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Efficacy and safety of extracorporeal shock wave therapy combined with sodium hyaluronate in treatment of knee osteoarthritis:a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2024年第2期44卷 243-250页

作者： ZHOU Mingwang DONG Zhuanli WEI Changhao FENG Lufang WANG Xiaoping LIU Haiping ji xing YANG Kehu LI Shenghua Department of Orthopaedics Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730050China Department of Quality Management Lanzhou Petrochemical General HospitalLanzhou 730050China Department of Orthopaedics Lanzhou Petrochemical General HospitalLanzhou 730050China Evidence-Based Social Science Research Center School of Public HealthLanzhou UniversityLanzhou730000China Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province Lanzhou 730000China Center for Translational Medicine Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730050China Department of Orthopaedics Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730000China

OBJECTIVE:To assess the efficacy and safety of extracorporeal shockwave therapy(ESWT)combined with sodium hyaluronate(HA)for the treatment of knee osteoarthritis(KOA).METHODS:PubM ed,Embase,the Cochrane Library,Web of Science,China National Knowledge Infrastructure,Wanfang database,China Science and Technology Journal Database,and SinoMed were searched from inception to July *** quality of the randomized controlled trials was evaluated independently by two reviewers according to the criteria in the Cochrane Collaboration for Systematic *** identified articles were then screened individually using EndnoteX9 for eligibility in this *** heterogeneity among the articles was evaluated using ***:A total of 17 studies,comprising 2000 individuals,were included in this *** results showed that a significant improvement was observed in knee pain and function based on the clinical efficacy of ESWT combined with *** analysis of clinical efficacy showed that[relative risk(RR)=1.21,95%confidence interval(CI)(1.12,1.30),P<0.01].Statistical analysis of visual analog scale showed that[standardized mean difference(SMD)=-2.84,95%CI(-4.01,-1.66),P<0.01].Western Ontario and McMaster University osteoarthritis index statistical analysis showed that[SMD=-1.57,95%CI(-2.52,-0.61),P<0.01].Lysholm score statistical analysis showed that[SMD=1.71,95%CI(0.98,2.44),P<0.01].In addition,only minor side effects,such as redness and swelling of the skin,were ***:Medium to low quality evidence showed that ESWT combined with HA offers an inexpensive,welltolerated,safe,and effective method to improve pain and functionality in patients with ***,tightly controlled,randomized,large multicenter trials are warranted to validate the current findings.

关键词： osteoarthritis knee randomized controlled trial extracorporeal shockwave therapy hyaluronic acid Meta-analysis

Clinical analysis of secondary penile cancer:a case series at a tertiary referral center in China

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Asian Journal of Andrology 2024年第2期26卷 225-226页

作者： Xiao-Yu Li Chun-Ru Xu xing ji Zhen-Peng Zhu Zhen-Ke Guo Tian-Yu Cai jian Lin Department of Urology Peking University First HospitalBeijing 100034China Institute of Urology Peking UniversityBeijing 100034China National Urological Cancer Center Beijing 100034China Beijing Key Laboratory of Urogenital Diseases(Male)Molecular Diagnosis and Treatment Center Beijing 100034China

Dear Editor,Secondary penile cancer is an extremely rare condition that refers to the metastasis of other malignancies to the *** are limited reports on secondary penile cancer in Asian populations,and perceptions about this disease are extremely *** reviewed and analyzed the data of patients diagnosed with secondary penile cancer based on the pathological findings at Peking University First Hospital in Beijing,China,aiming to expand the clinical reference for this rare disease.

关键词： cancer rare finding

因子von Neumann代数正锥上的凸序列积自同构

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数学学报（中文版） 2024年第3期67卷 521-530页

作者：卜浪梅吉国兴陕西师范大学数学与统计学院西安710119

设H是复Hilbert空间,M是H上维数大于1的因子von Neumann代数,M+是M的正锥.设λ∈[0,1],定义Ao_λ=λA1/2BA1/2+(1-λ)B1/2AB1/2,?A,B∈M+,称o_λ为M+上的凸序列积.本文证明了M+上的凸序列积自同构是由M的一个*-同构或*-反同构实现.

