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Metal natural product complex Ru-procyanidins with quadruple enzymatic activity combat infections from drug-resistant bacteria

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2298-2316页

作者： Jie Shan Xu Jin Cong Zhang Muchen Huang Jianghao xing Qingrong Li Yuyu Cui Qiang Niu Xu Lin Chen Xianwen Wang department of Burns the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China School of Biomedical Engineering Research and Engineering Center of Biomedical MaterialsAnhui Provincial Institute of Translational MedicineAnhui Medical UniversityHefei 230032China Division of Gastroenterology the First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China The Second Clinical Medical College Anhui Medical UniversityHefei 230022China department of Oncology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China College and Hospital of Stomatology Anhui Medical UniversityKey Lab.of Oral Diseases Research of Anhui ProvinceHefei 230032China

Bacterial infection hampers wound repair by impeding the healing ***,inflammation at the wound site triggers the production of reactive oxygen species(ROS),causing oxidative stress and damage to proteins and *** can lead to chronic wounds,posing severe ***,eliminating bacterial infection and reducing ROS levels are crucial for effective wound ***,possessing enzyme-like catalytic activity,can convert endogenous substances into highly toxic substances,such as ROS,to combat bacteria and biofilms without inducing drug ***,the current nanozyme model with single enzyme activity falls short of meeting the complex requirements of antimicrobial ***,developing nanozymes with multiple enzymatic activities is ***,we engineered a novel metalloenzyme called Ru-procyanidin nanoparticles(Ru-PC NPs)with diverse enzymatic activities to aid wound healing and combat bacterial *** acidic conditions,due to their glutathione(GSH)depletion and peroxidase(POD)-like activity,Ru-PC NPs combined with H2.2.exhibit excellent antibacterial ***,in a neutral environment,the Ru-PC NPs,with catalase(CAT)activity,decompose H2.2.to O2.alleviating hypoxia and ensuring a sufficient oxygen ***,Ru-PC NPs possess exceptional antioxidant capacity through their superior superoxide dismutase(SOD)enzyme activity,effectively scavenging excess ROS and reactive nitrogen species(RNS)in a neutral *** maintains the balance of the antioxidant system and prevents ***-PC NPs also promote the polarization of macrophages from M1 to M2.facilitating wound *** importantly,Ru-PC NPs show good biosafety with negligible *** vivo wound infection models have confirmed the efficacy of Ru-PC NPs in inhibiting bacterial infection and promoting wound *** focus of this work highlights the quadruple enzymatic activity of Ru-PC NPs and its potential to reduce inf

关键词： Nanozymes Quadruple enzymatic activity Antibacterial therapy Wound therapy RNA-seqAnti-inflammatory Reactive oxygen species Reactive nitrogen species

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Amplification effect of intra-seasonal variability of soil moisture on heat extremes over Eurasia

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Advances in Climate Change Research 2024年第1期15卷 1-8页

作者： Yi-Nuo WANG Zhi-Yan ZUO Liang QIAO Kai-Wen ZHANG Mei-Yu CHANG Dong XIAO Zou-xing LIN Huan WANG department of Atmospheric and Oceanic Sciences Institute of Atmospheric SciencesFudan UniversityShanghai 200438China CMA-FDU Joint Laboratory of Marine Meteorology Shanghai 200438China Key Laboratory of Cites Mitigation and Adaptation to Climate Change in Shanghai China Meteorological AdministrationShanghai 200030China Collaborative Innovation Centeron Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 211800China Shanghai Frontiers Science Center of Atmosphere-Ocean Interaction Shanghai 200123China College of Geography and Resources Science Sichuan Normal UniversityChengdu 610101China National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary Shanghai 202183China Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081China

