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Cross-species transmission and host range genes in poxviruses

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Virologica Sinica 2024年第2期39卷 177-193页

作者： Chen-Hui Yang A-ling Song Ye Qiu xing-yi Ge College of Biology Hunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha410012China

The persistent epidemic of human mpox, caused by mpox virus (MPXV), raises concerns about the future spread ofMPXV and other poxviruses. MPXV is a typical zoonotic virus which can infect human and cause smallpox-likesymptoms. MPXV belongs to the Poxviridae family, which has a relatively broad host range from arthropods tovertebrates. Cross-species transmission of poxviruses among different hosts has been frequently reported andresulted in numerous epidemics. Poxviruses have a complex linear double-strand DNA genome that encodeshundreds of proteins. Genes related to the host range of poxvirus are called host range genes (HRGs). This reviewbriefly introduces the taxonomy, phylogeny and hosts of poxviruses, and then comprehensively summarizes thecurrent knowledge about the cross-species transmission of poxviruses. In particular, the HRGs of poxvirus aredescribed and their impacts on viral host range are discussed in depth. We hope that this review will provide acomprehensive perspective about the current progress of researches on cross-species transmission and HRGvariation of poxviruses, serving as a valuable reference for academic studies and disease control in the future.

关键词： Poxvirus Host range gene(HRG) Host spectrum Cross-species transmission

Reinforcement Learning-Based Dynamic Order Recommendation for On-Demand Food Delivery

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Tsinghua Science and Technology 2024年第2期29卷 356-367页

作者： xing Wang ling Wang Chenxin Dong Hao Ren Ke xing Department of Automation Tsinghua UniversityBeijing 100080China School of Mechanical and Automotive Engineering Qingdao Hengxing University of Science and TechnologyQingdao 266100China Meituan Beijing 100015China

On-demand food delivery(OFD)is gaining more and more popularity in modern *** a kernel order assignment manner in OFD scenario,order recommendation directly influences the delivery efficiency of the platform and the delivery experience of *** paper addresses the dynamism of the order recommendation problem and proposes a reinforcement learning solution *** actor-critic network based on long short term memory(LSTM)unit is designed to deal with the order-grabbing conflict between different ***,three rider sequencing rules are accordingly proposed to match different time steps of the LSTM unit with different *** test the performance of the proposed method,extensive experiments are conducted based on real data from Meituan delivery *** results demonstrate that the proposed reinforcement learning based order recommendation method can significantly increase the number of grabbed orders and reduce the number of order-grabbing conflicts,resulting in better delivery efficiency and experience for the platform and riders.

关键词： on-demand food delivery order recommendation reinforcement learning actor-critic network long short term memory

Applications of mercury stable isotopes for tracing volcanism in the geologic record

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Science China Earth Sciences 2024年第5期67卷 1436-1458页

作者： Qing GONG Ming-xing ling Wang ZHENG State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China School of Earth System Science Institute of Surface-Earth System ScienceTianjin UniversityTianjin 300072China

Mercury(Hg)enrichments in ancient sediments have been used as a proxy of volcanism,especially large igneous province(LIP)***,considering the existence of other potential Hg sources besides volcanoes and the diverse factors(e.g.,organic matters,clay minerals,sulfide minerals and Fe oxides)that can affect Hg sequestration,there are considerable uncertainties to simply regard sedimentary Hg anomalies as signatures of volcanic *** stable isotopes,a promising tool for tracing the origins and transformations of Hg,have been increasingly used for determining the causes of Hg spikes and understanding the geochemical behavior of Hg in the geologic *** date,lots of researches have applied Hg concentrations and Hg isotopes to identify LIP volcanisms linking with significant geological events such as mass extinctions,ocean anoxic events and other environmental perturbations that mainly occurred in the ***,the results in previous studies clearly show that not all Hg enrichments are derived from volcanic inputs,which emphasize the need for more caution in using Hg as a fingerprint of *** a better understanding of Hg isotopes in the future,there will be important implications for Hg isotopes to reconstruct volcanic activities in the rock records and their impacts on biological evolution.

