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老年骨质疏松性胸腰椎压缩性骨折患者PKP术后再发骨折的风险分析及列线图预测模型的构建

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解剖学报 2024年第1期55卷 98-104页

作者：孙雷王星宇谢水华江西省中西医结合医院江西省中医药骨蚀病重点实验室南昌330000

目的探讨老年骨质疏松性胸腰椎压缩性骨折患者经皮椎体后凸成形术(PKP)后再发骨折的风险因素并构建列线图预测模型。方法选取2016年1月~2019年11月行PKP治疗的182例老年骨质疏松性胸腰椎压缩性骨折患者为研究对象,术后3年持续跟踪随访,... 详细信息

目的探讨老年骨质疏松性胸腰椎压缩性骨折患者经皮椎体后凸成形术(PKP)后再发骨折的风险因素并构建列线图预测模型。方法选取2016年1月~2019年11月行PKP治疗的182例老年骨质疏松性胸腰椎压缩性骨折患者为研究对象,术后3年持续跟踪随访,根据术后恢复情况将患者分为再发骨折组(n=36)与无再发骨折组(n=146)。收集两组患者的临床资料;对计量指标行接受者操作特性(ROC)曲线分析;经Logistic回归分析影响PKP术后再发骨折的独立危险因素;R语言软件4.0“rms”包构建列线图预测模型,校正及决策曲线对列线图预测模型进行内部验证及临床预测效能评估。结果两组患者在骨密度、损伤椎体数、单节骨水泥注入量、骨水泥分布类型、骨水泥渗漏、PKP术前后椎体高度差、后凸角变化方面的差异具有统计学意义(P0.22,可提供临床净收益,且临床净收益均高于独立预测因子。结论骨密度、损伤椎体数、单节骨水泥注入量、骨水泥渗漏、PKP术前和术后椎体高度差、后凸角变化是影响老年骨质疏松性胸腰椎压缩性骨折患者PKP术后再发骨折的独立危险因素,并构建了预测老年骨质疏松性胸腰椎压缩性骨折患者PKP术后再发骨折的列线图模型。

关键词：骨质疏松胸腰椎压缩性骨折经皮椎体后凸成形术再发骨折列线图预测模型人

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减污降碳:低碳城市试点的协同效应

干旱区资源与环境 2024年第5期38卷 10-19页

作者：邢华李向阳中央财经大学政府管理学院北京100081

生态环境保护与碳达峰碳中和是中国生态文明建设的两大战略任务。低碳城市试点作为综合性环境政策,为研究减污降碳现实成效提供良好的政策视角。文中基于281个地级市数据,建立双重差分模型,探究低碳城市试点政策对环境污染和碳排放的协... 详细信息

生态环境保护与碳达峰碳中和是中国生态文明建设的两大战略任务。低碳城市试点作为综合性环境政策,为研究减污降碳现实成效提供良好的政策视角。文中基于281个地级市数据,建立双重差分模型,探究低碳城市试点政策对环境污染和碳排放的协同效应,并且进一步阐释影响机制和分析异质性。研究结果表明:1)低碳城市试点在降低城市碳排放的同时,显著减少了环境污染,实现减污和降碳的协同治理。2)试点城市通过规模效应、结构效应和技术效应三种影响机制来实现政策效应。3)东部、更小人口规模和更高行政级别的城市表现出更显著的政策效应。因此,文中提出优化政策设计、提升政策效能和分类推进实施的政策建议,促进低碳城市建设下减污降碳协同增效。

关键词：减污降碳低碳城市试点协同治理双重差分

数智时代教师权威的消解与重构——基于雅斯贝尔斯教育权威观

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教育理论与实践 2024年第13期44卷 40-45页

作者：王丹华孟宝兴新疆师范大学教育科学学院新疆乌鲁木齐830017 西北师范大学教育技术学院甘肃兰州730070

数智技术冲击着传统教育范式,打破了传统“知识壁垒”,师生情感被虚拟空间隔离,教师的外在权威、知识权威和感召权威均受到一定程度的消解,亟需寻找新的支撑点。雅斯贝尔斯系统阐述了教育权威观,为我们思考数智时代教师权威提供了依据:... 详细信息

数智技术冲击着传统教育范式,打破了传统“知识壁垒”,师生情感被虚拟空间隔离,教师的外在权威、知识权威和感召权威均受到一定程度的消解,亟需寻找新的支撑点。雅斯贝尔斯系统阐述了教育权威观,为我们思考数智时代教师权威提供了依据:数智时代需要教师“适度强权”规约学生自由、克服“技术局限”引导学生学习、“生命示范”培育学生精神。数智时代下教师可从以下几个方面重构教师权威:明确惩戒规则和各级制度,重塑角色,重拾信心;明确学生本位,打造人机协同高质量课堂;明确育人理念,体认技术伦理,以中华优秀传统文化和社会主义核心价值观引领学生。

