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Maresin 1 alleviates neuroinflammation and cognitive decline in a mouse model of cecal ligation and puncture

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中南大学学报（医学版） 2024年第6期49卷 890-902页

作者： LI Longyan xing Manyu w.ng Lu ZHAO Yixia Department of Anesthesiology Xiangya HospitalCentral South UniversityChangsha 410008 Department of Cardiology Xiangya HospitalCentral South UniversityChangsha 410008 National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China

Objective:Inflammation in the central nervous system plays a crucial role in the occurrence and development of sepsis-associated *** study aims to explore the effects of maresin 1(MaR1),an anti-inflammatory and pro-resolving lipid mediator,on sepsis-induced neuroinflammation and cognitive ***:Mice were randomly assigned to 4 groups:A sham group(sham operation+vehicle),a cecal ligation and puncture(CLP)group(CLP operation+vehicle),a MaR1-LD group(CLP operation+1 ng MaR1),and a MaR1-HD group(CLP operation+10 ng MaR1).MaR1 or vehicle was intraperitoneally administered starting 1 h before CLP operation,then every other day for 7 *** rates were monitored,and serum inflammatory cytokines[tumor necrosis factor alpha(TNF-α),interleukin(IL)-1β,and IL-6]were measured 24 h after operation using enzyme-linked immunosorbent assay(ELISA).Cognitive function was assessed 7 days after operation using the Morris water maze(MwM)test and novel object recognition(NOR)*** mRNA expression of TNF-α,IL-1β,IL-6,inducible nitric oxide synthase(iNOS),IL-4,IL-10,and arginase 1(Arg1)in cortical and hippocampal tissues was determined by real-time reverse transcription PCR(RT-PCR).western blotting was used to determine the protein expression of iNOS,Arg1,signal transducer and activator of transcription 6(STAT6),peroxisome proliferator-activated receptor gamma(PPARγ),and phosphorylated STAT6(p-STAT6)in hippocampal *** activation was visualized via *** were also treated with the PPARγantagonist Gw9662 to confirm the involvement of this pathway in MaR1’s ***:CLP increased serum levels of TNF-α,IL-1β,and IL-6,and reduced body weight and survival rates(all Png and 10 ng doses of MaR1 significantly reduced serum TNF-α,IL-1β,and IL-6 levels,improved body weight,and increased survival rates(all Pwas observed between the 2 doses(all P>0.05).MwM test and NOR t

关键词： sepsis cognitive decline maresin 1 microglia neuroinflammation

Using choroidal thickness to detect myopic macular degeneration

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 317-323页

作者： Ran Liu Meng Xuan De-Cai w.ng Ou Xiao Xin-xing Guo Jian Zhang wei w.ng Monica Jong Padmaja Sankaridurg Kyoko Ohno-Matsui Qiu-Xia Yin Ming-Guang He Zhi-Xi Li State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina New England College of Optometry BostonMassachusetts 02115USA wilmer Eye Institute Johns Hopkins UniversityBaltimoreMD 21231USA Brien Holden Vision Institute Sydney 2052Australia School of Optometry and Vision Science University of New South WalesSydney 2052Australia Department of Ophthalmology and Visual Science Tokyo Medical and Dental UniversityTokyo 113-8510Japan School of Optometry the Hong Kong Polytechnic UniversityHong Kong SARChina Research Centre for SHARP Vision the Hong Kong Polytechnic UniversityHong Kong SARChina Center for Eye and Vision Research(CEVR) 17W Hong Kong Science ParkHong Kong SARChina

AIM:To explore the usage of choroidal thickness measured by swept-source optical coherence tomography(SS-OCT)to detect myopic macular degeneration(MMD)in high myopic ***:Participants with bilateral high myopia(≤−6 diopters)were recruited from a subset of the Guangzhou Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Cohort ***-OCT was performed to determine the choroidal thickness,and myopic maculopathy was graded by the International Meta-Analysis for Pathologic Myopia(META-PM)Classiﬁ*** of MMD was defined as META-PM category 2 or ***:A total of 568 right eyes were included for *** with MMD(n=106,18.7%)were found to have older age,longer axial lengths(AL),higher myopic spherical equivalents(SE),and reduced choroidal thickness in each Early Treatment Diabetic Retinopathy Study(ETDRS)grid sector(Png characteristic(ROC)curves(AUC)for subfoveal choroidal thickness(0.907)was greater than that of the model,including age,AL,and SE at 0.6249,0.8208,and 0.8205,*** choroidal thickness of the inner and outer nasal sectors was the most accurate indicator of MMD(AUC of 0.928 and 0.923,respectively).An outer nasal sector choroidal thickness of less than 74μm demonstrated the highest odds of predicting MMD(OR=33.8).CONCLUSION:Choroidal thickness detects the presence of MMD with high agreement,particularly of the inner and outer nasal sectors of the posterior pole,which appears to be a biometric parameter more precise than age,AL,or SE.

