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KAT7/HMGN1 signaling epigenetically induces tyrosine phosphorylation-regulated kinase 1A expression to ameliorate insulin resistance in Alzheimer’s disease

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World Journal of Psychiatry 2024年第3期14卷 445-455页

作者： Qun-Shan Lu Lin Ma Wen-Jing Jiang xing-bang wang Mei Lu Department of Geriatric Medicine Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Key Laboratory of Cardiovascular Proteomics of Shandong Province Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Epidemiological studies have revealed a correlation between Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2D).Insulin resistance in the brain is a common feature in patients with T2D and ***7 is a histone acetyltransferase that participates in the modulation of various *** To determine the effects of KAT7 on insulin patients with *** APPswe/PS1-dE9 double-transgenic and db/db mice were used to mimic AD and diabetes,*** in vitro model of AD was established by Aβ*** resistance was induced by chronic stimulation with high insulin *** expression of microtubule-associated protein 2(MAP2)was assessed using *** protein levels of MAP2,Aβ,dual-specificity tyrosine phosphorylation-regulated kinase-1A(DYRK1A),IRS-1,p-AKT,total AKT,p-GSK3β,total GSK3β,DYRK1A,and KAT7 were measured via western *** of reactive oxygen species(ROS),malondialdehyde(MDA),and SOD activity was measured to determine cellular oxidative *** cytometry and CCK-8 assay were performed to evaluate neuronal cell death and proliferation,*** RNA levels of KAT7 and DYRK1A were examined using quantitative PCR.A chromatin immunoprecipitation assay was conducted to detect H3K14ac in *** KAT7 expression was suppressed in the AD *** of KAT7 decreased Aβaccumulation and MAP2 expression in AD ***7 overexpression decreased ROS and MDA levels,elevated SOD activity in brain tissues and neurons,and simultaneously suppressed neuronal ***7 upregulated levels of p-AKT and p-GSK3βto alleviate insulin resistance,along with elevated expression of ***7 depletion suppressed DYRK1A expression and impaired H3K14ac of ***1 overexpression recovered DYRK1A levels and reversed insulin resistance caused by KAT7 *** We determined that KAT7 overexpression recovered insulin sensitivity in AD by recruiting HMGN1 to enhance DYRK1A acetylati

关键词： Alzheimer's disease Diabetes Insulin resistance KAT7 Dual-specificity tyrosine phosphorylation-regulated kinase-1A HMGN1

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Enhancing thermoelectric performance of p-type SnTe through manipulating energy band structures and decreasing electronic thermal conductivity

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Rare Metals 2024年第7期43卷 3232-3241页

作者： Xin Qian Hao-Ran Guo Jia-Xin Lyu bang-Fu Ding xing-Yuan San Xiao Zhang Jiang-Long wang Shu-Fang wang Hebei Key Lab of Optic-Electronic Information and Materials College of Physics Science and TechnologyHebei UniversityBaoding 071002China College of Electron and Information Engineering Hebei UniversityBaoding 071002China Research Institute for Frontier Science Beihang UniversityBeijing100191China

SnTe has received considerable attention as an environmentally friendly alternative to the representative thermoelectric material of ***,excessive hole carrier concentration in SnTe results in an extremely low Seebeck coefficient and high thermal conductivity,which makes it exhibit relatively inferior thermoelectric *** this work,the thermoelectric performance of p-type SnTe is enhanced through regulating its energy band structures and reducing its electronic thermal conductivity by combining Bi doping with CdSe ***,the carrier concentration of SnTe is successfully suppressed via Bi doping,which significantly decreases the electronic thermal ***,the convergence and flattening of the valence bands by alloying CdSe effectively improves the effective mass of SnTe while restraining its carrier ***,a maximum figure of merit(ZT) of~ 0.87 at 823 K and an average ZT of~ 0.51 at 300-823 K have been achieved in Sn_(0.96)Bi_(0.04)Te-5%*** results indicate that decreasing the electronic thermal conductivity is an effective means of improving the performance of thermoelectric materials with a high carrier concentration.