Drying soil has been conducive to a high frequency of extreme high-temperature events over many regions worldwide in recent ***,changes in the intraseasonal variability of soil moisture can also influence the likelihood of extremely high *** previous investigators have examined the association between extremely high temperatures and large-scale atmospheric circulation variability,the role of land-atmosphere coupling dominated by soil moisture variability in extremely high temperatures,particularly over the Eurasian continent,is not well *** this study,on the basis of the Land Surface,Snow,and Soil Moisture Model Intercomparison Project,we found that land-atmosphere feedback amplified the variability of soil moisture in most regions of Eurasia during summer from 1980 to *** amplification of soil moisture variability is closely correlated with more intensive intraseasonal variability of surface air temperature and more frequent occurrences of extreme high-temperature events,particularly in Europe,Siberia,Northeast Asia,and the Indochina *** correlation implies that increasing the intraseasonal variability of soil moisture results in a high likelihood of heat extremes during summer in most parts of Eurasia except Asian desert *** the intraseasonal timescale,the land-atmosphere coupling increases the variability of surface sensible heat flux and net long-wave radiation heating the atmosphere by intensifying the soil moisture variability,thus amplifying the variability of surface air temperature and enhancing the extreme high-temperature *** finding demonstrates the importance of changes in intraseasonal soil moisture variability for the increasing likelihood of heat extremes in summer.

关键词： Soil moisture Intraseasonal variability Land-atmosphere coupling Heat extremes

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Mpox(formerly monkeypox):pathogenesis,prevention,and treatment

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Signal Transduction and Targeted Therapy 2024年第1期9卷 234-248页

作者： Junjie Lu Hui xing Chunhua Wang Mengjun Tang Changcheng Wu Fan Ye Lijuan Yin Yang Yang Wenjie Tan Liang Shen Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and ScienceHubei ProvinceXiangyang 441021China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China College of Biotechnology Tianjin University of Science&TechnologyTianjin 300457China Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for infectious diseaseState Key Discipline of Infectious DiseaseShenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China

In 2.2.,a global outbreak of Mpox(formerly monkeypox)occurred in various countries across Europe and America and rapidly spread to more than 100 countries and *** World Health Organization declared the outbreak to be a public health emergency of international concern due to the rapid spread of the Mpox ***,nations intensified their efforts to explore treatment strategies aimed at combating the infection and its ***,the available therapeutic options for Mpox virus infection remain *** far,only a few numbers of antiviral compounds have been approved by regulatory *** the high mutability of the Mpox virus,certain mutant strains have shown resistance to existing pharmaceutical *** highlights the urgent need to develop novel antiviral drugs that can combat both drug resistance and the potential threat of ***,there is a lack of comprehensive literature on the pathophysiology and treatment of *** address this issue,we conducted a review covering the physiological and pathological processes of Mpox infection,summarizing the latest progress of anti-Mpox *** analysis encompasses approved drugs currently employed in clinical settings,as well as newly identified small-molecule compounds and antibody drugs displaying potential antiviral efficacy against ***,we have gained valuable insights from the process of Mpox drug development,including strategies for repurposing drugs,the discovery of drug targets driven by artificial intelligence,and preclinical drug *** purpose of this review is to provide readers with a comprehensive overview of the current knowledge on Mpox.

关键词： prevention treatment intensified

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Aerobic Enantioselective Epoxidation of Styrene Analogues Induced by (β-Diketone)-iron( Ⅲ ) Complex

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Chinese Chemical Letters 2005年第11期 51-54页

作者： Qing Fang CHENG1, 2. xing You XU1,2. Wei xing MA1, Shu Jie YANG2. Tian Pa YOU3 1 {2. of Chemical technology, Huaihai institute of technology, Lianyungang 2.2.05 2.Meterials Chemistry Laboratory, Nanjing University of Science and technology, Nanjing 2.0094 3 {2. of Chemistry, University of Science and technology of china, Hefei 2.002. Qing Fang CHENG(department of Chemical technology Huaihai Institute of Technology Lianyungang 222005 Meterials Chemistry Laboratory Nanjing University of Science and Technology Nanjing 210094) xing You XU(department of Chemical {2. Huaihai Institute of Technology Lianyungang 222005) Wei xing MA(Meterials Chemistry Laboratory Nanjing University of Science and Technology Nanjing 210094) Shu Jie YANG(department of Chemistry University of Science and Technology of China Hefei 230026)

Tris(d,d-dicampholylmethanato) iron(III)complex, Fe(dcm)3, was found to be an excellent catalyst for asymmetric oxygenation of styrene analogues into the corresponding epoxides. Good chemical yields and higher enantioselectivity were obtained with combined use of molecular oxygen and an aldehyde at 30 ℃. Some factors influencing enantioselectivity were discussed.

