检索结果-南通市图书馆

Generation of mitochondrial replacement monkeys by female pronucleus transfer

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第2期45卷 292-298页

作者： Chun-Yang li xing-Chen liu Yu-Zhuo li Yan Wang Yan-Hong Nie Yu-Ting Xu xiao-Tong Zhang Yong Lu Qiang Sun Institute of Neuroscience Center for Excellence in Brain Science and Intelligence TechnologyState Key Laboratory of NeuroscienceChinese Academy of SciencesShanghai 200031China Key Laboratory of Genetic Evolution and Animal Models Chinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China

Mutations in mitochondrial DNA(mtDNA)are maternally inherited and have the potential to cause severe *** replacement therapies,including spindle,polar body,and pronuclear transfers,are promising strategies for preventing the hereditary transmission of mtDNA *** pronuclear transfer has been used to generate mitochondrial replacement mouse models and human embryos,its application in non-human primates has not been previously *** this study,we successfully generated four healthy cynomolgus monkeys(Macaca fascicularis)via female pronuclear *** individuals all survived for more than two years and exhibited minimal mtDNA carryover(3.8%–6.7%),as well as relatively stable mtDNA heteroplasmy dynamics during *** successful establishment of this nonhuman primate model highlights the considerable potential of pronuclear transfer in reducing the risk of inherited mtDNA diseases and provides a valuable preclinical research model for advancing mitochondrial replacement therapies in humans.

关键词： Non-human primates Mitochondrial replacement Female pronuclear transfer

Investigation of gravity influence on EOR and CO_(2) geological storage based on pore-scale simulation

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 987-1001页

作者： Yong-Mao Hao Gui-Cheng Wu Zong-Fa li Zhong-Hui Wu Yong-Quan Sun Ran liu xing-xing li Bo-Xin Pang Nan li Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdao266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina School of Petroleum Engineering Yangtze UniversityWuhan430100HubeiChina Dongsheng Jinggong Petroleum Development Group Co. LtdShengli Oilfield CompanySINOPECDongying257001ShandongChina

Gravity assistance is a critical factor influencing CO_(2)-Oil mixing and miscible flow during EOR and CO_(2)geological *** on the Navier-Stokes equation,component mass conservation equation,and fluid property-composition relationship,a mathematical model for pore-scale CO_(2) injection in oilsaturated porous media was developed in this *** model can reflect the effects of gravity assistance,component diffusion,fluid density variation,and velocity change on EOR and CO_(2) *** nonhomogeneous porous media,the gravity influence and large density difference help to minimize the velocity difference between the main flow path and the surrounding area,thus improving the oil recovery and CO_(2) *** CO_(2) injection angles and oil-CO_(2) density differences can increase the oil recovery by 22.6% and 4.2%,respectively,and increase CO_(2) storage by 37.9% and 4.7%,*** diffusion facilitates the transportation of the oil components from the low-velocity region to the main flow path,thereby reducing the oil/CO_(2) concentration difference within the porous *** diffusion can increase oil recovery and CO_(2) storage by 5.7% and 6.9%,*** addition,combined with the component diffusion,a low CO_(2) injection rate creates a more uniform spatial distribution of the oil/CO_(2) component,resulting in increases of 9.5% oil recovery and 15.7% CO_(2) storage,*** study provides theoretical support for improving the geological CO_(2) storage and EOR processes.

关键词： Gravity Flow simulation CO_(2)-oil mixing Enhanced oil recovery(EOR) Geological storage

在线全文

学校读者我要写书评

暂无评论

论陈忠实的创作道路与文学地位

西北大学学报（哲学社会科学版） 2014年第3期44卷 88-95页

作者：邢小利陕西省作家协会陕西西安710001

陈忠实的创作道路大致可以分为四个时期。代表作《白鹿原》实现了创作上的重大跨越以至超越,堪称一部史诗般的巨作。陈忠实是描写农民生活、农村社会和乡村文化的高手。陈忠实既不属于传统意义上的文人,也不属于现代意义上的知识分子。... 详细信息

陈忠实的创作道路大致可以分为四个时期。代表作《白鹿原》实现了创作上的重大跨越以至超越,堪称一部史诗般的巨作。陈忠实是描写农民生活、农村社会和乡村文化的高手。陈忠实既不属于传统意义上的文人,也不属于现代意义上的知识分子。陈忠实的创作道路、身份变化与新中国的文艺政策、文学体制密切相关。当把文学当作终生事业孜孜以求的时候,陈忠实努力从理性高度自觉反思自己的思想观念、思维方式和文学观念。经历了听命与顺随、反思与寻找、蜕变与完成的三级跳跃,陈忠实走过了从没有自我到寻找自我并最后完成自我的漫长过程,从而成为一个具有时代文学标志性和代表性的大作家。