关键词： Thermoelectric materials SnTe Energy band structure Electronic thermal conductivity ZT value

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Acetylene/argon mixture plasma to build ultrathin carbon bridge of CF_(x)/C/MnO_(2) for high-rate lithium primary battery

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Rare Metals 2024年第6期43卷 2574-2584页

作者： Da-Wei Zou xing-Guang Fu Gao-bang Chen Yi-Fan Liu Bao-Shan Wu Xian Jian School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 31300lChina

Forming an ultrathin conducting layer on a fluorinated carbon(CFx)surface for reducing severe electrochemical polarization in lithium/fluorinated carbon primary batteries(Li/CF_(x))remains a considerable challenge for achieving batteries with excellent rate ***,CFxwas modified by using acetylene/argon mixture plasma combined with MnO_(2)*** CF_(x)/C/MnO_(2)composite effectively reduced the voltage hysteresis and improved the electrochemical performance of Li/CF_(x).The excellent rate performance of CF_(x)/C/MnO_(2)was due to the high electrochemical activity provided by the atomicscale conductive carbon layer and ultrafine MnO_(2)*** with pristine CF_(x),the charge transfer resistance of the optimized CF_(x)/C/MnO_(2)decreased from 218.5 to 48.2Ω,the discharge rate increased from 2C to 10C,and the power density increased from 3.11 to 13.44 kW·g^(-1),The intrinsic reason for the enhanced rate performance was attributed to the fact that the ultrathin carbon layer acted as a conductive bridge to reduce the voltage hysteresis at the initial stage of the Li/CF_(x)discharge,and the high electrochemical activity of the ultrafine MnO_(2)particles provided a faster lithium-ion diffusion rate.

关键词： C_(2)H_(2)/Ar plasma Fluorinated carbon Lithium primary battery MnO_(2)

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Simultaneous Bulk-and Surface-initiated Living Polymerization Studied with a Heterogeneous Stochastic Reaction Model

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Chinese Journal of Polymer Science 2024年第3期42卷 364-372,I0008页

作者： Jia-Shu Ma Zhi-Ning Huang Jia-Hao Li bang-Ping Jiang Yan-Da Liao Shi-Chen Ji xing-Can Shen State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China School of Computer Science and Engineering&School of Software Guangxi Normal UniversityGuilin 541004China

To better characterize the properties of surface-initiated polymers, simultaneous bulk-and surface-initiated polymerizations are usually carried out by assuming that the properties of the surface-initiated polymers resemble those of the bulk-initiated polymers. Through a Monte Carlo simulation using a heterogeneous stochastic reaction model, it was discovered that the bulk-initiated polymers exhibit a higher molecular weight and a lower dispersity than the corresponding surface-initiated polymers, which indicates that the equivalent assumption is invalid. Furthermore, the molecular weight distributions of the two types of polymers are also different, suggesting different polymerization mechanisms. The results can be simply explained by the heterogeneous distributions of reactants in the system. This study is helpful to better understand surface-initiated polymerization.

关键词： Surface-initiated polymerization Polymer brush Stochastic reaction model Heterogeneous polymerization Simultaneous polymerization

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1,6-Conjugate addition of para-quinone methides using gem-diborylcarbanions: Practical access to gem-diborylalkanes bearing vicinal tertiary/quaternary stereocenters

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Green Synthesis and Catalysis 2024年第1期5卷 68-72页

作者： Pu-Zhang Zi xing-bang Liu Quan-Hong Zhao Min He Yuan Huang Department of Medicinal Chemistry School of PharmacyXi'an Jiaotong UniversityXi'an710061China

A novel,efficient and pragmatic method to prepare gem-diboron products with vicinal tertiary/quaternary stereocenters using LiTMP-mediated 1,6-conjugate addition of gem-diborylalkanes to para-quinone methides was described for the first *** results showed that various gem-diboron products with vicinal tertiary and quaternary stereocenters could be formed within 15 min at ambient *** simple protocol has also been applied for the efficient synthesis of the analogue of Bedaquiline.

