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Covering corneal stromal lenticule for macular hole in pathological myopia

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1675-1680页

作者： Zi-Yan Tang Gang Qiao Xiao-Juan Zhang Li-Jun Xie Qiang-xing Zou Chun-Mei He Long Zhao hua-Qing Yang Yu Quan Kui Cao Hui Jiang Yu-Kun He Wanjiang Eye Hospital of Mianyang Mianyang 621000Sichuan ProvinceChina

AIM:To evaluate the clinical effect of a new surgery technique(covering corneal stromal lenticule,CSL)for macular hole(MH)in pathological ***:This was a prospective non-randomized series case *** eyes of 14 patients whose axial length were more than 29 mm and suffered from MH and macular hole retinal detachment(MHRD)were included in this *** cases were treated with 25-gauge pars plana vitrectomy(PPV)with internal limiting membrane(ILM)peeling,covering CSL and C_(3)F_(8) gas *** cases were followed for 6mo,and the best-corrected visual acuity(BCVA),healing status of MH,the reattached rate of retinal detachment(RD),and reoperation rate were ***:All cases were successfully performed the surgery and the postoperative follow-up was *** surgery,MHs were healed in all 14 eyes(100%,14/14)after assessed by optical coherence *** reattachment of retina was achieved in all 6 eyes(100%,6/6)with *** was improved in 12 eyes(85.71%,12/14),and had no significant change in 2 eyes(14.29%,2/14).The overall mean BCVA was improved from 1.80±0.77 to 0.82±0.46 logMAR(F=10.46,P<0.01).No serious complications occurred in all ***:The new surgery technique(covering CSL)has high reattached rate of RD and high healing rate of MH in pathological myopia in the preliminary *** it can effectively improve the visual function of *** new technique offers meaningful new ideas for treating refractory MH in pathological myopia.

关键词： corneal stromal lenticule macular hole pathological myopia

Physicochemical characterization of Dendrobium officinale polysaccharides and regulation of immunometabolic homeostasis in Sub-health mice based on the CD4-Th17/Treg immunity axis

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Food Science and Human Wellness 2024年

作者： Bo Li Ze-hua Zhang Hao-Ru Guan xing-Li-Shang He Ning wang Ying-Jie Dong Mei Rong Jiu-Jie Jia Ting-Ting Chen Zhi-Yuan Li Gui-Yuan Lv Lin-Nan Zhang Su-Hong Chen Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals， Zhejiang University of Technology Zhejiang Provincial Key Laboratory of TCM for Innovative R & D and Digital Intelligent Manufacturing of TCM Great Health Products.Huzhou College of Pharmaceutical Science， Zhejiang Chinese Medical University

The aim of this study was to investigate the role of DOPS and DOPS100 in attenuating immune dysfunction in subfertile mice. The results of the study revealed several noteworthy findings. First， DOPS and DOPS100 treatments led to significant improvement in weight gain and reversal of fatigue-related behaviors compared to the normal group. Second， both DOPS and DOPS100 showed effectiveness in reducing immune organ swelling， modulating immunoglobulin （IgA and IgM） levels， and restoring complement （C3c and C4） levels. In addition， they demonstrated a significant ability to enhance the integrity of the intestinal mechanical barrier by differentially upregulating the tight junction proteins Occludin and ZO-1. In addition， it was found that DOPS100 specifically enhanced the CD4+-Th17/Treg immune axis in the gut， as evidenced by increased expression of Foxp3 as well as decreased expression of RORγt， and further modulation of IL-10， IL-22， and IL-17A expression levels of inflammatory factors. These findings collectively suggest that DOPS100 holds significant potential in improving sub-healthy status by repairing the intestinal barrier， restoring local immune homeostasis， and activating the intestinal immune regulatory network. The study's outcomes provide valuable insights into the therapeutic implications of DOPS and DOPS100 in addressing immune dysfunction in sub-healthy conditions.

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汽车散热器的一种新型试验方法

天津大学学报（自然科学与工程技术版） 2002年第4期35卷 535-540页

作者：周兴华王玉春周建和天津大学机械工程学院天津300072

研制出汽车散热器的一种新型试验方法 ,它不仅满足而且优于JB2 2 93 78的要求 .试验装置风洞的试验段为开口自由射流 ,其核心区的流场是均匀的 ,免去了JB2 2 93 78中所采用的风筒安装汽车散热器的麻烦 .在风洞的风速调节和水循环系统... 详细信息

研制出汽车散热器的一种新型试验方法 ,它不仅满足而且优于JB2 2 93 78的要求 .试验装置风洞的试验段为开口自由射流 ,其核心区的流场是均匀的 ,免去了JB2 2 93 78中所采用的风筒安装汽车散热器的麻烦 .在风洞的风速调节和水循环系统中水流量和水温采用了计算机控制 ,不仅节省了测试时间 ,而且大大地提高了测试精度 .为确保测试的顺利进行。

关键词：试验方法汽车散热器射流核心区风洞水箱风速调节水循环系统

Simultaneous guidance of electromagnetic and elastic waves via glide symmetry phoxonic crystal waveguides