关键词：因子von Neumann代数正锥凸序列积自同构

Advanced Lung Adenocarcinoma with EGFR 19-del Mutation Transformed into SCC after EGFR-tyrosine Kinase inhibitors Treatment:A Case report

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World Journal of Clinical Cases 2024年第20期12卷 4405-4411页

作者： xing-Zu ji Zhong-Da Liu Yi-Ping Ye Quan Li Xiao-jing Liu Min-Hua Zhou Yi jin Department of Respiratory and Critical Care Medicine Lishui Hospital of Traditional Chinese MedicineLishui 323000Zhejiang ProvinceChina Traditional Chinese Medicine Oncology Lishui Hospital of Traditional Chinese MedicineLishui 323000Zhejiang ProvinceChina Department of Emergency Medicine Lishui People's HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND Epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)significantly improve the survival of patients with Epidermal growth factor receptor(EGFR)sensitive mutations in non-small cell lung cancer(NSCLC).CASE SUMMARY A 67-year-old female patient in advanced lung adenocarcinoma suffered from drug resistance after EGFR-TKIs *** pathological tissue biopsy confirmed squamous cell carcinoma(SCC)*** inevitably encountered drug resistance issues after receiving EGFR-TKIs treatment for a certain period of time,while EGFR-TKIs can significantly improve the survival of patients with EGFR-sensitive mutations in ***,EGFR-TKIs resistance includes primary and *** transformation is one of the mechanisms of acquired resistance in EGFR-TKIs,with SCC transformation being relatively *** results provide more detailed results of the patient’s diagnosis and treatment process on SCC transformation after EGFR-TKIs treatment for lung *** Squamous cell carcinoma transformation is one of the acquired resistance mechanisms of EGFR-TKIs in advanced lung adenocarcinoma with EGFR mutations.

关键词： Lung adenocarcinoma Squamous cell carcinoma Pathological histological transformation Epidermal growth factor receptor tyrosine kinase inhibitors Drug resistance Case report

The role of titanium at the interface of hematite photoanode in multisite mechanism:Reactive site or cocatalyst site?

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Chinese Journal of Catalysis 2024年第9期64卷 77-86页

作者： Minfei Xie xing ji Huaying Meng Nanbing jiang Zhenyu Luo Qianqian Huang Geng Sun Yunhuai Zhang Peng Xiao Chongqing Key Laboratory of Interface Physics in Energy Conversion College of PhysicsChongqing UniversityChongqing 401331China College of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China

Hematite(α-Fe_(2)O_(3))constitutes one of the most promising photoanode materials for oxygen evolution reaction(OER).Recent research on Fe_(2)O_(3)have found a fast OER rate dependence on surface hole density,suggesting a multisite reaction ***,the effect of heteroatom in Fe_(2)O_(3)on the multisite mechanism is still poorly *** we synthesized Fe_(2)O_(3)on Ti substrates(Fe_(2)O_(3)/Ti)to study the oxygen intermediates of OER by light-dark electrochemical *** identified the Fe-OH species disappeared and Ti-OH intermediates appeared on Fe_(2)O_(3)/Ti when pH=11‒14,which significantly improved the OER performance of Fe_(2)O_(3)/*** with the density functional theory calculations,we propose that Ti atom acts as cocatalyst site and captures proton from neighboring Fe-OH species under highly alkaline condition,thereby promoting the coupling of Fe=O and reducing the energy barrier of the non-electrochemical *** work provides a new insight into the role of heteroatom in OER multisite mechanism based on clarifying the reaction intermediates.

关键词： Hematite Oxygen evolution reaction Multisite mechanism Intermediate Proton capture

基于双步抽取的低资源中文工业领域术语抽取方法

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武汉大学学报（理学版） 2024年第3期70卷 329-340页

作者：邢季刘瑾张建伟上海工程技术大学电子电气学院上海201620

工业领域数据集由各类操作文档、维修文档、设备图纸,以及不断增加的工单和工作记录等数据组成。现有的通用术语抽取方法在中文情景下效果受限,同时先验资源的匮乏也导致了传统的监督学习流程难以实现,因此业内常见模型在工业垂直领域... 详细信息

工业领域数据集由各类操作文档、维修文档、设备图纸,以及不断增加的工单和工作记录等数据组成。现有的通用术语抽取方法在中文情景下效果受限,同时先验资源的匮乏也导致了传统的监督学习流程难以实现,因此业内常见模型在工业垂直领域术语抽取任务中的效果并不理想。为了解决上述问题,提出了一种基于预抽取和细化微调的双步抽取策略。在XLNet预训练模型的基础上,结合字符、字形和字音特征,增强了模型捕获语义信息的能力。采用LSTM编码器-解码器模型,生成含有错别字的负样本扩充数据集,旨在提升模型对噪音文本的鲁棒性。将本文方法应用于汽车工业领域,实验结果显示,本方法在该垂直领域的性能比现有传统方法提高了17%,充分证明了其有效性。

关键词：深度学习自然语言处理术语抽取低资源抽取 XLNet

Research on General-Purpose Brain-Inspired Computing Systems

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Journal of Computer Science & Technology 2024年第1期39卷 4-21页

作者：渠鹏纪兴龙陈嘉杰庞猛李宇晨刘晓义张悠慧 Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China Department of Precision Instrument Tsinghua UniversityBeijing 100084China