关键词： gem-Diborylalkanes Quaternary stereocenter Conjugate addition para-Quinone methides Organoboron compounds

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Clinical significance of upregulated Rho GTPase activating protein 12 causing resistance to tyrosine kinase inhibitors in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4244-4263页

作者： Xiao-Wei wang Yu-xing Tang Fu-Xi Li Jia-Le wang Gao-Peng Yao Da-Tong Zeng Yu-Lu Tang bang-Teng Chi Qin-Yan Su Lin-Qing Huang Di-Yuan Qin Gang Chen Zhen-Bo Feng Rong-Quan He Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Red Cross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChi Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Computer Science and Technology School of Computer and Electronic InformationGuangxi UniversityNanning 530004Guangxi Zhuang Autonomous RegionChina

BACKGROUND Hepatocellular carcinoma(HCC)is a major health challenge with high incidence and poor survival rates in *** therapies,particularly tyrosine kinase inhibitors(TKIs),are the first-line treatment for advanced HCC,but resistance is *** Rho GTPase family member Rho GTPase activating protein 12(ARHGAP12),which regulates cell adhesion and invasion,is a potential therapeutic target for overcoming TKI resistance in ***,no studies on the expression of ARHGAP12 in HCC and its role in resistance to TKIs have been *** To unveil the expression of ARHGAP12 in HCC,its role in TKI resistance and its potential associated *** This study used single-cell RNA sequencing(scRNA-seq)to evaluate ARHGAP12 mRNA levels and explored its mechanisms through enrichment *** was used to investigate focal adhesion(FA)pathway *** integrated bulk RNA data(RNA-seq and microarray),immunohistochemistry and proteomics to analyze ARHGAP12 mRNA and protein levels,correlating with clinical *** assessed ARHGAP12 expression in TKI-resistant HCC,integrated conventional HCC to explore its mechanism,identified intersecting FA pathway genes with scRNA-seq data and evaluated its response to TKI and *** ARHGAP12 mRNA was found to be highly expressed in malignant hepatocytes and to regulate *** malignant hepatocytes in high-score FA groups,MDK-[integrin alpha 6(ITGA6)+integrinβ-1(ITGB1)]showed specificity in ligand-receptor ***12 mRNA and protein were upregulated in bulk RNA,immunohistochemistry and proteomics,and higher expression was associated with a worse ***12 was also found to be a TKI resistance gene that regulated the FA ***1 was identified as a crossover gene in the FA pathway in both scRNA-seq and bulk *** expression of ARHGAP12 was associated with adverse reactions to sorafenib,cabozantinib and regorafenib,but not to *** ARHGAP12 expre

关键词： Hepatocellular carcinoma Focal adhesion Tyrosine kinase inhibitor Rho GTPase activating protein 12 Drug resistance Molecular mechanism Biomarker

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CFD modeling of gas−liquid flow phenomenon in lead smelting oxygen-enriched side-blown furnace

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2671-2685页

作者： Zhen-yu ZHU Ping ZHOU xing-bang WAN Zhuo CHEN Ling ZHANG Shi-bo KUANG School of Energy Science and Engineering Central South UniversityChangsha 410083China Changsha Design and Research Institute of Nonferrous Metallurgy Changsha 410019China ARC Research Hub for Computational Particle Technology Department of Chemical EngineeringMonash UniversityWellington RdClaytonVIC 3800Australia

A validated numerical model was established to simulate gas−liquid flow behaviors in the oxygen-enriched side-blown bath *** model included the slip velocity between phases and the gas thermal expansion *** modeling results were verified with theoretical correlations and experiments,and the nozzle-eroded states in practice were also involved in the *** comparison,it is confirmed that the thermal expansion effect influences the flow pattern significantly,which may lead to the backward motion of airflow and create a potential risk to production ***,the influences of air injection velocity and furnace width on airflow behavior were investigated to provide operating and design *** is found that the thin layer melt,which avoids high-rate oxygen airflow eroding nozzles,shrinks as the injection velocity increases,but safety can be guaranteed when the velocity ranges from 175 to 275 m/***,the isoline patterns and heights of thin layers change slightly when the furnace width increases from 2.2 to 2.8 m,indicating that the furnace width shows a limited influence on production safety.

关键词： multiphase flow horizontal gas injection backward motion of airflow gas thermal expansion side-blown furnace lead smelting

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盐碱地甜高粱间作大豆对作物生产性能和光合特性的影响

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草地学报 2024年第1期32卷 219-228页

作者：张朝辉张邦彦谢小伟许兴王彬宁夏大学林业与草业学院宁夏银川750021 宁夏大学农学院宁夏银川750021

为研究盐碱地甜高粱(Sorghum bicolor)间作大豆(Glycine max)行比对光合特性变化生产性能的影响,确定科学合理的间作行比,本研究以甜高粱单作(TS),大豆单作(DS)为对照,设置甜高粱-大豆间作1∶1(T1D1),1∶3(T1D3),2∶2(T2D2)和2∶4(T2D4)... 详细信息