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Chinese Physics B 2024年第3期33卷 363-368页

作者：雷林霖何灵娟廖清华刘文兴于天宝 School of Physics and Materials Science Nanchang UniversityNanchang 330031China

A phoxonic crystal waveguide with the glide symmetry is designed,in which both electromagnetic and elastic waves can propagate along the glide plane at the same *** to the glide symmetry,the bands of the phoxonic crystal super-cell degenerate in pairs at the boundary of the Brillouin *** is the so-called band-sticking effect and it causes the appearance of gapless *** adjusting the magnitude of the glide dislocation the edge bandgaps,the bandgap of the guided-modes at the boundary of the Brillouin zone,can be further *** photonic and phononic guided-modes can then possess only one mode for a certain frequency with relatively low group velocities,achieving single-mode guided-bands with relatively flat dispersion *** addition,there exists acousto-optic interaction in the cavity constructed by the glide *** proposed waveguide has potential applications in the design of novel optomechanical devices.

关键词： phoxonic crystals glide symmetry waveguide acousto-optic interaction

煤及燃煤产物中稀土元素的分布赋存特征研究进展

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煤炭科学技术 2024年第3期52卷 269-282页

作者：邢艳阳丁华白向飞何金煤炭科学研究总院北京100013 煤炭科学技术研究院有限公司煤化工分院北京100013 国家能源煤炭高效利用与节能减排技术装备重点实验室北京100013

稀土元素因其特殊的性质被广泛用于永磁、冶金、储氢材料等领域,消费量逐年递增。我国是稀土元素储量大国,至2020年我国稀土元素矿产量在世界占比逐年下降,近几年有所回升,但仍需要寻找和开发其他可作为稀土元素供应源的材料。煤作为一... 详细信息

稀土元素因其特殊的性质被广泛用于永磁、冶金、储氢材料等领域,消费量逐年递增。我国是稀土元素储量大国,至2020年我国稀土元素矿产量在世界占比逐年下降,近几年有所回升,但仍需要寻找和开发其他可作为稀土元素供应源的材料。煤作为一种有机矿产,形成过程中可富集稀土元素。深入认识煤中稀土元素含量及赋存状态对后续研究其燃烧产物中稀土元素赋存和提取回收具有重要意义。国内外学者分时代、地区、煤级研究煤中稀土元素含量,对煤及其燃烧产物中的稀土元素赋存状态研究进行总结,并初步认识到我国煤及其燃烧产物中的稀土元素分布赋存特征。目前研究表明,中国煤中的平均稀土元素含量是世界煤中的平均稀土元素含量的两倍;晚二叠世时期煤中稀土元素相对富集;煤中稀土元素主要以硅酸盐态存在。稀土元素性质稳定,经过燃烧后可在燃煤产物中明显富集,主要富集在非磁性的细飞灰颗粒中。对于煤中稀土元素含量的统计应综合考虑样品来源矿区的覆盖率、样品处理方式、微量元素测试方式等因素,以提高统计数据的代表性和准确性。综合直接观测、表征测试方法、逐级化学提取法及数理统计方法以推测得到较为可靠的赋存状态。我国煤炭消费量可观,能源供应以火力发电为主,燃煤产物产量巨大,煤中稀土元素至燃煤产物中可得到几十倍的富集,探明电厂燃煤产物中稀土元素富集分布规律,结合其提取的难易程度提出对应的回收工艺,以实现对燃煤产物资源化利用。

关键词：煤稀土元素赋存状态燃煤产物富集行为

Suppression of MyD88 disturbs gut microbiota and activates the NLR pathway and hence fails to ameliorate DsS-inducedcolitis

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Precision Clinical Medicine 2024年第2期7卷 146-158页

作者： Jun-hua Li Yu Chen Zheng-hao Ye Li-ping Chen Jia-xin Xu Jian Han Lin Xie Shuai xing De-an Tian Ursula Seidler Jia-zhi Liao Fang Xiao Department of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannover 30625Germany

Background:Myeloid differentiation factor 88(MyD88)is the core adaptor for Toll-like receptors defending against microbial invasion and initiating a downstream immune response during microbiota-host ***,the role of MyD88 in the pathogenesis of inflammatory bowel disease is *** study aims to investigate the impact of MyD88 on intestinal inflammation and ***:MyD88 knockout(MyD88^(-/-))mice and the MyD88 inhibitor(TJ-M2010-5)were used to investigate the impact of MyD88 on acute dextran sodium sulfate(Dss)-induced *** activity index,colon length,histological score,and inflammatory cytokines were examined to evaluate the severity of *** transcriptome analysis and 16S rDNA sequencing were used to detect the potential ***:In an acute DSS-colitis model,the severity of colitis was not alleviated in MyD88^(-/-)mice and TJ-M2010-5-treated mice,despite significantly lower levels of NF-kB activation being exhibited compared to control ***,16S rDNA sequencing and RNA transcriptome analysis revealed a higher abundance of intestinal Proteobacteria and an up-regulation of the nucleotide oligomerization domain-like receptors(NLRs)signaling pathway in colitis mice following MyD88 *** blockade of the NLRs signaling pathway or elimination of gut microbiota with broad-spectrum antibiotics in DsS-induced colitis mice treated with TJ-M2010-5 ameiorated the disease severity,which was not improved solely by MyD88 *** treatment with broad-spectrum antibiotics,downregulation of the NLR signaling pathway was ***:Our study suggests that the suppression of MyD88 might be associated with unfavorable changes in the composition of gut microbiota,leading to NLR-mediated immune activation and intestinal inflammation.