关键词：陈忠实当代文学乡村反思自我

Navigation Finsler metrics on a gradient Ricci soliton

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 266-275页

作者： li Ying MO xiao-huan WANG xiao-yang Department of Applied Mathematics Zhejiang University of TechnologyHangzhou 310023China Key Laboratory of Pure and Applied Mathematics School of Mathematical SciencesPeking UniversityBeijing 100871China School of Mathematics and Statistics Beijing Institute of TechnologyBeijing 100081China

In this paper,we study a class of Finsler metrics defined by a vector field on a gradient Ricci *** obtain a necessary and sufficient condition for these Finsler metrics on a compact gradient Ricci soliton to be of isotropic S-curvature by establishing a new integral *** we determine the Ricci curvature of navigation Finsler metrics of isotropic S-curvature on a gradient Ricci soliton generalizing result only known in the case when such soliton is of Einstein *** its application,we obtain the Ricci curvature of all navigation Finsler metrics of isotropic S-curvature on Gaussian shrinking soliton.

关键词： gradient Ricci soliton navigation Finsler metric isotropic S-curvature Ricci curvature Gaussian shrinking soliton

Experience of humanistic nursing in hemodialysis nursing for patients with diabetic kidney disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第2期15卷 186-195页

作者： xiao-Ying Chai xiao-Yan Bao Ying Dai xing-xing Dai Yu Zhang Yu-ling Yang Department of Nephrology The Affiliated Hospital of Jiangnan UniversityWuxi 214000Jiangsu ProvinceChina Department of Hemodialysis The Affiliated Hospital of Jiangnan UniversityWuxi 214000Jiangsu ProvinceChina Department of Endocrinology The Affiliated Hospital of Jiangnan UniversityWuxi 214000Jiangsu ProvinceChina

BACKGROUND Diabetic kidney disease(DKD)is a prevalent complication of diabetes that often requires hemodialysis for *** the field of nursing,there is a growing recognition of the importance of humanistic care,which focuses on the holistic needs of patients,including their emotional,psychological,and social ***,the application of humanistic nursing in the context of hemodialysis for DKD patients remains relatively *** To explore the experience of humanistic nursing in hemodialysis nursing for DKD *** Ninety-six DKD patients treated with hemodialysis from March 2020 to June 2022 were included in the study and divided into the control cluster(48 cases)and the study cluster(48 cases)according to different nursing methods;the control cluster was given routine nursing and the study cluster was given humanized *** variances of negative emotion mark,blood glucose,renal function,the incidence of complications,life mark and nursing satisfaction before and after nur-sing were contrasted between the two *** No significant difference in negative emotion markers between the two clusters were observed before nursing(P>0.05),and the negative emotion markers of the two clusters decreased after *** Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale markers were lower in the study cluster than the control *** healing rate of patients in the study cluster was significantly higher than the control cluster(97.92%vs 85.42%,P0.05).However,after nursing,blood urea nitrogen and serum creatinine(SCr)levels in the study cluster were lower than those in the control cluster(Plications was significantly lower in the study group compared to the control cluster(6.25%vs 20.83%,Plife markers between the two clusters be

关键词： Diabetic kidney disease Hemodialysis Humanistic nursing Incidence of complication Effect

Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior:Synthesis,Characterization and Biological Applications

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第6期42卷 826-837页

作者： Feng-Ming Yin li-li Wu Shu-Sheng li xiao-Na Pan xiao-li Zhu Xu-Bao Jiang Xiang Zheng Kong College of Chemistry and Chemical Engineering University of JinanJinan250022China Shandong Institute for Product Quality Inspection Jinan250102China College of Chemical Engineering Tianjin UniversityTianjin300072China

Non-aromatic fluorescent and multi-responsive materials,exhibiting inherent fluorescence emission and controlled phase change,have garnered significant attention in recent ***,the underlying interaction between their fluorescent properties and phase transition remains *** this study,we synthesized a series of catalyst-free aza-Michael addition-based polyethyleneimine(RFPEI)materials by reacting polyethyleneimine(PEI)with N-isopropyl acrylamide(NIPAM).The resulting RFPEI was comprehensively characterized,and demonstrated dual-phase transition behavior(LCST and UCST)in water,which could be finely tuned by adjusting its composition or external factors such as ***,upon UV irradiation(365 nm),RFPEI exhibited strong fluorescence *** further investigated the effects of NIPAM grafting percentage to PEI,polymer concentration,and pH on the LCST/UCST and fluorescent properties of RFPEI aqueous ***,we showcased the great potential of RFPEI as a versatile tool for physiological cell imaging,trace detection,and controlled release of *** study presents a novel class of stimuli-responsive fluorescent materials with promising applications in the field of biomedicine.

