolution-Transformer for Image Feature Extraction

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 87-106页

作者： Lirong yin lei Wang Siyu Lu Ruiyang Wang Youshuai Yang Bo Yang Shan Liu Ahmed AlSanad Salman A.AlQahtani Zhengtong yin Xiaolu Li Xiaobing Chen Wenfeng Zheng Department of Geography and Anthropology Louisiana State UniversityBaton RougeLA70803USA School of Automation University of Electronic Science and Technology of ChinaChengdu610054China College of Computer and Information Sciences King Saud UniversityRiyadh11574Saudi Arabia College of Resources and Environmental Engineering Key Laboratory of Karst Georesources and Environment(Guizhou University)Ministry of EducationGuiyang550025China School of Geographical Sciences Southwest UniversityChongqing400715China School of Electrical and Computer Engineering Louisiana State UniversityBaton RougeLA70803USA

This study addresses the limitations of Transformer models in image feature extraction,particularly their lack of inductive bias for visual *** to Convolutional Neural Networks(CNNs),the Transformers are more sensitive to different hyperparameters of optimizers,which leads to a lack of stability and slow *** tackle these challenges,we propose the Convolution-based Efficient Transformer Image Feature Extraction Network(CEFormer)as an enhancement of the Transformer *** model incorporates E-Attention,depthwise separable convolution,and dilated convolution to introduce crucial inductive biases,such as translation invariance,locality,and scale invariance,into the Transformer ***,we implement a lightweight convolution module to process the input images,resulting in faster convergence and improved *** results in an efficient convolution combined Transformer image feature extraction *** results on the ImageNet1k Top-1 dataset demonstrate that the proposed network achieves better accuracy while maintaining high computational *** achieves up to 85.0%accuracy across various model sizes on image classification,outperforming various baseline *** integrated into the Mask Region-ConvolutionalNeuralNetwork(R-CNN)framework as a backbone network,CEFormer outperforms other models and achieves the highest mean Average Precision(mAP)*** research presents a significant advancement in Transformer-based image feature extraction,balancing performance and computational efficiency.

关键词： Transformer E-Attention depth convolution dilated convolution CEFormer

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Atorvastatin, etanercept and the nephrogenic cardiac sympathetic remodeling in chronic renal failure rats

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Journal of Geriatric Cardiology 2024年第4期21卷 443-457页

作者： Jing-Yue XU Zheng-Kai XUE Ya-Ru ZHANG xing LIU Xue ZHANG Xi YANG Tong LIU Kang-yin CHEN Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of Cardiologythe Second Hospital of Tianjin Medical UniversityTianjinChina

BACKGROUND Chronic renal failure(CRF) patients are predisposed to arrhythmias, while the detailed mechanisms are unclear. We hypothesized the chronic inflammatory state of CRF patients may lead to cardiac sympathetic remodeling, increasing the incidence of ventricular arrhythmia(VA) and sudden cardiac death. And explored the role of atorvastatin and etanercept in this *** A total of 48 rats were randomly divided into sham operation group(Sham group), CRF group, CRF + atorvastatin group(CRF + statin group), and CRF + etanercept group(CRF + rhTNFR-Fcgroup). Sympathetic nerve remodeling was assessed by immunofluorescence of growth-associated protein 43(GAP-43) and tyrosine hydroxylase positive area fraction. Electrophysiological testing was performed to assess the incidence of VA by assessing the ventricular effective refractory period and ventricular fibrillation threshold. The levels of tumor necrosis factor-alpha(TNF-α) and interleukin-1beta were determined by Western blotting and enzyme-linked immunosorbent *** Echocardiogram showed that compared with the Sham group, left ventricular end-systolic diameter and ventricular weight/body weight ratio were significantly higher in the CRF group. Hematoxylin-eosin and Masson staining indicated that myocardial fibers were broken, disordered, and fibrotic in the CRF group. Western blotting, enzyme-linked immunosorbent assay,immunofluorescence and electrophysiological examination suggested that compared with the Sham group, GAP-43 and TNF-α proteins were significantly upregulated, GAP-43 and tyrosine hydroxylase positive nerve fiber area was increased, and ventricular fibrillation threshold was significantly decreased in the CRF group. The above effects were inhibited in the CRF + statin group and the CRF + *** In CRF rats, TNF-α was upregulated, cardiac sympathetic remodeling was more severe, and the nephrogenic cardiac sympathetic remodeling existed. Atorvastatin and etanercept c

关键词： remodeling cardiac inhibited

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Cost-efficient quantum access network boosts practical deployment of quantum key distribution network

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 169-169页

作者： Hua-lei yin Zeng-Bing Chen Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education)Renmin University of ChinaBeijing 100872China National Laboratory of Solid State Microstructures and School of Physics Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

The security of information is not assured over extended periods,especially with the rapid advancement of quantum *** address this challenge,quantum cryptography,rooted in quantum physics,offers comprehensive toolkits for key distribution[1],secret sharing[2],digital signatures[3]and other cryptographic tasks[4]with information-theoretical *** feasibility of quantum cryptography,particularly quantum key distribution(QKD)。

关键词： quantum distribution signature

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Relationship between physical activity and specific working memory indicators of depressive symptoms in university students

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World Journal of Psychiatry 2024年第1期14卷 148-158页

作者： Qun Zhao xing Wang Shu-Fan Li Peng Wang Xiang Wang Xin Xin Suo-Wang yin Zhao-Song yin Li-Juan Mao School of Physical Education Shanghai University of SportShanghai 200438China Department of Physical Education Donghua UniversityShanghai 201620China

BACKGROUND The detection rate of depression among university students has been increasing in recent years,becoming one of the main psychological diseases that endangers their physical and mental *** to statistics,self-harm and suicide,for which there is no effective intervention,are the second leading causes of *** To explore the relationship between different elements and levels of physical activity and college students’depression-symptom-specific working memory *** Of 143 college students were analyzed using the Beck Depression Self-Rating Scale,the Physical Activity Rating Scale,and the Working Memory *** There was a significant difference between college students with depressive symptoms and healthy college students in completing verbal and spatial working memory(SWM)tasks correctly(all P0.05).CONCLUSION An increase in physical exercise among college students,particularly medium-and high-intensity exercise and exercise of 30 min or more,can improve the correct rate of completing working memory tasks.

关键词： Physical activity Depression symptoms University students Working memory

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