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Recent advances in nanomedicines for the treatment of ischemic stroke

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Acta Pharmaceutica Sinica B 2021年第7期11卷 1767-1788页

作者： chao Li Tao Sun Chen jiang Key Laboratory of Smart Drug Delivery Ministry of EducationState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceDepartment of PharmaceuticsSchool of PharmacyResearch Center on Aging and MedicineFudan UniversityShanghai 201203China

Ischemic stroke is a cerebrovascular disease normally caused by interrupted blood supply to the *** would initiate the cascade reaction consisted of multiple biochemical events in the damaged areas of the brain,where the ischemic cascade eventually leads to cell death and brain *** researches focusing on different stages of the cascade reaction have been conducted with the aim of curing ischemic ***,traditional treatment methods based on antithrombotic therapy and neuroprotective therapy are greatly limited for their poor safety and treatment *** provides new possibilities for treating stroke as they could improve the pharmacokinetic behavior of drugs in vivo,achieve effective drug accumulation at the target site,enhance the therapeutic effect and meanwhile reduce the side *** this review,we comprehensively describe the pathophysiology of stroke,traditional treatment strategies and emerging nanomedicines,summarize the barriers and methods for transporting nanomedicine to the lesions,and illustrate the latest progress of nanomedicine in treating ischemic stroke,with a view to providing a new feasible path for the treatment of cerebral ischemia.

关键词： Stroke Ischemic cascade Reperfusion Neuroprotectant Thrombolytics Nanomedicine Blood-brain barrier

Fullerenes for rechargeable battery applications:Recent developments and future perspectives

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Journal of Energy Chemistry 2021年第4期30卷 70-79页

作者： Zhipeng jiang Yuming Zhao xing Lu Jia Xie State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina Shenzhen Power Supply Bureau Co. Ltd.Shenzhen 518000GuangdongChina

The development of high-performance batteries is inseparable from the exploration of new *** them,fullerene C60 as an allotrope of carbon has many unique properties that are beneficial for battery applications,including precise structure,controllable derivatization,good solubility,and rich redox *** this review,we summarize the recent progress of fullerene-based materials in the field of rechargeable batteries and the key issues that need to be solved in the future application of *** hope this review can provide guidance and stimulate research about the applications of fullerenes in the field of energy storage.

关键词： Batteries Fullerene Carbon materials Energy storage

Condition-based maintenance optimization for continuously monitored degrading systems under imperfect maintenance actions

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Journal of Systems Engineering and Electronics 2020年第4期31卷 841-851页

作者： CHEN Chuang LU Ningyun jiang Bin xing Yin College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China jiangsu Key Laboratory of Internet of Things and Control Technologies Nanjing University of Aeronautics and AstronauticsNanjing 211106China School of Earth Sciences and Engineering Hohai UniversityNanjing 211100China

Condition-based maintenance(CBM) is receiving increasing attention in various engineering systems because of its effectiveness. This paper formulates a new CBM optimization problem for continuously monitored degrading systems considering imperfect maintenance actions. In terms of maintenance actions,in practice, they scarcely restore the system to an as-good-as new state due to residual damage. According to up-to-data researches, imperfect maintenance actions are likely to speed up the degradation process. Regarding the developed CBM optimization strategy, it can balance the maintenance cost and the availability by the searching the optimal preventive maintenance *** maximum number of maintenance is also considered, which is regarded as an availability constraint in the CBM optimization problem. A numerical example is introduced, and experimental results can demonstrate the novelty, feasibility and flexibility of the proposed CBM optimization strategy.

关键词： condition-based maintenance(CBM) imperfect maintenance maintenance cost availability constraint optimization

C:N:P stoichiometry of perennial herbs’ organs in the alpine steppe of the northern Tibetan Plateau

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Journal of Mountain Science 2019年第9期16卷 2039-2047页

作者： MA xing-xing HONG jiang-tao WANG Xiao-dan College of Geographical Sciences Shanxi Normal University Linfen 041000 China Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu 610041 China

The patterns of C:N:P stoichiometry across ecosystems are important in understanding biogeochemical processes. The stoichiometry of nutrients at the leaf and root level have been reported previously, but relationships of other plant organs, such as stems and the reproductive organs, remain unclear. We collected 228 samples of leaves, roots, stems and reproductive organs from 11 common plant species at 25 sites on the Tibetan Plateau to explore the relationships of C:N:P stoichiometry both within and across plant organs. The average C concentrations in the roots, leaves, stems and reproductive organs were 427.32, 410.51, 421.11 and 416.72 mg g-1, respectively. The shoot tissues(leaves, stems and reproductive organs) had significantly higher N and P concentrations than the roots. The N and P concentrations had a significant positive correlation within the same organ. The nutrient concentrations(N and P) and nutrient ratios(C:N, C:P and N:P) were significantly correlated across all pairwise organ combinations. Our data suggest that alpine perennial herbs share similar evolutionary histories and have constrained patterns of covariation for C concentrations, with differential patterns for N and P stoichiometry across organs. Our data also indicate that covarying sets of nutrient traits are consistent across environments and biogeographical regions and demonstrate convergent evolution in plant nutritional characteristics in extreme alpine environments.

关键词： Shoot tissues Chemical elements Biogeochemical process Alpine steppe Tibet Plateau

Single-Channel Speech Enhancement Based on Improved Frame-Iterative Spectral Subtraction in the Modulation Domain

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China Communications 2021年第9期18卷 100-115页

作者： chao Li Ting jiang Sheng Wu School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

Aiming at the problem of music noise introduced by classical spectral subtraction,a shorttime modulation domain(STM)spectral subtraction method has been successfully applied for singlechannel speech ***,due to the inaccurate voice activity detection(VAD),the residual music noise and enhanced performance still need to be further improved,especially in the low signal to noise ratio(SNR)*** address this issue,an improved frame iterative spectral subtraction in the STM domain(IMModSSub)is *** specifically,with the inter-frame correlation,the noise subtraction is directly applied to handle the noisy signal for each frame in the STM ***,the noisy signal is classified into speech or silence frames based on a predefined threshold of segmented *** these classification results,a corresponding mask function is developed for noisy speech after noise ***,exploiting the increased sparsity of speech signal in the modulation domain,the orthogonal matching pursuit(OMP)technique is employed to the speech frames for improving the speech quality and *** effectiveness of the proposed method is evaluated with three types of noise,including white noise,pink noise,and hfchannel *** obtained results show that the proposed method outperforms some established baselines at lower SNRs(-5 to +5 dB).

关键词： short-time modulation domain single-channel speech enhancement modulation improved frame iterative spectral subtraction low SNRs

中国特色高等教育话语体系的历史演进、核心要义与建构理路

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高校教育管理 2025年第1期19卷 84-98页

作者：姜嘉伟厦门大学教育研究院厦门大学教师发展中心福建厦门361005

中国特色高等教育话语体系本质上是一种坚持民族理想、推动国家治理、促进知识发展、开展对外交流的关系性实践。百年来,中国高等教育发展历经萌芽期、探索期、发展期和成长期,形成了以“救国”“革命”“改革”“复兴”为代表的高等教... 详细信息

中国特色高等教育话语体系本质上是一种坚持民族理想、推动国家治理、促进知识发展、开展对外交流的关系性实践。百年来,中国高等教育发展历经萌芽期、探索期、发展期和成长期,形成了以“救国”“革命”“改革”“复兴”为代表的高等教育话语体系。本土化是中国特色高等教育话语体系逐渐成形的关键线索,民族图像的大众化、国家权力的人民性、知识建构的自主性以及对外交流的平等性则在话语主体、话语权力、话语知识、话语秩序四个方面构成其核心要义。中国特色高等教育话语体系通过提升话语主体的民族自信、夯实话语意识形态的思想根基、提升高等教育的治理效能、激发话语知识的内生动力、重塑话语秩序的国际格局以推动中国高等教育本土化转型,不断形成具有中国现代性的高等教育理论与实践体系,全面增强中国特色高等教育话语体系的理论概括力、实践生命力、现实感召力和国际影响力。

关键词：中国特色话语体系高等教育话语体系本土化中国式现代化

Speech Enhancement Based on Approximate Message Passing

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China Communications 2020年第8期17卷 187-198页

作者： chao Li Ting jiang Sheng Wu School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

To overcome the limitations of conventional speech enhancement methods, such as inaccurate voice activity detector(VAD) and noise estimation, a novel speech enhancement algorithm based on the approximate message passing(AMP) is adopted. AMP exploits the difference between speech and noise sparsity to remove or mute the noise from the corrupted speech. The AMP algorithm is adopted to reconstruct the clean speech efficiently for speech enhancement. More specifically, the prior probability distribution of speech sparsity coefficient is characterized by Gaussian-model, and the hyper-parameters of the prior model are excellently learned by expectation maximization(EM) algorithm. We utilize the k-nearest neighbor(k-NN) algorithm to learn the sparsity with the fact that the speech coefficients between adjacent frames are correlated. In addition, computational simulations are used to validate the proposed algorithm, which achieves better speech enhancement performance than other four baseline methods-Wiener filtering, subspace pursuit(SP), distributed sparsity adaptive matching pursuit(DSAMP), and expectation-maximization Gaussian-model approximate message passing(EM-GAMP) under different compression ratios and a wide range of signal to noise ratios(SNRs).

关键词： speech enhancement approximate message passing Gaussian model expectation maximization algorithm

Solar flare forecasting based on a Fusion Model

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Earth and Planetary Physics 2025年第1期9卷 171-181页

作者： YiYang Li ShiYong Huang SiBo Xu ZhiGang Yuan Kui jiang QiYang Xiong RenTong Lin School of Earth and Space Science Technology Hubei Luojia LaboratoryWuhan UniversityWuhan 430072China

Solar flare prediction is an important subject in the field of space *** learning technology has greatly promoted the development of this *** this study,we propose a novel solar flare forecasting model integrating Deep Residual Network(ResNet)and Support Vector Machine(SVM)for both≥C-class(C,M,and X classes)and≥M-class(M and X classes)*** collected samples of magnetograms from May 1,2010 to September 13,2018 from Space-weather Helioseismic and Magnetic Imager(HMI)Active Region Patches and then used a cross-validation method to obtain seven independent data *** then utilized five metrics to evaluate our fusion model,based on intermediate-output extracted by ResNet and SVM using the Gaussian kernel *** results show that the primary metric true skill statistics(TSS)achieves a value of 0.708±0.027 for≥C-class prediction,and of 0.758±0.042 for≥M-class prediction;these values indicate that our approach performs significantly better than those of previous *** metrics of our fusion model’s performance on the seven datasets indicate that the model is quite stable and robust,suggesting that fusion models that integrate an excellent baseline network with SVM can achieve improved performance in solar flare ***,we also discuss the performance impact of architectural innovation in our fusion model.

关键词： solar flare pace weather deep learning Fusion Model

Accurate manipulation of anthropomorphic robotic arm based on 3D human eye gazing with posture error compensation

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Science China Technological Sciences 2025年

作者： Quanlin LI Xianzong WANG Jiaji MA Qianjun HUANG Qizhi jiang Wenbin CHEN Caihua XIONG State Key Laboratory of Intelligent Manufacturing Equipment and Technology School of Mechanical Science and Engineering Huazhong University of Science and Technology Institute of Medical Equipment Science and Engineering Huazhong University of Science and Technology

As humans and robots work closer together than ever, anthropomorphic robotic arms with intuitive human-robot interaction interfaces have drawn massive attention to improving the quality of robot-assisted manipulation. In pursuit of this,we designed a dedicated 7-degrees-of-freedom (DoF) anthropomorphic robotic arm having three compact differential joints and a head-mounted gaze tracker enabling head-pose-tracked 3D gaze estimation. Moreover, two key challenges were addressed to achieve accurate robot-assisted manipulation of the object indicated by the direction of human gaze. First, a novel predictive pupil feature was proposed for 3D gaze estimation. Differing from most existing features subjected to the common paraxial approximation assumption, the proposed novel predictive pupil feature considered the light refraction at two corneal surfaces with a more realistic eye model, significantly improving the 3D gaze estimation accuracy when the eyeball rotates at large angles. Second, a novel optimization-based approach was developed to efficiently compensate for the posture errors of the designed 7-DoF anthropomorphic robotic arm for accurate manipulation. Compared with the existing Jacobian-based or optimization-based approaches with nominal joint values as iteration initial, the proposed approach computed the optimal iteration initial and realized faster convergence for real-time posture error compensation. With the posture error compensation in real time and 3D gaze estimated accurately, the human can command accurate robot-assisted manipulation using his eyes intuitively. The proposed system was successfully tested on five healthy subjects.

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