关键词： microbiota innate immunity myeloid differentiation factor 88,MyD88 inhibitor NOD-like receptor inflammatory bowel disease

ITER氦冷固态实验包层模块第一壁氢同位素双向输运数值分析

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核化学与放射化学 2024年第2期46卷 125-130,I0004页

作者：王俊张龙王晓宇武兴华李茹烟核工业西南物理研究院四川成都610225

氦冷固态实验包层模块(HCCB-TBM)安装于国际热核聚变实验堆(ITER)中,用以验证HCCB包层概念的氚增殖能力与热移出能力。HCCB-TBM第一壁用于承受堆芯等离子体粒子轰击和包容内部功能材料。外侧等离子体驱动氘、氚粒子渗透与内侧氢分压驱... 详细信息

氦冷固态实验包层模块(HCCB-TBM)安装于国际热核聚变实验堆(ITER)中,用以验证HCCB包层概念的氚增殖能力与热移出能力。HCCB-TBM第一壁用于承受堆芯等离子体粒子轰击和包容内部功能材料。外侧等离子体驱动氘、氚粒子渗透与内侧氢分压驱动渗透的同时存在,形成了第一壁的双向氢同位素输运。此双向输运可能对第一壁外表面再循环系数、包层增殖氚的纯化产生重要影响。基于商业软件COMSOL建立第一壁双向氢同位素输运模型,研究第一壁的氢同位素的输运特征。仿真结果表明:第一壁中的冷却剂流道具有强的氢同位素移出能力,使得双向输运解耦合;在ITER等离子体脉冲周期中,放电过程中已扩散到材料内部的氚在等离子体关停时扩散回流到真空室侧,关停时的回流将降低向冷却剂流道的氚渗透损失。

关键词： HCCB-TBM 第一壁氢同位素双向输运

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女子柔道运动员的体能特征

体育科学 2004年第3期24卷 15-16,19页

作者：任弘邢文华王利群北京体育大学北京100084

以北京体育大学竞技体校女子柔道队、天津女子柔道队、北京女子柔道队和山东省滨州地区女子柔道队共 6 1名运动员为研究对象 ,测试了 5 6项指标 ,包括基础指标 4项 ,形态指标 35项 ,机能指标 5项和身体素质指标 12项。利用因子分析的方... 详细信息

以北京体育大学竞技体校女子柔道队、天津女子柔道队、北京女子柔道队和山东省滨州地区女子柔道队共 6 1名运动员为研究对象 ,测试了 5 6项指标 ,包括基础指标 4项 ,形态指标 35项 ,机能指标 5项和身体素质指标 12项。利用因子分析的方法 ,得出有效反映运动员的体能水平的 11项指标为 :上肢长、起桥推 /体重 ,立定跳远 /身高 ,胸围 /身高× 10 0 ,4 0 0 m跑 ,肩宽 /骨盆宽 ,握力重复 /最大握力× 10 0 ,心功指数、肺活量 /体重 ,立位体前屈 /下肢长× 10 0和转肩 /下肢长。

关键词：柔道运动员体能特征女子

切向入流旋流竖井在深圳市前海-南山排水深层隧道中的应用研究

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中国农村水利水电 2024年第2期 74-82,90页

作者：黄春华邢方亮王斌珠江水利委员会珠江水利科学研究院广东广州510611 珠江水利委员会广东广州510611

为探究切向入流旋流竖井的水力特性,采用物理模型手段,结合深圳市前海-南山排水深层隧道中郑宝坑渠旋流竖井方案,研究旋流竖井内的水流流态、消能特性、排气效果及特征压力值。结果表明:各工况下进口位置处水流逐渐形成水翅,进入竖井后... 详细信息

为探究切向入流旋流竖井的水力特性,采用物理模型手段,结合深圳市前海-南山排水深层隧道中郑宝坑渠旋流竖井方案,研究旋流竖井内的水流流态、消能特性、排气效果及特征压力值。结果表明:各工况下进口位置处水流逐渐形成水翅,进入竖井后沿内壁形成螺旋跌落流,水流流态较好,当竖井流量极小时竖井内无法形成螺旋跌落流,水流进入竖井后呈射流形态跌落至竖井底部;旋流竖井总消能率在81.9%~89.5%之间,消能率随着流量的增大而逐步减小;旋流竖井相对于传统水工旋流竖井,具有消能效果好、结构简单等优点,在城市深层排水系统中具有较大的应用空间。

关键词：切向入口旋流竖井深层隧道消能率