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DAPK2 promotes autophagy to accelerate the progression of ossification of the posterior longitudinal ligament through the mTORC1 complex

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BIOCELL 2024年第9期48卷 1389-1400页

作者： lei SHI JIANSHI yin YU CHEN JIANGANG SHI JINHAO MIAO Department of Spine Surgery Shanghai Changzheng HospitalShanghai200003China Department of Orthopedics The 967th Hospital of Chinese People’s Liberation ArmyDalian116000China

Background:Ossification of the posterior longitudinal ligament(OPLL)is a prevalent condition in *** death-associated protein kinase 2(DAPK2)is known to play roles in cellular apoptosis and autophagy,its specific contributions to the advancement of OPLL are not well ***:Ligament fibroblasts were harvested from patients diagnosed with *** such as real-time reverse transcriptasepolymerase chain reaction(RT-qPCR)and Western blot analysis were employed to assess DAPK2 levels in both ligament tissues and cultured *** extent of osteogenic differentiation in these cells was evaluated using an alizarin red S(ARS)***,the expression of ossification markers and autophagy markers was *** autophagic activity was further analyzed through LC3 immunofluorescence and transmission electron microscopy(TEM).An in vivo heterotopic bone formation assay was conducted in mice to assess the role of DAPK2 in ***:Elevated DAPK2 expression was confirmed in both OPLL patient tissues and derived fibroblasts,in contrast to non-OPLL *** of DAPK2 significantly curtailed osteogenic differentiation and autophagy in these fibroblasts,evidenced by decreased levels of LC3,and Beclin1,and reduced autophagosome ***,DAPK2 was found to inhibit the mechanistic target of the rapamycin complex 1(mTORC1)complex’s *** vivo studies demonstrated that DAPK2 facilitates ossification,and this effect could be counteracted by the mTORC1 inhibitor ***:DAPK2 enhances autophagy and osteogenic processes in OPLL through modulation of the mTORC1 pathway.

关键词： Ossification of the posterior longitudinal ligament DAPK2 Autophagy mTORC1

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Robotic versus laparoscopic surgery for sporadic benign insulinoma:Short-and long-term outcomes

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 399-405页

作者： Zhu-Zeng yin Yuan-xing Gao Zhi-Ming Zhao Ming-Gen Hu Wen-Bo Tang Rong Liu Faculty of Hepato-Pancreato-Biliary Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China Institute of Hepatobiliary Surgery of Chinese PLA Beijing 100853China Key Laboratory of Digital Hepatobiliary Surgery of Chinese PLA Beijing 100853China

Background:Minimally invasive surgery is the optimal treatment for *** present study aimed to compare short-and long-term outcomes of laparoscopic and robotic surgery for sporadic benign ***:A retrospective analysis of patients who underwent laparoscopic or robotic surgery for insulinoma at our center between September 2007 and December 2019 was *** demographic,perioperative and postoperative follow-up results were compared between the laparoscopic and robotic ***:A total of 85 patients were enrolled,including 36 with laparoscopic approach and 49 with robotic *** was the preferred surgical ***-nine patients(69.4%)underwent enucleation;among them,26 and 33 patients underwent laparoscopic and robotic surgery,*** enucleation had a lower conversion rate to laparotomy(0 vs.19.2%,P=0.013),shorter operative time(102.0 vs.145.5 min,P=0.008)and shorter postoperative hospital stay(6.0 vs.8.5 d,P=0.002)than laparoscopic *** were no differences between the groups in terms of intraoperative blood loss,the rates of postoperative pancreatic fistula and *** a median follow-up of 65 months,two patients in the laparoscopic group developed a functional recurrence and none of the patients in the robotic group had a ***:Robotic enucleation can reduce the conversion rate to laparotomy and shorten operative time,which might lead to a reduction in postoperative hospital stay.

关键词： Robotic surgical procedures Laparoscopy Insulinoma Enucleation Pancreatectomy

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Binary Program Vulnerability Mining Based on Neural Network

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Computers, Materials & Continua 2024年第2期78卷 1861-1879页

作者： Zhenhui Li Shuangping xing Lin Yu Huiping Li Fan Zhou Guangqiang yin Xikai Tang Zhiguo Wang School of Information and Software Engineering University of Electronic Science and Technology of ChinaChengdu611731China School of Electrical and Computer Engineering University ofWaterlooWaterlooN2L 3G1Canada