为研究盐碱地甜高粱(Sorghum bicolor)间作大豆(Glycine max)行比对光合特性变化生产性能的影响,确定科学合理的间作行比,本研究以甜高粱单作(TS),大豆单作(DS)为对照,设置甜高粱-大豆间作1∶1(T1D1),1∶3(T1D3),2∶2(T2D2)和2∶4(T2D4)4种间作模式,对两种作物生产性能、光合特性及甜高粱营养价值进行研究。结果表明,间作促进甜高粱的生长,但对大豆无明显差异。间作行比下,土地当量比均大于1,其中T1D3土地当量比最大,达1.22;甜高粱Pn,Ci,Gs,Tr表现最好的是T2D4,大豆光合特性表现最好的是T1D3处理;同时,T2D4处理甜高粱也拥有较高的粗蛋白含量,为10.03%。经主成分(PCA)分析得出T2D4最好,该间作行比有利于创造良好的群体冠层内部光环境,从而收获较高较优的甜高粱草产量和大豆产量。

关键词：盐碱地间作产量光合特性

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竹炭-沸石混合料可渗透反应墙修复镉污染地下水的试验

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中国环境科学 2024年第10期44卷 5607-5619页

作者：李子邦张亮刘豪龚星广东工业大学土木与交通工程学院广东广州510006 水利部长江勘测技术研究所湖北武汉430011 广东粤路勘察设计有限公司广东广州510630

本文结合物理力学测试、静态批和动态柱试验、微观表征分析、地下水数值模拟等手段分析了竹炭-沸石混合料填充可渗透性反应墙(PRB)对镉的吸附机理和时效性.竹炭(粒径大于0.18mm)和沸石(粒径大于0.5mm)按照质量分数1:10∼3:10混合时,不... 详细信息

本文结合物理力学测试、静态批和动态柱试验、微观表征分析、地下水数值模拟等手段分析了竹炭-沸石混合料填充可渗透性反应墙(PRB)对镉的吸附机理和时效性.竹炭(粒径大于0.18mm)和沸石(粒径大于0.5mm)按照质量分数1:10∼3:10混合时,不仅能有效去除地下水中镉,而且具备良好的渗透性和抗剪强度.竹炭-沸石混合料对镉的吸附能力随竹炭配比增加而增大,随粒径减小而增加;PRB柱穿透和耗竭时间随地下水流量和镉浓度增加而缩短.竹炭-沸石混合料去除镉的过程主要是发生络合反应、螯合作用、离子交换反应.地下水镉污染场地的PRB墙体厚度越大,地下水流速越慢,PRB的有效运行时间越长.

关键词：地下水镉污染可渗透反应墙长效性

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基于K-means聚类和极限学习机组合算法的短期光伏功率预测

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水电能源科学 2024年第2期42卷 217-220,216页

作者：黄牧涛邢芳菲陈兴邦卢明华中科技大学电气与电子工程学院湖北武汉430074 华中科技大学土木与水利工程学院湖北武汉430074 国网河南省电力公司电力科学研究院河南郑州450052

考虑光伏功率的预测精度强依赖于天气模态和气候条件等因素影响,提出了基于极限学习机组合算法的短期光伏功率预测方法。首先,基于K-means聚类算法进行天气分型,分为4个季节下晴天、多云天气、阴雨天气共12组不同天气类别。其次,针对天... 详细信息

考虑光伏功率的预测精度强依赖于天气模态和气候条件等因素影响,提出了基于极限学习机组合算法的短期光伏功率预测方法。首先,基于K-means聚类算法进行天气分型,分为4个季节下晴天、多云天气、阴雨天气共12组不同天气类别。其次,针对天气分型结果,基于极限学习机ELM、遗传算法改进的极限学习机GA-ELM、鸟群算法改进的极限学习机BSA-ELM3种算法构建光伏功率预测模型。最后,以某光伏电站数据进行所提模型验证。预测结果表明,BSA-ELM预测精度最高,12种天气预测精度达到90%左右,各季节中预测精度最高的天气类型均为晴天,多云天气精度高于阴雨天气精度,可为含高比例光伏并网的新型电力系统安全稳定运行提供有效数据支撑。

关键词：光伏发电功率预测 K-means聚类天气分型极限学习机算法遗传算法鸟群算法

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