关键词： Epoxidation oliefin asymmetric catalysis (β-diketone)-iron (III) complex

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Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties

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Military Medical Research 2024年第4期11卷 543-566页

作者： Ying Chen xing Wang Sheng Tao Qi Wang Pan-Qin Ma Zi-Biao Li Yun-Long Wu Da-Wei Li Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology School of Pharmaceutical SciencesXiamen UniversityXiamen 361102FujianChina beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100090China University of Chinese Academy of Sciences Beijing 100049China Senior department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijing 100091China institute of Materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)Singapore 138634Singapore

The treatment of chronic and non-healing wounds in diabetic patients remains a major medical *** reports have shown that hydrogel wound dressings might be an effective strategy for treating diabetic wounds due to their excellent hydrophilicity,good drug-loading ability and sustained drug release *** a typical example,hyaluronic acid dressing(Healoderm)has been demonstrated in clinical trials to improve wound-healing efficiency and healing rates for diabetic foot ***,the drug release and degradation behavior of clinically-used hydrogel wound dressings cannot be adjusted according to the wound *** to the intricacy of diabetic wounds,antibiotics and other medications are frequently combined with hydrogel dressings in clinical practice,although these medications are easily hindered by the hostile *** this case,scientists have created responsive-hydrogel dressings based on the microenvironment features of diabetic wounds(such as high glucose and low pH)or combined with external stimuli(such as light or magnetic field)to achieve controllable drug release,gel degradation,and microenvironment improvements in order to overcome these clinical *** responsive-hydrogel dressings are anticipated to play a significant role in diabetic therapeutic wound ***,we review recent advances on responsive-hydrogel dressings towards diabetic wound healing,with focus on hydrogel structure design,the principle of responsiveness,and the behavior of *** but not least,the advantages and limitations of these responsive-hydrogels in clinical applications will also be *** hope that this review will contribute to furthering progress on hydrogels as an improved dressing for diabetic wound healing and practical clinical application.

关键词： Responsive-hydrogel Diabetic wound Anti-inflammation Tissue remodeling

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Recent advances in the application of MXenes for neural tissue engineering and regeneration

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Neural Regeneration Research 2024年第2期19卷 258-263页

作者： Menghui Liao Qingyue Cui Yangnan Hu Jiayue xing Danqi Wu Shasha Zheng Yu Zhao Yafeng Yu Jingwu Sun Renjie Chai State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologyAdvanced Institute for Life and HealthJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjingJiangsu ProvinceChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina department of Oto-Rhino-Laryngology West China HospitalSichuan UniversityChengduSichuan ProvinceChina First Affiliated Hospital of Soochow University SuzhouJiangsu ProvinceChina department of Otolaryngology-Head and Neck Surgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina department of Otolaryngology Head and Neck Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina beijing Key Laboratory of Neural Regeneration and Repair Capital Medical UniversityBeijingChina

Transition metal carbides and nitrides(MXenes)are crystal nanomaterials with a number of surface functional groups such as fluorine,hydroxyl,and oxygen,which can be used as carriers for proteins and *** have excellent biocompatibility,electrical conductivity,surface hydrophilicity,mechanical properties and easy surface ***,at present,the stability of most MXenes needs to be improved,and more synthesis methods need to be *** are good substrates for nerve cell regeneration and nerve reconstruction,which have broad application prospects in the repair of nervous system *** the application of MXenes in neuroscience,mainly at the cellular level,the long-term in vivo biosafety and effects also need to be further *** review focuses on the progress of using MXenes in nerve regeneration over the last few years;discussing preparation of MXenes and their biocompatibility with different cells as well as the regulation by MXenes of nerve cell regeneration in two-dimensional and three-dimensional environments in *** have great potential in regulating the proliferation,differentiation,and maturation of nerve cells and in promoting regeneration and recovery after nerve *** addition,this review also presents the main challenges during optimization processes,such as the preparation of stable MXenes and long-term in vivo biosafety,and further discusses future directions in neural tissue engineering.