关键词： high myopia choroidal thickness myopic macular degeneration swept-source optical coherence tomography

Aurora B promotes the CENP-T–CENP-w interaction to guide accurate chromosome segregation in mitosis

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Journal of Molecular Cell Biology 2024年第2期16卷 11-23页

作者： wei Liu Zhen Dou Chunyue w.ng Gangyin Zhao Fengge wu Chunli w.ng Felix Aikhionbare Mingliang Ye Divine Mensah Sedzro Zhenye Yang Chuanhai Fu Zhikai w.ng Xinjiao Gao Xuebiao Yao Xiaoyu Song xing Liu MOE Key Laboratory for Cellular Dynamics Center for Advanced Interdisciplinary Science and Biomedicine of IHMUniversity of Science and Technology of China School of Life SciencesHefei 230027China Keck Center for Cellular Dynamics and Organoids Plasticity AtlantaGA 30310USA Anhui Key Laboratory for Cellular Dynamics and Chemical Biology Hefei National Research Center for Interdisciplinary Sciences at the MicroscaleHefei 230026China National Chromatographic Research and Analysis Center Chinese Academy of SciencesDalian 116023China

Accurate chromosome segregation in mitosis depends on kinetochores that connect centromeric chromatin to spindle *** are captured by individual microtubules via a kinetochore constitutive centromere-associated network(CCAN)during chromosome *** contains 16 subunits,including CENP-w and ***,the molecular recognition and mitotic regulation of the CCAN assembly remain ***,we revealed that CENP-w binds to the histone fold domain and an uncharacterized N-terminal region of *** B phosphorylates CENP-w at threonine 60,which enhances the interaction between CENP-w and CENP-T to ensure robust metaphase chromosome alignment and accurate chromosome segregation in *** findings delineate a conserved signaling cascade that integrates protein phosphorylation with CCAN integrity for the maintenance of genomic stability.

关键词： mitosis kinetochore Aurora B CENP-T CENP-w phosphorylation

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结合面部动作单元感知的三维人脸重建算法

软件学报 2024年第5期35卷 2176-2191页

作者：章毅吕嘉仪兰星薛健中国科学院大学工程科学学院北京100049

三维人脸重建在计算机视觉及动画领域是一项重要任务,它可以为人脸多模态应用提供三维模型结构和丰富的语义信息.然而,单目二维人脸图像缺乏深度信息,预测的三维模型参数不够可靠,从而导致重建效果不佳.提出采用与模型参数高度相关的面... 详细信息

三维人脸重建在计算机视觉及动画领域是一项重要任务,它可以为人脸多模态应用提供三维模型结构和丰富的语义信息.然而,单目二维人脸图像缺乏深度信息,预测的三维模型参数不够可靠,从而导致重建效果不佳.提出采用与模型参数高度相关的面部动作单元和人脸关键点作为桥梁,引导模型相关参数回归,以解决单目人脸重建的不适定问题.基于人脸重建的现有数据集,提供一套完整的面部动作单元半自动标注方案,并构建300w-LP-AU数据集.进而提出一种结合动作单元感知的三维人脸重建算法.该算法实现端到端的多任务学习,有效降低了整体训练难度.实验结果表明,该算法能有效地提升三维人脸重建性能,重建的人脸模型具有更高的保真度.

关键词：面部动作单元人脸关键点三维人脸重建

Enhanced electrical properties and Vickers hardness of calcium bismuth niobate ceramics by w/Co substituted at B-site

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Journal of Advanced Dielectrics 2024年第4期14卷 92-103页

作者： Fei w.ng Jia Yang Qing Yang Ning Chen Xinji Yang Mingyue Mo Jie xing Zhi Tan Zhongqing Tian Fancheng Meng Yuheng Guo Huixing Lin Jianguo Zhu College of Materials Science and Engineering Chongqing University of TechnologyChongqing 400054P.R.China College of Materials Science and Engineering Sichuan UniversityChengdu 610064P.R.China School of Electronic Engineering Chengdu Technological UniversityChengdu 611730P.R.China Key Laboratory of Inorganic Functional Material and Device Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899P.R.China