关键词：数智时代教师权威雅斯贝尔斯教育权威观外在权威知识权威感召权威

在役钢桥面板纵肋与顶板焊根疲劳裂纹内焊加固方法

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交通运输工程学报 2024年第1期24卷 85-99页

作者：张清华李明哲李俊王昊高兴西南交通大学土木工程学院四川成都610031 中交第二航务工程局有限公司湖北武汉430048 青岛市市政工程设计研究院山东青岛266100 武汉锂鑫自动化科技有限公司湖北武汉430000

为实现纵肋与顶板焊根疲劳裂纹的有效加固,提出了能够满足在役钢桥面板加固需求的内焊加固方法,研发了自动化焊接机器人和相关关键装备;设计了4个试验模型对方法和装备的有效性和适用性进行研究,验证了纵肋与顶板焊根产生疲劳裂纹的开... 详细信息

为实现纵肋与顶板焊根疲劳裂纹的有效加固,提出了能够满足在役钢桥面板加固需求的内焊加固方法,研发了自动化焊接机器人和相关关键装备;设计了4个试验模型对方法和装备的有效性和适用性进行研究,验证了纵肋与顶板焊根产生疲劳裂纹的开裂模式;使用所研发的专用焊接设备在纵肋内部进行焊接加固,进行了加固结构的疲劳破坏试验;对比了试验结果与有限元模拟结果,分析了加固后结构的疲劳性能,验证了内焊加固方法的有效性。研究结果表明:内焊加固方法能够将既有的焊根裂纹转化为内部缺陷,研发的装备能够实现原位加固,有效抑制疲劳裂纹的扩展,使已开裂焊接细节的疲劳寿命提高了66%~157%;由于各开裂模式具有不同程度疲劳损伤累积,加固后焊接细节会发生主导开裂模式迁移;对于包含多开裂模式的焊接细节,加固后的剩余疲劳寿命与各开裂模式的实际疲劳损伤累积程度以及加固方法对各开裂模式受力特性的扰动程度两方面的因素密切相关。

关键词：桥梁工程钢桥面板疲劳开裂加固纵肋与顶板焊接细节焊根开裂模式内焊加固方法疲劳性能

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基于分布参数模型的满液式蒸发器性能模拟

上海交通大学学报 2004年第7期38卷 1164-1169页

作者：黄兴华王启杰王如竹上海交通大学机械与动力工程学院上海200030 上海电力学院动力工程系上海200090

基于流动沸腾换热的 Chen氏加和模型 ,建立了满液式蒸发器分布参数的热力计算模型 .采用分相流动模型计算制冷剂横掠管束的两相压降 ,考虑了压降对制冷剂饱和温度的影响 ;对于流程上下布置的满液式蒸发器 ,模型计算了制冷剂流量沿轴向... 详细信息

基于流动沸腾换热的 Chen氏加和模型 ,建立了满液式蒸发器分布参数的热力计算模型 .采用分相流动模型计算制冷剂横掠管束的两相压降 ,考虑了压降对制冷剂饱和温度的影响 ;对于流程上下布置的满液式蒸发器 ,模型计算了制冷剂流量沿轴向的分布 ,改进了前人忽略制冷剂流量轴向分布对蒸发器性能的影响 .应用该模型对一水平布置、2流程、采用强化管的满液式蒸发器进行了性能计算 ,热负荷的计算值与试验值吻合良好 .同时 ,研究了不同管型。

关键词：满液式蒸发器分布参数模型流动沸腾

Investigation for Bone Marrow Hematopoietic Microenviroment Damaged With Irradiation, Burn Injury and Irradiation Compound Burn Injury in Mice

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Investigation for Bone Marrow Hematopoietic Microenviroment ...

CPN建模与on-the-fly方法相结合的测试用例生成

中华医学会第八次全国血液学学术会议

作者： CHEN xing- hua, wang Ping, LUO Chengji, PENG Xian - gui, ZHANG Xi, KONG Peiyan, LIU Lin, GUO Chaohua, wang Qingyu Department of Hematology, Xinqiao Hoapital, Third Military Medical University, Chongqing 400037, China

Objective: To explore the mechanisms of bone marrow hematopoietic microenviroment damaged with irradiation,bum injury and irradiation compound injury in mice. Methods: The experimental mice were treated with 5.0 Gy 60Coγtotal body irradiation (abbreviated group R), 15% Ⅲ°total body surface area bum injury (abbreviated group B), and R compound B (abbreviated group RB) respectinely. Bone marrow strom cells from injured mice are exam-

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软件学报 2017年第10期28卷 2564-2582页