关键词： hydrogels MXenes nerve regeneration neural cells neural stem cells organoids spiral ganglion neurons

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Dual-Mode Resonant Sectorial Monopole Antenna with Stable Backfire Gain

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Chinese Journal of Electronics 2024年

作者： Feiyan JI Heng ZHANG Xiuqiong xing Wenjun LU Lei ZHU Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and Telecommunications Key Laboratory of Wireless Sensor Network & Communication Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences department of Electrical and Computer Engineering Faculty of Science and Technology University of Macau

A novel design approach to wideband, dual-mode resonant monopole antenna with stable, enhanced backfire gain is advanced. The sectorial monopole evolves from a linear, 0.75-wavelength electric prototype monopole under wideband dual-mode resonant operation. As theoretically predicted by the two resonant modes TE9/5,1and experimentally validated at 2.4-GHz band, the designed antenna exhibits a wide impedance bandwidth over 90.1%(i.e., 2.06-5.44 GHz), in which the stable gain bandwidth in the backfire,-x-direction(θ = 90°, φ = 180°) with peak value of 3.2.dBi and fluctuation less than 3 dB is up to 45.3%(i.e., 3.74-5.44 GHz). It is concluded that the stable wideband backfire gain frequency response should be owing to the high-order resonant mode in the unique sectorial monopole antennas.

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Controlling the Molecular Weight and Molecular Weight Distribution using Compressed CO_2.Antisolvent

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Chinese Chemical Letters 2000年第10期11卷 933-934页

作者： Jun LIU, Zhi Min LIU, Bu xing HAN, Jian WANG, Qing HUO, Fang Fang LIU (Center For Molecular Sciences, institute of Chemistry, Chinese Academy of Sciences, {2. 100080 (Chemical Engineering College of {2. United University, {2. 10002.) (department of Chemical Engineering, University of Science and technology of Hebei, Shijiazhuang 050018) Chinese Acad Sci Inst Chem Ctr Mol Sci Beijing 100080 Peoples R China beijing United Univ Chem Engn Coll Beijing 100023 Peoples R China Univ Sci & Technol Hebei Dept Chem Engn Shijiazhuang 050018 Peoples R China

Effect of CO2.dissolved in tetrahydrofuran (THF) on the polymerization of styrene in THF was studied at 333.2.K and different pressures. It was found that the molecular weight (MW) and MW distribution of the polystyre... 详细信息

关键词： CO_2 antisolvent styrene polymerization

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Atorvastatin, etanercept and the nephrogenic cardiac sympathetic remodeling in chronic renal failure rats

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Journal of Geriatric Cardiology 2024年第4期21卷 443-457页

作者： Jing-Yue XU Zheng-Kai XUE Ya-Ru ZHANG xing LIU Xue ZHANG Xi YANG Tong LIU Kang-Yin CHEN Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of Cardiologythe Second Hospital of Tianjin Medical UniversityTianjinChina