Calcium bismuth niobate(CBN)ceramic,as a core element of high-temperature piezoelectric sensors,has attracted widespread attention due to its high Curie temperature within the class of Aurivillius ***,CBN usually faces two *** piezoelectric constant and low *** this work,CBN-based ceramics with donor–acceptor ions(w/Co)co-substituted at B-site were prepared by solid-state reaction method,and structure–property relationship of ceramics was studied in ***-substitution of w/Co ions effectively improved the electrical property and hardness of CBN ***_(2)Nb_(1.91)(w_(2/3)Co_(1/3)T_(0.09)O_(9))exhibits enhanced electrical and mechanical properties including high resistivity of-10^(7)Ω·cm at 500℃,piezoelectric constant of-15.3 pC/N and hardness value of-3.57 *** values are two orders of magnitude,over two times,and 1.36 times higher than those of pure CBN ceramic,*** work provides a reference for exploring other bismuth-layered structural ceramics.

关键词： Calcium bismuth niobate ceramics donor and acceptor ions B-site electrical properties Vickers hardness

Encapsulated Fe(IV)Molecular Complex for Photoacoustic Imaging

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CCS Chemistry 2024年第5期6卷 1184-1197页

作者： Ye Xu Chao Li Zhong-Yu Yu Jiamin w.ng Zhaoyang Liu Chao Jiang Zhen-Feng Chen Xiaoyu wu Ming-xing Li Hong Yang Zhao-Xi w.ng Jonathan L.Sessler Department of Chemistry Center for Supramolecular Chemistry and CatalysisInnovative Drug Research CenterShanghai UniversityShanghai 200444 College of Chemistry and Materials Science Shanghai Key Laboratory of Rare Earth Functional MaterialsShanghai Frontiers Science Center of Biomimetic CatalysisShanghai Normal UniversityShanghai 200234 Sijing Community Health Service Center of Songjiang District Shanghai 201601 Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuilin 541004 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224

stable neutral Fe(IV)complex(Fe-HDCL),readily accessible on the g scale,was found to possess high water solubility and good stability(<5%degradation over 4 h upon photoirradiation).Fe-HDCL is green and absorbs light e... 详细信息

stable neutral Fe(IV)complex(Fe-HDCL),readily accessible on the g scale,was found to possess high water solubility and good stability(with aλmax at 650 nm(ɛ=7830 M^(−1)cm^(−1)).Fe-HDCL also exhibits photothermal(PT)behavior comparable to single-wall carbon nanotubes in the solid *** aqueous solution,high PT conversion(η=72.6%)is achieved,and a strong hyperthermia-based inhibition of cell growth is observed upon subjecting Fe-HDCL to near-infrared 730 nm laser *** biological studies in vitro and in vivo confirmed that Fe-HDCL is biocompatible,clears readily,and allows the visual detection of blood *** subjecting mice to intravenous injection at low doses(e.g.,50μmol·kg^(−1)),Fe-HDCL also permits the photoacoustic(PA)imaging of kidneys and the evaluation of renal fibrosis in mouse *** addition,Fe-HDCL allows PA-based imaging of brain tissues,presumably reflecting its ability to pass through the blood-brain *** thus propose that Fe-HDCL has a role to play as PT agent and as a photodiagnostic.

关键词： stable Fe(IV)complex blood-brain barrier molecular cage photoacoustic imaging renal fibrosis

Generation and regulation of electromagnetic pulses generated by femtosecond lasers interacting with multitargets

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Nuclear Science and Techniques 2024年第1期35卷 96-107页

作者： Ya-Dong Xia De-Feng Kong Qiang-You He Zhen Guo Dong-Jun Zhang Tong Yang Hao Cheng Yu-Ze Li Yang Yan Xiao Liang Ping Zhu xing-Long Xie Jian-Qiang Zhu Ting-Shuai Li Chen Lin wen-Jun Ma Xue-Qing Yan State Key Laboratory of Nuclear Physics and Technology and Key Laboratory of HEDP of the Ministry of EducationCAPTPeking UniversityBeijing 100871China Beijing Laser Acceleration Innovation Center Beijing 101407China Institute of Guangdong Laser Plasma Technology Guangzhou 510540China National Laboratory on High Power Laser and Physics Shanghai Institute of Optics and FineChinese Academy of SciencesShanghai 201800China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China

Ultrashort and powerful laser interactions with a target generate intense wideband electromagnetic pulses(EMPs).In this study,we report EMPs generated by the interactions between petawatt(30 fs,1.4×10^(20) w/cm^(2))femtosecond(fs)lasers with metal flat,plastic flat,and plastic nanowire-array(NwA)*** analyses are conducted on the EMPs in terms of their spatial distribution,time and frequency domains,radiation energy,and *** results indicate that EMPs from metal targets exhibit larger amplitudes at varying angles than those generated by other types of targets and are enhanced significantly for NwA *** a plastic target holder and increasing the laser focal spot can significantly decrease the radiation energy of the ***,the composite shielding materials indicate an effective shielding effect against *** simulation results show that the NwA targets exert a collimating effect on thermal electrons,which directly affects the distribution of *** study provides guidance for regulating EMPs by controlling the laser focal spot,target parameters,and target rod material and is beneficial for electromagnetic-shielding design.