Brain-inspired computing is a new technology that draws on the principles of brain science and is oriented to the efficient development of artificial general intelligence(AGI),and a brain-inspired computing system is a hierarchical system composed of neuromorphic chips,basic software and hardware,and algorithms/applications that embody this *** the system is developing rapidly,it faces various challenges and opportunities brought by interdisciplinary research,including the issue of software and hardware *** paper analyzes the status quo of brain-inspired computing *** by some design principle and methodology of general-purpose computers,it is proposed to construct"general-purpose"brain-inspired computing systems.A general-purpose brain-inspired computing system refers to a brain-inspired computing hierarchy constructed based on the design philosophy of decoupling software and hardware,which can flexibly support various brain-inspired computing applications and neuromorphic chips with different ***,this paper introduces our recent work in these aspects,including the ANN(artificial neural network)/SNN(spiking neural network)development tools,the hardware agnostic compilation infrastructure,and the chip micro-archi-tecture with high flexibility of programming and high performance;these studies show that the"general-purpose"system can remarkably improve the efficiency of application development and enhance the productivity of basic software,thereby being conductive to accelerating the advancement of various brain-inspired algorithms and *** believe that this is the key to the collaborative research and development,and the evolution of applications,basic software and chips in this field,and conducive to building a favorable software/hardware ecosystem of brain-inspired computing.

关键词： brain-inspired computing neuromorphic chip compiler spiking neural network

基于MMC模型的Q460C高强结构钢延性断裂性能研究

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工程力学 2024年第9期41卷 179-190页

作者：陈爱国张佩雲蔺军邢佶慧北京交通大学土木建筑工程学院北京100044 结构风工程与城市风环境北京市重点实验室北京100044 深圳特区建工科工集团有限公司深圳518000

为研究Q460C高强结构钢的延性断裂性能,对处于不同应力状态的9个试件进行了单调加载断裂试验。采用修正加权平均(MWA)法获得了Q460C钢材直至断裂的全过程真实应力-真实应变曲线,通过编写MATLAB优化程序校准了VGM和MMC断裂预测模型的参... 详细信息

为研究Q460C高强结构钢的延性断裂性能,对处于不同应力状态的9个试件进行了单调加载断裂试验。采用修正加权平均(MWA)法获得了Q460C钢材直至断裂的全过程真实应力-真实应变曲线,通过编写MATLAB优化程序校准了VGM和MMC断裂预测模型的参数。借助VUMAT子程序将相关参数代入ABAQUS/Explicit求解器模拟各试件的断裂行为,评估了两种断裂模型对各试件断裂预测的相对精度。通过对已有文献中两个圆周缺口试件的断裂模拟,验证了该文校准的MMC模型参数对Q460钢断裂预测的普适性。研究结果表明:采用MMC模型进行数值模拟得到的荷载-位移响应与试验结果吻合度较好,尤其是对纯剪和剪拉试件的断裂模拟;带应力软化的MMC模型可准确且形象地再现各试件的起裂和裂缝扩展;该文校准的MMC断裂模型参数对Q460钢材断裂行为预测具有相对较好的适用性。

关键词：高强结构钢延性断裂应力状态应力软化裂纹扩展

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早期胚胎发育合子基因组激活调控

生物化学与生物物理进展 2024年第3期51卷 525-543页

作者：邢吉祥李寒霜李海成左永春内蒙古大学生命科学学院呼和浩特010070 内蒙古大学省部共建草原家畜生殖调控与繁育国家重点实验室呼和浩特010070

动物早期胚胎发育始于分化成熟的雌雄配子经受精后重编程为全能性合子。在胚胎发育的初期,合子基因组的转录水平处于静默状态,母源物质调控占据主导地位。随着胚胎发育的进行,母源物质会经历分阶段的降解,合子基因组开始逐渐激活转录,... 详细信息

动物早期胚胎发育始于分化成熟的雌雄配子经受精后重编程为全能性合子。在胚胎发育的初期,合子基因组的转录水平处于静默状态,母源物质调控占据主导地位。随着胚胎发育的进行,母源物质会经历分阶段的降解,合子基因组开始逐渐激活转录,标志着早期胚胎发育从母源性调控向合子基因组调控的转变,也称为母源-合子转换(maternal-zygotic transition,MZT)。其中一个关键的转折性事件就是合子基因组激活(zygotic genome activation,ZGA),ZGA的正确发生对于早期胚胎发育和细胞命运决定至关重要。然而,目前对于ZGA的调控因子和具体的分子机制仍知之甚少。研究表明,ZGA在不同物种中存在较大差异,可能受到DNA甲基化、组蛋白修饰、非编码RNA、染色质重塑以及ZGA相关因子等多种调控因素的影响。本文探讨了上述几种调控因素影响合子基因组激活的研究进展,对进一步研究早期胚胎ZGA的相关机制具有借鉴意义。

关键词：母源-合子转换合子基因组激活 DNA甲基化组蛋白变体组蛋白修饰