BACKGROUND Chronic renal failure(CRF) patients are predisposed to arrhythmias, while the detailed mechanisms are unclear. We hypothesized the chronic inflammatory state of CRF patients may lead to cardiac sympathetic remodeling, increasing the incidence of ventricular arrhythmia(VA) and sudden cardiac death. And explored the role of atorvastatin and etanercept in this *** A total of 48 rats were randomly divided into sham operation group(Sham group), CRF group, CRF + atorvastatin group(CRF + statin group), and CRF + etanercept group(CRF + rhTNFR-Fcgroup). Sympathetic nerve remodeling was assessed by immunofluorescence of growth-associated protein 43(GAP-43) and tyrosine hydroxylase positive area fraction. Electrophysiological testing was performed to assess the incidence of VA by assessing the ventricular effective refractory period and ventricular fibrillation threshold. The levels of tumor necrosis factor-alpha(TNF-α) and interleukin-1beta were determined by Western blotting and enzyme-linked immunosorbent *** Echocardiogram showed that compared with the Sham group, left ventricular end-systolic diameter and ventricular weight/body weight ratio were significantly higher in the CRF group. Hematoxylin-eosin and Masson staining indicated that myocardial fibers were broken, disordered, and fibrotic in the CRF group. Western blotting, enzyme-linked immunosorbent assay,immunofluorescence and electrophysiological examination suggested that compared with the Sham group, GAP-43 and TNF-α proteins were significantly upregulated, GAP-43 and tyrosine hydroxylase positive nerve fiber area was increased, and ventricular fibrillation threshold was significantly decreased in the CRF group. The above effects were inhibited in the CRF + statin group and the CRF + *** In CRF rats, TNF-α was upregulated, cardiac sympathetic remodeling was more severe, and the nephrogenic cardiac sympathetic remodeling existed. Atorvastatin and etanercept c

关键词： remodeling cardiac inhibited

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Penumbra-targeted CircOGDH siRNA-loaded nanoparticles alleviate neuronal apoptosis in focal brain ischaemia

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Stroke & Vascular Neurology 2024年第2期9卷 134-144,I0396-I0413页

作者： Yanfang Liu Tianyuan Zhang xing Zou Zhongwen Yuan Yufeng Li Jiankun Zang Niu He Lizhen He Anding Xu Dan Lu department of Neurology and Stroke Center Jinan University First Affiliated HospitalGuangzhouGuangdongChina department of Clinical Neuroscience institute The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdongChina Key Lab of Guangzhou Basic and Translational Research of Pan-vascular Diseases The First Affiliated Hospital of Jinan UniversityGuangzhouChina

Background Nanoparticles(NPs)are a class of substances that can be loaded with therapeutic agents delivered to specific *** our earlier research,we identified a neuron-derived circular RNA(circRNA),circular oxoglutarate dehydrogenase(CircOGDH),as a promising therapeutic target for acute ischaemic *** study dedicated to explore a prospective preliminary strategy of CircOGDH-based NP delivered to the ischaemic penumbra region in middle cerebral artery occlusion/reperfusion(MCAO/R)*** Immunofluorescence in primary cortex neurons and in vivo fluorescence imaging revealed endocytosis of Poly(lactide-co-glycolide)(PLGA)poly amidoamine(PAMAM)@CircOGDH small interfering RNA(siRNA)*** blotting analysis and CCK8 assay were performed to evaluate the apoptotic level in ischaemic neurons treated with PLGA–PAMAM@CircOGDH siRNA *** reverse transcription PCR experiments,mice behaviour test,T2.MRI analysis,Nissl and TdT-mediated dUTP nick end labeling(TUNEL)co-staining were performed to evaluate the apoptosis level of ischaemic penumbra neurons in MCAO/R *** evaluation of NPs in MCAO/R mice was detected by blood routine examination,liver and kidney function examination and HE *** PLGA–PAMAM@CircOGDH siRNA NPs were successfully *** of PLGA–PAMAM@CircOGDH siRNA NPs in ischaemic neurons alleviated neuronal apoptotic level in vitro and in ***,mice behaviour test showed that the neurological defects of MCAO/R mice were significantly alleviated after the tail injection of PLGA–PAMAM@CircOGDH siRNA NPs,and no toxic effects were *** In conclusion,our results suggest that PLGA–PAMAM@CircOGDH siRNA NPs can be delivered to the ischaemic penumbra region and alleviate neuron apoptosis in MCAO/R mice and in ischaemic neurons;therefore,our study provides a desirable approach for using circRNA-based NPs for the treatment of ischaemic stroke.

关键词： OGD routine loaded

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