关键词： Mercury stable isotopes Large igneous province Mass extinction event Ocean anoxic event

Oxidation of emerging organic contaminants by in-situ H_(2)O_(2) fenton system

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Green Energy & Environment 2024年第3期9卷 417-434页

作者： Yuqin Ni Chuxiang Zhou Mingyang xing yi Zhou State Environmental Protection Key Lab of Environmental Risk Assessment and Control on Chemical Processes School of Resources&Environmental EngineeringEast China University of Science and TechnologyShanghai200237China Key Laboratory for Advanced Materials and Institute of Fine Chemicals National Engineering Laboratory for Industrial Wastewater TreatmentSchool of Chemistry and Molecular EngineeringEast China University of Science and Technology130 Meilong RoadShanghai200237China Department of Applied Natural Sciences Technische Hochschule LubeckMonkhofer Weg 23923562 LubeckGermany

The existence and risk of emerging organic contaminants(EOCs)have been under consideration and paid much effort to degrade these *** system is one of the most widely used technologies to solve this *** original Fenton system relies on the hydroxyl radicals produced by Fe(Ⅱ)/H_(2)O_(2) to oxidize the organic ***,the application of the Fenton system is limited by its low iron cycling efficiency and the high risks of hydrogen peroxide transportation and *** introduction of external energy(including light and electricity etc.)can effectively promote the Fe(Ⅲ)/Fe(Ⅱ)cycle and the reduction of oxygen to produce hydrogen peroxide in *** review introduces three in-situ Fenton systems,which are electro-Fenton,Photo-Fenton,and chemical *** mechanism,influencing factors,and catalysts of these three in-situ Fenton systems in degrading EOCs are discussed *** review strengthens the understanding of Fenton and in-situ Fenton systems in degradation,offering further insight into the real application of the in-situ Fenton system in the removal of EOCs.

关键词： In-situ H_(2)O_(2)production Fenton Emerging organic contaminants Photocatalysis Electrocatalysis

LncRNA HCP5-encoded protein contributes to adriamycin resistance through ERK/mTOR pathway-mediated autophagy in breast cancer cells

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Genes & Diseases 2024年第4期11卷 69-72页

作者： Jia-Ni xing yi-Ni Shang Zheng-ling Yu Shun-Heng Zhou Wang-Yang Chen Li-Hong Wang Department of Pathophysiology Medical College of Southeast UniversityNanjingJiangsu 210009China Department of Biomedical Engineering Nanjing University of Aeronautics and AstronauticsNanjingJiangsu 211106China School of Medicine Taizhou UniversityTaizhouZhejiang 318000China Jiangsu Provincial Key Laboratory of Critical Care Medicine NanjingJiangsu 210009China

Adriamycin(ADR),also known as doxorubicin,is an anthracycline anticancer drug and a chemotherapeutic drug commonly used in breast cancer treatments.1 However,breast cancer patients can gradually become tolerant to ***,improving the curative effect of ADR remains an urgent problem to be *** is a complex catabolic process;normal living cells break down damaged organelles or aggregated molecules and absorb energy to maintain homeostasis through autophagy.

关键词： breast cancer homeostasis

New black-to-white hole solutions with improved geometry and energy conditions

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 30-43页

作者： Zhongwen Feng yi ling Xiaoning Wu Qingquan Jiang School of Physics and Astronomy China West Normal UniversityNanchong 637009China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physics University of Chinese Academy of SciencesBeijing 100049China Institute of Mathematics Academy of Mathematics and System Science and Hua Loo-Keng Key Laboratory of MathematicsChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100190China

We construct new black-to-white hole solutions which connect the geometry of spacetime at some gluing surface inside the *** continuity of the metric can be guaranteed up to the arbitrary order which is controlled by the power factor *** sort of black-to-white holes is characterized by the sub-Planckian scalar curvature,independent of the mass of black-to-white *** importantly,we show that the energy condition is only violated within a small region near the gluing *** geodesics of particles within the region from black hole to white hole is also *** turns out that the matter falling into the black hole may pass through the center without singularity and come out from the white *** scenario provides novel ideas for understanding the information loss paradox in traditional black hole physics.