Software security analysts typically only have access to the executable program and cannot directly access the source code of the *** poses significant challenges to security *** it is crucial to identify vulnerabilities in such non-source code programs,there exists a limited set of generalized tools due to the low versatility of current vulnerability mining ***,these tools suffer from some *** terms of targeted fuzzing,the path searching for target points is not streamlined enough,and the completely random testing leads to an excessively large search ***,when it comes to code similarity analysis,there are issues with incomplete code feature extraction,which may result in information *** this paper,we propose a cross-platform and cross-architecture approach to exploit vulnerabilities using neural network obfuscation *** leveraging the Angr framework,a deobfuscation technique is introduced,along with the adoption of a VEX-IR-based intermediate language conversion *** combination allows for the unified handling of binary programs across various architectures,compilers,and compilation ***,binary programs are processed to extract multi-level spatial features using a combination of a skip-gram model with self-attention mechanism and a bidirectional Long Short-Term Memory(LSTM)***,the graph embedding network is utilized to evaluate the similarity of program *** on these similarity scores,a target function is determined,and symbolic execution is applied to solve the target *** solved content serves as the initial seed for targeted *** binary program is processed by using the de-obfuscation technique and intermediate language transformation method,and then the similarity of program functions is evaluated by using a graph embedding network,and symbolic execution is performed based on these similarity *** approach facilitates

关键词： Vulnerability mining de-obfuscation neural network graph embedding network symbolic execution

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Quantum Neural Network for Quantum Neural Computing

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Research 2024年第1期2023卷 71-80页

作者： Min-Gang Zhou Zhi-Ping Liu Hua-lei yin Chen-Long Li Tong-Kai Xu Zeng-Bing Chen National Laboratory of Solid State Microstructures School of PhysicsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China MatricTime Digital Technology Co.Ltd. Nanjing 211899China

Neural networks have achieved impressive breakthroughs in both industry and *** to effectively develop neural networks on quantum computing devices is a challenging open ***,we propose a new quantum neural network model for quantum neural computing using(classically controlled)single-qubit operations and measurements on real-world quantum systems with naturally occurring environment-induced decoherence,which greatly reduces the difficulties of physical *** model circumvents the problem that the state-space size grows exponentially with the number of neurons,thereby greatly reducing memory requirements and allowing for fast optimization with traditional optimization *** benchmark our model for handwritten digit recognition and other nonlinear classification *** results show that our model has an amazing nonlinear classification ability and robustness to ***,our model allows quantum computing to be applied in a wider context and inspires the earlier development of a quantum neural computer than standard quantum computers.

关键词： quantum thereby breakthrough

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Research advancement of DNA-based intelligent hydrogels:Manufacture, characteristics, application of disease diagnosis and treatment

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Chinese Chemical Letters 2024年第10期35卷 92-101页

作者： Zhe-Han Yang Jie yin lei Xin Yuanfang Li Yijie Huang Ruo Yuan ying Zhuo Chongqing Key Laboratory of Catalysis and Functional Organic Molecules College of Environment and ResourcesChongqing Technology and Business UniversityChongqing 400067China Key Laboratory of Luminescence and Real-Time Analytic Chemistry(Southwest University) Ministry of EducationCollege of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China

DNA-based hydrogels are exceptional materials for biological applications because of their numerous advantages such as biodegradability,biocompatibility,hydrophilicity,super absorbency,porosity,and *** these advantages,the ability of DNA-based hydrogels to respond to specific physical and chemical triggers and undergo reversible phase transitions has garnered significant attention in the fields of disease diagnosis(biosensors)and treatment(drug delivery).This article focuses on the recent advancements in the research of DNA-based hydrogels and discusses the different types of these hydrogels,the synthetic methods,their unique properties,and their applications in biosensors and drug *** types of DNA hydrogels are categorized based on their building blocks,and the process of synthesis as well as the unique characteristics of DNA-based hydrogels are ***,DNA-based responsive hydrogels utilized as intelligent materials for the development of biosensors are ***,this article also presents the current status of DNA-based responsive hydrogels in drug delivery for cancer treatment,wound healing,and other therapeutic ***,this paper discusses the current challenges in expanding the practical application of DNA-based hydrogels.

关键词： DNA-based hydrogel Intelligent hydrogel Manufacture Characteristics Diseasediagnosis and treatment

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“Three-in-one” strategy of trifluoromethyl regulated blood-brain barrier permeable fluorescent probe for peroxynitrite and antiepileptic evaluation of edaravone

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Chinese Chemical Letters 2024年第10期35卷 360-363页

作者： lei Shen Hongmei Liu Ming Jin Jinchao Zhang Caixia yin Shuxiang Wang Yutao Yang Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Chemical Biology Key Laboratory of Hebei ProvinceState Key Laboratory of New Pharmaceutical Preparations and ExcipientsCollege of Chemistry and Materials ScienceHebei UniversityBaoding 071002China Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular ScienceShanxi UniversityTaiyuan 030006China