关键词： Electromagnetic pulses Laser plasma interaction Electromagnetic shielding Electron distribution

牛奶中喹诺酮类药物残留的AlphaLISA检测方法的研究

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食品工业科技 2024年第14期45卷 264-270页

作者：马立才邢维维于莹贾良曦秦誉金兴丁亚芳北京维德维康生物技术有限公司北京100095

本文旨在建立一种可检测牛奶中喹诺酮类药物(Quinolones,QNS)残留的均相光激化学发光免疫分析方法(Amplifiedluminescent proximity homogeneous assay linkedimmune sorbent assay,AlphaLISA)。采用EDC/NHS活泼酯法在诺氟沙星分子连接6-氨基己酸作为间隔臂,制备生物素修饰诺氟沙星半抗原(Biotin-6AS-NOR),并在受体微球上偶联QNS单克隆抗体,Biotin-6AS-NOR可与牛奶样品中的QNS竞争结合喹诺酮抗体;通过优化受体微球的QNS抗体偶联量,Biotin-6AS-NOR及供/受体微球的用量等参数,以及牛奶样品的稀释方案,建立了牛奶中QNS残留的AlphaLISA检测方法。采用1:5牛奶样品稀释方案,所建立牛奶中QNS残留的AlphaLISA检测方法的检出限和定量限分别为0.19 ng/mL和0.46 ng/mL,回收率在85.97%~110.11%之间,日内和日间变异系数均小于10%,与诺氟沙星、恩诺沙星、环丙沙星、氧氟沙星、培氟沙星、达氟沙星和洛美沙星的交叉反应率均高于70%。本研究所建立AlphaLISA检测方法具有灵敏度和准确度高、重复性好等优点,且在整个检测过程中不需要繁琐洗涤操作,具有较高的应用和推广价值。

关键词：喹诺酮类半抗原生物素 AlphaLISA

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High-repetition-rate and high-power efficient picosecond thin-disk regenerative amplifier

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High Power Laser Science and Engineering 2024年第2期12卷 16-23页

作者： Sizhi Xu Yubo Gao xing Liu Yew.ng Chen Deqin Ouyang Junqing Zhao Minqiu Liu Xu wu Chunyu Guo Cangtao Zhou Qitao Lue Shuangchen Ruan Key Laboratory of Advanced Optical Precision Manufacturing Technology of Guangdong Higher Education Institutes Sino-German College of Intelligent ManufacturingShenzhen Technology UniversityShenzhenChina Han’s Laser Technology Industry Group Co. Ltd.ShenzhenChina Shenzhen Key Laboratory of Laser Engineering College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhenChina Shenzhen Key Laboratory of Ultraintense Laser and Advanced Material Technology College of Engineering PhysicsShenzhen Technology UniversityShenzhenChina

we present an effective approach to realize a highly efficient,high-power and chirped pulse amplification-free ultrafast ytterbium-doped yttrium aluminum garnet thin-disk regenerative amplifier pumped by a zero-phonon line 969 nm laser *** amplifier delivers an output power exceeding 154 w at a pulse repetition rate of 1 MHz with custom-designed 48 pump *** exceptional thermal management on the thin disk through high-quality bonding,efficient heat dissipation and a fully locked spectrum collectively contributes to achieving a remarkable optical-to-optical efficiency of 61%and a near-diffraction-limit beam quality with an M2 factor of *** the best of our knowledge,this represents the highest conversion efficiency reported in ultrafast thin-disk regenerative ***,the amplifier operates at room temperature and exhibits exceptional stability,with root mean square stability of less than 0.33%.This study significantly represents advances in the field of laser amplification systems,particularly in terms of efficiency and average *** advantageous combination of high efficiency and diffraction limitation positions the thin-disk regenerative amplifier as a promising solution for a wide range of scientific and industrial applications.

关键词： high efficiency high power picosecond laser regenerative amplifier thin-disk laser