关键词： Polyethyleneimine Multi-responsiveness Intrinsic fluorescence emission Cell imaging Controlled drug release

Embedded Majorana islands

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 154-164页

作者： Jin-xing Hou Alex Weststrom Rui Wang Wen-li Yang Jian li Institute of Modern Physics Northwest UniversityXi’an 710127China Department of Physics School of ScienceWestlake UniversityHangzhou 310030China Shaanxi Key Laboratory for Theoretical Physics Frontiers Xi’an 710127China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China National Laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210093China Collaborative Innovation Center for Advanced Microstructures Nanjing 210093China Peng Huanwu Center for Fundamental Theory Xi’an 710127China

Mesoscopic superconducting islands hosting Majorana zero modes(MZMs),or Majorana islands in short,offer a prototype of topological *** this work we investigate theoretically the model of a generic Majorana island tunneling-coupled to a singlepiece metallic substrate,hence an embedded Majorana *** show the crucial consequences of an interplay between the topological ground states nonlocally addressed by the MZMs and the metallic bath with coherent electron propagation:on the one hand,the topological degeneracy on the Majorana island can be preserved,by virtue of the particle-hole symmetry,despite the apparent bath-induced coupling between MZMs;on the other hand,the electronic interference in the metallic bath may lead to profound alterations to the renormalization group behavior of the hybrid system towards low energy/temperature compared with conventional Kondo *** work serves to establish the model of embedded Majorana islands as an experimentally relevant and theoretically intriguing problem particularly in the direction of topological quantum computation.

关键词： topological quantum computation Majorana zero modes topological qubit mesoscopic superconductor topological Kondo effect

同方期刊数据库

Lymphatic plastic bronchitis and primary chylothorax: A study based on computed tomography lymphangiography

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第14期12卷 2350-2358页

作者： xing-Peng li Yan Zhang xiao-li Sun Kun Hao Meng-Ke liu Qi Hao Ren-Gui Wang Department of Radiology Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijing 100038China Department of Radiology Qilu HospitalShandong UniversityJinan 250063Shandong ProvinceChina Department of Lymph Surgery Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijing 100038China Department of Radiology People's Hospital of Peking UniversityThe Second School of Clinical Medicine of Peking UniversityBeijing 100034China

BACKGROUND This study presents an evaluation of the computed tomography lymphangio-graphy(CTL)features of lymphatic plastic bronchitis(PB)and primary chylotho-rax to improve the diagnostic accuracy for these two *** To improve the diagnosis of lymphatic PB or primary chylothorax,a retrospective analysis of the clinical features and CTL characteristics of 71 patients diagnosed with lymphatic PB or primary chylothorax was *** The clinical and CTL data of 71 patients(20 with lymphatic PB,41 with primary chylothorax,and 10 with lymphatic PB with primary chylothorax)were collected *** was performed in all *** clinical manifestations,CTL findings,and conventional chest CT findings of the three groups of patients were *** chi-square test or Fisher's exact test was used to compare the differences among the three groups.A difference was considered to be statistically significant when Plities on conven-tional chest CT in the three groups were as follows:Ground-glass opacity in 19(95.0%),18(43.9%)and 8(80.0%)patients;atelectasis in 4(20.0%),26(63.4%)and 7(70.0%)patients;interlobular septal thickening in 12(60.0%),11(26.8%)and 3(30.0%)patients;bronchovascular bundle thickening in 14(70.0%),6(14.6%)and 4(40.0%)patients;localized mediastinal changes in 14(70.0%),14(34.1%),and 7(70.0%)patients;diffuse mediastinal changes in 6(30.0%),5(12.2%),and 3(30.0%)patients;cystic lesions in the axilla in 2(10.0%),6(14.6%),and 2(20.0%)patients;and cystic lesions in the chest wall in 0(0%),2(4.9%),and 2(4.9%)*** CTL is

关键词： Lymphatic Plastic bronchitis Primary chylothorax Direct lymphangiography Computed tomography lymphangiography

Annexin A1 in the nervous and ocular systems

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第3期19卷 591-597页

作者： Aijia Wang Hong Zhang xing li Yin Zhao Department of Ophthalmology 2Department of AnesthesiologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

The therapeutic potential of Annexin A1,an important member of the Annexin superfamily,has become evident in results of experiments with multiple human systems and animal *** anti-inflammatory and pro-resolving effects of Annexin A1 are characteristic of pathologies involving the nervous *** this review,we initially describe the expression sites of Annexin A1,then outline the mechanisms by which Annexin A1 maintains the neurological homeostasis through either formyl peptide receptor 2 or other molecular approaches;and,finally,we discuss the neuroregenerative potential qualities of Annexin *** eye and the nervous system are anatomically and functionally connected,but the association between visual system pathogenesis,especially in the retina,and Annexin A1 alterations has not been well ***,we explain the beneficial effects of Annexin A1 for ocular diseases,especially for retinal diseases and glaucoma on the basis of published findings,and we explore present and future delivery strategies for Annexin A1 to the retina.

关键词： Annexin A1(ANXA1) glaucoma nervous system neuroprotection neuroregeneration ocular disease retina