Epilepsy,as a chronic neurological disease of the brain,is closely related to oxidative stress,and the peroxynitrite(ONOO-)significantly rise up in this ***,ONOO-is considered as a potential biomarker for early prediction of ***,some potential diagnostic reagents for epilepsy are hindered by the blood-brain barrier(BBB).Meanwhile,“drug repurposing”is attracting a growing ***(EDA),as a first-line drug in the clinical treatment of cerebral ischemia,plays antioxidant roles in scavenging free radicals,promising potential antiepileptic ***,it is imperative to develop fluorescent probes for monitoring ONOO-fluctuations in the epileptic ***,we proposed a novel fluorescent probe with the thiocarbonate as the promising recognition unit for ONOO-and dicyanoisophorone derivative as the ***,by the“three-in-one”strategy,the introduction of trifluoromethyl into DCI-ONOO-3 can extend the emission wavelength of the fluorophore,shorten the response and increase ***,DCI-ONOO-3 was used for monitoring ONOO-fluxes in brain of epileptic mice and evaluating the antiepileptic efficacy of *** opens up a new way for the design of BBB permeable fluorescent probes,and provides a convincing new method for the diagnosis and treatment of epilepsy.

关键词： Fluorescent probe Blood-brain barrier Peroxynitrite Epilepsy Drug repurposing

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Formation environment and hydrocarbon potential of the Paleogene Enping Formation coal measures in the ZhuⅠDepression of northern South China Sea

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Acta Oceanologica Sinica 2024年第4期43卷 119-135页

作者： Yuting yin lei Lan Dongdong Wang ying Chen Yan Liu Youchuan Li Zengxue Li Jiamin Liu College of Earth Science and Engineering Shandong University of Science and TechnologyQingdaoShandong 266590China China National Offshore Oil Corporation Research Institute Co. Ltd.Beijing 100028China School of Geography Earth and Environmental SciencesUniversity of BirminghamBirminghamB152TTUK

The coal-measure source rock in the Chinese sea area plays a significant role as a hydrocarbon source rock,with its genetic environment,development and distribution,and hydrocarbon generation potential serving as essential factors for the exploration of coal-type oil and gas *** study focuses on the coal-measure source rock of the Paleogene Enping Formation in the ZhuⅠDepression,located in the northern South China *** main geological insights obtained are as *** coal measures of the Enping Formation are developed in a warm and wet tropical-subtropical *** development environment of the coal-measure source rock in the Enping Formation includes the braided river delta upper plain peat swamp,characterized by dry forest swamp coal facies with relatively thick coal seams and a small number of *** braided river delta lower plain swamp-interdistributary bay of braided river delta front represents a forest edge-wetland herbaceous swamp coal facies with numerous layers of thin coal seams and poor *** shore swamp corresponds to an open water swamp coal facies with multiple layers of thin coal seams and poor *** organic matter abundance in the braided river delta upper plain is the highest,followed by the braided river delta lower plain-braided river delta front,and the shore-shallow *** organic matter type is predominantly typeⅡ*** evolution analysis suggests that the organic matter has progressed into a substantial oil generation *** hydrocarbon generation potential of the coal-measure source rock in the Enping Formation is the highest in the braided river delta upper plain,followed by the braided river delta lower plain-braided river delta front and the shore-shallow ***,this study proposes three organic facies in the coal-measure source rock of the Enping Formation:upper-plain swamp-dry forest swamp facies,lower plain-interdistributary bay-forest-herbaceous swamp facies,and lake swamp-herbaceo

关键词： coal-measure source rock Paleogene genetic environment hydrocarbon generation characteristic ZhuⅠDepression

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DPAL-BERT:A Faster and Lighter Question Answering Model

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 771-786页

作者： Lirong yin lei Wang Zhuohang Cai Siyu Lu Ruiyang Wang Ahmed AlSanad Salman A.AlQahtani Xiaobing Chen Zhengtong yin Xiaolu Li Wenfeng Zheng Department of Geography and Anthropology Louisiana State UniversityBaton RougeLA 70803USA School of Automation University of Electronic Science and Technology of ChinaChengdu610054China College of Computer and Information Sciences King Saud UniversityRiyadh11574Saudi Arabia School of Electrical and Computer Engineering Louisiana State UniversityBaton RougeLA 70803USA College of Resources and Environmental Engineering Guizhou UniversityGuiyang550025China School of Geographical Sciences Southwest UniversityChongqing400715China

Recent advancements in natural language processing have given rise to numerous pre-training language models in question-answering ***,with the constant evolution of algorithms,data,and computing power,the increasing size and complexity of these models have led to increased training costs and reduced *** study aims to minimize the inference time of such models while maintaining computational *** also proposes a novel Distillation model for PAL-BERT(DPAL-BERT),specifically,employs knowledge distillation,using the PAL-BERT model as the teacher model to train two student models:DPAL-BERT-Bi and *** research enhances the dataset through techniques such as masking,replacement,and n-gram sampling to optimize knowledge *** experimental results showed that the distilled models greatly outperform models trained from *** addition,although the distilled models exhibit a slight decrease in performance compared to PAL-BERT,they significantly reduce inference time to just 0.25%of the *** demonstrates the effectiveness of the proposed approach in balancing model performance and efficiency.

关键词： DPAL-BERT question answering systems knowledge distillation model compression BERT Bi-directional long short-term memory(BiLSTM) knowledge information transfer PAL-BERT training efficiency natural language processing

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Co-adsorption and selective-adsorption of heavy metals and dyes from aqueous solution by bio-based humus/chitosan hydrogels

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Journal of Environmental Sciences 2024年第11期145卷 193-204页

作者： Rongping Chen Chenghao Gan Bingcai Cai Ruxue Liu Wenjie Xu Weize yin Hongyi Li lei Yu Qiang Yong College of Biology and the Environment Nanjing Forestry UniversityNanjing 210037China College of Chemical Engineering Nanjing Forestry UniversityNanjing 210037China

An eco-friendly adsorbent was prepared by reverse suspension crosslinking method to remove multiple pollutants from aqueous *** raw materials,derived from humus(HS)and chitosan(CS),are biodegradable and low-cost natural *** combining HS with CS,the adsorption capacity was significantly improved due to compensation effects between the two ***/CS exhibited the features of amphoteric adsorption through pH adjustment,enabling it to adsorb not only anionic pollutants(Methyl Orange(MO)and Cr(VI)),but also cationic ones(Methylene Blue(MB)and Pb(II)).The adsorption capacities were approximately 242 mg/g,69 mg/g,188 mg/g and 57 mg/g for MO,Cr(VI),MB and Pb(II),***/CS showed a slight preference for MO in MO/Cr(VI)co-adsorption system,whereas strong selectivity for MB over Pb(II)in MB/Pb(II)system under acidic condition(pH<3.0).This selective behavior would allow for potential applications in separating MB/Pb(II)effluents and selectively recycling Pb(II)in acidic *** isothermal and kinetic adsorption behaviors followed Langmuir model and pseudo-second-order model,*** density functional theory(DFT)confirmed that the interaction between metal ions and adsorbents was primarily attributed to chelation and electrostatic adsorption,owing to nitric and oxygenic functional ***,the adsorption mechanisms for dyes were involved in electrostatic attraction,H-bond andπ-πbond,due to available hydrogen,oxygen,nitrogen atoms and aromatic groups on the surface of adsorbent and *** adsorbent could be efficiently regenerated and retained over 90%of its adsorption capacity after five cycles,which has a potential for practical applications in water treatment.

关键词： Adsorption Density functional theory(DFT) Humus Chitosan

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Understanding the factors influencing cloud-core vertical accelerations during deep convection formation in the WRF model

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Atmospheric and Oceanic Science Letters 2024年第3期17卷 1-7页

作者： Na Li Jin Wang Lingkun Ran lei yin Xiba Tang Yuchen Liu Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Guizhou Meteorological Bureau GuiyangChina University of Chinese Academy of Sciences BeijingChina Nanjing University of Posts and Telecommunications NanjingChina Yunnan Key Laboratory of Meteorological Disasters and Climate Resources in the Great Mekong Subregion Yunnan UniversityKunmingChina

本文将扰动气压利用一个线性诊断关系代替,重新推导了WRF模式框架地形追随坐标系下的垂直动量方程,建立了垂直加速与对流触发(DCI)影响因子(如温度,水汽等)的直接联系.研究发现,DCI过程与对流核垂直加速相关,三维副散,扰动位势在垂直方... 详细信息

本文将扰动气压利用一个线性诊断关系代替,重新推导了WRF模式框架地形追随坐标系下的垂直动量方程,建立了垂直加速与对流触发(DCI)影响因子(如温度,水汽等)的直接联系.研究发现,DCI过程与对流核垂直加速相关,三维副散,扰动位势在垂直方向的二阶非均匀性,扰动位温垂直梯度,比湿及其垂直梯度,水凝物拖曳,均是能够直接影响垂直加速和对流触发的物理因子,这些量与模式基本预报量相关,通过解析基本预报量对对流发展的直接影响,可能有助于理解模式对DCI过程预测失败的原因.

关键词：垂直加速深对流垂直速度冰雹

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