作者：张玉荣李华邢熠王显荣阮宏玮张素梅内蒙古大学计算机学院内蒙古呼和浩特010021 内蒙古大学网络信息中心内蒙古呼和浩特010021

在对复杂的软件系统进行测试时,生成的系统状态空间可能会非常庞大.为了避免对整个状态空间进行遍历,提出将on-the-fly方法与CPN形式化建模方法结合起来,用于生成测试例.在这种方法中,无需对整个状态空间进行遍历,只是仅对测试人员感兴... 详细信息

在对复杂的软件系统进行测试时,生成的系统状态空间可能会非常庞大.为了避免对整个状态空间进行遍历,提出将on-the-fly方法与CPN形式化建模方法结合起来,用于生成测试例.在这种方法中,无需对整个状态空间进行遍历,只是仅对测试人员感兴趣的部分状态空间进行针对性的测试.首先,给出CPN和扩展可达图的定义,介绍了on-the-fly测试方法中涉及的相关概念,包括系统规约、测试目的、同步乘积和测试例等.然后,实现了同步乘积算法,并设计相关测试例对其进行了测试.最后,选定一个被测系统示例CPN建模与on-the-fly结合的方法,并通过适配器实现与被测系统的交互,生成和执行测试例,由此验证了方法的可行性和有效性.

关键词： on-the-fly测试 CPN层次模型扩展可达图同步乘积测试例

The cytochrome P4501A1(CYP1A1)inhibitor bergamottin enhances host tolerance to multidrug-resistant Vibrio vulnificus infection

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Chinese Journal of Traumatology 2024年第5期27卷 295-304页

作者： Ruo-Bai Qiao Wei-Hong Dai Wei Li Xue Yang Dong-Mei He Rui Gao Yin-Qin Cui Ri-xing wang Xiao-Yuan Ma Fang-Jie wang hua-Ping Liang The College of Emergency and Trauma Hainan Medical UniversityHaikou571199China The First Research Department State Key Laboratory of Trauma and Chemical PoisoningArmy Medical Center(Daping Hospital)Army Medical UniversityChongqing400042China Emergency Department The Second Affiliated HospitalHainan Medical UniversityHaikou570311China

Purpose:Vibrio vulnificus (V. Vulnificus) infection is characterized by rapid onset, aggressive progression, and challenging treatment. Bacterial resistance poses a significant challenge for clinical anti-infection treatment and is thus the subject of research. Enhancing host infection tolerance represents a novel infection prevention strategy to improve patient survival. Our team initially identified cytochrome P4501A1 (CYP1A1) as an important target owing to its negative modulation of the body''s infection tolerance. This study explored the superior effects of the CYP1A1 inhibitor bergamottin compared to antibiotic combination therapy on the survival of mice infected with multidrug-resistantV. Vulnificus and the protection of their vital ***:An increasing concentration gradient method was used to induce multidrug-resistantV. Vulnificus development. We established a lethal infection model in C57BL/6J male mice and evaluated the effect of bergamottin on mouse survival. A mild infection model was established in C57BL/6J male mice, and the serum levels of creatinine, urea nitrogen, aspartate aminotransferase, and alanine aminotransferase were determined using enzyme-linked immunosorbent assay to evaluate the effect of bergamottin on liver and kidney function. The morphological changes induced in the presence of bergamottin in mouse organs were evaluated by hematoxylin and eosin staining of liver and kidney tissues. The bacterial growth curve and organ load determination were used to evaluate whether bergamottin has a direct antibacterial effect on multidrug-resistantV. Vulnificus. Quantification of inflammatory factors in serum by enzyme-linked immunosorbent assay and the expression levels of inflammatory factors in liver and kidney tissues by real-time quantitative polymerase chain reaction were performed to evaluate the effect of bergamottin on inflammatory factor levels. Western blot analysis of IκBα, phosphorylated IκBα, p65, and phosphorylated p65 prot

关键词： Multidrug-resistant Vibrio vulnificus Bergamottin CYP1A1 inhibitors Infection tolerance

Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis

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Military Medical Research 2024年第1期11卷 19-33页

作者： Liang-Kun Guo Yi Su Yu-Ya-Nan Zhang Hao Yu Zhe Lu Wen-Qiang Li Yong-Feng Yang Xiao Xiao Hao Yan Tian-Lan Lu Jun Li Yun-Dan Liao Zhe-Wei Kang Li-Fang wang Yue Li Ming Li Bing Liu Hai-Liang huang Lu-Xian Lv Yin Yao Yun-Long Tan Gerome Breen Ian Everall Hong-xing wang Zhuo huang Dai Zhang Wei-hua Yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University Huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China Department of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been ***,further research is imperative to enhance precision medicine in SCZ ***:Participants with SCZ were recruited from two randomized *** discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,*** study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin *** learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve ***:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics