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Electric and thermo spin transfer torques in Fe/Vacuum/Fe tunnel junction

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Frontiers of physics 2014年第6期9卷 768-773页

作者： xing-tao jia Ke Xia Department of Physics Beijing Normal University Beijing 100875 China Department of Physics and Chemistry Henan Polytechnic University Jiaozuo 454000 China

We present first-principle calculations of electric and thermo spin transfer torques （STT） in Fe/Vacuum（Vac）/Fe magnetic tunnel junctions （MTJs）. Our quantitative studies demonstrate rich bias dependence of STT and tunnel inagneto resistance （TMR） behaviors with respect to the interface roughness. Thermoelectric effects in Fe/Vac/Fe MTJs is remarkable. We observe larger ZT of 6.2 in 8 ML clean Vacuum barrier, where responsible for. Thermo-STT in Fe/Vac/Fe with similar barrier thickness. the heavily restraitmd thermal conductance should be MTJs show same order as that in Fe/MgO/Fe MTJs with similar barrier thickness.

关键词： spin transfer torque Fe/Vacuum/Fe tunnel junction thermoelectric effect

Thermal spin transfer torque in Fe｜Ag｜YIG multilayers

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Frontiers of physics 2017年第3期12卷 87-92页

作者： Hui-Min Tang xing-tao jia Shi-Zhuo Wang Department of Physics Beijing Normal University Beijing 100875 China School of Physics and Electronic Information Engineering Henan Polytechnic University Jiaozuo 454000 China

We investigated the thermal spin transfer effect in FM｜NM｜YIG multilayers using the first princi- ples scattering theory. At room temperature, the spin Seebeck torque TZSE -1.0 μJ/（K-m^2） in an Ag＋｜Fe｜Ag｜YIG multilayer, which is around 40% larger than that estimated from mixing conductance. The quantum effects such as interlayer exchange coupling between FM and YIG could be responsible for the enhancements. Based on the LLG equation, reverse the magnetic configurations, circularly, in a we predict that a temperature bias of -10 K can multilayer at room temperature.

关键词： spin Seebeck torque spin transfer torque YIG

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai Lei Ye tao Song Shuai Huang jia Wang tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

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论网球教育对高校学生个性发展的影响

体育科技文献通报 2008年第4期16卷 68-68,89页

作者：孙海生邢加涛山东淄博市张店区第四中学山东淄博255000 山东淄博市张店区第三中学山东淄博255000

网球运动在我国的飞速发展,特别是在高校,对处于人生中个性成熟与发展重要时期的大学生这个特殊人群来说,利用网球教育来帮助他们形成良好的个性,是值得我们探讨的问题。本文通过对高校网球教育的发展、高校学生的个性特征的分析,探讨... 详细信息

网球运动在我国的飞速发展,特别是在高校,对处于人生中个性成熟与发展重要时期的大学生这个特殊人群来说,利用网球教育来帮助他们形成良好的个性,是值得我们探讨的问题。本文通过对高校网球教育的发展、高校学生的个性特征的分析,探讨了网球教育对高校学生个性发展的影响。

关键词：网球教育大学生个性影响

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-jia Chen Xin-Ning Yu Hua-tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

Direct numerical simulation of Open Von Kármán Swirling Flow

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Journal of Hydrodynamics 2014年第2期26卷 165-177页

作者： xing tao Department of Mechanical Engineering College of EngineeringUniversity of Idaho

Direct numerical simulations are used to investigate the Open Von Kfirmfin Swirling Flow, a new type of unsteady three-dimensional flow that is formed between two counter-rotating coaxial disks with an axial extraction enclosed by a cylinder chamber. Solution verification shows that monotonic convergence is achieved on three systematically refined grids for average pressure at the disk periphery with a small grid uncertainty at 3.5%. Effects of the rotational speeds and flow rates on the flow field are examined. When the disks are rotating at the lowest speed, ＋100 RPM, only circular vortices are formed regardless of the flow rates. When the disks are rotating at ＋300 RPM and ＋500 RPM, negative spiral vortex network is formed. The radial counterflow concept for such spiral vortex network is verified by examining various horizontal cuts and radial velocity component, which show radial outflows in two bands near the two disks and radial inflow in one band between them. Overall, the flow is similar to the Stewartson type flow but with significant differences for all three velocity components due to the axial suction at the upper disk center and gap between the disk periphery and chamber wall.

关键词： direct numerical simulation Open Von Kfirmfin flow swirling radial counterflow

A general framework for verification and validation of large eddy simulations

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Journal of Hydrodynamics 2015年第2期27卷 163-175页

作者： xing tao Department of Mechanical Engineering College of EngineeringUniversity of Idaho

A general framework（methodology and procedures） for verification and validation（V＆V） of large eddy simulations in computational fluid dynamics（CFD） is derived based on two hypotheses. The framework allows for quantitative estimations of numerical error, modeling error, their coupling, and the associated uncertainties. To meet different needs of users based on their affordable computational cost, various large eddy simulation（LES） V＆V methods are proposed. These methods range from the most sophisticated seven equation estimator to the simplest one-grid estimator, which will be calibrated using factors of safety to achieve the objective reliability and confidence level. Evaluation, calibration and validation of various LES V＆V methods in this study will be performed using rigorous statistical analysis based on an extensive database. Identification of the error sources and magnitudes has the potential to improve existing or derive new LES models. Based on extensive parametric studies in the database, it is expected that guidelines for performing large eddy simulations that meet pre-specified quality and credibility criteria can be obtained. Extension of this framework to bubbly flow is also discussed.

关键词： framework verification and validation large eddy simulation(LES)

Highly Efficient Degradation of Thiophosphate Pesticides Catalyzed by Cyclopalladated Ferrocenylketimines

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Chinese Chemical Letters 2002年第12期13卷 1170-1173页

作者： Jing Chao tao Jun jia xing Wang WANG Song tao ZANG Department of Chemistry Zhengzhou UniversityZhengzhou 450052

In this paper, four functional substituted derivatives of cyclopalladated ferrocenyl- ketimines 1~4, which were as mimetics of metal-dependent esterases for catalyzing the hydrolysis of thiophosphoric acid esters pesticides, were synthesized and characterized. All the four cyclopalladated complexes can efficiently catalyze the degradation of thiophosphoric acid pesticides, such as methyl parathion. The Pd catalyst with coordinated oxime is more active and exhibits an increased selectivity towards sulfur containing pesticides.

关键词： Ferrocenylketimine cyclopalladation thiophosphate catalysis.