关键词： regular black hole energy condition singularity quantum gravity

CO_(2)capture by modifed clinoptilolite and its regeneration performance

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International Journal of Coal Science & Technology 2024年第2期11卷 81-90页

作者： Bo Jiang Bo Zhang Xuqin Duan yi xing School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource-Oriented Treatment of Industrial Pollutants University of Science and Technology BeijingBeijing 100083China YangQuan Coal Industry(Group)Co.Ltd. Yangquan 045000China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China

This study focuses on CO_(2) capture by pressure swing adsorption(PSA),with modified clinoptilolite as the *** clinoptilolite is modified by roasting,by acid pickling,by a combination of acid pickling and roasting,and by ion *** by acid pickling-roasting and by ion exchange are found to give the highest CO_(2) adsorption capacities,of 730 mL/g and 876.7 mL/g,*** is found that regeneration of clinoptilolite by a combination of vacuum desorption and heating enables recovery of as much as 89%of its previous CO_(2) adsorption *** examine the CO_(2) adsorption capacity of clinoptilolite when applied to mixed gas,a simulated coking exhaust containing 12%CO_(2) and 4%O_(2) is used,and it is found that ion exchange modified clinoptilolite achieves a CO_(2) removal efficiency of 92.5%.A BET test reveals that acid pickling-roasting and Na^(+) modification enhance the porosity of clinoptilolite,thereby improving its adsorption *** work demonstrates the feasibility of applying modified clinoptilolite as an effective adsorbent for COO_(2)capture,providing a promising tool for dealing with greenhouse gases.

关键词： Clinoptilolite Carbon dioxide capture Pressure swing adsorption(PSA)

Ultrahigh spatiotemporal resolution beam signal reconstruction with bunch phase compensation

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Nuclear Science and Techniques 2024年第5期35卷 99-108页

作者： You-Ming Deng Yong-Bin Leng xing-yi Xu Jian Chen yi-Mei Zhou Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of the Chinese Academy of Sciences Beijing 100049China Shanghai Synchrotron Radiation Facility Chinese Academy of SciencesShanghai 201204China University of Science and Technology of China Hefei 230026China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China

Various electromagnetic signals are excited by the beam in the acceleration and beam-diagnostic elements of a particle *** is important to obtain time-domain waveforms of these signals with high temporal resolution for research,such as the study of beam–cavity interactions and bunch-by-bunch parameter ***,a signal reconstruction algorithm with ultrahigh spatiotemporal resolution and bunch phase compensation based on equivalent sampling is proposed in this *** with traditional equivalent sampling,the use of phase compensation and setting the bunch signal zero-crossing point as the time reference can construct a more accurate reconstructed *** basic principles of the method,simulation,and experimental comparison are also *** on the beam test platform of the Shanghai Synchrotron Radiation Facility(SSRF)and the method of experimental verification,the factors that affect the reconstructed signal quality are analyzed and discussed,including the depth of the sampled data,quantization noise of analog-to-digital converter,beam transverse oscillation,and longitudinal *** results of the beam experiments show that under the user operation conditions of the SSRF,a beam excitation signal with an amplitude uncertainty of 2%can be reconstructed.

关键词： Turn-by-turn bunch phase compensation technique Equivalent sampling Signal reconstruction algorithm Ultrahigh spatiotemporal resolution SSRF

Microwave irradiation-induced alterations in physicochemical properties and methane adsorption capability of coals:An experimental study using carbon molecular sieve

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Chinese Journal of Chemical Engineering 2024年第4期68卷 165-180页

作者： Xuexiang Fu xing Tang yi Xu Xintao Zhou Dengfeng Zhang Faculty of Chemical Engineering Kunming University of Science and TechnologyKunming 650500China

In order to comprehend the applicability of microwave irradiation for recovering coalbed methane,it is necessary to evaluate the microwave irradiation-induced alterations in coals with varying levels of *** this work,the carbon molecular sieve combined with KMnO_(4)oxidation was selected to fabricate carbon molecular sieve with diverse oxidation degrees,which can serve as model substances toward ***,the microwave irradiation dependences of pores,functional groups,and highpressure methane adsorption characteristics of model substances were *** results indicated that microwave irradiation causes rearrangement of oxygen-containing functional groups,which could block the micropores with a size of 0.40-0.60 nm in carbon molecular sieve;meanwhile,naphthalene and phenanthrene generated by macro-molecular structure pyrolysis due to microwave irradiation could block the micropores with a size of 0.70-0.90 *** alterations in micropore structure weaken the saturated methane adsorption capacity of oxidized carbon molecular sieve by 2.91%-23.28%,suggesting that microwave irradiation could promote methane ***,the increased mesopores found for oxidized carbon molecular sieve after microwave irradiation could benefit CH4 *** summary,the oxidized carbon molecular sieve can act as model substances toward coals with different ***,microwave irradiation is a promising technology to enhance coalbed methane recovery.

关键词： Microwave irradiation Physicochemical property Coal matrix Adsorption Carbon molecular sieve